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Thirty female RA patients with a diagnosis time of less than two years, seropositive, with low disease activity\/remission, and without active arthritis in their hands were included in the study. Participants were randomized 1:1 to intervention and control groups. The intervention group underwent 10 hand massage sessions over a two-week period, in addition to regular medical care. The control group received only regular medical care. All assessments were performed at baseline (T1) and at week 2 (T2). Outcome measures included hand grip strength, pinch strength, pain threshold (dolorimetry), tactile sensory threshold (Semmes-Weinstein monofilament test), Duru\u00f6z Hand Index (DHI), and patient global assessment (PGA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 30 RA patients were included in the study (intervention group,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200915; control group,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200915). At baseline, no significant differences were observed between the groups in demographic, laboratory, or clinical characteristics (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05). In the intervention group, significant improvements in hand grip strength and pinch force were observed at T2 compared with baseline (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.008 and\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.023, respectively). Median hand grip strength increased from 55 (40\u201375) to 65 (45\u201380) kg, and median pinch strength increased from 15 (6\u201318) to 16 (11\u201321) kg. No significant alterations were noted in these parameters within the control group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05). In the control group, median hand grip strength was 45 (25\u201380) kg at baseline and 45 (20\u201380) kg at week 2, while median pinch strength was 14 (6\u201318) kg at baseline and 14 (5\u201319) kg at week 2. In the intervention group, significant reductions in DHI and PGA scores were recorded at the end of therapy (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005 and\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001, respectively). No significant differences were noted in DHI and PGA levels in the control group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05). Moreover, median PGA scores were significantly lower in the intervention group than in the control group at T2 (4 [2\u20135] vs. 5 [3\u20136];\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). No significant changes were found in dolorimeter and touch sensory thresholds in either group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Hand massage interventions for patients with RA enhance grip strength, hand function, and overall patient evaluations. No effect on pain or tactile thresholds was observed. Further studies with larger sample sizes and longer follow-up periods are required to corroborate these findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00296-026-06095-3","type":"journal-article","created":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T00:59:11Z","timestamp":1775437151000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The effect of structured hand massage on hand function and grip strength in rheumatoid arthritis patients: a randomized controlled pilot study"],"prefix":"10.1007","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-6967-4641","authenticated-orcid":false,"given":"Umida","family":"Khojakulova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9033-5095","authenticated-orcid":false,"given":"G\u00fcl\u015fah Ya\u015fa","family":"\u00d6zt\u00fcrk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9028-9930","authenticated-orcid":false,"given":"Burak","family":"Okyar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4188-8486","authenticated-orcid":false,"given":"Olena","family":"Zimba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6065-8002","authenticated-orcid":false,"given":"Burhan Fatih","family":"Kocyigit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,6]]},"reference":[{"key":"6095_CR1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-026-07931-4","author":"N Hajialilou","year":"2026","unstructured":"Hajialilou N, Khabbazi A, Hajialilo M, Malek Mahdavi A (2026) Comparing clinical outcomes of rheumatoid arthritis by onset type: palindromic rheumatism, undifferentiated arthritis, and typical rheumatoid arthritis. 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