{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T03:36:33Z","timestamp":1740108993929,"version":"3.37.3"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2018,11,30]],"date-time":"2018-11-30T00:00:00Z","timestamp":1543536000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81773830"],"award-info":[{"award-number":["81773830"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"High-level Teachers in Beijing Municipal Universities in the Period of 13th Five-year Plan","award":["CIT&TCD20170324"],"award-info":[{"award-number":["CIT&TCD20170324"]}]},{"name":"the Key project at central government level: The ability establishment of sustainable use for valuable Chinese medicine resources","award":["2060302"],"award-info":[{"award-number":["2060302"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Plant Cell Rep"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1007\/s00299-018-2363-9","type":"journal-article","created":{"date-parts":[[2018,11,29]],"date-time":"2018-11-29T23:57:37Z","timestamp":1543535857000},"page":"211-220","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Probing the function of protein farnesyltransferase in Tripterygium wilfordii"],"prefix":"10.1007","volume":"38","author":[{"given":"Ping","family":"Su","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linhui","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongyu","family":"Guan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yifeng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yujun","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianyuan","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lichan","family":"Tu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiawei","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baowei","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xihong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luqi","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,11,30]]},"reference":[{"key":"2363_CR1","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1038\/nrm3255","volume":"13","author":"IM Ahearn","year":"2011","unstructured":"Ahearn IM, Haigis K, Bar-Sagi D, Philips MR (2011) Regulating the regulator: post-translational modification of RAS. Nat Rev Mol Cell Biol 13:39\u201351","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2363_CR2","first-page":"920","volume":"14","author":"P Bartel","year":"1993","unstructured":"Bartel P, Chien CT, Sternglanz R, Fields S (1993) Elimination of false positives that arise in using the two-hybrid system. Biotechniques 14:920\u2013924","journal-title":"Biotechniques"},{"key":"2363_CR3","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1007\/s11103-013-0070-z","volume":"82","author":"G Beck","year":"2013","unstructured":"Beck G, Coman D, Herren E, Ruiz-Sola MA, Rodr\u00edguez-Concepci\u00f3n M, Gruissem W, Vranov\u00e1 E (2013) Characterization of the GGPP synthase gene family in Arabidopsis thaliana. Plant Mol Biol 82:393\u2013416","journal-title":"Plant Mol Biol"},{"key":"2363_CR4","doi-asserted-by":"publisher","first-page":"1416","DOI":"10.1104\/pp.126.4.1416","volume":"126","author":"D Caldelari","year":"2001","unstructured":"Caldelari D, Sternberg H, Rodr\u00edguez-Concepci\u00f3n M, Gruissem W, Yalovsky S (2001) Efficient prenylation by a plant geranylgeranyltransferase-I requires a functional CaaL box motif and a proximal polybasic domain. Plant Physiol 126:1416\u20131429","journal-title":"Plant Physiol"},{"key":"2363_CR5","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/0076-6879(95)50060-X","volume":"250","author":"PB Cassidy","year":"1995","unstructured":"Cassidy PB, Dolence JM, Poulter CD (1995) Continuous fluorescence assay for protein prenyltransferases. Methods Enzymol 250:30\u201343","journal-title":"Methods Enzymol"},{"key":"2363_CR6","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/j.apsb.2016.12.002","volume":"7","author":"Q Cheng","year":"2017","unstructured":"Cheng Q, Tong Y, Wang Z, Su P, Gao W, Huang L (2017) Molecular cloning and functional identification of a cDNA encoding 4-hydroxy-3-methylbut-2-enyl diphosphate reductase from Tripterygium wilfordii. Acta Pharm Sin B 7:208\u2013214","journal-title":"Acta Pharm Sin B"},{"key":"2363_CR7","doi-asserted-by":"publisher","first-page":"156ra39","DOI":"10.1126\/scitranslmed.3004334","volume":"4","author":"R Chugh","year":"2012","unstructured":"Chugh R, Sangwan V, Patil SP, Dudeja V, Dawra RK, Banerjee S, Schumacher RJ, Blazar BR, Georg GI, Vickers SM et al (2012) A preclinical evaluation of Minnelide as a therapeutic agent against pancreatic cancer. Sci Transl Med 4:156ra39","journal-title":"Sci Transl Med"},{"key":"2363_CR8","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1016\/j.cell.2007.08.021","volume":"130","author":"TW Corson","year":"2007","unstructured":"Corson TW, Crews CM (2007) Molecular understanding and modern application of traditional medicines: triumphs and trials. Cell 130:769\u2013774","journal-title":"Cell"},{"key":"2363_CR9","doi-asserted-by":"publisher","first-page":"1239","DOI":"10.1126\/science.273.5279.1239","volume":"273","author":"S Cutler","year":"1996","unstructured":"Cutler S, Ghassemian M, Bonetta D, Cooney S, McCourt P (1996) A protein farnesyl transferase involved in abscisic acid signal transduction in Arabidopsis. Science 273:1239\u20131241","journal-title":"Science"},{"key":"2363_CR10","first-page":"514","volume":"7","author":"SG Del","year":"1989","unstructured":"Del SG, Manfioletti G, Schneider C (1989) The CTAB-DNA precipitation method: a common mini-scale preparation of template DNA from phagemids, phages or plasmids suitable for sequencing. Biotechniques 7:514\u2013520","journal-title":"Biotechniques"},{"key":"2363_CR11","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.1021\/bc500240p","volume":"25","author":"JK Dozier","year":"2014","unstructured":"Dozier JK, Khatwani SL, Wollack JW, Wang YC, Schmidt-Dannert C, Distefano MD (2014) Engineering protein farnesyltransferase for enzymatic protein labeling applications. Bioconjug Chem 25:1203\u20131212","journal-title":"Bioconjug Chem"},{"key":"2363_CR12","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1186\/s12864-017-4303-4","volume":"18","author":"F Du","year":"2017","unstructured":"Du F, Fan J, Wang T, Wu Y, Grierson D, Gao Z, Xia Y (2017) Identification of differentially expressed genes in flower, leaf and bulb scale of Lilium oriental hybrid \u2018Sorbonne\u2019 and putative control network for scent genes. BMC Genom 18:899","journal-title":"BMC Genom"},{"key":"2363_CR13","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1111\/pce.12605","volume":"39","author":"C Dutilleul","year":"2016","unstructured":"Dutilleul C, Ribeiro I, Blanc N, Nezames CD, Deng XW, Zglobicki P, Palacio Barrera AM, Atehort\u00f9a L, Courtois M, Labas V et al (2016) ASG2 is a farnesylated DWD protein that acts as ABA negative regulator in Arabidopsis. Plant Cell Environ 39:185\u2013198","journal-title":"Plant Cell Environ"},{"key":"2363_CR14","doi-asserted-by":"publisher","first-page":"3637","DOI":"10.1002\/1873-3468.12862","volume":"591","author":"A Hagemann","year":"2017","unstructured":"Hagemann A, M\u00fcller G, Manthey I, Bachmann HS (2017) Exploring the putative self-binding property of the human farnesyltransferase alpha-subunit. FEBS Lett 591:3637\u20133648","journal-title":"FEBS Lett"},{"key":"2363_CR15","doi-asserted-by":"publisher","first-page":"1708","DOI":"10.1016\/j.cell.2017.11.045","volume":"171","author":"F Hauser","year":"2017","unstructured":"Hauser F, Li Z, Waadt R, Schroeder JI (2017) SnapShot: abscisic acid signaling. Cell 171:1708","journal-title":"Cell"},{"key":"2363_CR16","first-page":"1693","volume":"8","author":"K Iwabuchi","year":"1993","unstructured":"Iwabuchi K, Li B, Bartel P, Fields S (1993) Use of the two-hybrid system to identify the domain of p53 involved in oligomerization. Oncogene 8:1693\u20131696","journal-title":"Oncogene"},{"key":"2363_CR17","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1104\/pp.105.065045","volume":"139","author":"CD Johnson","year":"2005","unstructured":"Johnson CD, Chary SN, Chernoff EA, Zeng Q, Running MP, Crowell DN (2005) Protein geranylgeranyltransferase I is involved in specific aspects of abscisic acid and auxin signaling in Arabidopsis. Plant Physiol 139:722\u2013733","journal-title":"Plant Physiol"},{"key":"2363_CR18","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1093\/jxb\/err258","volume":"63","author":"LP Manavalan","year":"2012","unstructured":"Manavalan LP, Chen X, Clarke J, Salmeron J, Nguyen HT (2012) RNAi-mediated disruption of squalene synthase improves drought tolerance and yield in rice. J Exp Bot 63:63\u201375","journal-title":"J Exp Bot"},{"key":"2363_CR19","doi-asserted-by":"publisher","first-page":"1381","DOI":"10.1093\/jxb\/ert003","volume":"64","author":"H Manmathan","year":"2013","unstructured":"Manmathan H, Shaner D, Snelling J, Tisserat N, Lapitan N (2013) Virus-induced gene silencing of Arabidopsis thaliana gene homologues in wheat identifies genes conferring improved drought tolerance. J Exp Bot 64:1381\u20131392","journal-title":"J Exp Bot"},{"key":"2363_CR20","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1038\/nature12754","volume":"504","author":"I Manolaridis","year":"2013","unstructured":"Manolaridis I, Kulkarni K, Dodd RB, Ogasawara S, Zhang Z, Bineva G, Reilly NO, Hanrahan SJ, Thompson AJ, Cronin N et al (2013) Mechanism of farnesylated CAAX protein processing by the intramembrane protease Rce1. Nature 504:301\u2013305","journal-title":"Nature"},{"key":"2363_CR21","doi-asserted-by":"publisher","first-page":"5363","DOI":"10.1158\/0008-5472.CAN-12-1006","volume":"72","author":"SG Manzo","year":"2012","unstructured":"Manzo SG, Zhou ZL, Wang YQ, Marinello J, He JX, Li YC, Ding J, Capranico G, Miao ZH (2012) Natural product triptolide mediates cancer cell death by triggering CDK7-dependent degradation of RNA polymerase II. Cancer Res 72:5363\u20135373","journal-title":"Cancer Res"},{"key":"2363_CR22","doi-asserted-by":"publisher","first-page":"16114","DOI":"10.1038\/nplants.2016.114","volume":"2","author":"JG Northey","year":"2016","unstructured":"Northey JG, Liang S, Jamshed M, Deb S, Foo E, Reid JB, McCourt P, Samuel MA (2016) Farnesylation mediates brassinosteroid biosynthesis to regulate abscisic acid responses. Nature Plants 2:16114","journal-title":"Nature Plants"},{"key":"2363_CR23","doi-asserted-by":"publisher","first-page":"1756","DOI":"10.3389\/fpls.2017.01756","volume":"8","author":"P Su","year":"2017","unstructured":"Su P, Guan H, Zhang Y, Wang X, Gao L, Zhao Y, Hu T, Zhou J, Ma B, Tu L et al (2017) Probing the single key amino acid responsible for the novel catalytic function of ent-kaurene oxidase supported by NADPH-cytochrome P450 reductases in Tripterygium wilfordii. Front Plant Sci 8:1756","journal-title":"Front Plant Sci"},{"key":"2363_CR24","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1111\/tpj.13756","volume":"93","author":"P Su","year":"2018","unstructured":"Su P, Guan H, Zhao Y, Tong Y, Xu M, Zhang Y, Hu T, Yang J, Cheng Q, Gao L et al (2018) Identification and functional characterization of diterpene synthases for triptolide biosynthesis from Tripterygium wilfordii. Plant J 93:50\u201365","journal-title":"Plant J"},{"key":"2363_CR25","doi-asserted-by":"publisher","first-page":"248","DOI":"10.6026\/97320630011248","volume":"11","author":"PA Subramani","year":"2015","unstructured":"Subramani PA, Narala VR, Michael RD, Lomada D, Reddy MC (2015) Molecular docking and simulation of curcumin with Geranylgeranyl Transferase1 (GGTase1) and Farnesyl Transferase (FTase). Bioinformation 11:248\u2013253","journal-title":"Bioinformation"},{"key":"2363_CR26","doi-asserted-by":"publisher","first-page":"2725","DOI":"10.1093\/molbev\/mst197","volume":"30","author":"K Tamura","year":"2013","unstructured":"Tamura K, Stecher G, Peterson D, Filipski A, Kumar S (2013) MEGA6: Molecular evolutionary genetics analysis version 6.0. Mol Biol Evol 30:2725\u20132729","journal-title":"Mol Biol Evol"},{"key":"2363_CR27","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1038\/nchembio.522","volume":"7","author":"DV Titov","year":"2011","unstructured":"Titov DV, Gilman B, He QL, Bhat S, Low WK, Dang Y, Smeaton M, Demain AJ, Miller PS, Kugel JF et al (2011) XPB, a subunit of TFIIH, is a target of the natural product triptolide. Nat Chem Biol 7:182\u2013188","journal-title":"Nat Chem Biol"},{"key":"2363_CR28","doi-asserted-by":"publisher","first-page":"25516","DOI":"10.3390\/ijms161025516","volume":"16","author":"Y Tong","year":"2015","unstructured":"Tong Y, Su P, Zhao Y, Zhang M, Wang X, Liu Y, Zhang X, Gao W, Huang L (2015) Molecular cloning and characterization of DXS and DXR genes in the terpenoid biosynthetic pathway of Tripterygium wilfordii. Int J Mol Sci 16:25516\u201325535","journal-title":"Int J Mol Sci"},{"key":"2363_CR29","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/S0254-6272(09)60043-1","volume":"29","author":"SH Tu","year":"2009","unstructured":"Tu SH (2009) Difficulties and countermeasures in treatment of rheumatoid arthritis with Tripterygium. Chin J Integr Tradit West Med 29:104\u2013105","journal-title":"Chin J Integr Tradit West Med"},{"key":"2363_CR30","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1111\/j.1365-313X.2005.02463.x","volume":"43","author":"Y Wang","year":"2005","unstructured":"Wang Y, Ying J, Kuzma M, Chalifoux M, Sample A, McArthur C, Uchacz T, Sarvas C, Wan J, Dennis DT et al (2005) Molecular tailoring of farnesylation for plant drought tolerance and yield protection. Plant J 43:413\u2013424","journal-title":"Plant J"},{"key":"2363_CR31","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1093\/mp\/ssn088","volume":"2","author":"Y Wang","year":"2009","unstructured":"Wang Y, Beaith M, Chalifoux M, Ying J, Uchacz T, Sarvcs C, Griffiths R, Kuzma M, Wan J, Huang Y (2009) Shoot-specific down-regulation of protein farnesyltransferase (alpha-subunit) for yield protection against drought in canola. Mol Plant 2:191\u2013200","journal-title":"Mol Plant"},{"key":"2363_CR32","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1111\/j.1440-1681.2011.05586.x","volume":"39","author":"KF Wong","year":"2012","unstructured":"Wong KF, Yuan Y, Luk JM (2012) Tripterygium wilfordii bioactive compounds as anticancer and anti-inflammatory agents. Clin Exp Pharmacol Physiol 39:311\u2013320","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"2363_CR33","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1111\/nph.14212","volume":"213","author":"JR Wu","year":"2017","unstructured":"Wu JR, Wang LC, Lin YR, Weng CP, Yeh CH, Wu SJ (2017) The Arabidopsis heat-intolerant 5 (hit5)\/enhanced response to aba 1 (era1) mutant reveals the crucial role of protein farnesylation in plant responses to heat stress. New Phytol 213:1181\u20131193","journal-title":"New Phytol"},{"key":"2363_CR34","first-page":"2814","volume":"27","author":"Q Zhai","year":"2015","unstructured":"Zhai Q, Zhang X, Wu F, Feng H, Deng L, Xu L, Zhang M, Wang Q, Li C (2015) Transcriptional mechanism of jasmonate receptor COI1-mediated delay of flowering time in Arabidopsis. Plant Cell 27:2814\u20132828","journal-title":"Plant Cell"},{"key":"2363_CR35","doi-asserted-by":"publisher","first-page":"2179","DOI":"10.1007\/s00299-015-1860-3","volume":"34","author":"M Zhang","year":"2015","unstructured":"Zhang M, Su P, Zhou YJ, Wang XJ, Zhao YJ, Liu YJ, Tong YR, Hu TY, Huang LQ, Gao W (2015) Identification of geranylgeranyl diphosphate synthase genes from Tripterygium wilfordii. Plant Cell Rep 34:2179\u20132188","journal-title":"Plant Cell Rep"},{"key":"2363_CR36","doi-asserted-by":"publisher","first-page":"e0125415","DOI":"10.1371\/journal.pone.0125415","volume":"10","author":"YJ Zhao","year":"2015","unstructured":"Zhao YJ, Chen X, Zhang M, Su P, Liu YJ, Tong YR, Wang XJ, Huang LQ, Gao W (2015) Molecular cloning and characterisation of farnesyl pyrophosphate synthase from Tripterygium wilfordii. PloS One 10:e0125415","journal-title":"PloS One"},{"key":"2363_CR37","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1039\/c2np00088a","volume":"29","author":"ZL Zhou","year":"2012","unstructured":"Zhou ZL, Yang YX, Ding J, Li YC, Miao ZH (2012) Triptolide: structural modifications, structure-activity relationships, bioactivities, clinical development and mechanisms. Nat Prod Rep 29:457\u2013475","journal-title":"Nat Prod Rep"}],"container-title":["Plant Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00299-018-2363-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00299-018-2363-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00299-018-2363-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,11,29]],"date-time":"2019-11-29T19:07:37Z","timestamp":1575054457000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00299-018-2363-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,30]]},"references-count":37,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["2363"],"URL":"https:\/\/doi.org\/10.1007\/s00299-018-2363-9","relation":{},"ISSN":["0721-7714","1432-203X"],"issn-type":[{"type":"print","value":"0721-7714"},{"type":"electronic","value":"1432-203X"}],"subject":[],"published":{"date-parts":[[2018,11,30]]},"assertion":[{"value":"6 August 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 November 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 November 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}