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For each patient, 1\u20133 randomly selected controls from the Population Register Centre were matched. Data regarding pregnancies were obtained from the Finnish Medical Birth Register, Care Register and Register of Congenital Malformations until 2018. The study utilized data from the Drug Purchase Register and educational information from Statistic Finland.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>A total of 163 deliveries for 103 mothers with SLE and 580 deliveries for 371 population controls were identified. The duration of pregnancies in SLE women was significantly shorter compared to controls (38.9 versus 39.6\u00a0weeks). There were more urgent Caesarean Sections.\u00a0(15% versus 9%) and need for care at neonatal intensive care unit (NICU) (21% versus 11%) among deliveries in SLE mothers. No statistical difference was observed between SLE and control groups in the occurrence of preeclampsia or major congenital malformations. Gestational age was 2.5\u00a0weeks shorter when the mother experienced pre-eclampsia. Hydroxychloroquine was purchased by 30% of SLE mothers during pregnancy.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>The course of pregnancies in Finnish SLE patients seems to be quite moderate compared to controls, and no new safety issues were detected. The low utilization of hydroxychloroquine indicates that the benefits of the drug to pregnancy and disease course are not optimally recognized by specialists treating SLE mothers.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00296-024-05564-x","type":"journal-article","created":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T17:03:13Z","timestamp":1712077393000},"page":"1101-1109","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Pregnancies in patients with systemic lupus erythematosus during 2000\u20132018 in Finland: a case\u2013control study"],"prefix":"10.1007","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9885-7242","authenticated-orcid":false,"given":"Pia","family":"Elfving","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8355-0531","authenticated-orcid":false,"given":"Simo","family":"Kariniemi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0786-0858","authenticated-orcid":false,"given":"Hannu","family":"Kautiainen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7470-3070","authenticated-orcid":false,"given":"Vappu","family":"Rantalaiho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6909-3178","authenticated-orcid":false,"given":"Lauri J.","family":"Virta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1307-7421","authenticated-orcid":false,"given":"Kari","family":"Puolakka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1848-1514","authenticated-orcid":false,"given":"Merja K.","family":"Laine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,4,2]]},"reference":[{"key":"5564_CR1","doi-asserted-by":"publisher","first-page":"2310","DOI":"10.1177\/09612033211061478","volume":"30","author":"V Erazo-Mart\u00ednez","year":"2021","unstructured":"Erazo-Mart\u00ednez V, Nieto-Aristizabal I, Ojeda I, Gonz\u00e1lez M, Aragon C, Zambrano M et al (2021) Systemic lupus erythematosus and pregnancy outcomes in a Columbian cohort. 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The authors report the following financial activities outside the submitted work: H.K., L.J.V., K.P. and M.J.K. have no competing interests. P.E. has been on advisory board for Astra Zeneca and Otsuka, has received lecture fees from Abbvie and reimbursement of training and congress costs from Abbvie and received a research grant from the Finnish Cultural Foundation, North Savo Regional fund and the Research Committee of the Kuopio University Hospital Catchment Area for the State Research Funding. V.R. has received a lecture fee from Novartis and Viatris, reimbursement of training and congress costs from Abbvie and Pfizer and received BMS Research grant for Nord-Star trial, received a research grant from the Research Committee of the Tampere and Tavastia Catchment Area for the State Research Funding. S.K. has received reimbursement of training and congress costs from Abbvie, Medac and UCB and received a research grant from the Finnish Rheumatic Disease Research Foundation, the Maire Lisko Foundation and\u00a0the Research Committee of the Kuopio University Hospital Catchment Area for the State Research Funding.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interests"}}]}}