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Borrelia\u2019s structural adaptations and ability to persist in diverse host tissues underscore its pathogenic potential. Beyond traditional infectious responses, Borrelia engages in complex interactions with the host immune system, contributing to autoimmune mechanisms such as molecular mimicry and persistent infections. This intricate interplay manifests in symptoms resembling various autoimmune diseases, including systemic lupus erythematosus, dermatomyositis, local scleroderma, and systemic sclerosis. However, these associations lack a precise explanation, emphasizing the need for further investigation. The cases of misdiagnosis between Lyme borreliosis and autoimmune diseases highlight the critical importance of accurate diagnostics and adherence to guidelines. Understanding Borrelia\u2019s impact on immune responses is pivotal for advancing diagnostics and targeted therapeutic interventions in Lyme borreliosis and its potential autoimmune implications.<\/jats:p>","DOI":"10.1007\/s00296-024-05580-x","type":"journal-article","created":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T12:02:07Z","timestamp":1712318527000},"page":"2265-2271","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Borrelia burgdorferi and autoimmune mechanisms: implications for mimicry, misdiagnosis, and mismanagement in Lyme disease and autoimmune disorders"],"prefix":"10.1007","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1650-8928","authenticated-orcid":false,"given":"Bohdana","family":"Doskaliuk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4188-8486","authenticated-orcid":false,"given":"Olena","family":"Zimba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,4,5]]},"reference":[{"issue":"10","key":"5580_CR1","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.3390\/biology10101036","volume":"10","author":"G Trevisan","year":"2021","unstructured":"Trevisan G, Cinco M, Trevisini S et al (2021) Borreliae part 1: Borrelia Lyme group and echidna-reptile group. 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