{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T11:48:22Z","timestamp":1780573702189,"version":"3.54.1"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T00:00:00Z","timestamp":1750118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T00:00:00Z","timestamp":1750118400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Rheumatol Int"],"DOI":"10.1007\/s00296-025-05909-0","type":"journal-article","created":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T05:49:57Z","timestamp":1750139397000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Long-term changes in Sj\u00f6gren\u2019s disease: a 9-year prospective follow-up study from the SJOGRENSER Registry"],"prefix":"10.1007","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4081-2751","authenticated-orcid":false,"given":"M\u00f3nica","family":"Fern\u00e1ndez-Castro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zulema","family":"Plaza-Almuedo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose","family":"Rosas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Mart\u00ednez-Taboada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Oliv\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ra\u00fal","family":"Menor-Almagro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belen","family":"Serrano-Benavente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judit","family":"Font-Urgelles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angel","family":"Garc\u00eda-Aparicio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Manrique-Arija","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesus Alberto","family":"Garc\u00eda-Vadillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"L\u00f3pez-Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Narv\u00e1ez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Rodriguez-Lozano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Galisteo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Gonz\u00e1lez-Mart\u00edn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paloma","family":"Vela-Casasempere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Boh\u00f3rquez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celia","family":"Erausquin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Paredes-Romero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leyre","family":"Riancho-Zarrabeitia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheila","family":"Melchor-Diaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Maria","family":"Pego-Reigosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergi","family":"Heredia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Moriano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Angeles","family":"Blazquez-Ca\u00f1amero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Estrada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"J\u00fadez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaqu\u00edn Mar\u00eda","family":"Belzunegui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Consuelo","family":"Ramos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"S\u00e1nchez-Alonso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Luis","family":"Andreu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Systemic Autoimmune Diseases Group of the Spanish Society of Rheumatology (EAS-SER)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,6,17]]},"reference":[{"key":"5909_CR1","doi-asserted-by":"publisher","first-page":"2299","DOI":"10.3390\/jcm9072299","volume":"9","author":"D Parisis","year":"2020","unstructured":"Parisis D, Chivasso C, Perret J, Soyfoo MS, Delporte C (2020) Current state of knowledge on primary Sj\u00f6gren\u2019s syndrome, an autoimmune exocrinopathy. J Clin Med 9:2299. https:\/\/doi.org\/10.3390\/jcm9072299","journal-title":"J Clin Med"},{"key":"5909_CR2","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1056\/NEJMcp1702514","volume":"378","author":"X Mariette","year":"2018","unstructured":"Mariette X, Criswell LA (2018) Primary Sj\u00f6gren\u2019s syndrome. N Engl J Med 378:931\u2013939. https:\/\/doi.org\/10.1056\/NEJMcp1702514","journal-title":"N Engl J Med"},{"key":"5909_CR3","doi-asserted-by":"publisher","first-page":"2343","DOI":"10.55563\/clinexprheumatol\/255qsx","volume":"41","author":"S Longhino","year":"2023","unstructured":"Longhino S, Chatzis LG, Dal Pozzolo R, Perreti S, Fulvio G, La Rocca G, Navarro Garcia IC, Orlandi M, Quartuccio L, Baldini C, Bartolini E (2023) Sj\u00f6gren\u2019s syndrome: one year in review 2023. Clin Exp Rheumatol 41:2343\u20132356. https:\/\/doi.org\/10.55563\/clinexprheumatol\/255qsx","journal-title":"Clin Exp Rheumatol"},{"key":"5909_CR4","doi-asserted-by":"publisher","first-page":"10627","DOI":"10.1038\/s41598-020-67462-z","volume":"10","author":"J Narv\u00e1ez","year":"2020","unstructured":"Narv\u00e1ez J, S\u00e1nchez-Fern\u00e1ndez SA, Seoane-Mato D, D\u00edaz-Gonz\u00e1lez F, Bustabad S (2020) Prevalence of Sj\u00f6gren\u2019s syndrome in the general adult population in Spain: estimating the proportion of undiagnosed cases. Sci Rep 10:10627. https:\/\/doi.org\/10.1038\/s41598-020-67462-z","journal-title":"Sci Rep"},{"key":"5909_CR5","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1038\/s41584-023-01057-6","volume":"20","author":"M Beydon","year":"2024","unstructured":"Beydon M, McCoy S, Nguyen Y, Sumida T, Mariette X, Seror R (2024) Epidemiology of Sj\u00f6gren syndrome. Nat Rev Rheumatol 20:158\u2013169. https:\/\/doi.org\/10.1038\/s41584-023-01057-6","journal-title":"Nat Rev Rheumatol"},{"key":"5909_CR6","doi-asserted-by":"publisher","first-page":"e636","DOI":"10.1016\/S2665-9913(24)00039-0","volume":"6","author":"S Gandolfo","year":"2024","unstructured":"Gandolfo S, Bombardieri M, Pers JO, Mariette X, Ciccia F (2024) Precision medicine in Sj\u00f6gren\u2019s disease. Lancet Rheumatol 6:e636\u2013e647. https:\/\/doi.org\/10.1016\/S2665-9913(24)00039-0","journal-title":"Lancet Rheumatol"},{"key":"5909_CR7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1177\/1759720X221100295","volume":"14","author":"SZ Callegher","year":"2022","unstructured":"Callegher SZ, Giovannini I, Zenz S, Manfre V, Stradner MH, Hocevar A, Gutierrez M, Quartuccio L, De Vita S, Zabotti A (2022) Sj\u00f6gren syndrome: looking forward to the future. Ther Adv Musculoskelet Dis 14:1\u201323. https:\/\/doi.org\/10.1177\/1759720X221100295","journal-title":"Ther Adv Musculoskelet Dis"},{"key":"5909_CR8","doi-asserted-by":"publisher","first-page":"101475","DOI":"10.1016\/j.berh.2019.101475","volume":"34","author":"G Noaiseh","year":"2020","unstructured":"Noaiseh G, Baer AN (2020) Toward better outcomes in Sjogren\u2019s syndrome: the promise of a stratified medicine approach. Best Pract Res Clin Rheumatol 34:101475. https:\/\/doi.org\/10.1016\/j.berh.2019.101475","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"5909_CR9","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.1016\/j.autrev.2015.07.002","volume":"14","author":"L Quartuccio","year":"2015","unstructured":"Quartuccio L, Baldini C, Bartoloni E, Priori R, Carubbi F, Corazza L, Alunno A, Colafrancesco S, Luciano N, Giacomelli R, Gerli R, Valesini G, Bombardieri S, De Vita S (2015) Anti-SSA\/SSB-negative Sj\u00f6gren\u2019s syndrome shows a lower prevalence of lymphoproliferative manifestations, and a lower risk of lymphoma evolution. Autoimmun Rev 14:1019\u20131022. https:\/\/doi.org\/10.1016\/j.autrev.2015.07.002","journal-title":"Autoimmun Rev"},{"key":"5909_CR10","doi-asserted-by":"publisher","first-page":"93","DOI":"10.4081\/reumatismo.2017.1032","volume":"69","author":"MC Leone","year":"2017","unstructured":"Leone MC, Alunno A, Cafaro G, Valentini V, Marcucci E, Bartolini E, Gerli R (2017) The clinical spectrum of primary Sj\u00f6gren\u2019s syndrome: beyond exocrine glands. Reumatismo 69:93\u2013100. https:\/\/doi.org\/10.4081\/reumatismo.2017.1032","journal-title":"Reumatismo"},{"key":"5909_CR11","doi-asserted-by":"publisher","first-page":"102062","DOI":"10.1016\/j.eclinm.2023.102062","volume":"61","author":"P Brito-Zer\u00f3n","year":"2023","unstructured":"Brito-Zer\u00f3n P, Flores-Ch\u00e1vez A, Horv\u00e1th IF et al (2023) Mortality risk factors in primary Sj\u00f6gren syndrome: a real-world, retrospective, cohort study. eClinicalMedicine 61:102062. https:\/\/doi.org\/10.1016\/j.eclinm.2023.102062","journal-title":"eClinicalMedicine"},{"key":"5909_CR12","doi-asserted-by":"publisher","first-page":"804","DOI":"10.3899\/jrheum.110754","volume":"39","author":"C Baldini","year":"2012","unstructured":"Baldini C, Pepe P, Luciano N, Ferro F, Talarico R, Grossi S, Tavoni A, Bombardieri S (2012) A clinical prediction rule for lymphoma development in primary Sjogren\u2019s syndrome. J Rheumatol 39:804\u2013808. https:\/\/doi.org\/10.3899\/jrheum.110754","journal-title":"J Rheumatol"},{"key":"5909_CR13","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1177\/0961203319857132","volume":"28","author":"S Retamozo","year":"2019","unstructured":"Retamozo S, Brito-Zeron P, Ramos-Casals M (2019) Prognostic markers of lymphoma development in primary Sjogren s\u00edndrome. Lupus 28:923\u2013936. https:\/\/doi.org\/10.1177\/0961203319857132","journal-title":"Lupus"},{"key":"5909_CR14","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/j.reuma.2015.09.002","volume":"12","author":"M Fern\u00e1ndez Castro","year":"2016","unstructured":"Fern\u00e1ndez Castro M, Andreu JL, Sanchez-Piedra C et al (2016) SJOGREN-SER: registro nacional de pacientes con s\u00edndrome de Sj\u00f6gren primario de la Sociedad Espa\u00f1ola de Reumatolog\u00eda, objetivos y metodolog\u00eda. Reumatol Clin 12:184\u2013189. https:\/\/doi.org\/10.1016\/j.reuma.2015.09.002","journal-title":"Reumatol Clin"},{"key":"5909_CR15","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1136\/annrheumdis-2013-204615","volume":"74","author":"R Seror","year":"2015","unstructured":"Seror R, Theander E, Brun JG et al (2015) Validation of EULAR primary Sj\u00f6gren\u2019s syndrome disease activity (ESSDAI) and patient indexes (ESSPRI). Ann Rheum Dis 74:859\u2013866. https:\/\/doi.org\/10.1136\/annrheumdis-2013-204615","journal-title":"Ann Rheum Dis"},{"key":"5909_CR16","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1136\/ard.61.6.554","volume":"61","author":"C Vitali","year":"2002","unstructured":"Vitali C, Bombardieri S, Jonsson R, Moutsopoulos HM, Alexander EL, Carsons SE, Daniels TE, Fox PC, Fox RI, Kassan SS, Pillemer SR, Talal N, Weisman MH (2002) Classification criteria for Sj\u00f6gren\u2019s syndrome: a revised version of the European criteria proposed by the American-European Consensus Group. Ann Rheum Dis 61:554\u2013558. https:\/\/doi.org\/10.1136\/ard.61.6.554","journal-title":"Ann Rheum Dis"},{"issue":"Suppl 112","key":"5909_CR17","first-page":"S198","volume":"36","author":"P Brito-Zer\u00f3n","year":"2018","unstructured":"Brito-Zer\u00f3n P, Retamozo S, Ramos-Casals M (2018) Phenotyping Sj\u00f6gren\u2019s syndrome: towards a personalised management of the disease. Clin Exp Rheumatol 36(Suppl 112):S198\u2013S209","journal-title":"Clin Exp Rheumatol"},{"key":"5909_CR18","doi-asserted-by":"publisher","first-page":"1569","DOI":"10.1002\/art.42238","volume":"74","author":"SS McCoy","year":"2022","unstructured":"McCoy SS, Woodham M, Bartels CM, Saldanha IJ, Bunya VY, Maerz N, Akpek EK, Makara MA, Baer AN (2022) Symptom-based cluster analysis catego- rizes Sj\u00f6gren\u2019s disease subtypes: an inter-national cohort study highlighting disease severity and treatment discordance. Arthritis Rheumatol 74:1569\u20131579. https:\/\/doi.org\/10.1002\/art.42238","journal-title":"Arthritis Rheumatol"},{"key":"5909_CR19","doi-asserted-by":"publisher","first-page":"e216","DOI":"10.1016\/S2665-9913(23)00340-5","volume":"6","author":"Y Nguyen","year":"2024","unstructured":"Nguyen Y, Nocturne G, Henry J et al (2024) Identification of distinct subgroups of Sj\u00f6gren\u2019s disease by cluster analysis based on clinical and biological manifestations: data from the cross-sectional Paris-Saclay and the prospective ASSESS cohorts. Lancet Rheumatol 6:e216\u2013e225. https:\/\/doi.org\/10.1016\/S2665-9913(23)00340-5","journal-title":"Lancet Rheumatol"},{"key":"5909_CR20","doi-asserted-by":"publisher","first-page":"2413","DOI":"10.55563\/clinexprheumatol\/3bvq48","volume":"40","author":"P Brito-Zer\u00f3n","year":"2022","unstructured":"Brito-Zer\u00f3n P, Retamozo S, Flores-Chavez A, Akasbi M, Sis\u00f3-Almirall A, Ramos-Casals M (2022) Practical diagnostic tips for the Sj\u00f6gren clinic: pearls, myths and mistakes. Clin Exp Rheumatol 40:2413\u20132427. https:\/\/doi.org\/10.55563\/clinexprheumatol\/3bvq48","journal-title":"Clin Exp Rheumatol"},{"key":"5909_CR21","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.autrev.2018.06.015","volume":"18","author":"A Mirouse","year":"2019","unstructured":"Mirouse A, Seror R, Vicaut E et al (2019) Arthritis in primary Sj\u00f6gren\u2019s syndrome: characteristics, outcome and treatment from French multicenter retrospective study. Autoimmun Rev 18:9\u201314. https:\/\/doi.org\/10.1016\/j.autrev.2018.06.015","journal-title":"Autoimmun Rev"},{"issue":"Suppl 133","key":"5909_CR22","doi-asserted-by":"publisher","first-page":"S197","DOI":"10.55563\/clinexprheumatol\/pal3z7","volume":"39","author":"A Siso-Almirall","year":"2021","unstructured":"Siso-Almirall A, Meijer JM, Brito-Zer\u00f3n P, Conangla L, Flores-Chavez A, Gonzalez de la Paz L, Bootsma H, Ramos Casals M (2021) Practical guidelines for the early diagnosis of Sj\u00f6gren\u2019s syndrome in primary healthcare. Clin Exp Rheumatol 39(Suppl 133):S197-205. https:\/\/doi.org\/10.55563\/clinexprheumatol\/pal3z7","journal-title":"Clin Exp Rheumatol"},{"key":"5909_CR23","doi-asserted-by":"publisher","first-page":"2211","DOI":"10.55563\/clinexprheumatol\/43z8gu","volume":"40","author":"V Manfr\u00e8","year":"2022","unstructured":"Manfr\u00e8 V, Chatzis LG, Cafaro G, Fonzetti S, Calvacchi S, Fulvio G, Navarro Garcia IC, La Rocca G, Ferro F, Perricone C, Bartolini E, Baldini C (2022) Sj\u00f6gren\u2019s syndrome: one year in review 2022. Clin Exp Rheumatol 40:2211\u20132224. https:\/\/doi.org\/10.55563\/clinexprheumatol\/43z8gu","journal-title":"Clin Exp Rheumatol"},{"issue":"Suppl 133","key":"5909_CR24","doi-asserted-by":"publisher","first-page":"S114","DOI":"10.55563\/clinexprheumatol\/volsh1","volume":"39","author":"JH Koh","year":"2021","unstructured":"Koh JH, Park Y, Lee J, Park SH, Kwok SK (2021) Hypergammaglobulinaemia predicts glandular and extra-glandular damage in primary Sj\u00f6gren\u2019s syndrome: results from the KISS cohort study. Clin Exp Rheumatol 39(Suppl 133):S114\u2013S122. https:\/\/doi.org\/10.55563\/clinexprheumatol\/volsh1","journal-title":"Clin Exp Rheumatol"},{"key":"5909_CR25","doi-asserted-by":"publisher","first-page":"2427","DOI":"10.1002\/art.39214","volume":"67","author":"E Theander","year":"2015","unstructured":"Theander E, Jonsson R, Sjostrom B, Brokstad K, Olsson P, Henriksson G (2015) Prediction of Sj\u00f6gren\u2019s syndrome years before diagnosis and identification of patients with early onset and severe disease course by autoantibody profiling. Arthritis Rheumatol 67:2427\u20132436. https:\/\/doi.org\/10.1002\/art.39214","journal-title":"Arthritis Rheumatol"},{"key":"5909_CR26","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1002\/art.39518","volume":"68","author":"G Nocturne","year":"2016","unstructured":"Nocturne G, Virone A, Ng WF et al (2016) Rheumatoid factor and disease activity are independent predictors of lymphoma in primary Sj\u00f6gren\u2019s syndrome. Arthritis Rheumatol 68:977\u2013985. https:\/\/doi.org\/10.1002\/art.39518","journal-title":"Arthritis Rheumatol"},{"key":"5909_CR27","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1093\/rheumatology\/keh407","volume":"44","author":"M Ramos-Casals","year":"2005","unstructured":"Ramos-Casals M, Brito-Zer\u00f3n P, Yag\u00fce J, Akasbi M, Bautista R, Ruano M, Claver G, Gil V, Font J (2005) Hypocomplementaemia as an immunological marker of morbidity and mortality in patients with primary Sj\u00f6gren\u2019s syndrome. Rheumatology 44:89\u201394. https:\/\/doi.org\/10.1093\/rheumatology\/keh407","journal-title":"Rheumatology"},{"key":"5909_CR28","doi-asserted-by":"publisher","first-page":"1359","DOI":"10.1093\/rheumatology\/kem079","volume":"46","author":"P Brito-Zer\u00f3n","year":"2007","unstructured":"Brito-Zer\u00f3n P, Ramos-Casals M, Bove A, Sentis J, Font J (2007) Predicting adverse outcomes in primary Sj\u00f6gren\u2019s syndrome: identification of prognostic factors. Rheumatology 46:1359\u20131362. https:\/\/doi.org\/10.1093\/rheumatology\/kem079","journal-title":"Rheumatology"},{"key":"5909_CR29","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1136\/annrheumdis-2021-222054","volume":"81","author":"R Seror","year":"2022","unstructured":"Seror R, Baron G, Camus M et al (2022) Development and preliminary validation of the Sj\u00f6gren\u2019s tool for assessing response (STAR): a consensual composite score for assessing treatment effect in primary Sj\u00f6gren\u2019s syndrome. Ann Rheum Dis 81:979\u2013989. https:\/\/doi.org\/10.1136\/annrheumdis-2021-222054","journal-title":"Ann Rheum Dis"},{"key":"5909_CR30","doi-asserted-by":"publisher","first-page":"e553","DOI":"10.1016\/S2665-9913(21)00122-3","volume":"3","author":"S Arends","year":"2021","unstructured":"Arends S, de Wolff L, van Nimwegen JF et al (2021) Composite of relevant endpoints for Sj\u00f6gren\u2019s Syndrome (CRESS): development and validation. Lancet Rheumatol 3:e553\u2013e562. https:\/\/doi.org\/10.1016\/S2665-9913(21)00122-3","journal-title":"Lancet Rheumatol"},{"key":"5909_CR31","doi-asserted-by":"publisher","first-page":"e59868","DOI":"10.1371\/journal.pone.0059868","volume":"8","author":"J-E Gottenberg","year":"2013","unstructured":"Gottenberg J-E, Seror R, Miceli-Richard C et al (2013) Serum levels of beta2-microglobulin and free light chains of immunoglobulins are associated with systemic disease activity in primary Sj\u00f6gren\u2019s syndrome. Data at enrollment in the prospective ASSESS cohort. PLoS ONE 8:e59868. https:\/\/doi.org\/10.1371\/journal.pone.0059868","journal-title":"PLoS ONE"},{"key":"5909_CR32","doi-asserted-by":"publisher","first-page":"3428","DOI":"10.3390\/jcm12103428","volume":"12","author":"G La Rocca","year":"2023","unstructured":"La Rocca G, Ferro F, Sambataro G, Elefante E, Fonzetti S, Fulvio G, Navarro IC, Mosca M, Baldini C (2023) Primary-Sj\u00f6gren\u2019s syndrome related interstitial lung disease: a clinical review discussing current controversies. J Clin Med 12:3428. https:\/\/doi.org\/10.3390\/jcm12103428","journal-title":"J Clin Med"},{"key":"5909_CR33","doi-asserted-by":"publisher","first-page":"4963","DOI":"10.3390\/jcm13164963","volume":"13","author":"G La Rocca","year":"2024","unstructured":"La Rocca G, Ferro F, Sambataro G, Elefante E, Fulvio G, Navarro IC, Moretti M, Romei C, Mosca M, Baldini C (2024) Interstitial lung disease phenotypes and predictive risk factors in primary Sj\u00f6gren\u2019s syndrome. J Clin Med 13:4963. https:\/\/doi.org\/10.3390\/jcm13164963","journal-title":"J Clin Med"},{"key":"5909_CR34","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1007\/s10067-024-07191-0","volume":"44","author":"R Pang","year":"2024","unstructured":"Pang R, Ma X, Guo H, Qi X (2024) Meta-analysis of mortality-associated factors in primary Sj\u00f6gren\u2019s syndrome patients with interstitial lung disease. Clin Rheumatol 44:23\u201331. https:\/\/doi.org\/10.1007\/s10067-024-07191-0","journal-title":"Clin Rheumatol"},{"issue":"Suppl 118","key":"5909_CR35","first-page":"S97","volume":"37","author":"S Retamozo","year":"2019","unstructured":"Retamozo S, Acar-Denizli N, Rasmus-Sen A et al (2019) Systemic manifestations of primary Sj\u00f6gren\u2019s syndrome out of the ESSDAI classification: prevalence and clinical relevance in a large international, multi-ethnic cohort of patients. Clin Exp Rheumatol 37(Suppl 118):S97-106","journal-title":"Clin Exp Rheumatol"},{"issue":"Suppl 126","key":"5909_CR36","first-page":"S283","volume":"38","author":"L de Wolff","year":"2020","unstructured":"de Wolff L, Arends S, Nimwegen JF, Bootsma H (2020) Ten years of the ESSDAI: is it fit for purpose. Clin Exp Rheumatol 38(Suppl 126):S283\u2013S290","journal-title":"Clin Exp Rheumatol"},{"key":"5909_CR37","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1080\/1744666X.2023.2234641","volume":"19","author":"S Arends","year":"2023","unstructured":"Arends S, Verstappen GM, Wolff L, Pringle S, Kroese F, Vissink A, Bootsma H (2023) Why do drug treatments fail in Sj\u00f6gren\u2019s disease considerations for treatment, trial design and interpretation of clinical efficacy. Expert Rev Clin Immunol 19:1187\u20131194. https:\/\/doi.org\/10.1080\/1744666X.2023.2234641","journal-title":"Expert Rev Clin Immunol"},{"key":"5909_CR38","doi-asserted-by":"publisher","first-page":"1945","DOI":"10.1136\/annrheumdis-2015-208504","volume":"75","author":"R Seror","year":"2016","unstructured":"Seror R, Meiners P, Baron G et al (2016) Development of the ClinESSDAI: a clinical score without biological domain. A tool for biological studies. Ann Rheum Dis 75:1945\u20131950. https:\/\/doi.org\/10.1136\/annrheumdis-2015-208504","journal-title":"Ann Rheum Dis"},{"issue":"Suppl 1","key":"5909_CR39","doi-asserted-by":"publisher","first-page":"POSS1447","DOI":"10.1136\/annrheumdis-2023-eular.4414","volume":"82","author":"L De Wolff","year":"2013","unstructured":"De Wolff L, Verstappen GM, Stel AJ et al (2013) Variation in systemic disease activity measured with ESSDAI in a prospective longitudinal cohort of patients with primary Sj\u00f6gren\u00b4s syndrome without immunosuppressive treatment. Ann Rheum Dis 82(Suppl 1):POSS1447. https:\/\/doi.org\/10.1136\/annrheumdis-2023-eular.4414","journal-title":"Ann Rheum Dis"},{"key":"5909_CR40","doi-asserted-by":"publisher","first-page":"0rkae035","DOI":"10.1093\/rap\/rkae035","volume":"8","author":"M Bandeira","year":"2024","unstructured":"Bandeira M, Silv\u00e9rio-Ant\u00f3nio M, Khmelinskii N, Fonseca JE, Romao VC (2024) Beyond sicca: high prevalence and predictors of baseline and worsening systemic involvement in patients with Sjogren\u2019s disease. Rheumatol Adv Pract 8:0rkae035. https:\/\/doi.org\/10.1093\/rap\/rkae035","journal-title":"Rheumatol Adv Pract"},{"key":"5909_CR41","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1038\/s41584-024-01135-3","volume":"20","author":"C Baldini","year":"2024","unstructured":"Baldini C, Fulvio G, La Rocca G, Ferro F (2024) Update on the pathophysiology and treatment of primary Sj\u00f6gren syndrome. Nat Rev Rheumatol 20:473\u2013491. https:\/\/doi.org\/10.1038\/s41584-024-01135-3","journal-title":"Nat Rev Rheumatol"},{"key":"5909_CR42","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1016\/j.chest.2020.10.011","volume":"159","author":"AS Lee","year":"2021","unstructured":"Lee AS, Scofield RH, Hammitt KM et al (2021) Consensus guidelines for evaluation and management of pulmonary disease in Sj\u00f6gren\u2019s. Chest 159:683\u2013698. https:\/\/doi.org\/10.1016\/j.chest.2020.10.011","journal-title":"Chest"},{"key":"5909_CR43","doi-asserted-by":"publisher","first-page":"78","DOI":"10.2478\/rir-2023-0012","volume":"4","author":"T Costa","year":"2023","unstructured":"Costa T, Rushton SP, Watson S, Ng WF (2023) UK primary Sj\u00f6gren\u2019s syndrome registry. Depression in Sj\u00f6gren\u2019s syndrome mediates the relationship between pain, fatigue, sleepiness, and overall quality of life. Rheumatol Immunol Res 4:78\u201389. https:\/\/doi.org\/10.2478\/rir-2023-0012","journal-title":"Rheumatol Immunol Res"},{"key":"5909_CR44","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1002\/acr.22227","volume":"66","author":"M Juarez","year":"2014","unstructured":"Juarez M, Toms TE, de Pablo P et al (2014) UK primary Sj\u00f6gren\u2019s syndrome registry. Cardiovascular risk factors in women with primary Sj\u00f6gren\u2019s syndrome: United Kingdom primary Sj\u00f6gren\u2019s syndrome registry results. Arthritis Care Res (Hoboken) 66:757\u2013764. https:\/\/doi.org\/10.1002\/acr.22227","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"5909_CR45","doi-asserted-by":"publisher","first-page":"e85","DOI":"10.1016\/S2665-9913(19)30042-6","volume":"1","author":"JR Tarm","year":"2019","unstructured":"Tarm JR, Howard-Tripp N, Lendrem D et al (2019) Symptom-based stratification of patients with primary Sj\u00f6gren\u2019s syndrome: multi-dimensional characterisation of international observational cohorts and reanalyses of randomised clinical trials. Lancet Rheumatol 1:e85\u2013e94. https:\/\/doi.org\/10.1016\/S2665-9913(19)30042-6","journal-title":"Lancet Rheumatol"},{"issue":"Suppl 118","key":"5909_CR46","first-page":"19","volume":"37","author":"N Acar-Denizli","year":"2019","unstructured":"Acar-Denizli N, Kostov B, Ramos-Casals M (2019) Sj\u00f6gren big data consortium the big data Sj\u00f6gren consortium: a project for a new data science era. Clin Exp Rheumatol 37(Suppl 118):19\u201323","journal-title":"Clin Exp Rheumatol"},{"key":"5909_CR47","unstructured":"Rasmussen A, Farris A, Baer A, Warner B, Lessard C, Shiboski S, Shiboski C (2024) Deconstruction and reconstruction of Sj\u00f6gren\u00b4s disease: AMP\u00ae-AIM partnership. Arthritis Rheumatol 76(Suppl9). https:\/\/acrabstracts.org\/abstract\/deconstruction-and-reconstruction-of-sjogrens-disease-amp-aim-partnership"},{"issue":"4","key":"5909_CR48","first-page":"23","volume":"126","author":"AG Tzioufas","year":"2020","unstructured":"Tzioufas AG, Bootsma H, Pers JO (2020) EULAR Sj\u00f6gren\u2019s syndrome study group: an eSSential way to address the unmet needs of the disease. Clin Exp Rheumatol 126(4):23\u201324","journal-title":"Clin Exp Rheumatol"},{"key":"5909_CR49","doi-asserted-by":"publisher","first-page":"4287","DOI":"10.1038\/s41467-022-30773-y","volume":"13","author":"B Khatri","year":"2022","unstructured":"Khatri B, Tessneer KL, Rasmussen A (2022) Genome-wide association study identifies Sj\u00f6gren\u2019s risk loci with functional implications in immune and glandular cells. Nat Commun 13:4287. https:\/\/doi.org\/10.1038\/s41467-022-30773-y","journal-title":"Nat Commun"},{"key":"5909_CR50","doi-asserted-by":"publisher","first-page":"2303","DOI":"10.55563\/clinexprheumatol\/mnqiy9","volume":"40","author":"L de Wolff","year":"2022","unstructured":"de Wolff L, Vissink A, van Nimwegen JF, van Zuiden G, Mossel E, Olie L, Stel AJ, Delli K, Verstappen G, Kroese F, Bootsman H, Arends S (2022) Patient acceptable symptom state (PASS) in patients with primary Sj\u00f6gren\u2019s syndrome in daily clinical practice. Clin Exp Rheumatol 40:2303\u20132309. https:\/\/doi.org\/10.55563\/clinexprheumatol\/mnqiy9","journal-title":"Clin Exp Rheumatol"}],"container-title":["Rheumatology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00296-025-05909-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00296-025-05909-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00296-025-05909-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T04:34:52Z","timestamp":1752726892000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00296-025-05909-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,17]]},"references-count":50,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2025,7]]}},"alternative-id":["5909"],"URL":"https:\/\/doi.org\/10.1007\/s00296-025-05909-0","relation":{},"ISSN":["1437-160X"],"issn-type":[{"value":"1437-160X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,17]]},"assertion":[{"value":"8 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 June 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"156"}}