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We compared the central macular thickness (CMT), retinal thickness (RT), central nerve fiber layer (RNFL) thickness, and ganglion cell layer (GCL) thickness using optical coherence tomography. In a cross-sectional study, we categorized 97 sarcoidosis patients (185 eyes) into four groups: patients without ocular or central nervous system sarcoidosis (Non-Ocular\/Non-CNS, <jats:italic>n<\/jats:italic>\u2009=\u200953), patients with OS (Ocular, <jats:italic>n<\/jats:italic>\u2009=\u200913), patients with NS (CNS, <jats:italic>n<\/jats:italic>\u2009=\u200916), and patients with combined OS and NS (Ocular\/CNS, <jats:italic>n<\/jats:italic>\u2009=\u200915). The mean age was 51 (14) years. We found no overall difference between the groups in the CMT (<jats:italic>p<\/jats:italic>\u2009=\u20090.3), RT (<jats:italic>p<\/jats:italic>\u2009=\u20090.9), RNFL (<jats:italic>p<\/jats:italic>\u2009=\u20090.3), and GCL measurements (<jats:italic>p<\/jats:italic> =\u20090.9). Only in patients with a disease duration of more than five years, the CMT was significantly thicker in the Ocular group (278\u00a0\u03bcm, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), the CNS group (267\u00a0\u03bcm, <jats:italic>p<\/jats:italic>\u2009=\u20090.04), and the Ocular\/CNS group (268\u00a0\u03bcm, <jats:italic>p<\/jats:italic>\u2009=\u20090.04), compared to the Non-Ocular\/Non-CNS group (249\u00a0\u03bcm). The RT was significantly thicker in the Ocular group (296\u00a0\u03bcm, <jats:italic>p<\/jats:italic>\u2009=\u20090.008) and the Ocular\/CNS group (291\u00a0\u03bcm, <jats:italic>p<\/jats:italic>\u2009=\u20090.03) compared to the Non-Ocular\/Non-CNS group (283\u00a0\u03bcm). In the RNFL measurements, the Ocular group (33.7\u00a0\u03bcm, <jats:italic>p<\/jats:italic>\u2009=\u20090.002) was thicker than the Non-ocular\/Non-CNS group (29.1\u00a0\u03bcm). We found an increased retinal thickness in patients with ocular sarcoidosis and long disease duration.<\/jats:p>","DOI":"10.1007\/s00296-025-05818-2","type":"journal-article","created":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T04:11:20Z","timestamp":1740629480000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Increased retinal thickness in sarcoidosis patients with ocular system involvement visualized with optical coherence tomography: a cross-sectional study"],"prefix":"10.1007","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4834-5457","authenticated-orcid":false,"given":"Keld-Erik","family":"Byg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0426-4962","authenticated-orcid":false,"given":"Torkell","family":"Ellingsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8895-1553","authenticated-orcid":false,"given":"Jimmi","family":"Wied","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michella","family":"Peiris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2882-5739","authenticated-orcid":false,"given":"Simon Joel","family":"Lowater","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7682-2188","authenticated-orcid":false,"given":"Tobias","family":"Sejbaek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5019-0736","authenticated-orcid":false,"given":"Jakob","family":"Grauslund","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,2,27]]},"reference":[{"issue":"1","key":"5818_CR1","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1038\/s41572-019-0096-x","volume":"5","author":"J Grunewald","year":"2019","unstructured":"Grunewald J, Grutters JC, Arkema EV, Saketkoo LA, Moller DR, Muller-Quernheim J (2019) Sarcoidosis. 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All participants signed an informed consent form before enrolment in the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Preliminary analysis of the data has been published as a congress abstract: Kindt A, Byg K-E, Wied J, Ellingsen T, R\u00f8mhild Davidsen J, Grauslund J (2021). Increased retinal thickness in patients with ocular sarcoidosis. Invest Ophthalmol Vis Sci. 2021;62:2508. AI has not been used to write and edit any part of this manuscript, including the text and graphics.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclaimer"}},{"value":"The authors have no competing interests to declare that are relevant to the content of this article.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"66"}}