{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T12:08:14Z","timestamp":1748002094015,"version":"3.37.3"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2024,3,10]],"date-time":"2024-03-10T00:00:00Z","timestamp":1710028800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,3,10]],"date-time":"2024-03-10T00:00:00Z","timestamp":1710028800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Rheumatol Int"],"DOI":"10.1007\/s00296-024-05559-8","type":"journal-article","created":{"date-parts":[[2024,3,10]],"date-time":"2024-03-10T15:01:40Z","timestamp":1710082900000},"page":"955-959","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Statin-induced immune-mediated necrotizing myopathy with concomitant increase of anti-HMGCR and anti-ACHR antibodies"],"prefix":"10.1007","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2095-1084","authenticated-orcid":false,"given":"Razmig","family":"Garabet","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjeev","family":"Herr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"Griffin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuruganti","family":"Reddy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,3,10]]},"reference":[{"issue":"7","key":"5559_CR1","doi-asserted-by":"publisher","first-page":"64","DOI":"10.3389\/fneur.2016.00064","volume":"20","author":"A Malik","year":"2016","unstructured":"Malik A, Hayat G, Kalia JS, Guzman MA (2016) Idiopathic inflammatory myopathies: clinical approach and management. Front Neurol 20(7):64. https:\/\/doi.org\/10.3389\/fneur.2016.00064","journal-title":"Front Neurol"},{"issue":"4","key":"5559_CR2","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1007\/s11926-018-0732-6","volume":"20","author":"I Pinal-Fernandez","year":"2018","unstructured":"Pinal-Fernandez I, Casal-Dominguez M, Mammen AL (2018) Immune-mediated necrotizing myopathy. Curr Rheumatol Rep 20(4):21. https:\/\/doi.org\/10.1007\/s11926-018-0732-6","journal-title":"Curr Rheumatol Rep"},{"issue":"3","key":"5559_CR3","doi-asserted-by":"publisher","first-page":"e5694","DOI":"10.1097\/MD.0000000000005694","volume":"96","author":"Y Troyanov","year":"2017","unstructured":"Troyanov Y, Landon-Cardinal O, Fritzler MJ, Ferreira J, Targoff IN, Rich E, Goulet M, Goulet JR, Bourr\u00e9-Tessier J, Robitaille Y, Drouin J, Albert A, Sen\u00e9cal JL (2017) Atorvastatin-induced necrotizing autoimmune myositis: an emerging dominant entity in patients with autoimmune myositis presenting with a pure polymyositis phenotype. Medicine (Baltimore) 96(3):e5694. https:\/\/doi.org\/10.1097\/MD.0000000000005694","journal-title":"Medicine (Baltimore)"},{"key":"5559_CR4","doi-asserted-by":"publisher","first-page":"874680","DOI":"10.1155\/2012\/874680","volume":"2012","author":"A JayamTrouth","year":"2012","unstructured":"JayamTrouth A, Dabi A, Solieman N, Kurukumbi M, Kalyanam J (2012) Myasthenia gravis: a review. Autoimmune Dis 2012:874680. https:\/\/doi.org\/10.1155\/2012\/874680","journal-title":"Autoimmune Dis"},{"issue":"5","key":"5559_CR5","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1586\/eci.12.34","volume":"8","author":"MN Meriggioli","year":"2012","unstructured":"Meriggioli MN, Sanders DB (2012) Muscle autoantibodies in myasthenia gravis: beyond diagnosis? Expert Rev Clin Immunol 8(5):427\u2013438. https:\/\/doi.org\/10.1586\/eci.12.34","journal-title":"Expert Rev Clin Immunol"},{"issue":"8","key":"5559_CR6","doi-asserted-by":"publisher","first-page":"1736","DOI":"10.3390\/jcm10081736","volume":"10","author":"RT Rousseff","year":"2021","unstructured":"Rousseff RT (2021) Diagnosis of myasthenia gravis. J Clin Med 10(8):1736. https:\/\/doi.org\/10.3390\/jcm10081736","journal-title":"J Clin Med"},{"issue":"5","key":"5559_CR7","doi-asserted-by":"publisher","first-page":"e03925","DOI":"10.1002\/ccr3.3925","volume":"9","author":"E Frasson","year":"2021","unstructured":"Frasson E, Simonetto M, Bertolasi L, Caneve G, Vilotti C, Ruzza G, Perelli A, Piccinno MG, Monaco S (2021) Statin-associated necrotizing autoimmune myopathy with concurrent myasthenia gravis. Clin Case Rep 9(5):e03925. https:\/\/doi.org\/10.1002\/ccr3.3925","journal-title":"Clin Case Rep"},{"issue":"4","key":"5559_CR8","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1111\/j.1582-4934.2001.tb00172.x","volume":"5","author":"C Stancu","year":"2001","unstructured":"Stancu C, Sima A (2001) Statins: mechanism of action and effects. J Cell Mol Med 5(4):378\u2013387. https:\/\/doi.org\/10.1111\/j.1582-4934.2001.tb00172.x","journal-title":"J Cell Mol Med"},{"issue":"15","key":"5559_CR9","doi-asserted-by":"publisher","first-page":"8364","DOI":"10.3390\/ijms23158364","volume":"23","author":"S Attardo","year":"2022","unstructured":"Attardo S, Musumeci O, Velardo D, Toscano A (2022) Statins neuromuscular adverse effects. Int J Mol Sci 23(15):8364. https:\/\/doi.org\/10.3390\/ijms23158364","journal-title":"Int J Mol Sci"},{"issue":"4","key":"5559_CR10","first-page":"257","volume":"37","author":"L Villa","year":"2018","unstructured":"Villa L, Lerario A, Calloni S, Peverelli L, Matinato C, De Liso F, Ceriotti F, Tironi R, Sciacco M, Moggio M, Triulzi F, Cinnante C (2018) Immune-mediated necrotizing myopathy due to statins exposure. Acta Myol 37(4):257\u2013262","journal-title":"Acta Myol"},{"issue":"6","key":"5559_CR11","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1038\/nrneurol.2011.63","volume":"7","author":"AL Mammen","year":"2011","unstructured":"Mammen AL (2011) Autoimmune myopathies: autoantibodies, phenotypes and pathogenesis. Nat Rev Neurol 7(6):343\u2013354. https:\/\/doi.org\/10.1038\/nrneurol.2011.63","journal-title":"Nat Rev Neurol"},{"issue":"1","key":"5559_CR12","doi-asserted-by":"publisher","first-page":"11","DOI":"10.3233\/JND-170282","volume":"5","author":"P Mohassel","year":"2018","unstructured":"Mohassel P, Mammen AL (2018) Anti-HMGCR myopathy. J Neuromuscul Dis 5(1):11\u201320. https:\/\/doi.org\/10.3233\/JND-170282","journal-title":"J Neuromuscul Dis"},{"issue":"3","key":"5559_CR13","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1080\/1744666X.2018.1440206","volume":"14","author":"A Selva-O'Callaghan","year":"2018","unstructured":"Selva-O\u2019Callaghan A, Alvarado-Cardenas M, Pinal-Fern\u00e1ndez I, Trallero-Aragu\u00e1s E, Milisenda JC, Mart\u00ednez M\u00c1, Mar\u00edn A, Labrador-Horrillo M, Ju\u00e1rez C, Grau-Junyent JM (2018) Statin-induced myalgia and myositis: an update on pathogenesis and clinical recommendations. Expert Rev Clin Immunol 14(3):215\u2013224. https:\/\/doi.org\/10.1080\/1744666X.2018.1440206. (Epub 2018 Feb 23)","journal-title":"Expert Rev Clin Immunol"},{"issue":"2022","key":"5559_CR14","doi-asserted-by":"publisher","first-page":"4647227","DOI":"10.1155\/2022\/4647227","volume":"31","author":"AI Joudeh","year":"2022","unstructured":"Joudeh AI, Albuni MK, Hassen SS, Iqbal P, Aziz Bedair EM, Mahdi S (2022) A case report of statin-induced immune-mediated necrotizing myopathy treatment challenges. Case Rep Rheumatol 31(2022):4647227. https:\/\/doi.org\/10.1155\/2022\/4647227","journal-title":"Case Rep Rheumatol"},{"issue":"4","key":"5559_CR15","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1186\/1752-1947-4-61","volume":"20","author":"MJ Keogh","year":"2010","unstructured":"Keogh MJ, Findlay JM, Leach S, Bowen J (2010) Statin-associated weakness in myasthenia gravis: a case report. J Med Case Rep 20(4):61. https:\/\/doi.org\/10.1186\/1752-1947-4-61","journal-title":"J Med Case Rep"},{"issue":"4","key":"5559_CR16","first-page":"169","volume":"89","author":"TM Roy","year":"1991","unstructured":"Roy TM, Walker JF, Farrow JR (1991) Respiratory failure associated with myasthenia gravis. J Ky Med Assoc 89(4):169\u2013173","journal-title":"J Ky Med Assoc"},{"issue":"4","key":"5559_CR17","doi-asserted-by":"publisher","first-page":"e7498","DOI":"10.7759\/cureus.7498","volume":"12","author":"E Ranjit","year":"2020","unstructured":"Ranjit E, Sapra A, Etherton A, Wasey W, Bhandari P (2020) \u201cShawl Sign\u201d as a paraneoplastic dermatosis. Cureus 12(4):e7498. https:\/\/doi.org\/10.7759\/cureus.7498","journal-title":"Cureus"},{"key":"5559_CR18","doi-asserted-by":"publisher","unstructured":"Merlant M, Fite C, Kottler D, Maisonobe L, Dossier A, Deschamps L, Descamps V (2019) Myopathie n\u00e9crosante auto-immune \u00e0 anticorps anti-HMGCR induite par les statines et r\u00e9v\u00e9l\u00e9e par un tableau \u00e9vocateur de dermatomyosite [Dermatomyositis-like syndrome revealing statin-induced necrotizing autoimmune myopathy with anti-HMGCR antibodies]. Ann Dermatol Venereol 146(8\u20139):550\u2013556. https:\/\/doi.org\/10.1016\/j.annder.2018.12.010(Epub 2019 Mar 29)","DOI":"10.1016\/j.annder.2018.12.010"},{"issue":"10","key":"5559_CR19","doi-asserted-by":"publisher","first-page":"513","DOI":"10.14740\/jmc4010","volume":"13","author":"Y Akivis","year":"2022","unstructured":"Akivis Y, Kurup M, John S (2022) Statin-induced necrotizing autoimmune myositis. J Med Cases 13(10):513\u2013516. https:\/\/doi.org\/10.14740\/jmc4010. (Epub 2022 Oct 31)","journal-title":"J Med Cases"},{"issue":"4","key":"5559_CR20","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1007\/s11739-023-03278-9","volume":"18","author":"CM Gagliardo","year":"2023","unstructured":"Gagliardo CM, Noto D, Giammanco A, Maltese S, Vecchio L, Lavatura G, Cacciatore V, Barbagallo CM, Ganci A, Nardi E, Ciaccio M, Lo Presti R, Cefal\u00f9 AB, Averna M (2023) Statin-induced autoimmune myositis: a proposal of an \u201cexperience-based\u201d diagnostic algorithm from the analysis of 69 patients. Intern Emerg Med 18(4):1095\u20131107. https:\/\/doi.org\/10.1007\/s11739-023-03278-9. (Epub 2023 May 5)","journal-title":"Intern Emerg Med"},{"issue":"9","key":"5559_CR21","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1001\/jamaneurol.2015.1207","volume":"72","author":"CD Kassardjian","year":"2015","unstructured":"Kassardjian CD, Lennon VA, Alfugham NB, Mahler M, Milone M (2015) Clinical features and treatment outcomes of necrotizing autoimmune myopathy. JAMA Neurol 72(9):996\u20131003. https:\/\/doi.org\/10.1001\/jamaneurol.2015.1207","journal-title":"JAMA Neurol"},{"issue":"7","key":"5559_CR22","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1056\/NEJMra1515161","volume":"374","author":"AL Mammen","year":"2016","unstructured":"Mammen AL (2016) Statin-associated autoimmune myopathy. N Engl J Med 374(7):664\u2013669. https:\/\/doi.org\/10.1056\/NEJMra1515161","journal-title":"N Engl J Med"},{"issue":"1","key":"5559_CR23","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/s13075-019-2093-6","volume":"22","author":"A Meyer","year":"2020","unstructured":"Meyer A, Troyanov Y, Drouin J, Oligny-Longpr\u00e9 G, Landon-Cardinal O, Hoa S, Hervier B, Bourr\u00e9-Tessier J, Mansour AM, Hussein S, Morin V, Rich E, Goulet JR, Chartrand S, Hudson M, Nehme J, Makhzoum JP, Zarka F, Villeneuve E, Raynauld JP, Landry M, O\u2019Ferrall EK, Ferreira J, Ellezam B, Karamchandani J, Larue S, Massie R, Isabelle C, Desch\u00eanes I, Leclair V, Couture H, Targoff IN, Fritzler MJ, Sen\u00e9cal JL (2020) Statin-induced anti-HMGCR myopathy: successful therapeutic strategies for corticosteroid-free remission in 55 patients. Arthritis Res Ther 22(1):5. https:\/\/doi.org\/10.1186\/s13075-019-2093-6","journal-title":"Arthritis Res Ther"}],"container-title":["Rheumatology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00296-024-05559-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00296-024-05559-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00296-024-05559-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,30]],"date-time":"2024-03-30T04:27:50Z","timestamp":1711772870000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00296-024-05559-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,10]]},"references-count":23,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2024,5]]}},"alternative-id":["5559"],"URL":"https:\/\/doi.org\/10.1007\/s00296-024-05559-8","relation":{},"ISSN":["1437-160X"],"issn-type":[{"type":"electronic","value":"1437-160X"}],"subject":[],"published":{"date-parts":[[2024,3,10]]},"assertion":[{"value":"13 January 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 February 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 March 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no conflict of interest to declare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The authors confirm that they have no funding, financial relationships, or other conflicts of interest to declare. No financial support was received for this study. All authors have reviewed and approved this manuscript for submission. Written informed consent was obtained by the patient to publish the case for research purposes.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical standards"}},{"value":"Written informed consent was obtained from the patient for publication of this report.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}}]}}