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In this study, expression profiling revealed that drought stress induces a global reprogramming of the m\n                      <jats:sup>6<\/jats:sup>\n                      A machinery in\n                      <jats:italic>Arabidopsis thaliana<\/jats:italic>\n                      , with the m\n                      <jats:sup>6<\/jats:sup>\n                      A demethylase\n                      <jats:italic>ALKBH10B<\/jats:italic>\n                      exhibiting a more pronounced time-dependent response.\n                      <jats:italic>ALKBH10B<\/jats:italic>\n                      transcription is induced by ABA, most likely via ABRE and MYB cis-elements, whereas jasmonate alleviates this activation. Moreover,\n                      <jats:italic>ALKBH10B<\/jats:italic>\n                      overexpressing plants (OX-1) accumulated wild type (WT) levels of ABA under drought stress but displayed a markedly reduced content in jasmonic acid (JA) and jasmonoyl-isoleucine (JA-Ile). They furthermore exhibit enhanced stomatal closure, improved water-use efficiency, and thus an enhanced drought tolerance. Transcriptome analysis revealed that drought stress induces fewer transcriptional changes in OX-1 plants compared to WT and the drought-sensitive\n                      <jats:italic>alkbh10b-1<\/jats:italic>\n                      mutant. Differential expression and GO enrichment analyses highlight that photosynthesis-related processes were most affected by ALKBH10B activity, correlating with a preserved chlorophyll content and PSII efficiency in OX-1. Analysis by m\u2076A-IP-qPCR showed that ALKBH10B directly demethylates specific photosynthesis-related and drought-responsive genes, while other transcripts are indirectly regulated by ALKBH10B-dependent processes. Moreover, transcripts associated with respiration were enriched in OX-1, indicating that ALKBH10B also supports mitochondrial energy metabolism during drought. Together, our results suggest that ALKBH10B enhances drought tolerance by coordinating m\u2076A-dependent transcriptional and post-transcriptional regulation to maintain photosynthetic capacity and mitochondrial energy metabolism, as well as fine-tuning ABA-jasmonate crosstalk.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00299-026-03951-1","type":"journal-article","created":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T18:27:10Z","timestamp":1787336830000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["ALKBH10B mediated epitranscriptomic regulation enhances drought tolerance of Arabidopsis thaliana via hormonal cross-talk and sustained photosynthesis"],"prefix":"10.1007","volume":"45","author":[{"given":"Yasira","family":"Shoaib","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongpeng","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabarna","family":"Bhattacharyya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Finkenauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Gutbrod","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"D\u00f6rmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hunseung","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8930-0127","authenticated-orcid":false,"given":"Ute C.","family":"Vothknecht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatima","family":"Chigri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,21]]},"reference":[{"issue":"6","key":"3951_CR1","first-page":"137","volume":"10","author":"D Aimar","year":"2011","unstructured":"Aimar D, Calafat M, Andrade A, Carassay L, Abdala G, Molas M (2011) Drought tolerance and stress hormones: from model organisms to forage crops. 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