{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T10:23:10Z","timestamp":1787998990802,"version":"build-2784847793"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2024,8,21]],"date-time":"2024-08-21T00:00:00Z","timestamp":1724198400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,8,21]],"date-time":"2024-08-21T00:00:00Z","timestamp":1724198400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100008349","name":"Boehringer Ingelheim","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008349","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Universit\u00e4tsklinikum Bonn"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Rheumatol Int"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Objectives<\/jats:title>\n                <jats:p>This cross-sectional study aimed to determine the prevalence, manifestation, and risk factors of pulmonary involvement in newly diagnosed, untreated rheumatoid arthritis (RA) and psoriatic arthritis (PsA) patients, and to evaluate the efficacy of various diagnostic tools in screening for pulmonary involvement.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Untreated, newly diagnosed patients with RA and PsA underwent an extensive multimodal diagnostic approach including clinical and laboratory assessment, pulmonary function tests, and chest radiography.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>We recruited 50 arthritis patients (26 RA, 24 PsA) and 26 control subjects. Respiratory symptoms were found in 36.0 % of arthritis patients and 11.5 % of controls (p = 0.031). Pathologically reduced breathing width (&lt; 3.0 cm) was significantly more common in arthritis patients (64.0 %) than in controls (23.1 %) (p &lt; 0.001). Pulmonary function test results did not differ significantly between groups. Chest radiography revealed pulmonary involvement in 37.0 % of arthritis patients, higher in RA (50.0 %) than in PsA (22.7 %). Notably, only 35.3 % of arthritis patients with radiographic pulmonary involvement were symptomatic, with 64.7 % being asymptomatic. Radiographic pulmonary involvement was associated with advanced age (p = 0.002) and increased rheumatoid factor levels (p = 0.024).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Our research underscores the significant prevalence of largely asymptomatic pulmonary involvement in newly diagnosed RA and PsA patients. These findings highlight the importance of an early, multidisciplinary screening approach, particularly for high-risk individuals. Further large-scale studies are needed to develop comprehensive screening protocols to improve early detection and treatment of pulmonary involvement in arthritis.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00296-024-05685-3","type":"journal-article","created":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T13:14:02Z","timestamp":1724332442000},"page":"1975-1986","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Exploring pulmonary involvement in newly diagnosed rheumatoid arthritis, and psoriatic arthritis: a single center study"],"prefix":"10.1007","volume":"44","author":[{"given":"Valentin Sebastian","family":"Sch\u00e4fer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lone","family":"Winter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Skowasch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus-J\u00fcrgen","family":"Bauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Pizarro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel","family":"Weber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"K\u00fctting","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Behning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Brossart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4686-1143","authenticated-orcid":false,"given":"Simon Michael","family":"Petzinna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,8,21]]},"reference":[{"key":"5685_CR1","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1016\/j.berh.2016.10.004","volume":"30","author":"C Kelly","year":"2016","unstructured":"Kelly C, Iqbal K, Iman-Gutierrez L, Evans P, Manchegowda K (2016) Lung involvement in inflammatory rheumatic diseases. Best Pract Res Clin Rheumatol 30:870\u2013888. https:\/\/doi.org\/10.1016\/j.berh.2016.10.004","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"5685_CR2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-68888-6_9","author":"M Jani","year":"2017","unstructured":"Jani M, Dixon WG, Matteson EL (2017) Management of the rheumatoid arthritis patient with interstitial lung disease. Lung Dis Rheum Arthritis. https:\/\/doi.org\/10.1007\/978-3-319-68888-6_9","journal-title":"Lung Dis Rheum Arthritis"},{"key":"5685_CR3","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1136\/annrheumdis-2016-209233","volume":"75","author":"A Baillet","year":"2016","unstructured":"Baillet A, Gossec L, Carmona L, de Wit M, van Eijk-Hustings Y, Bertheussen H et al (2016) Points to consider for reporting, screening for and preventing selected comorbidities in chronic inflammatory rheumatic diseases in daily practice: a EULAR initiative. Ann Rheum Dis 75:965\u2013973. https:\/\/doi.org\/10.1136\/annrheumdis-2016-209233","journal-title":"Ann Rheum Dis"},{"key":"5685_CR4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-3-319-68888-6_1","volume-title":"Lung disease in rheumatoid arthritis","author":"S West","year":"2018","unstructured":"West S (2018) Clinical overview of rheumatoid arthritis. In: Fischer A, Lee JS (eds) Lung disease in rheumatoid arthritis. Springer International Publishing, Cham, pp 1\u201318. https:\/\/doi.org\/10.1007\/978-3-319-68888-6_1"},{"key":"5685_CR5","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1007\/978-3-319-68888-6_4","volume-title":"The epidemiology of rheumatoid arthritis-associated lung disease","author":"M Kristen Demoruelle","year":"2018","unstructured":"Kristen Demoruelle M, Olson AL, Solomon JJ (2018) The epidemiology of rheumatoid arthritis-associated lung disease. Springer International Publishing, Cham, pp 45\u201358. https:\/\/doi.org\/10.1007\/978-3-319-68888-6_4"},{"key":"5685_CR6","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1007\/s00296-006-0234-0","volume":"27","author":"F Kanat","year":"2007","unstructured":"Kanat F, Levendoglu F, Teke T (2007) Radiological and functional assessment of pulmonary involvement in the rheumatoid arthritis patients. Rheumatol Int 27:459\u2013466. https:\/\/doi.org\/10.1007\/s00296-006-0234-0","journal-title":"Rheumatol Int"},{"key":"5685_CR7","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/406927","volume":"2013","author":"J Chen","year":"2013","unstructured":"Chen J, Shi Y, Wang X, Huang H, Ascherman D (2013) Asymptomatic preclinical rheumatoid arthritis-associated interstitial lung disease. Clin Dev Immunol 2013:406927. https:\/\/doi.org\/10.1155\/2013\/406927","journal-title":"Clin Dev Immunol"},{"key":"5685_CR8","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1016\/j.ccm.2019.05.003","volume":"40","author":"AJ Esposito","year":"2019","unstructured":"Esposito AJ, Chu SG, Madan R, Doyle TJ, Dellaripa PF (2019) Thoracic manifestations of rheumatoid arthritis. Clin Chest Med 40:545\u2013560. https:\/\/doi.org\/10.1016\/j.ccm.2019.05.003","journal-title":"Clin Chest Med"},{"key":"5685_CR9","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1007\/s00330-003-2026-1","volume":"14","author":"J Biederer","year":"2004","unstructured":"Biederer J, Schnabel A, Muhle C, Gross WL, Heller M, Reuter M (2004) Correlation between HRCT findings, pulmonary function tests and bronchoalveolar lavage cytology in interstitial lung disease associated with rheumatoid arthritis. Eur Radiol 14:272\u2013280. https:\/\/doi.org\/10.1007\/s00330-003-2026-1","journal-title":"Eur Radiol"},{"key":"5685_CR10","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1007\/978-3-319-68888-6_8","volume-title":"Rheumatoid arthritis-associated interstitial lung disease","author":"J Morisset","year":"2018","unstructured":"Morisset J, Lee JS (2018) Rheumatoid arthritis-associated interstitial lung disease. Springer International Publishing, Cham, pp 109\u2013119. https:\/\/doi.org\/10.1007\/978-3-319-68888-6_8"},{"key":"5685_CR11","doi-asserted-by":"publisher","first-page":"17","DOI":"10.2174\/1573397116666200905122757","volume":"17","author":"D Dejcman","year":"2021","unstructured":"Dejcman D, Skowasch D, Pizarro C, Krause A, Thomas D, Sch\u00e4fer VS (2021) Pulmonary manifestations of rheumatoid arthritis, psoriatic arthritis and peripheral spondyloarthritis: prevalence, diagnostic approach and treatment options. Curr Rheumatol Rev 17:17\u201328. https:\/\/doi.org\/10.2174\/1573397116666200905122757","journal-title":"Curr Rheumatol Rev"},{"key":"5685_CR12","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1080\/03009740310004621","volume":"33","author":"C Turesson","year":"2004","unstructured":"Turesson C, Jacobsson LTH (2004) Epidemiology of extra-articular manifestations in rheumatoid arthritis. Scand J Rheumatol 33:65\u201372. https:\/\/doi.org\/10.1080\/03009740310004621","journal-title":"Scand J Rheumatol"},{"key":"5685_CR13","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1136\/ard.62.8.722","volume":"62","author":"C Turesson","year":"2003","unstructured":"Turesson C, O\u2019Fallon WM, Crowson CS, Gabriel SE, Matteson EL (2003) Extra-articular disease manifestations in rheumatoid arthritis: incidence trends and risk factors over 46 years. Ann Rheum Dis 62:722\u2013727. https:\/\/doi.org\/10.1136\/ard.62.8.722","journal-title":"Ann Rheum Dis"},{"key":"5685_CR14","doi-asserted-by":"publisher","first-page":"1583","DOI":"10.1002\/art.27405","volume":"62","author":"T Bongartz","year":"2010","unstructured":"Bongartz T, Nannini C, Medina-Velasquez YF, Achenbach SJ, Crowson CS, Ryu JH et al (2010) Incidence and mortality of interstitial lung disease in rheumatoid arthritis: a population-based study. Arthritis Rheum 62:1583\u20131591. https:\/\/doi.org\/10.1002\/art.27405","journal-title":"Arthritis Rheum"},{"key":"5685_CR15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1183\/09059180.00008014","volume":"24","author":"M Shaw","year":"2015","unstructured":"Shaw M, Collins BF, Ho LA, Raghu G (2015) Rheumatoid arthritis-associated lung disease. Eur Respir Rev 24:1\u201316. https:\/\/doi.org\/10.1183\/09059180.00008014","journal-title":"Eur Respir Rev"},{"key":"5685_CR16","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8122038","author":"E Bendstrup","year":"2019","unstructured":"Bendstrup E, M\u00f8ller J, Kronborg-White S, Prior TS, Hyldgaard C (2019) Interstitial lung disease in rheumatoid arthritis remains a challenge for clinicians. J Clin Med. https:\/\/doi.org\/10.3390\/jcm8122038","journal-title":"J Clin Med"},{"key":"5685_CR17","doi-asserted-by":"publisher","first-page":"1700","DOI":"10.1136\/annrheumdis-2017-211138","volume":"76","author":"C Hyldgaard","year":"2017","unstructured":"Hyldgaard C, Hilberg O, Pedersen AB, Ulrichsen SP, L\u00f8kke A, Bendstrup E, Ellingsen T (2017) A population-based cohort study of rheumatoid arthritis-associated interstitial lung disease: comorbidity and mortality. Ann Rheum Dis 76:1700\u20131706. https:\/\/doi.org\/10.1136\/annrheumdis-2017-211138","journal-title":"Ann Rheum Dis"},{"key":"5685_CR18","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1097\/BOR.0000000000000380","volume":"29","author":"C Johnson","year":"2017","unstructured":"Johnson C (2017) Recent advances in the pathogenesis, prediction, and management of rheumatoid arthritis-associated interstitial lung disease. Curr Opin Rheumatol 29:254\u2013259. https:\/\/doi.org\/10.1097\/BOR.0000000000000380","journal-title":"Curr Opin Rheumatol"},{"key":"5685_CR19","doi-asserted-by":"publisher","first-page":"874","DOI":"10.18553\/jmcp.2015.21.10.874","volume":"21","author":"SR Feldman","year":"2015","unstructured":"Feldman SR, Zhao Y, Shi L, Tran MH (2015) Economic and comorbidity burden among patients with moderate-to-severe psoriasis. J Manag Care Spec Pharm 21:874\u2013888. https:\/\/doi.org\/10.18553\/jmcp.2015.21.10.874","journal-title":"J Manag Care Spec Pharm"},{"key":"5685_CR20","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1007\/s10067-014-2652-9","volume":"34","author":"R Peluso","year":"2015","unstructured":"Peluso R, Iervolino S, Vitiello M, Bruner V, Lupoli G, Di Minno MND (2015) Extra-articular manifestations in psoriatic arthritis patients. Clin Rheumatol 34:745\u2013753. https:\/\/doi.org\/10.1007\/s10067-014-2652-9","journal-title":"Clin Rheumatol"},{"key":"5685_CR21","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1007\/s10067-011-1692-7","volume":"30","author":"M Khraishi","year":"2011","unstructured":"Khraishi M, MacDonald D, Rampakakis E, Vaillancourt J, Sampalis JS (2011) Prevalence of patient-reported comorbidities in early and established psoriatic arthritis cohorts. Clin Rheumatol 30:877\u2013885. https:\/\/doi.org\/10.1007\/s10067-011-1692-7","journal-title":"Clin Rheumatol"},{"key":"5685_CR22","doi-asserted-by":"publisher","first-page":"1868","DOI":"10.1002\/art.1780401021","volume":"40","author":"K Wong","year":"1997","unstructured":"Wong K, Gladman DD, Husted J, Long JA, Farewell VT (1997) Mortality studies in psoriatic arthritis: results from a single outpatient clinic. I. Causes and risk of death. Arthritis Rheum. 40:1868\u201372. https:\/\/doi.org\/10.1002\/art.1780401021","journal-title":"Arthritis Rheum."},{"key":"5685_CR23","doi-asserted-by":"publisher","first-page":"2569","DOI":"10.1002\/art.27584","volume":"62","author":"D Aletaha","year":"2010","unstructured":"Aletaha D, Neogi T, Silman AJ, Funovits J, Felson DT, Bingham CO et al (2010) 2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology\/European League Against Rheumatism collaborative initiative. Arthritis Rheum 62:2569\u20132581. https:\/\/doi.org\/10.1002\/art.27584","journal-title":"Arthritis Rheum"},{"key":"5685_CR24","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1002\/art.39573","volume":"68","author":"LC Coates","year":"2016","unstructured":"Coates LC, Kavanaugh A, Mease PJ, Soriano ER, Laura Acosta-Felquer M, Armstrong AW et al (2016) Group for research and assessment of psoriasis and psoriatic arthritis 2015 treatment recommendations for psoriatic arthritis. Arthritis Rheumatol 68:1060\u20131071. https:\/\/doi.org\/10.1002\/art.39573","journal-title":"Arthritis Rheumatol"},{"key":"5685_CR25","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1007\/s10067-011-1758-6","volume":"31","author":"N Sathi","year":"2012","unstructured":"Sathi N, Chikura B, Kaushik VV, Wiswell R, Dawson JK (2012) How common is methotrexate pneumonitis? A large prospective study investigates. Clin Rheumatol 31:79\u201383. https:\/\/doi.org\/10.1007\/s10067-011-1758-6","journal-title":"Clin Rheumatol"},{"key":"5685_CR26","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/j.rdc.2014.12.004","volume":"41","author":"ZX Yunt","year":"2015","unstructured":"Yunt ZX, Solomon JJ (2015) Lung disease in rheumatoid arthritis. Rheum Dis Clin North Am 41:225\u2013236. https:\/\/doi.org\/10.1016\/j.rdc.2014.12.004","journal-title":"Rheum Dis Clin North Am"},{"key":"5685_CR27","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1038\/nrrheum.2013.197","volume":"10","author":"M Jani","year":"2014","unstructured":"Jani M, Hirani N, Matteson EL, Dixon WG (2014) The safety of biologic therapies in RA-associated interstitial lung disease. Nat Rev Rheumatol 10:284\u2013294. https:\/\/doi.org\/10.1038\/nrrheum.2013.197","journal-title":"Nat Rev Rheumatol"},{"key":"5685_CR28","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1007\/s00296-004-0472-y","volume":"25","author":"A Bilgici","year":"2005","unstructured":"Bilgici A, Ulusoy H, Kuru O, Celenk C, Unsal M, Danaci M (2005) Pulmonary involvement in rheumatoid arthritis. Rheumatol Int 25:429\u2013435. https:\/\/doi.org\/10.1007\/s00296-004-0472-y","journal-title":"Rheumatol Int"},{"key":"5685_CR29","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1007\/s10067-020-05320-z","volume":"40","author":"Y Dai","year":"2021","unstructured":"Dai Y, Wang W, Yu Y, Hu S (2021) Rheumatoid arthritis-associated interstitial lung disease: an overview of epidemiology, pathogenesis and management. Clin Rheumatol 40:1211\u20131220. https:\/\/doi.org\/10.1007\/s10067-020-05320-z","journal-title":"Clin Rheumatol"},{"key":"5685_CR30","doi-asserted-by":"publisher","first-page":"979","DOI":"10.3899\/jrheum.101261","volume":"38","author":"F Aubart","year":"2011","unstructured":"Aubart F, Crestani B, Nicaise-Roland P, Tubach F, Bollet C, Dawidowicz K et al (2011) High levels of anti-cyclic citrullinated peptide autoantibodies are associated with co-occurrence of pulmonary diseases with rheumatoid arthritis. J Rheumatol 38:979\u2013982. https:\/\/doi.org\/10.3899\/jrheum.101261","journal-title":"J Rheumatol"},{"key":"5685_CR31","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.1164\/rccm.201411-1950OC","volume":"191","author":"TJ Doyle","year":"2015","unstructured":"Doyle TJ, Patel AS, Hatabu H, Nishino M, Wu G, Osorio JC et al (2015) Detection of rheumatoid arthritis-interstitial lung disease is enhanced by serum biomarkers. Am J Respir Crit Care Med 191:1403\u20131412. https:\/\/doi.org\/10.1164\/rccm.201411-1950OC","journal-title":"Am J Respir Crit Care Med"},{"key":"5685_CR32","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1136\/ard.61.6.517","volume":"61","author":"JK Dawson","year":"2002","unstructured":"Dawson JK, Fewins HE, Desmond J, Lynch MP, Graham DR (2002) Predictors of progression of HRCT diagnosed fibrosing alveolitis in patients with rheumatoid arthritis. Ann Rheum Dis 61:517\u2013521. https:\/\/doi.org\/10.1136\/ard.61.6.517","journal-title":"Ann Rheum Dis"},{"key":"5685_CR33","doi-asserted-by":"publisher","first-page":"14897","DOI":"10.1038\/srep14897","volume":"5","author":"T Wang","year":"2015","unstructured":"Wang T, Zheng X-J, Liang B-M, Liang Z-A (2015) Clinical features of rheumatoid arthritis-associated interstitial lung disease. Sci Rep 5:14897. https:\/\/doi.org\/10.1038\/srep14897","journal-title":"Sci Rep"},{"key":"5685_CR34","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.jbspin.2018.03.016","volume":"86","author":"CI Da\u00efen","year":"2019","unstructured":"Da\u00efen CI, Tubery A, Beurai-Weber M, Du Cailar G, Picot M-C, Jaussent A et al (2019) Relevance and feasibility of a systematic screening of multimorbidities in patients with chronic inflammatory rheumatic diseases. Joint Bone Spine 86:49\u201354. https:\/\/doi.org\/10.1016\/j.jbspin.2018.03.016","journal-title":"Joint Bone Spine"},{"key":"5685_CR35","volume-title":"Lung disease in rheumatoid arthritis","year":"2018","unstructured":"Fischer A, Lee JS (eds) (2018) Lung disease in rheumatoid arthritis. Springer International Publishing, Cham"}],"container-title":["Rheumatology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00296-024-05685-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00296-024-05685-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00296-024-05685-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T02:05:50Z","timestamp":1726193150000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00296-024-05685-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,21]]},"references-count":35,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2024,10]]}},"alternative-id":["5685"],"URL":"https:\/\/doi.org\/10.1007\/s00296-024-05685-3","relation":{},"ISSN":["1437-160X"],"issn-type":[{"value":"1437-160X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,21]]},"assertion":[{"value":"29 May 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 August 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 August 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors report no disclosures relevant to the manuscript.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was conducted in accordance with the Declaration of Helsinki and has been reviewed and approved by the ethics committee of the University Hospital Bonn, Germany (reference number: 209\/18). Written informed consent was obtained from every patient prior to inclusion in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all subjects before enrollment.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Patient consent for publication"}},{"value":"Patients and\/or the public were not involved in the design, or conduct, or reporting, or dissemination plans of this research.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Patient and public involvement"}}]}}