{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T21:43:05Z","timestamp":1774647785765,"version":"3.50.1"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2016,2,17]],"date-time":"2016-02-17T00:00:00Z","timestamp":1455667200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"CONACYT","award":["102109"],"award-info":[{"award-number":["102109"]}]},{"DOI":"10.13039\/501100005324","name":"UASLP","doi-asserted-by":"crossref","award":["FAI 2015"],"award-info":[{"award-number":["FAI 2015"]}],"id":[{"id":"10.13039\/501100005324","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Plant Cell Rep"],"published-print":{"date-parts":[[2016,5]]},"DOI":"10.1007\/s00299-016-1946-6","type":"journal-article","created":{"date-parts":[[2016,2,17]],"date-time":"2016-02-17T14:14:35Z","timestamp":1455718475000},"page":"1133-1141","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Chlamydomonas reinhardtii chloroplasts express an orally immunogenic protein targeting the p210 epitope implicated in atherosclerosis immunotherapies"],"prefix":"10.1007","volume":"35","author":[{"given":"Josu\u00e9 I.","family":"Beltr\u00e1n-L\u00f3pez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Romero-Maldonado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Monreal-Escalante","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernardo","family":"Ba\u00f1uelos-Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luz MT","family":"Paz-Maldonado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Rosales-Mendoza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,2,17]]},"reference":[{"issue":"8","key":"1946_CR1","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1586\/erv.10.78","volume":"9","author":"T Cardi","year":"2010","unstructured":"Cardi T, Lenzi P, Maliga P (2010) Chloroplasts as expression platforms for plant-produced vaccines. Expert Rev Vaccin 9(8):893\u2013911","journal-title":"Expert Rev Vaccin"},{"key":"1946_CR2","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1111\/pbi.12073","volume":"11","author":"HC Chen","year":"2013","unstructured":"Chen HC, Melis A (2013) Marker-free genetic engineering of the chloroplast in the green microalga Chlamydomonas reinhardtii. Plant Biotechnol J 11:818\u2013828","journal-title":"Plant Biotechnol J"},{"issue":"3","key":"1946_CR3","doi-asserted-by":"crossref","first-page":"380","DOI":"10.5114\/ceji.2015.54603","volume":"40","author":"P Conti","year":"2015","unstructured":"Conti P, Shaik-Dasthagirisaeb Y (2015) Atherosclerosis: a chronic inflammatory disease mediated by mast cells. Cent Eur J Immunol 40(3):380\u2013386","journal-title":"Cent Eur J Immunol"},{"key":"1946_CR4","first-page":"111","volume":"286","author":"H Daniell","year":"2005","unstructured":"Daniell H, Ruiz ON, Dhingra A (2005) Chloroplast genetic engineering to improve agronomic traits. Methods Mol Biol 286:111\u2013138","journal-title":"Methods Mol Biol"},{"key":"1946_CR5","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.jbiotec.2009.12.006","volume":"145","author":"IA Dreesen","year":"2010","unstructured":"Dreesen IA, Charpin-El Hamri G, Fussenegger M (2010) Heat-stable oral alga-based vaccine protects mice from Staphylococcus aureus infection. J Biotechnol 145:273\u2013280","journal-title":"J Biotechnol"},{"issue":"6","key":"1946_CR6","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1046\/j.1365-313X.2002.01319.x","volume":"30","author":"S Franklin","year":"2002","unstructured":"Franklin S, Ngo B, Efuet E, Mayfield SP (2002) Development of a GFP reporter gene for Chlamydomonas reinhardtii chloroplast. Plant J 30(6):733\u2013744","journal-title":"Plant J"},{"issue":"5","key":"1946_CR7","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1161\/01.ATV.0000067935.02679.B0","volume":"23","author":"GN Fredrikson","year":"2003","unstructured":"Fredrikson GN, Hedblad B, Berglund G, Alm R, Ares M, Cercek B, Chyu KY, Shah PK, Nilsson J (2003a) Identification of immune responses against aldehyde-modified peptide sequences in apoB associated with cardiovascular disease. Arterioscler Thromb Vasc Biol 23(5):872\u2013878","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"1946_CR8","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1161\/01.ATV.0000067937.93716.DB","volume":"23","author":"GN Fredrikson","year":"2003","unstructured":"Fredrikson GN, S\u00f6derberg I, Lindholm M, Dimayuga P, Chyu KY, Shah PK, Nilsson J (2003b) Inhibition of atherosclerosis in apoE-null mice by immunization with apoB-100 peptide sequences. Arterioscler Thromb Vasc Biol 23:879\u2013884","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"1946_CR9","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.cardiores.2004.01.028","volume":"62","author":"J George","year":"2004","unstructured":"George J, Yacov N, Breitbart E, Bangio L, Shaish A, Gilburd B, Shoenfeld Y, Harats D (2004) Suppression of early atherosclerosis in LDL receptor deficient mice by oral tolerance with beta 2-glycoprotein I. Cardiovasc Res 62:603\u2013609","journal-title":"Cardiovasc Res"},{"issue":"3","key":"1946_CR10","doi-asserted-by":"crossref","first-page":"e59822","DOI":"10.1371\/journal.pone.0059822","volume":"8","author":"AK Gloudemans","year":"2013","unstructured":"Gloudemans AK, Plantinga M, Guilliams M, Willart MA, Ozir-Fazalalikhan A, van der Ham A, Boon L, Harris NL, Hammad H, Hoogsteden HC, Yazdanbakhsh M, Hendriks RW, Lambrecht BN, Smits HH (2013) The mucosal adjuvant cholera toxin B instructs non-mucosal dendritic cells to promote IgA production via retinoic acid and TGF-\u03b2. PLoS One 8(3):e59822","journal-title":"PLoS One"},{"key":"1946_CR11","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1073\/pnas.54.6.1665","volume":"54","author":"DS Gorman","year":"1965","unstructured":"Gorman DS, Levine RP (1965) Cytochrome f and plastocyanin: their sequence in the photosynthetic electron transport chain of Chlamydomonas reinhardtii. Proc Natl Acad Sci USA 54:1665\u20131669","journal-title":"Proc Natl Acad Sci USA"},{"key":"1946_CR12","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1016\/S0735-1097(02)02135-6","volume":"40","author":"D Harats","year":"2002","unstructured":"Harats D, Yacov N, Gilburd B, Shoenfeld Y, George J (2002) Oral tolerance with heat shock protein 65 attenuates mycobacterium tuberculosis induced and high-fat-diet-driven atherosclerotic lesions. J Am Coll Cardiol 40:1333\u20131338","journal-title":"J Am Coll Cardiol"},{"key":"1946_CR13","volume-title":"Comparative quantification of health risks: global and regional burden of disease attributable to selected major risk factors","author":"AM Hauri","year":"2003","unstructured":"Hauri AM, Armstrong GL, Hutin YJF (2003) Contaminated injections in health care settings. In: Ezzati M, Lopez AD, Rodgers A, Murray CJL (eds) Comparative quantification of health risks: global and regional burden of disease attributable to selected major risk factors. World Health Organization, Geneva"},{"issue":"3","key":"1946_CR14","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1586\/14760584.2014.883285","volume":"13","author":"C Herzog","year":"2014","unstructured":"Herzog C (2014) Influence of parenteral administration routes and additional factors on vaccine safety and immunogenicity: a review of recent literature. Expert Rev Vaccin 13(3):399\u2013415","journal-title":"Expert Rev Vaccin"},{"issue":"12","key":"1946_CR15","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1016\/0264-410X(93)90039-Z","volume":"11","author":"J Holmgren","year":"1993","unstructured":"Holmgren J, Lycke N, Czerkinsky C (1993) Cholera toxin and cholera B subunit as oral-mucosal adjuvant and antigen vector systems. Vaccine 11(12):1179\u20131184","journal-title":"Vaccine"},{"issue":"7","key":"1946_CR16","first-page":"491","volume":"81","author":"Y Hutin","year":"2003","unstructured":"Hutin Y, Hauri A, Chiarello L, Catlin M, Stilwell B, Ghebrehiwet T, Garner J (2003) Injection Safety Best Practices Development Group. Best infection control practices for intradermal, subcutaneous, and intramuscular needle injections. Bull World Health Organ 81(7):491\u2013500","journal-title":"Bull World Health Organ"},{"key":"1946_CR17","doi-asserted-by":"crossref","first-page":"245","DOI":"10.3389\/fimmu.2013.00245","volume":"4","author":"C Keijzer","year":"2013","unstructured":"Keijzer C, van der Zee R, van Eden W, Broere F (2013) Treg inducing adjuvants for therapeutic vaccination against chronic inflammatory diseases. Front Immunol 4:245","journal-title":"Front Immunol"},{"issue":"5","key":"1946_CR18","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1161\/ATVBAHA.109.202671","volume":"30","author":"R Klingenberg","year":"2010","unstructured":"Klingenberg R, Lebens M, Hermansson A, Fredrikson GN, Strodthoff D, Rudling M, Ketelhuth DF, Gerdes N, Holmgren J, Nilsson J, Hansson GK (2010) Intranasal immunization with an apolipoprotein B-100 fusion protein induces antigen-specific regulatory T cells and reduces atherosclerosis. Arterioscler Thromb Vasc Biol 30(5):946\u2013952","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"1946_CR19","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1136\/hrt.69.6.476","volume":"69","author":"DS Leake","year":"1993","unstructured":"Leake DS (1993) Oxidised low density lipoproteins and atherogenesis. Br Heart J 69:476\u2013478","journal-title":"Br Heart J"},{"key":"1946_CR20","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1161\/01.CIR.0000029750.99462.30","volume":"106","author":"R Maron","year":"2002","unstructured":"Maron R, Sukhova G, Faria AM, Hoffmann E, Mach F, Libby P, Weiner HL (2002) Mucosal administration of heat shock protein-65 decreases atherosclerosis and inflammation in aortic arch of low-density lipoprotein receptor-deficient mice. Circulation 106:1708\u20131715","journal-title":"Circulation"},{"issue":"6","key":"1946_CR21","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1097\/MOG.0b013e32830d58be","volume":"24","author":"J Mestecky","year":"2008","unstructured":"Mestecky J, Nguyen H, Czerkinsky C, Kiyono H (2008) Oral immunization: an update. Curr Opin Gastroenterol 24(6):713\u2013719","journal-title":"Curr Opin Gastroenterol"},{"issue":"3","key":"1946_CR22","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1007\/s00299-014-1720-6","volume":"34","author":"L Orellana-Escobedo","year":"2015","unstructured":"Orellana-Escobedo L, Rosales-Mendoza S, Romero-Maldonado A, Parsons J, Decker EL, Monreal-Escalante E, Moreno-Fierros L, Reski R (2015) An Env-derived multi-epitope HIV chimeric protein produced in the moss Physcomitrella patens is immunogenic in mice. Plant Cell Rep 34(3):425\u2013433","journal-title":"Plant Cell Rep"},{"key":"1946_CR23","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1016\/j.vaccine.2015.02.065","volume":"33","author":"S Pagliusi","year":"2015","unstructured":"Pagliusi S, Jain R, Suri RK (2015) DCVMN Executive Committee Group. Vaccines, our shared responsibility. Vaccine 33:2197\u20132202","journal-title":"Vaccine"},{"issue":"6","key":"1946_CR24","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1007\/s11936-013-0268-z","volume":"15","author":"MJ Patel","year":"2013","unstructured":"Patel MJ, Blazing MA (2013) Inflammation and Atherosclerosis: disease modulating Therapies. Curr Treat Options Cardiovasc Med 15(6):681\u2013695","journal-title":"Curr Treat Options Cardiovasc Med"},{"issue":"1","key":"1946_CR25","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1007\/s12026-013-8383-1","volume":"56","author":"C Pierides","year":"2013","unstructured":"Pierides C, Bermudez-Fajardo A, Fredrikson GN, Nilsson J, Oviedo-Orta E (2013) Immune responses elicited by apoB-100-derived peptides in mice. Immunol Res 56(1):96\u2013108","journal-title":"Immunol Res"},{"key":"1946_CR26","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1586\/14760584.2013.825455","volume":"12","author":"S Rosales-Mendoza","year":"2013","unstructured":"Rosales-Mendoza S (2013) Future directions for the development of Chlamydomonas-based vaccines. Expert Rev Vaccin 12:1011\u20131019","journal-title":"Expert Rev Vaccin"},{"issue":"7","key":"1946_CR27","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1007\/s00299-007-0310-2","volume":"26","author":"S Rosales-Mendoza","year":"2007","unstructured":"Rosales-Mendoza S, Soria-Guerra RE, de Jes\u00fas Olivera-Flores MT, L\u00f3pez-Revilla R, Arg\u00fcello-Astorga GR, Jim\u00e9nez-Bremont JF, Garc\u00eda-de la Cruz RF, Loyola-Rodr\u00edguez JP, Alpuche-Sol\u00eds AG (2007) Expression of Escherichia coli heat-labile enterotoxin b subunit (LTB) in carrot (Daucus carota L.). Plant Cell Rep 26(7):969\u2013976","journal-title":"Plant Cell Rep"},{"key":"1946_CR28","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.hlc.2013.03.001","volume":"22","author":"K Sakakura","year":"2013","unstructured":"Sakakura K, Nakano M, Otsuka F, Ladich E, Kolodgie FD, Virmani R (2013) Pathophysiology of atherosclerosis plaque progression. Heart Lung Circ 22:399\u2013411","journal-title":"Heart Lung Circ"},{"key":"1946_CR29","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1016\/j.vaccine.2013.01.005","volume":"31","author":"JA Salazar-Gonz\u00e1lez","year":"2013","unstructured":"Salazar-Gonz\u00e1lez JA, Rosales-Mendoza S (2013) A perspective for atherosclerosis vaccination: is there a place for plant-based vaccines? Vaccine 31:1364\u20131369","journal-title":"Vaccine"},{"issue":"18","key":"1946_CR30","doi-asserted-by":"crossref","first-page":"2218","DOI":"10.1093\/eurheartj\/ehn336","volume":"29","author":"P Sj\u00f6gren","year":"2008","unstructured":"Sj\u00f6gren P, Fredrikson GN, Samnegard A, Ericsson CG, Ohrvik J, Fisher RM, Nilsson J, Hamsten A (2008) High plasma concentrations of autoantibodies against native peptide 210 of apoB-100 are related to less coronary atherosclerosis and lower risk of myocardial infarction. Eur Heart J 29(18):2218\u20132226","journal-title":"Eur Heart J"},{"key":"1946_CR31","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1161\/CIRCULATIONAHA.106.615609","volume":"114","author":"GH Puijvelde van","year":"2006","unstructured":"van Puijvelde GH, Hauer AD, de Vos P, van den Heuvel R, van Herwijnen MJ, van der Zee R, van Eden W, van Berkel TJ, Kuiper J (2006) Induction of oral tolerance to oxidized low-density lipoprotein ameliorates atherosclerosis. Circulation 114:1968\u20131976","journal-title":"Circulation"},{"issue":"5","key":"1946_CR32","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1111\/j.1365-2796.2010.02311.x","volume":"269","author":"M Wigren","year":"2011","unstructured":"Wigren M, Kolbus D, Dun\u00e9r P, Ljungcrantz I, S\u00f6derberg I, Bj\u00f6rkbacka H, Fredrikson GN, Nilsson J (2011) Evidence for a role of regulatory T cells in mediating the atheroprotective effect of apolipoprotein B peptide vaccine. J Intern Med 269(5):546\u2013556","journal-title":"J Intern Med"},{"key":"1946_CR33","unstructured":"World Health Organization (2015) Descriptive note 317 Ene\/2015, http:\/\/www.who.int\/mediacentre\/factsheets\/fs317\/en\/ . Accessed on 22 Sep 2015"},{"issue":"1","key":"1946_CR34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jjcc.2015.02.002","volume":"66","author":"T Yamashita","year":"2015","unstructured":"Yamashita T, Sasaki N, Kasahara K, Hirata KI (2015) Anti-inflammatory and immune-modulatory therapies for preventing atherosclerotic cardiovascular disease. J Cardiol 66(1):1\u20138","journal-title":"J Cardiol"}],"container-title":["Plant Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00299-016-1946-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00299-016-1946-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00299-016-1946-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,16]],"date-time":"2020-05-16T13:29:08Z","timestamp":1589635748000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00299-016-1946-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,17]]},"references-count":34,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["1946"],"URL":"https:\/\/doi.org\/10.1007\/s00299-016-1946-6","relation":{},"ISSN":["0721-7714","1432-203X"],"issn-type":[{"value":"0721-7714","type":"print"},{"value":"1432-203X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,17]]}}}