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The present investigation encompassed a total of 88 pregnancies seen in a cohort of 35 patients who met the criteria outlined by the American College of Rheumatology in 1990 for the classification of Takayasu arteritis (TA). Pregnancies were classified into two categories. 1. Pregnancies that occurred before the diagnosis (pre-d or pre-TA) 2. Pregnancies that happened following a diagnosis (post-d or post-TA). Fifty-nine pregnancies (67.0%) occurred in 21 TA patients before the diagnosis with and a complication rate of 15.2%, and twenty-nine pregnancies (33.0%) occurred in 14 patients concomitant with or after TA diagnosis and complication rate 100%. Although the hypertension rate was higher in the pre-d group than in the post-d group, it was not significant (32.2% vs. 10.3%, <jats:italic>p<\/jats:italic>\u2009=\u20090.160). However, preeclampsia (20.6% vs. 0%, <jats:italic>p<\/jats:italic>\u2009=\u20090.001), low birth weight (27.5% vs. 1.6%, <jats:italic>p\u2009<\/jats:italic>=\u20090.001), and prematurity (24.1% vs. 1.6%, <jats:italic>p<\/jats:italic>\u2009=\u20090.035) were observed more frequently in the post-d group compared to the pre-d group. The frequency of abortions and in-utero deaths were similar in both groups (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05). Patients with hypertension had significantly higher rates of preeclampsia (<jats:italic>p<\/jats:italic>\u2009=\u20090.003), preterm birth (<jats:italic>p<\/jats:italic>\u2009=\u20090.036), low birth weight (<jats:italic>p<\/jats:italic>\u2009=\u20090.250), abortion (<jats:italic>p<\/jats:italic>\u2009=\u20090.018), in utero death (<jats:italic>p<\/jats:italic>\u2009=\u20090.128), and cesarean section (<jats:italic>p<\/jats:italic>\u2009=\u20090.005) than those without hypertension. Renal artery involvement was detected in 15 (42.8%) patients. All patients with renal artery involvement had hypertension, and they had significantly more pregnancy complications than the other group (<jats:italic>p<\/jats:italic>\u2009=\u20090.001). TA negatively affects pregnancy outcomes. A good control of arterial hypertension before conception and during pregnancy is critical to improve both maternal and fetal outcomes. In addition, detecting renal artery stenosis before pregnancy is important in reducing possible negative pregnancy outcomes.<\/jats:p>","DOI":"10.1007\/s00296-024-05538-z","type":"journal-article","created":{"date-parts":[[2024,2,16]],"date-time":"2024-02-16T10:02:32Z","timestamp":1708077752000},"page":"1111-1117","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Poor obstetric outcomes in women with takayasu arteritis: a retrospective cohort study"],"prefix":"10.1007","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0402-1525","authenticated-orcid":false,"given":"Erdal","family":"Bodak\u00e7i","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6543-3905","authenticated-orcid":false,"given":"D\u00f6nd\u00fc \u00dcsk\u00fcdar","family":"Cansu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2679-0699","authenticated-orcid":false,"given":"Cengiz","family":"Korkmaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,16]]},"reference":[{"key":"5538_CR1","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.jaut.2014.01.012","volume":"48\u201349","author":"AWS De Souza","year":"2014","unstructured":"De Souza AWS, de Carvalho JF (2014) Diagnostic and classification criteria of takayasu arteritis. 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All patients provided written informed consent.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical statement"}},{"value":"The authors declare that this review or its part has not been copied or published before in whole or in part and that it is not under consideration for publication anywhere else.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}