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Sensors located at more central body positions may be more accurate as these as less prone to Raynaud attacks. To determine the validity and reliability of the SpO<jats:sub>2<\/jats:sub> measured at the finger, forehead, and earlobe during the 6-Minute Walk Test (6MWT). Eighty two patients with SSc had an arterial line placed while performing the 6MWT. Peripheral oxygen saturation was simultaneously measured by finger, forehead, and earlobe sensors and compared to the arterial oxygen saturation (SaO<jats:sub>2<\/jats:sub>) measured before and after the 6MWT. 40 patients repeated the 6MWT one week later to determine re-test reliability. We used Bland\u2013Altman plots to display the agreement between SpO<jats:sub>2<\/jats:sub> and SaO<jats:sub>2<\/jats:sub>. The intraclass correlation coefficient for repeated measurement of minimum SpO<jats:sub>2<\/jats:sub> was calculated. The mean difference between SpO2 and SaO2 after the 6MWT was \u2212\u00a03% (SD:\u2009\u00b1\u20095), 0% (SD:\u2009\u00b1\u20092), and 1% (SD:\u2009\u00b1\u20092) for the finger, forehead, and earlobe, respectively. The minimum SpO<jats:sub>2<\/jats:sub> measured at the finger demonstrated the poorest re-test reliability: The ICC (95% CI) showed good agreement using the ear and forehead probe (ICC<jats:sub>ear<\/jats:sub>\u2009=\u20090.89 [95% CI 0.80; 0.94]; ICC<jats:sub>forehead<\/jats:sub>\u2009=\u20090.77 [95% CI 0.60; 0.87]), while a modest reliability was found using the finger probe (ICC<jats:sub>finger<\/jats:sub>\u2009=\u20090.65 95% CI [0.43; 0.80]). SpO<jats:sub>2<\/jats:sub> should be measured using either the earlobe or forehead during the 6MWT in patients with SSc. Clinical Trials.Gov (NCT04650659).<\/jats:p>","DOI":"10.1007\/s00296-024-05532-5","type":"journal-article","created":{"date-parts":[[2024,2,10]],"date-time":"2024-02-10T11:02:10Z","timestamp":1707562930000},"page":"611-620","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Validity and reliability of measurement of peripheral oxygen saturation during the 6-Minute Walk Test in patients with systemic sclerosis"],"prefix":"10.1007","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6802-432X","authenticated-orcid":false,"given":"Amanda Lynggaard","family":"Elkj\u00e6r","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8185-9666","authenticated-orcid":false,"given":"Esben Uggerby","family":"N\u00e6ser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9096-2489","authenticated-orcid":false,"given":"Katja Thorup","family":"Aaen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6447-1790","authenticated-orcid":false,"given":"Henrik Lynge","family":"Hovgaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1951-9091","authenticated-orcid":false,"given":"Peter","family":"Juhl-Olsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4238-6963","authenticated-orcid":false,"given":"Elisabeth","family":"Bendstrup","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8357-2789","authenticated-orcid":false,"given":"Klaus","family":"S\u00f8ndergaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,10]]},"reference":[{"key":"5532_CR1","doi-asserted-by":"publisher","first-page":"1809","DOI":"10.1136\/ard.2009.114264","volume":"69","author":"AJ Tyndall","year":"2010","unstructured":"Tyndall AJ, Bannert B, Vonk M et al (2010) Causes and risk factors for death in systemic sclerosis: A study from the EULAR Scleroderma Trials and Research (EUSTAR) database. 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HL Hovgaard reports unrestricted research grant from Aarhus University and the Novo Nordisk Foundation; travel support from Aarhus University. K S\u00f8ndergaard reports unrestricted research grants from Boehringer Ingelheim and the Danish Rheumatism Association. K S\u00f8ndergaard also reports consultant and lecturing fees from Boehringer Ingelheim; travel fees from UCB. E Bendstrup reports lecture fees from Boehringer Ingelheim, Daiichi-Sankyo, and Astra Zeneca. E Bendstrup also reports; travel and congress, and consulting fees from Boehringer Ingelheim. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"The research project was approved by the Central Denmark Region Committees on Health Research Ethics (1-10-72-203-20) and listed in the Central Denmark Region register of internal research projects (1-16-02-270-20). ClinicalTrials.gov identifier: NCT04650659.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}}]}}