{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:12:07Z","timestamp":1792782727977,"version":"4.5.0"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T00:00:00Z","timestamp":1787356800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T00:00:00Z","timestamp":1787356800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Selcuk University","id":[{"id":"https:\/\/ror.org\/045hgzm75","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Rheumatol Int"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The objectives of this study were, firstly, to assess medication adherence and, secondly, to evaluate the relationships between medication adherence and symptoms, disease activity, and patient-reported outcomes in patients with newly diagnosed primary Sj\u00f6gren disease (pSjD). In this prospective observational cohort study, 54 patients with newly diagnosed pSjD were enrolled in a tertiary rheumatology clinic. Forty patients (74.1%) were reassessed after a mean follow-up of 21.36\u2009\u00b1\u20094.79\u00a0months. Medication adherence was evaluated using the Compliance Questionnaire for Rheumatology-5 (CQR-5), classifying patients as low or high adherence. Disease activity, symptom burden, psychological symptoms, fatigue, functional status, health-related quality of life, and medication beliefs were evaluated using ESSDAI, ESSPRI, HADS, fatigue severity assessment, HAQ, SF-12, and the Beliefs about Medicines Questionnaire (BMQ). The necessity-concern differential (NCD) was calculated as the BMQ-specific necessity score minus the concern score. Logistic regression analysis was exploratory. The cohort was predominantly female (52\/54, 96.3%), with a mean age of 49.7\u2009\u00b1\u20099.5\u00a0years. At follow-up, 16 patients (40%) were classified as low adherence and 24 (60%) as high adherence. Baseline clinical and sociodemographic characteristics were comparable between groups. ESSDAI scores remained low and stable over time, and ESSPRI increased modestly in both groups without significant between-group differences. Psychological status, fatigue, functional status, and quality of life were similar across adherence categories. Specific necessity scores were numerically higher in high-adherence patients (3.37\u2009\u00b1\u20090.79 vs. 3.04\u2009\u00b1\u20091.06;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.267), whereas concern scores tended to be higher in low-adherence patients (3.46\u2009\u00b1\u20090.92 vs. 3.07\u2009\u00b1\u20090.63;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.115). The NCD was significantly lower in the low-adherence group than in the high-adherence group (\u2212\u20090.43\u2009\u00b1\u20091.16 vs. 0.30\u2009\u00b1\u20090.96;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.038). In exploratory logistic regression, higher NCD was associated with high adherence (OR 1.95, 95% CI 1.01\u20133.76). In patients with newly diagnosed pSjD, low medication adherence was frequent and was associated with patients\u2019 necessity-concern balance rather than clinical disease activity or patient-reported burden. Because adherence and medication beliefs were assessed at the same time point and CQR-5 has not been specifically validated in pSjD, these findings should be interpreted as exploratory and non-causal.\n                  <\/jats:p>","DOI":"10.1007\/s00296-026-06201-5","type":"journal-article","created":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T08:32:10Z","timestamp":1787387530000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Medication adherence is associated with the necessity-concern differential in newly diagnosed primary Sj\u00f6gren disease: a prospective observational cohort study"],"prefix":"10.1007","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0673-3961","authenticated-orcid":false,"given":"Kemal","family":"Erol","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4988-1270","authenticated-orcid":false,"given":"Ezgi","family":"Aky\u0131ld\u0131z Tezcan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8751-3306","authenticated-orcid":false,"given":"Naciye","family":"Ba\u015f Bilen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7507-0666","authenticated-orcid":false,"given":"Cemal","family":"G\u00fcrb\u00fcz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,22]]},"reference":[{"issue":"4","key":"6201_CR1","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1016\/j.jht.2025.02.007","volume":"38","author":"K Erol","year":"2025","unstructured":"Erol K, Akyildiz Tezcan E, Akg\u00f6l S (2025) Exploring hand function in newly diagnosed primary Sj\u00f6gren\u2019s syndrome: clinical, radiographic, and ultrasonographic insights. 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Sel\u00e7uk \u00dcniversitesi Rekt\u00f6rl\u00fc\u011f\u00fc Yerel Etik Kurulu; approval no: 2024\/296; meeting date: 04 June 2024; official document date and number: 05 June 2024, E-70632468\u2013050.04\u2013768772). The approved study title was \u201cEvaluation of Medication Adherence in Primary Sj\u00f6gren Syndrome.\u201d The study was conducted in accordance with the ethical principles of the Declaration of Helsinki, October 2024 version, and Good Clinical Practice principles.","order":2,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Written informed consent was obtained from all participants before inclusion in the study.","order":3,"name":"Ethics","label":"Consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Artificial intelligence-assisted tools were used only for language editing and improvement of grammar and readability. All AI-assisted edits were critically reviewed, verified, and approved by the authors. No artificial intelligence tool was used to generate original data, perform statistical analyses, interpret the results, or draw scientific conclusions.","order":4,"name":"Ethics","label":"Use of artificial intelligence","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The questionnaires and scales used in this study were administered in accordance with their published instructions, validated versions, and applicable academic-use or licensing requirements. No full questionnaire forms or copyrighted item content are reproduced in this manuscript.","order":5,"name":"Ethics","label":"Permission to use questionnaires","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This work has not been previously presented or published as a congress abstract.","order":6,"name":"Ethics","label":"Related congress abstract publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"No part of this manuscript has been copied from or published elsewhere, in whole or in part.","order":7,"name":"Ethics","label":"Disclaimer","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"242"}}