{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T16:20:16Z","timestamp":1783527616183,"version":"3.55.0"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T00:00:00Z","timestamp":1779494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T00:00:00Z","timestamp":1779494400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Rheumatol Int"],"DOI":"10.1007\/s00296-026-06154-9","type":"journal-article","created":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T13:01:04Z","timestamp":1779541264000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Diffuse splenic calcifications in systemic lupus erythematosus: a case-based review"],"prefix":"10.1007","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-6698-1518","authenticated-orcid":false,"given":"Celine","family":"Tack","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Stuer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5753-2794","authenticated-orcid":false,"given":"Jean-Baptiste","family":"Vulsteke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,23]]},"reference":[{"key":"6154_CR1","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/0049-0172(90)90059-o","volume":"20","author":"P Piliero","year":"1990","unstructured":"Piliero P, Furie R (1990) Functional asplenia in systemic lupus erythematosus. Semin Arthritis Rheum 20:185\u2013189. https:\/\/doi.org\/10.1016\/0049-0172(90)90059-o","journal-title":"Semin Arthritis Rheum"},{"key":"6154_CR2","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/s0049-0172(97)80013-3","volume":"27","author":"D Fishman","year":"1997","unstructured":"Fishman D, Isenberg DA (1997) Splenic involvement in rheumatic diseases. Semin Arthritis Rheum 27:141\u2013155. https:\/\/doi.org\/10.1016\/s0049-0172(97)80013-3","journal-title":"Semin Arthritis Rheum"},{"key":"6154_CR3","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.semarthrit.2010.10.003","volume":"41","author":"AT Tieng","year":"2011","unstructured":"Tieng AT, Sadow CA, Hochsztein JG et al (2011) Diffuse calcifications of the spleen: a novel association with systemic lupus erythematosus. Semin Arthritis Rheum 41:187\u2013193. https:\/\/doi.org\/10.1016\/j.semarthrit.2010.10.003","journal-title":"Semin Arthritis Rheum"},{"key":"6154_CR4","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1136\/annrheumdis-2018-214819","volume":"78","author":"M Aringer","year":"2019","unstructured":"Aringer M, Costenbader K, Daikh D et al (2019) 2019 European League Against Rheumatism\/American College of Rheumatology classification criteria for systemic lupus erythematosus. Ann Rheum Dis 78:1151\u20131159. https:\/\/doi.org\/10.1136\/annrheumdis-2018-214819","journal-title":"Ann Rheum Dis"},{"key":"6154_CR5","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1177\/0961203308099626","volume":"18","author":"M Danieli","year":"2009","unstructured":"Danieli M, Marchetti A, Monteforte F et al (2009) Splenic microcalcifications in systemic lupus erythematosus. Lupus 18:570\u2013571. https:\/\/doi.org\/10.1177\/0961203308099626","journal-title":"Lupus"},{"key":"6154_CR6","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1007\/s00296-017-3872-5","volume":"38","author":"D \u00dcsk\u00fcdar Cansu","year":"2018","unstructured":"\u00dcsk\u00fcdar Cansu D, \u00dcsk\u00fcdar Teke H, Musmul A et al (2018) Is thrombocytosis always an indicator of autosplenectomy in patients with systemic lupus erythematosus? Rheumatol Int 38:239\u2013247. https:\/\/doi.org\/10.1007\/s00296-017-3872-5","journal-title":"Rheumatol Int"},{"key":"6154_CR7","doi-asserted-by":"publisher","first-page":"e225","DOI":"10.3346\/jkms.2024.39.e225","volume":"39","author":"IC Benlidayi","year":"2024","unstructured":"Benlidayi IC, Gupta L (2024) CAse-BAsed REview sTandards (CABARET): considerations for authors, reviewers, and editors. J Korean Med Sci 39:e225. https:\/\/doi.org\/10.3346\/jkms.2024.39.e225","journal-title":"J Korean Med Sci"},{"key":"6154_CR8","doi-asserted-by":"publisher","first-page":"n71","DOI":"10.1136\/bmj.n71","volume":"372","author":"MJ Page","year":"2021","unstructured":"Page MJ, McKenzie JE, Bossuyt PM et al (2021) The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ 372:n71. https:\/\/doi.org\/10.1136\/bmj.n71","journal-title":"BMJ"},{"key":"6154_CR9","doi-asserted-by":"publisher","unstructured":"Elzein FE, Elzein S, Albalawi R (2017) Splenic calcification in systemic lupus erythematosus. BMJ Case Rep. https:\/\/doi.org\/10.1136\/bcr-2017-222206","DOI":"10.1136\/bcr-2017-222206"},{"key":"6154_CR10","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1097\/RHU.0b013e318228b945","volume":"17","author":"Y Nonomura","year":"2011","unstructured":"Nonomura Y, Miyabe Y, Tanaka M et al (2011) Prominent splenic microcalcifications in a patient with systemic lupus erythematosus complicated by antiphospholipid syndrome. JCR J Clin Rheumatol 17:288. https:\/\/doi.org\/10.1097\/RHU.0b013e318228b945","journal-title":"JCR J Clin Rheumatol"},{"key":"6154_CR11","doi-asserted-by":"publisher","first-page":"138","DOI":"10.37897\/RJR.2022.3.5","volume":"31","author":"PCA Richter","year":"2022","unstructured":"Richter PCA, Burlui AM, Macovei LA, Bratoiu I, Mihai R et al (2022) Total spleen calcification\u2014a rare clinical manifestation in systemic lupus erythematosus. Ro J Rheumatol 31:138\u2013141. https:\/\/doi.org\/10.37897\/RJR.2022.3.5","journal-title":"Ro J Rheumatol"},{"key":"6154_CR12","doi-asserted-by":"publisher","first-page":"414102","DOI":"10.1155\/2015\/414102","volume":"2015","author":"AG Vaiopoulos","year":"2015","unstructured":"Vaiopoulos AG, Kanakis MA, Katsouri K et al (2015) Diffuse calcifications of the spleen in a woman with systemic lupus erythematosus. Case Rep Med 2015:414102. https:\/\/doi.org\/10.1155\/2015\/414102","journal-title":"Case Rep Med"},{"key":"6154_CR13","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1177\/0961203314527038","volume":"23","author":"M Rumbullaku","year":"2014","unstructured":"Rumbullaku M, Fiorucci MC, Cagnati P et al (2014) Diffuse spleen calcification in a patient with systemic lupus erithematosus (SLE). Lupus 23:496. https:\/\/doi.org\/10.1177\/0961203314527038","journal-title":"Lupus"},{"key":"6154_CR14","doi-asserted-by":"publisher","first-page":"e927","DOI":"10.1002\/iid3.927","volume":"11","author":"S Su","year":"2023","unstructured":"Su S, Zhong H (2023) Systemic lupus erythematosus with diffuse splenic calcification: a case report. Immun Inflamm Dis 11:e927. https:\/\/doi.org\/10.1002\/iid3.927","journal-title":"Immun Inflamm Dis"},{"key":"6154_CR15","doi-asserted-by":"publisher","first-page":"37","DOI":"10.4103\/ara.ara_28_24","volume":"5","author":"AS Al Arfaj","year":"2025","unstructured":"Al Arfaj AS, Khalil N (2025) Splenic calcifications in a patient with systemic lupus erythematosus: a case report. Ann Rheumatol Autoimmun 5:37\u201339. https:\/\/doi.org\/10.4103\/ara.ara_28_24","journal-title":"Ann Rheumatol Autoimmun"},{"key":"6154_CR16","doi-asserted-by":"publisher","first-page":"2591","DOI":"10.1007\/s10067-022-06161-8","volume":"41","author":"S Chalen-Reyes","year":"2022","unstructured":"Chalen-Reyes S, Fernandez HA, Cevallos-Guerrero A et al (2022) Splenic calcifications: an unusual finding in systemic lupus erythematosus. Clin Rheumatol 41:2591\u20132592. https:\/\/doi.org\/10.1007\/s10067-022-06161-8","journal-title":"Clin Rheumatol"},{"key":"6154_CR17","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1590\/0100-3984.2017.0109","volume":"51","author":"GF Louza","year":"2018","unstructured":"Louza GF, Barreto MM, Zanetti G et al (2018) Systemic lupus erythematosus with diffuse splenic calcifications: a rare combination. Radiol Bras 51:407\u2013408. https:\/\/doi.org\/10.1590\/0100-3984.2017.0109","journal-title":"Radiol Bras"},{"key":"6154_CR18","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1111\/j.1440-1827.1985.tb02220.x","volume":"35","author":"H Kitamura","year":"1985","unstructured":"Kitamura H, Kitamura H, Ito T et al (1985) Systemic lupus erythematosus with multiple calcified fibrous nodules of the spleen. Acta Pathol Jpn 35:213\u2013226. https:\/\/doi.org\/10.1111\/j.1440-1827.1985.tb02220.x","journal-title":"Acta Pathol Jpn"},{"key":"6154_CR19","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1016\/j.jbspin.2016.04.009","volume":"84","author":"CA Durel","year":"2017","unstructured":"Durel CA, Groh M, Le Guern V (2017) A glittering spleen. Joint Bone Spine 84:363. https:\/\/doi.org\/10.1016\/j.jbspin.2016.04.009","journal-title":"Joint Bone Spine"},{"key":"6154_CR20","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1002\/kjm2.12355","volume":"37","author":"LJ Chiu","year":"2021","unstructured":"Chiu LJ, Lee CH (2021) Diffuse spleen calcifications in a patient with systemic lupus erythematosus. Kaohsiung J Med Sci 37:531\u2013532. https:\/\/doi.org\/10.1002\/kjm2.12355","journal-title":"Kaohsiung J Med Sci"},{"key":"6154_CR21","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1007\/BF02030250","volume":"9","author":"D Van Linthoudt","year":"1990","unstructured":"Van Linthoudt D, Greder B, Ott H (1990) Overlap syndrome with multiple calcifications of the spleen. Clin Rheumatol 9:88\u201391. https:\/\/doi.org\/10.1007\/BF02030250","journal-title":"Clin Rheumatol"},{"key":"6154_CR22","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1007\/s00261-020-02659-4","volume":"46","author":"TC Winter","year":"2021","unstructured":"Winter TC, Shaaban A (2021) The characteristic splenic calcifications of systemic lupus erythematosus. Abdom Radiol 46:607\u2013608. https:\/\/doi.org\/10.1007\/s00261-020-02659-4","journal-title":"Abdom Radiol"},{"key":"6154_CR23","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1097\/rhu.0000000000000256","volume":"21","author":"RM Kwee","year":"2015","unstructured":"Kwee RM, Kwee TC (2015) Characteristic splenic calcifications in systemic lupus erythematosus. J Clin Rheumatol 21:449\u2013450. https:\/\/doi.org\/10.1097\/rhu.0000000000000256","journal-title":"J Clin Rheumatol"},{"key":"6154_CR24","doi-asserted-by":"publisher","unstructured":"Dondeti K, Aryal S (2025) Splenic calcification in a patient with systemic lupus erythematosus. Am J Respir Crit Care Med. https:\/\/doi.org\/10.1164\/ajrccm.2025.211.Abstracts.A3610","DOI":"10.1164\/ajrccm.2025.211.Abstracts.A3610"},{"key":"6154_CR25","first-page":"165","volume":"18","author":"A Venturelli","year":"2024","unstructured":"Venturelli A, Renna E, Trotta C et al (2024) Splenic calcification in systemic lupus erythematosus: a case report. Italian J Med 18:165","journal-title":"Italian J Med"},{"key":"6154_CR26","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.ejim.2022.01.008","volume":"96","author":"S Takeyama","year":"2022","unstructured":"Takeyama S, Abe N, Atsumi T (2022) Autosplenectomy. Eur J Intern Med 96:109\u2013110. https:\/\/doi.org\/10.1016\/j.ejim.2022.01.008","journal-title":"Eur J Intern Med"},{"key":"6154_CR27","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1002\/acr2.11576","volume":"5","author":"M Deeb","year":"2023","unstructured":"Deeb M, AlDaabil M (2023) Clinical image: splenic calcifications in systemic lupus erythematosus. ACR Open Rheumatol 5:522. https:\/\/doi.org\/10.1002\/acr2.11576","journal-title":"ACR Open Rheumatol"},{"key":"6154_CR28","first-page":"97","volume":"67","author":"AS Galante","year":"2023","unstructured":"Galante AS, Tollefson LJ (2023) Splenic calcifications in a patient with systemic lupus erythematosus: an imaging case review. J Can Chiropr Assoc 67:97\u2013100","journal-title":"J Can Chiropr Assoc"},{"key":"6154_CR29","doi-asserted-by":"publisher","first-page":"75","DOI":"10.5152\/eurjrheum.2015.0085","volume":"3","author":"O \u00dcnl\u00fc","year":"2016","unstructured":"\u00dcnl\u00fc O, Zuily S, Erkan D (2016) The clinical significance of antiphospholipid antibodies in systemic lupus erythematosus. Eur J Rheumatol 3:75\u201384. https:\/\/doi.org\/10.5152\/eurjrheum.2015.0085","journal-title":"Eur J Rheumatol"},{"key":"6154_CR30","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.2214\/ajr.19.22246","volume":"214","author":"N Consul","year":"2020","unstructured":"Consul N, Javed-Tayyab S, Lall C et al (2020) Calcified splenic lesions: pattern recognition approach on CT with pathologic correlation. AJR Am J Roentgenol 214:1083\u20131091. https:\/\/doi.org\/10.2214\/ajr.19.22246","journal-title":"AJR Am J Roentgenol"},{"key":"6154_CR31","doi-asserted-by":"publisher","first-page":"808","DOI":"10.1111\/j.1365-2141.2008.07420.x","volume":"144","author":"AJ Fyfe","year":"2009","unstructured":"Fyfe AJ, Gallipoli P (2009) Multiple splenic calcifications. Br J Haematol 144:808. https:\/\/doi.org\/10.1111\/j.1365-2141.2008.07420.x","journal-title":"Br J Haematol"}],"container-title":["Rheumatology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00296-026-06154-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00296-026-06154-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00296-026-06154-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T15:39:25Z","timestamp":1783525165000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00296-026-06154-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,23]]},"references-count":31,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2026,6]]}},"alternative-id":["6154"],"URL":"https:\/\/doi.org\/10.1007\/s00296-026-06154-9","relation":{},"ISSN":["1437-160X"],"issn-type":[{"value":"1437-160X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,23]]},"assertion":[{"value":"8 April 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no relevant financial or non-financial interests to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was approved by the ethics committee of AZ DELTA Roeselare Hospital with registration number B1172026000005.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Written informed consent was obtained from the patient for publication of this case report.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"Artificial intelligence tools were used solely to improve language clarity and manuscript structure. The literature search, study selection, data interpretation and scientific content were performed entirely by the authors through manual searches of databases. All content was reviewed, verified, and approved by the authors, who take full responsibility for the accuracy and integrity of the manuscript. Tool used: Microsoft 365 Copilot (Microsoft), accessed between May 2025 and April 2026.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"AI assistance statement"}}],"article-number":"103"}}