{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T06:52:52Z","timestamp":1791528772950,"version":"4.3.4"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31970321"],"award-info":[{"award-number":["31970321"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U1903201"],"award-info":[{"award-number":["U1903201"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31670298"],"award-info":[{"award-number":["31670298"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Natural Science Foundation of Jiangsu Bureau of Science and Technology","award":["BK20191254"],"award-info":[{"award-number":["BK20191254"]}]},{"DOI":"10.13039\/501100012269","name":"Science and Technology Innovative Research Team in Higher Educational Institutions of Hunan Province","doi-asserted-by":"publisher","award":["IRT_14R27"],"award-info":[{"award-number":["IRT_14R27"]}],"id":[{"id":"10.13039\/501100012269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Plant Cell Rep"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1007\/s00299-024-03242-7","type":"journal-article","created":{"date-parts":[[2024,6,3]],"date-time":"2024-06-03T00:01:32Z","timestamp":1717372892000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["In vivo transgenic studies confirm the critical acylation function of LeBAHD56 for shikonin in Lithospermum erythrorhizon"],"prefix":"10.1007","volume":"43","author":[{"given":"Liu","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changyi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohui","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suo","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongling","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minkai","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aliya","family":"Fazal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhang","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongyi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinfeng","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guihua","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwei","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonghua","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0448-9259","authenticated-orcid":false,"given":"Jinliang","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,6,3]]},"reference":[{"key":"3242_CR1","doi-asserted-by":"publisher","first-page":"735","DOI":"10.3389\/fpls.2017.00735","volume":"8","author":"MZ Ahmad","year":"2017","unstructured":"Ahmad MZ, Li P, Wang J, Rehman NU, Zhao J (2017) Isoflavone malonyltransferases GmIMaT1 and GmIMaT3 differently modify isoflavone glucosides in soybean (Glycine max) under various stresses. Front Plant Sci 8:735","journal-title":"Front Plant Sci"},{"issue":"3","key":"3242_CR2","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1111\/nph.13498","volume":"208","author":"T Bontpart","year":"2015","unstructured":"Bontpart T, Cheynier V, Ageorges A, Terrier N (2015) BAHD or SCPL acyltransferase? What a dilemma for acylation in the world of plant phenolic compounds. New Phytol 208(3):695\u2013707","journal-title":"New Phytol"},{"issue":"3","key":"3242_CR3","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1007\/s00425-015-2430-1","volume":"243","author":"MMdO Buanafina","year":"2016","unstructured":"Buanafina MMdO, Fescemyer HW, Sharma M, Shearer EA (2016) Functional testing of a PF02458 homologue of putative rice arabinoxylan feruloyl transferase genes in Brachypodium distachyon. Planta 243(3):659\u2013674","journal-title":"Planta"},{"key":"3242_CR4","doi-asserted-by":"publisher","first-page":"121077","DOI":"10.1016\/j.lfs.2022.121077","volume":"310","author":"QQ Chen","year":"2022","unstructured":"Chen QQ, Han HW, Lin FX, Yang LJ, Feng L, Lai XH, Wen ZL, Yang MK, Wang CY, Ma YD, Yin TM, Lu GH, Lin HY, Qi JL, Yang YH (2022) Novel shikonin derivatives suppress cell proliferation, migration and induce apoptosis in human triple-negative breast cancer cells via regulating PDK1\/PDHC axis. Life Sci 310:121077","journal-title":"Life Sci"},{"issue":"6","key":"3242_CR5","doi-asserted-by":"publisher","first-page":"1889","DOI":"10.1093\/mp\/sst085","volume":"6","author":"AX Cheng","year":"2013","unstructured":"Cheng AX, Gou JY, Yu XH, Yang HJ, Fang X, Chen XY, Liu CJ (2013) Characterization and ectopic expression of a populus hydroxyacid hydroxycinnamoyltransferase. Mol Plant 6(6):1889\u20131903","journal-title":"Mol Plant"},{"issue":"8","key":"3242_CR6","doi-asserted-by":"publisher","first-page":"4308","DOI":"10.1093\/nar\/gkz113","volume":"47","author":"X Cheng","year":"2019","unstructured":"Cheng X, Zhao Y, Jiang Q, Yang J, Zhao W, Taylor IA, Peng Y, Wang D, Liu J (2019) Structural basis of dimerization and dual W-box DNA recognition by rice WRKY domain. Nucleic Acids Res 47(8):4308\u20134318","journal-title":"Nucleic Acids Res"},{"issue":"3","key":"3242_CR7","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.pbi.2006.03.016","volume":"9","author":"JC D\u2019Auria","year":"2006","unstructured":"D\u2019Auria JC (2006) Acyltransferases in plants: a good time to be BAHD. Curr Opin Plant Biol 9(3):331\u2013340","journal-title":"Curr Opin Plant Biol"},{"key":"3242_CR8","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1046\/j.1365-313X.1998.00121.x","volume":"14","author":"N Dudareva","year":"1998","unstructured":"Dudareva N, D\u2019Auria JC, Nam KH, Raguso RA, Pichersky E (1998) Acetyl-CoA-benzylalcohol acetyltransferase-an enzyme involved in floral scent production in Clarkia breweri. Plant J 14:297\u2013304","journal-title":"Plant J"},{"issue":"4\u20135","key":"3242_CR9","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1007\/s11103-015-0421-z","volume":"90","author":"RJ Fang","year":"2016","unstructured":"Fang RJ, Wu FY, Zou A, Zhu Y, Zhao H, Zhao H, Liao YH, Tang RJ, Yang TY, Pang YJ, Wang XM, Yang RW, Qi JL, Lu GH, Yang YH (2016) Transgenic analysis reveals LeACS-1 as a positive regulator of ethylene-induced shikonin biosynthesis in Lithospermum erythrorhizon hairy roots. Plant Mol Biol 90(4\u20135):345\u2013358","journal-title":"Plant Mol Biol"},{"issue":"2","key":"3242_CR10","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1080\/01480545.2018.1536710","volume":"44","author":"R Figat","year":"2021","unstructured":"Figat R, Zgadzaj A, Geschke S, Sieczka P, Pietrosiuk A, Sommer S, Skrzypczak A (2021) Cytotoxicity and antigenotoxicity evaluation of acetylshikonin and shikonin. Drug Chem Toxicol 44(2):140\u2013147","journal-title":"Drug Chem Toxicol"},{"issue":"4","key":"3242_CR11","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1046\/j.1365-313x.1998.00312.x","volume":"16","author":"H Fujiwara","year":"1998","unstructured":"Fujiwara H, Tanaka Y, Yonekura-Sakakibara K, Fukuchi-Mizutani M, Nakao M, Fukui Y, Yamaguchi M, Ashikari T, Kusumi T (1998) cDNA cloning, gene expression and subcellular localization of anthocyanin 5-aromatic acyltransferase from Gentiana triflora. Plant J 16(4):421\u2013431","journal-title":"Plant J"},{"key":"3242_CR12","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1016\/0031-9422(83)83022-2","volume":"22","author":"H Fukui","year":"1983","unstructured":"Fukui H, Tsukada M, Mizukami H, Abata M (1983) Formation of stereoisomeric mixtures of naphthoquinone derivatives in Echium lycopsis callus cultures. Phytochemistry 22:453\u2013456","journal-title":"Phytochemistry"},{"key":"3242_CR13","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2019.104463","volume":"149","author":"C Guo","year":"2019","unstructured":"Guo C, He J, Song X, Tan L, Wang M, Jiang P, Li Y, Cao Z, Peng C (2019) Pharmacological properties and derivatives of shikonin\u2014a review in recent years. Pharmacol Res 149:104463","journal-title":"Pharmacol Res"},{"issue":"9","key":"3242_CR14","doi-asserted-by":"publisher","first-page":"2351","DOI":"10.1248\/cpb.39.2351","volume":"39","author":"Y Ikeda","year":"1991","unstructured":"Ikeda Y, Ishida N, Fukaya C, Yokoyama K, Tabata M, Fukui H, Honda G (1991) Determination of the ratio between optical isomers, shikonin and alkannin by high performance liquid chromatography analysis. Chem Pharm Bull 39(9):2351\u20132352","journal-title":"Chem Pharm Bull"},{"key":"3242_CR15","volume":"4","author":"YS Lee","year":"2015","unstructured":"Lee YS, Lee DY, Kim YB, Lee DY (2015) The mechanism underlying the antibacterial activity of shikonin against methicillin-resistant Staphylococcus aureus. Evid Based Complement Alternat Med 4:520578","journal-title":"Evid Based Complement Alternat Med"},{"key":"3242_CR16","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.chroma.2015.11.028","volume":"1425","author":"M Liao","year":"2015","unstructured":"Liao M, Li A, Chen C, Ouyang H, Zhang Y, Xu Y, Feng Y, Jiang H (2015) Systematic identification of shikonins and shikonofurans in medicinal Zicao species using ultra-high performance liquid chromatography quadrupole time of flight tandem mass spectrometry combined with a data mining strategy. J Chromatogr A 1425:158\u2013172","journal-title":"J Chromatogr A"},{"key":"3242_CR17","first-page":"1","volume":"2021","author":"HM Lim","year":"2021","unstructured":"Lim HM, Lee J, Nam MJ, Park SH, Quiles JL (2021) Acetylshikonin induces apoptosis in human colorectal cancer HCT-15 and LoVo cells via nuclear translocation of FOXO3 and ROS level elevation. Oxid Med Cell Longev 2021:1\u201319","journal-title":"Oxid Med Cell Longev"},{"key":"3242_CR18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2022\/9139338","volume":"2022","author":"HM Lim","year":"2022","unstructured":"Lim HM, Lee J, Yu SH, Nam MJ, Cha HS, Park K, Yang YH, Jang KY, Park SH, Chen L (2022) Acetylshikonin, a novel CYP2J2 inhibitor, induces apoptosis in RCC cells via FOXO3 activation and ROS elevation. Oxid Med Cell Longev 2022:1\u201320","journal-title":"Oxid Med Cell Longev"},{"issue":"5","key":"3242_CR19","doi-asserted-by":"publisher","first-page":"1413","DOI":"10.1111\/nph.16506","volume":"226","author":"S Liu","year":"2020","unstructured":"Liu S, Liao LL, Nie MM, Peng WT, Zhang MS, Lei JN, Zhong YJ, Liao H, Chen ZC (2020) A VIT-like transporter facilitates iron transport into nodule symbiosomes for nitrogen fixation in soybean. New Phytol 226(5):1413\u20131428","journal-title":"New Phytol"},{"issue":"8","key":"3242_CR20","doi-asserted-by":"publisher","first-page":"1274","DOI":"10.1016\/j.molp.2015.04.007","volume":"8","author":"XL Ma","year":"2015","unstructured":"Ma XL, Zhang QY, Zhu QL, Liu W, Chen Y, Qiu R, Wang B, Yang ZF, Li HY, Lin YR, Xie YY, Shen RX, Chen SF, Wang Z, Chen YL, Guo JX, Chen LT, Zhao XC, Dong ZC, Liu YG (2015) A robust CRISPR\/Cas9 system for convenient, high-efficiency multiplex genome editing in monocot and dicot plants. Mol Plant 8(8):1274\u20131284","journal-title":"Mol Plant"},{"issue":"4","key":"3242_CR21","doi-asserted-by":"publisher","first-page":"2481","DOI":"10.1093\/plphys\/kiac239","volume":"189","author":"Z Ma","year":"2022","unstructured":"Ma Z, Zhao X, He A, Cao Y, Han Q, Lu Y, Yong JWH, Huang J (2022) Mycorrhizal symbiosis reprograms ion fluxes and fatty acid metabolism in wild jujube during salt stress. Plant Physiol 189(4):2481\u20132499","journal-title":"Plant Physiol"},{"issue":"4","key":"3242_CR22","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1007\/s00299-014-1721-5","volume":"34","author":"I Molina","year":"2015","unstructured":"Molina I, Kosma D (2015) Role of HXXXD-motif\/BAHD acyltransferases in the biosynthesis of extracellular lipids. Plant Cell Rep 34(4):587\u2013601","journal-title":"Plant Cell Rep"},{"key":"3242_CR23","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1093\/pcp\/pcad158","volume":"65","author":"H Oshikiri","year":"2023","unstructured":"Oshikiri H, Li H, Manabe M, Yamamoto H, Yazaki K, Takanashi K (2023) Comparative analysis of shikonin and alkannin acyltransferases reveals their functional conservation in boraginaceae. Plant Cell Physiol 65:362\u2013371","journal-title":"Plant Cell Physiol"},{"issue":"2","key":"3242_CR24","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1104\/pp.20.00207","volume":"184","author":"H Oshikiri","year":"2020","unstructured":"Oshikiri H, Watanabe B, Yamamoto H, Yazaki K, Takanashi K (2020) Two BAHD acyltransferases catalyze the last step in the shikonin\/alkannin biosynthetic pathway. Plant Physiol 184(2):753\u2013761","journal-title":"Plant Physiol"},{"issue":"3","key":"3242_CR25","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1002\/(SICI)1521-3773(19990201)38:3<270::AID-ANIE270>3.0.CO;2-0","volume":"38","author":"VP Papageorgiou","year":"1999","unstructured":"Papageorgiou VP, Assimopoulou AN, Couladouros EA, Hepworth D, Nicolaou KC (1999) The chemistry and biology of alkannin, shikonin, and related naphthazarin natural products. Chem Int Ed Engl 38(3):270\u2013301","journal-title":"Chem Int Ed Engl"},{"issue":"2","key":"3242_CR26","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1111\/j.1365-313X.2010.04144.x","volume":"62","author":"O Serra","year":"2010","unstructured":"Serra O, Hohn C, Franke R, Prat S, Molinas M, Figueras M (2010) A feruloyl transferase involved in the biosynthesis of suberin and suberin-associated wax is required for maturation and sealing properties of potato periderm. Plant J 62(2):277\u2013290","journal-title":"Plant J"},{"key":"3242_CR27","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2020.112375","volume":"175","author":"W Song","year":"2020","unstructured":"Song W, Zhuang Y, Liu T (2020) Potential role of two cytochrome P450s obtained from Lithospermum erythrorhizon in catalyzing the oxidation of geranylhydroquinone during shikonin biosynthesis. Phytochemistry 175:112375","journal-title":"Phytochemistry"},{"issue":"7","key":"3242_CR28","doi-asserted-by":"publisher","first-page":"2455","DOI":"10.1021\/acs.orglett.1c00360","volume":"23","author":"W Song","year":"2021","unstructured":"Song W, Zhuang Y, Liu T (2021) CYP82AR subfamily proteins catalyze C-1\u2032 hydroxylations of deoxyshikonin in the biosynthesis of shikonin and alkannin. Org Lett 23(7):2455\u20132459","journal-title":"Org Lett"},{"issue":"12","key":"3242_CR29","doi-asserted-by":"publisher","first-page":"3132","DOI":"10.1111\/j.1742-4658.2005.04732.x","volume":"272","author":"EJF Souleyre","year":"2005","unstructured":"Souleyre EJF, Greenwood DR, Friel EN, Karunairetnam S, Newcomb RD (2005) An alcohol acyl transferase from apple (cv. Royal Gala), MpAAT1, produces esters involved in apple fruit flavor. FEBS J 272(12):3132\u20133144","journal-title":"FEBS J"},{"issue":"6","key":"3242_CR30","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1046\/j.1365-313x.1998.00174.x","volume":"14","author":"B St-Pierre","year":"1998","unstructured":"St-Pierre B, Laflamme P, Alarco AM, Luca VD (1998) The terminal O-acetyltransferase involved in vindoline biosynthesis defines a new class of proteins responsible for coenzyme A-dependent acyl transfer. Plant J 14(6):703\u2013713","journal-title":"Plant J"},{"key":"3242_CR31","doi-asserted-by":"crossref","unstructured":"Suttiyut T, Auber RP, Ghaste M, Kane CN, McAdam SAM, Wisecaver JH, Widhalm JR (2022) Integrative analysis of the shikonin metabolic network identifies new gene connections and reveals evolutionary insight into shikonin biosynthesis. Hortic Res 9:uhab087","DOI":"10.1093\/hr\/uhab087"},{"key":"3242_CR32","doi-asserted-by":"publisher","first-page":"154109","DOI":"10.1016\/j.phymed.2022.154109","volume":"101","author":"Y Tang","year":"2022","unstructured":"Tang Y, Wang Y, Wang X, Zhao Z, Cai H, Xie M, Jiang X, Zhang L, Cheng J, Yang L, Wang L, Zhao C, Huang X (2022) Acetylshikonin exerts anti-tumor effects on non-small cell lung cancer through dual inhibition of STAT3 and EGFR. Phytomedicine 101:154109","journal-title":"Phytomedicine"},{"issue":"1","key":"3242_CR33","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1186\/s13068-021-02068-9","volume":"14","author":"Y Tian","year":"2021","unstructured":"Tian Y, Lin CY, Park JH, Wu CY, Kakumanu R, Pidatala VR, Vuu KM, Rodriguez A, Shih PM, Baidoo EEK, Temple S, Simmons BA, Gladden JM, Scheller HV, Eudes A (2021) Overexpression of the rice BAHD acyltransferase AT10 increases xylan-bound p-coumarate and reduces lignin in Sorghum bicolor. Biotechnol Biofuels 14(1):217","journal-title":"Biotechnol Biofuels"},{"key":"3242_CR34","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1055\/s-2007-969725","volume":"50","author":"M Tsukada","year":"1984","unstructured":"Tsukada M, Tabata M (1984) Intracellular localization and secretion of naphthoquinone pigments in cell cultures of Lithospermum erythrorhizon. Planta Med 50:338\u2013341","journal-title":"Planta Med"},{"issue":"4","key":"3242_CR35","doi-asserted-by":"publisher","first-page":"1933","DOI":"10.1104\/pp.19.00999","volume":"182","author":"H Ueoka","year":"2020","unstructured":"Ueoka H, Sasaki K, Miyawaki T, Ichino T, Tatsumi K, Suzuki S, Yamamoto H, Sakurai N, Suzuki H, Shibata D, Yazaki K (2020) A cytosol-localized geranyl diphosphate synthase from Lithospermum erythrorhizon and its molecular evolution. Plant Physiol 182(4):1933\u20131945","journal-title":"Plant Physiol"},{"key":"3242_CR36","doi-asserted-by":"publisher","first-page":"105123","DOI":"10.1016\/j.phrs.2020.105123","volume":"161","author":"J Wang","year":"2020","unstructured":"Wang J, Iannarelli R, Pucciarelli S, Laudadio E, Galeazzi R, Giangrossi M, Falconi M, Cui L, Navia AM, Buccioni M, Marucci G, Tomassoni D, Serini L, Sut S, Maggi F, DallAcqua S, Marchini C, Amici A (2020) Acetylshikonin isolated from Lithospermum erythrorhizon roots inhibits dihydrofolate reductase and hampers autochthonous mammary carcinogenesis in \u039416HER2 transgenic mice. Pharmacol Res 161:105123","journal-title":"Pharmacol Res"},{"issue":"2","key":"3242_CR37","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1104\/pp.18.01056","volume":"179","author":"S Wang","year":"2019","unstructured":"Wang S, Wang RS, Liu T, Lv CG, Liang JW, Kang CZ, Zhou LY, Guo J, Cui GH, Zhang Y, Werck-Reichhart D, Guo LP, Huang LQ (2019) CYP76B74 catalyzes the 3\u2032\u2032-hydroxylation of geranylhydroquinone in shikonin biosynthesis. Plant Physiol 179(2):402\u2013414","journal-title":"Plant Physiol"},{"issue":"11","key":"3242_CR38","doi-asserted-by":"publisher","first-page":"1775","DOI":"10.3390\/life12111775","volume":"12","author":"X Wang","year":"2022","unstructured":"Wang X, He ZY, Yang H, He C, Wang CY, Fazal A, Lai XH, Yang LJ, Wen ZL, Yang MK, Ma SL, Jie WC, Cai JF, Yin TM, Liu B, Yang YH, Qi JL (2022) Genome-wide identification of LeBAHDs in Lithospermum erythrorhizon and in vivo transgenic studies confirm the critical roles of LeBAHD1\/LeSAT1 in the conversion of shikonin to acetylshikonin. Life 12(11):1775","journal-title":"Life"},{"issue":"15","key":"3242_CR39","doi-asserted-by":"publisher","first-page":"12532","DOI":"10.3390\/ijms241512532","volume":"24","author":"X Wang","year":"2023","unstructured":"Wang X, Wang C, Yang M, Jie W, Fazal A, Fu J, Yin T, Cai J, Liu B, Lu G, Lin H, Han H, Wen Z, Qi J, Yang Y (2023) Genome-wide comparison and functional characterization of HMGR gene family associated with shikonin biosynthesis in Lithospermum erythrorhizon. Int J Mol Sci 24(15):12532","journal-title":"Int J Mol Sci"},{"issue":"7","key":"3242_CR40","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1007\/s002990100373","volume":"20","author":"Y Yamamura","year":"2001","unstructured":"Yamamura Y, Ogihara Y, Mizukami H (2001) Cinnamic acid 4-hydroxylase from Lithospermum erythrorhizon: cDNA cloning and gene expression. Plant Cell Rep 20(7):655\u2013662","journal-title":"Plant Cell Rep"},{"issue":"1","key":"3242_CR41","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1007\/s00425-020-03413-2","volume":"252","author":"X Yan","year":"2020","unstructured":"Yan X, Qin X, Li W, Liang D, Qiao J, Li Y (2020) Functional characterization and catalytic activity improvement of BAHD acyltransferase from Celastrus angulatus Maxim. Planta 252(1):6","journal-title":"Planta"},{"issue":"6","key":"3242_CR42","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1023\/A:1005878622437","volume":"35","author":"Q Yang","year":"1997","unstructured":"Yang Q, Reinhard K, Schiltz E, Matern U (1997) Characterization and heterologous expression of hydroxycinnamoylbenzoyl-CoAanthranilate N-hydroxycinnamoylbenzoyltransferase from elicited cell cultures of carnation. Plant Mol Biol 35(6):777\u2013789","journal-title":"Plant Mol Biol"},{"key":"3242_CR43","doi-asserted-by":"publisher","first-page":"1995","DOI":"10.1271\/bbb.61.1995","volume":"61","author":"K Yazaki","year":"1997","unstructured":"Yazaki K, Kataoka M, Honda G, Severin K, Heide L (1997) cDNA cloning and gene expression of phenylalanine ammonia-lyase in Lithospermum erythrorhizon. Biosci Biotech Bioch 61:1995\u20132003","journal-title":"Biosci Biotech Bioch"},{"key":"3242_CR44","first-page":"1319","volume":"36","author":"K Yazaki","year":"1995","unstructured":"Yazaki K, Ogawa A, Tabata M (1995) Isolation and characterization of two cDNAs encoding 4-coumarate-CoA ligase in Lithospermum cell cultures. Plant Cell Physiol 36:1319\u20131329","journal-title":"Plant Cell Physiol"},{"issue":"2","key":"3242_CR45","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1007\/s11240-010-9670-3","volume":"101","author":"WJ Zhang","year":"2010","unstructured":"Zhang WJ, Su J, Tan M, Liu G, Pang Y, Shen H, Qi J, Yang Y (2010) Expression analysis of shikonin-biosynthetic genes in response to M9 medium and light in Lithospermum erythrorhizon cell cultures. Plant Cell Tiss Organ Cult 101(2):135\u2013142","journal-title":"Plant Cell Tiss Organ Cult"},{"issue":"1","key":"3242_CR46","doi-asserted-by":"publisher","first-page":"950","DOI":"10.1080\/13880209.2020.1818793","volume":"58","author":"Z Zhang","year":"2020","unstructured":"Zhang Z, Bai J, Zeng Y, Cai M, Yao Y, Wu H, You L, Dong X, Ni J (2020) Pharmacology, toxicity and pharmacokinetics of acetylshikonin: a review. Pharm Biol 58(1):950\u2013958","journal-title":"Pharm Biol"},{"issue":"3","key":"3242_CR47","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1007\/s10535-014-0411-z","volume":"58","author":"H Zhao","year":"2014","unstructured":"Zhao H, Baloch SK, Kong LR, Zhang WJ, Zou AL, Wang XM, Qi JL, Yang YH (2014) Molecular cloning, characterization, and expression analysis of LeMYB1 from Lithospermum erythrorhizon. Biol Plant 58(3):436\u2013444","journal-title":"Biol Plant"},{"issue":"3","key":"3242_CR48","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1007\/s10535-015-0512-3","volume":"59","author":"H Zhao","year":"2015","unstructured":"Zhao H, Chang QS, Zhang DX, Fang RJ, Zhao H, Wu FY, Wang XM, Lu GH, Qi JL, Yang YH (2015) Overexpression of LeMYB1 enhances shikonin formation by up-regulating key shikonin biosynthesis-related genes in Lithospermum erythrorhizon. Biol Plant 59(3):429\u2013435","journal-title":"Biol Plant"},{"issue":"10","key":"3242_CR49","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1002\/bmc.1570","volume":"25","author":"W Zhou","year":"2011","unstructured":"Zhou W, Jiang HDGL, Peng Y, Li SS (2011) Comparative study on enantiomeric excess of main akannin\/shikonin derivatives isolated from the roots of three endemic Boraginaceae plants in China. Biomed Chromatogr 25(10):1067\u20131075","journal-title":"Biomed Chromatogr"}],"container-title":["Plant Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00299-024-03242-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00299-024-03242-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00299-024-03242-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T05:05:44Z","timestamp":1718600744000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00299-024-03242-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":49,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["3242"],"URL":"https:\/\/doi.org\/10.1007\/s00299-024-03242-7","relation":{},"ISSN":["0721-7714","1432-203X"],"issn-type":[{"value":"0721-7714","type":"print"},{"value":"1432-203X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"9 April 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 May 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 June 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"160"}}