{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T20:40:39Z","timestamp":1792701639349,"version":"4.5.0"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:00:00Z","timestamp":1792627200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:00:00Z","timestamp":1792627200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Rheumatol Int"],"DOI":"10.1007\/s00296-026-06341-8","type":"journal-article","created":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T07:16:36Z","timestamp":1792653396000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical and serological features according to anti-DFS70 antibody status in undifferentiated connective tissue disease: a retrospective cross-sectional study"],"prefix":"10.1007","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4368-3078","authenticated-orcid":false,"given":"Mehmet Nur","family":"Kaya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4544-3222","authenticated-orcid":false,"given":"Muhammed","family":"Canba\u015f","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9582-4376","authenticated-orcid":false,"given":"\u00d6zlem","family":"K\u0131l\u0131\u00e7","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6610-6540","authenticated-orcid":false,"given":"Kemal","family":"Tekin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4691-3417","authenticated-orcid":false,"given":"Sedat","family":"Y\u0131lmaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,22]]},"reference":[{"key":"6341_CR1","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1159\/000496483","volume":"98","author":"Y Lyu","year":"2019","unstructured":"Lyu Y, Boerner E, Theegarten D et al (2019) Utility of Anti-DSF70 Antibodies to Predict Connective Tissue Disease in Patients Originally Presenting with Idiopathic Interstitial Pneumonia. Respiration 98:29\u201337","journal-title":"Respiration"},{"key":"6341_CR2","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1007\/s12016-016-8564-5","volume":"52","author":"K Conrad","year":"2017","unstructured":"Conrad K, R\u00f6ber N, Andrade LEC et al (2017) The Clinical Relevance of Anti-DFS70 Autoantibodies. Clin Rev Allergy Immunol 52:202\u2013216","journal-title":"Clin Rev Allergy Immunol"},{"key":"6341_CR3","doi-asserted-by":"publisher","first-page":"829436","DOI":"10.3389\/fmed.2022.829436","volume":"9","author":"C Deng","year":"2022","unstructured":"Deng C, Wang A, Hu C et al (2022) The Prevalence and Clinical Relevance of the DFS Immunofluorescence Staining Pattern in a Large ANA-Positive Cohort. Front Med (Lausanne) 9:829436","journal-title":"Front Med (Lausanne)"},{"key":"6341_CR4","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1016\/j.autrev.2011.11.005","volume":"11","author":"M Mahler","year":"2012","unstructured":"Mahler M, Hanly JG, Fritzler MJ (2012) Importance of the dense fine speckled pattern on HEp-2 cells and anti-DFS70 antibodies for the diagnosis of systemic autoimmune diseases. Autoimmun Rev 11:642\u2013645","journal-title":"Autoimmun Rev"},{"key":"6341_CR5","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1007\/s12026-016-8836-4","volume":"65","author":"M Infantino","year":"2017","unstructured":"Infantino M, Meacci F, Grossi V et al (2017) The clinical impact of Anti-DFS70 antibodies in undifferentiated connective tissue disease: case reports and a review of the literature. Immunol Res 65:293\u2013295","journal-title":"Immunol Res"},{"key":"6341_CR6","doi-asserted-by":"publisher","first-page":"2037","DOI":"10.1136\/annrheumdis-2019-eular.6286","volume":"78","author":"O Lima","year":"2019","unstructured":"Lima O, Argibay A, Estevez M et al (2019) AB1154 Clinical Significance of Monospecific Anti-DFS70 In Antinucleolar Antibody (ANA)-Positive Patients. Ann Rheum Dis 78:2037\u20132038","journal-title":"Ann Rheum Dis"},{"key":"6341_CR7","doi-asserted-by":"publisher","first-page":"3627","DOI":"10.1007\/s10067-019-04730-y","volume":"38","author":"BO Peker","year":"2019","unstructured":"Peker BO, \u015eener AG, Tarhan EF et al (2019) Investigation of anti-DFS70 antibody in patients with systemic autoimmune rheumatic diseases. Clin Rheumatol 38:3627\u20133633","journal-title":"Clin Rheumatol"},{"key":"6341_CR8","doi-asserted-by":"publisher","first-page":"e000786","DOI":"10.1136\/rmdopen-2018-000786","volume":"4","author":"M Antunes","year":"2019","unstructured":"Antunes M, Scir\u00e8 CA, Talarico R et al (2019) Undifferentiated connective tissue disease: state of the art on clinical practice guidelines. RMD Open 4:e000786","journal-title":"RMD Open"},{"key":"6341_CR9","first-page":"615","volume":"17","author":"M Mosca","year":"1999","unstructured":"Mosca M, Neri R, Bombardieri S (1999) Undifferentiated connective tissue diseases (UCTD): a review of the literature and a proposal for preliminary classification criteria. Clin Exp Rheumatol 17:615\u2013620","journal-title":"Clin Exp Rheumatol"},{"key":"6341_CR10","doi-asserted-by":"publisher","first-page":"1400","DOI":"10.1002\/art.40930","volume":"71","author":"M Aringer","year":"2019","unstructured":"Aringer M, Costenbader K, Daikh D et al (2019) European League Against Rheumatism\/American College of Rheumatology classification criteria for systemic lupus erythematosus. Arthritis Rheumatol 71:1400\u20131412","journal-title":"Arthritis Rheumatol"},{"key":"6341_CR11","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1002\/art.39859","volume":"69","author":"CH Shiboski","year":"2017","unstructured":"Shiboski CH, Shiboski SC, Seror R et al (2017) American College of Rheumatology\/European League Against Rheumatism classification criteria for primary Sj\u00f6gren\u2019s syndrome: a consensus and data-driven methodology involving three international patient cohorts. Arthritis Rheumatol 69:35\u201345","journal-title":"Arthritis Rheumatol"},{"key":"6341_CR12","doi-asserted-by":"publisher","first-page":"2737","DOI":"10.1002\/art.38098","volume":"65","author":"F van den Hoogen","year":"2013","unstructured":"van den Hoogen F, Khanna D, Fransen J et al (2013) classification criteria for systemic sclerosis: an American College of Rheumatology\/European League Against Rheumatism collaborative initiative. Arthritis Rheum 65:2737\u20132747","journal-title":"Arthritis Rheum"},{"key":"6341_CR13","doi-asserted-by":"publisher","first-page":"1580","DOI":"10.1136\/ard.2010.138461","volume":"69","author":"D Aletaha","year":"2010","unstructured":"Aletaha D, Neogi T, Silman AJ et al (2010) rheumatoid arthritis classification criteria: an American College of Rheumatology\/European League Against Rheumatism collaborative initiative. Ann Rheum Dis 69:1580\u20131588","journal-title":"Ann Rheum Dis"},{"key":"6341_CR14","doi-asserted-by":"publisher","first-page":"2271","DOI":"10.1002\/art.40320","volume":"69","author":"IE Lundberg","year":"2017","unstructured":"Lundberg IE, Tj\u00e4rnlund A, Bottai M et al (2017) European League Against Rheumatism\/American College of Rheumatology classification criteria for adult and juvenile idiopathic inflammatory myopathies and their major subgroups. Arthritis Rheumatol 69:2271\u20132282","journal-title":"Arthritis Rheumatol"},{"key":"6341_CR15","first-page":"41","volume-title":"Mixed Connective Tissue Disease and Antinuclear Antibodies","author":"R Kasukawa","year":"1987","unstructured":"Kasukawa R, Tojo T, Miyawaki S (1987) Preliminary diagnostic criteria for classification of mixed connective tissue disease. In: Kasukawa R, Sharp GC (eds) Mixed Connective Tissue Disease and Antinuclear Antibodies. Elsevier, Amsterdam, pp 41\u201347"},{"key":"6341_CR16","doi-asserted-by":"publisher","first-page":"88","DOI":"10.3389\/fmed.2018.00088","volume":"5","author":"JB Carter","year":"2018","unstructured":"Carter JB, Carter S, Saschenbrecker S et al (2018) Recognition and Relevance of Anti-DFS70 Autoantibodies in Routine Antinuclear Autoantibodies Testing at a Community Hospital. Front Med (Lausanne) 5:88","journal-title":"Front Med (Lausanne)"},{"issue":"4","key":"6341_CR17","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1007\/s00296-011-2234-y","volume":"33","author":"LF Guerrero","year":"2013","unstructured":"Guerrero LF, Rueda JC, Arciniegas R, Rueda JM (2013) Undifferentiated connective tissue disease in a rheumatology center in Cali, Colombia: clinical features of 94 patients followed for a year. Rheumatol Int 33(4):1085\u20131088","journal-title":"Rheumatol Int"},{"key":"6341_CR18","doi-asserted-by":"publisher","first-page":"1423","DOI":"10.1007\/s00296-019-04299-4","volume":"39","author":"SY Kang","year":"2019","unstructured":"Kang SY, Lee WI, Kim MH, Jeon YL (2019) Clinical use of anti-DFS70 autoantibodies. Rheumatol Int 39:1423\u20131429","journal-title":"Rheumatol Int"},{"key":"6341_CR19","doi-asserted-by":"publisher","first-page":"1090","DOI":"10.1515\/cclm-2017-0541","volume":"56","author":"C Bonroy","year":"2018","unstructured":"Bonroy C, Schouwers S, Berth M et al (2018) The importance of detecting anti-DFS70 in routine clinical practice: comparison of different care settings. Clin Chem Lab Med 56:1090\u20131099","journal-title":"Clin Chem Lab Med"},{"key":"6341_CR20","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.3899\/jrheum.190533","volume":"47","author":"L Moroni","year":"2020","unstructured":"Moroni L, Restovic G, Cervera R et al (2020) Economic Analysis of the Use of Anti-DFS70 Antibody Test in Patients with Undifferentiated Systemic Autoimmune Disease Symptoms. J Rheumatol 47:1275\u20131284","journal-title":"J Rheumatol"}],"container-title":["Rheumatology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00296-026-06341-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00296-026-06341-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00296-026-06341-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T20:02:59Z","timestamp":1792699379000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00296-026-06341-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,22]]},"references-count":20,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2026,11]]}},"alternative-id":["6341"],"URL":"https:\/\/doi.org\/10.1007\/s00296-026-06341-8","relation":{},"ISSN":["1437-160X"],"issn-type":[{"value":"1437-160X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,22]]},"assertion":[{"value":"16 September 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 October 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 October 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Mehmet Nur Kaya, Muhammed Canba\u015f, \u00d6zlem K\u0131l\u0131\u00e7, Kemal Tekin and Sedat Y\u0131lmaz declare that they have no conflict of interest.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the Ethics Committee of Health Sciences University, G\u00fclhane Training and Research Hospital (Date: 24.04.2024 and Decision number: 2024\/136). All procedures performed in studies involving human participants were in accordance with the Helsinki Declaration as revised in 2013 and its later amendments.","order":2,"name":"Ethics","label":"Ethical approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"During the preparation of this article, the authors used Gemini (versions 1.5 Pro and 2.0 Flash) exclusively for language and grammar corrections. The authors have reviewed and edited the content as necessary and take full responsibility for the completeness and accuracy of the final report.","order":3,"name":"Ethics","label":"Artificial intelligence use","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors hereby declare that no part of this report has been copied from other sources, published elsewhere, or generated by Artificial Intelligence. This work represents original research conducted by the authors.","order":4,"name":"Ethics","label":"Disclaimer","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"294"}}