{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T16:23:15Z","timestamp":1773246195163,"version":"3.50.1"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2005,8,16]],"date-time":"2005-08-16T00:00:00Z","timestamp":1124150400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Radiol"],"published-print":{"date-parts":[[2005,12]]},"DOI":"10.1007\/s00330-005-2855-1","type":"journal-article","created":{"date-parts":[[2005,8,5]],"date-time":"2005-08-05T08:37:50Z","timestamp":1123231070000},"page":"2462-2468","source":"Crossref","is-referenced-by-count":30,"title":["Adrenal glands in beta-thalassemia major: magnetic resonance (MR) imaging features and correlation with iron stores"],"prefix":"10.1007","volume":"15","author":[{"given":"Eleni","family":"Drakonaki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olympia","family":"Papakonstantinou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Maris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Artemis","family":"Vasiliadou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex","family":"Papadakis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas","family":"Gourtsoyiannis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2005,8,16]]},"reference":[{"key":"2855_CR1","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1111\/j.1365-2141.1969.tb00400.x","volume":"16","author":"DJ Weatherall","year":"1969","unstructured":"Weatherall DJ, Clegg JB, Na-Nakorn S, Wasi P (1969) The pattern of disordered haemoglobin synthesis in homozygous and heterozygous b-thalassemia. Br J Haematol 16:251\u2013267","journal-title":"Br J Haematol"},{"key":"2855_CR2","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1111\/j.1365-2265.1981.tb00612.x","volume":"14","author":"S Vannasaeng","year":"1981","unstructured":"Vannasaeng S, Ploybutr S, Visutkul P, Tandhanand S, Suwanik R, Wasi P (1981) Endocrine function in thalassemia. Clin Endocrinol (Oxf) 14:165\u2013173","journal-title":"Clin Endocrinol (Oxf)"},{"key":"2855_CR3","first-page":"357","volume":"76","author":"Oerter","year":"1993","unstructured":"Oerter KE, Kamp GA, Munson PJ, Nienhuis AW, Cassorla FG, Manasco PK (1993) Multiple hormone deficiencies in children with hemochromatosis 76:357\u2013361","journal-title":"Multiple hormone deficiencies in children with hemochromatosis"},{"key":"2855_CR4","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1159\/000203853","volume":"95","author":"V Gabutti","year":"1996","unstructured":"Gabutti V, Piga A (1996) Results of long term iron chelating therapy. Acta Haematol 95:26\u201336","journal-title":"Acta Haematol"},{"key":"2855_CR5","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1148\/radiology.179.2.2014276","volume":"179","author":"JM Gomori","year":"1991","unstructured":"Gomori JM, Horev G, Tamary H, Zandback J, Kornreich L, Zaizov R, Freud E et al (1991) Hepatic iron overload: quantitative MR imaging. Radiology 179:367\u2013369","journal-title":"Radiology"},{"key":"2855_CR6","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1148\/radiology.199.1.8633135","volume":"199","author":"ES Siegelman","year":"1996","unstructured":"Siegelman ES, Mitchell DG, Semelka RC (1996) Abdominal iron deposition: metabolism, MR findings and clinical importance. Radiology 199:13\u201322","journal-title":"Radiology"},{"issue":"2","key":"2855_CR7","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1148\/radiology.193.2.7972774","volume":"193","author":"Y Gandon","year":"1994","unstructured":"Gandon Y, Guyader D, Heautot JF, Reda MI, Yaouanq J, Buhe T, Brissot P, Carsin M, Deugnier Y (1994) Hemochromatosis: diagnosis and quantification of liver iron with gradient echo MR imaging. Radiology 193(2):533\u2013538","journal-title":"Radiology"},{"key":"2855_CR8","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.2214\/ajr.168.5.9129412","volume":"168","author":"O Ernst","year":"1997","unstructured":"Ernst O, Sergent G, Bonvarlet P, Canva-Delcambre V, Paris JC, L\u2019Hermine C (1997) Hepatic iron overload: diagnosis and quantification with MR imaging. Am J Roentgenol 168:1205\u20131208","journal-title":"Am J Roentgenol"},{"key":"2855_CR9","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/0730-725X(95)00041-E","volume":"13","author":"OG Papakonstantinou","year":"1995","unstructured":"Papakonstantinou OG, Maris TG, Kostaridou V, Gouliamos AD, Koutoulas GK, Kalovidouris AE, Papavassiliou GB, Kordas G, Kattamis C, Vlahos LJ et al (1995) Assessment of liver iron overload by T2-quantitative magnetic resonance imaging: correlation of T2-QMRI measurements with serum ferritin concentration and histologic grading of siderosis. Magn Reson Imaging 13:967\u2013977","journal-title":"Magn Reson Imaging"},{"key":"2855_CR10","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1002\/jmri.10306","volume":"17","author":"A Fenzi","year":"2003","unstructured":"Fenzi A, Bortolazzi M, Marzola P (2003) Comparison between signal-to-noise ratio, liver-to-muscle ratio and 1\/T2 for the non invasive assessment of liver iron content by MRI. J Magn Reson Imaging 17:589\u2013592","journal-title":"J Magn Reson Imaging"},{"key":"2855_CR11","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1148\/radiol.2302020820","volume":"230","author":"JM Alustiza","year":"2004","unstructured":"Alustiza JM, Artetxe J, Castiella A, Agirre C, Emparanza JI, Otazua P, Garcia-Bengoechea M, Barrio J, Mujica F, Recondo JA (2004) Gipuzkoa hepatic iron concentration by MRI Study Group. MR quantification of hepatic iron concentration. Radiology 230:479\u2013484","journal-title":"Radiology"},{"key":"2855_CR12","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S0140-6736(04)15436-6","volume":"363","author":"Y Gandon","year":"2004","unstructured":"Gandon Y, Olivie D, Guyader D, Aube C, Oberti F, Sebille V, Deugnier Y (2004) Non-invasive assessment of hepatic iron stores by MRI. Lancet 363:357\u2013362","journal-title":"Lancet"},{"key":"2855_CR13","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1053\/euhj.2001.2822","volume":"22","author":"LJ Anderson","year":"2001","unstructured":"Anderson LJ, Holden S, Davis B, Prescott E, Charrier CC, Bunce NH, Firmin DN, Wonke B, Porter J, Walker JM, Pennell DJ (2001) Cardiovascular T2-star (T2*) magnetic resonance for the early diagnosis of myocardial iron overload. Eur Heart J 22:2171\u20132179","journal-title":"Eur Heart J"},{"key":"2855_CR14","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1046\/j.1365-2141.2003.04772.x","volume":"124","author":"GC Ooi","year":"2004","unstructured":"Ooi GC, Khong PL, Chan GC, Chan KN, Chan KL, Lam W, Ng I, Ha SY (2004) Magnetic resonance screening of iron status in transfusion-dependent beta-thalassemia patients. Br J Haematol 124:385\u2013390","journal-title":"Br J Haematol"},{"key":"2855_CR15","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1001\/archpedi.1979.02130050041009","volume":"133","author":"G Costin","year":"1979","unstructured":"Costin G, Kogut MD, Hyman CB, Ortega JA (1979) Endocrine abnormalities in thalassemia major. Am J Dis Child 133:497\u2013502","journal-title":"Am J Dis Child"},{"key":"2855_CR16","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1007\/s003830000401","volume":"16","author":"SA Banani","year":"2000","unstructured":"Banani SA, Omrani GH (2000) Cortisol and adrenocorticotropic hormone response to surgical stress (splenectomy) in thalassemic patients. Pediatr Surg Int 16:400\u2013403","journal-title":"Pediatr Surg Int"},{"key":"2855_CR17","first-page":"551","volume":"80","author":"D Bisbocci","year":"1989","unstructured":"Bisbocci D, Camaschella C, Sperone D, Livorno P, Gambino M, Modina P (1989) Hypothalamic pituitary adrenal function in patients with thalassemia major. Recent Prog Med 80: 551\u2013556","journal-title":"Recent Prog Med"},{"key":"2855_CR18","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1210\/jcem-58-4-667","volume":"58","author":"A Masala","year":"1984","unstructured":"Masala A, Meloni T, Gallisai D, Alagna S, Rovasio PP, Rassu S, Milia F (1984) Endocrine functioning in multitransfused prepubertal patients with homozygous b-thalassemia. J Clin Endocrinol Metab 58:667\u2013670","journal-title":"J Clin Endocrinol Metab"},{"key":"2855_CR19","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1001\/archpedi.1987.04460030105036","volume":"141","author":"CA Sklar","year":"1987","unstructured":"Sklar CA, Lew LQ, Yoon DJ, David R (1987) Adrenal function in thalassemia major following long term treatment with multiple transfusions and chelation therapy. Evidence for dissociation of cortisol and adrenal androgen secretion. Am J Dis Child 141:327\u2013330","journal-title":"Am J Dis Child"},{"key":"2855_CR20","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1136\/adc.51.3.195","volume":"51","author":"N McIntosh","year":"1976","unstructured":"McIntosh N (1976) Endocrinopathy in thalassemia major. Arch Dis Child 51:195\u2013201","journal-title":"Arch Dis Child"},{"key":"2855_CR21","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1001\/archinte.1960.00270170024004","volume":"105","author":"R McDonald","year":"1960","unstructured":"McDonald R, Mallory GK (1960) Hemochromatosis and hemosiderosis - a study of 211 autopsied cases. Arch Intern Med 105:686\u2013700","journal-title":"Arch Intern Med"},{"key":"2855_CR22","first-page":"287","volume":"30","author":"JT Ellis","year":"1954","unstructured":"Ellis JT, Schulman J, Smith CH (1954) Generalized siderosis with fibrosis of liver and pancreas in Cooley\u2019s (Mediterranean) anemia: with observations of the pathogenesis of the siderosis and fibrosis. Am J Pathol 30:287\u2013309","journal-title":"Am J Pathol"},{"key":"2855_CR23","first-page":"89","volume":"14","author":"A Jacobs","year":"1977","unstructured":"Jacobs A (1977) Iron overload-Clinical and pathologic aspects. Semin Hematol 14:89\u2013113","journal-title":"Semin Hematol"},{"key":"2855_CR24","first-page":"431","volume":"97","author":"CK Chuang","year":"1998","unstructured":"Chuang CK, Chu SH, Fang JT, Wu JH (1998) Adrenal extramedullary hematopoietic tumor in a patient with beta thalassemia. J Formos Med Assoc 97:431\u2013433","journal-title":"J Formos Med Assoc"},{"key":"2855_CR25","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1023\/A:1020578501167","volume":"33","author":"AB Porcaro","year":"2001","unstructured":"Porcaro AB, Novella G, Antoniolli SZ, Martignoni G, Brunelli M, Curti P (2001) Adrenal extramedullary hematopoiesis: report on a pediatric case and update of the literature. Int Urol Nephrol 33:601\u2013603","journal-title":"Int Urol Nephrol"},{"key":"2855_CR26","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1046\/j.1365-2141.1998.00619.x","volume":"100","author":"NMS Wat","year":"1998","unstructured":"Wat NMS, Tse KKM, Chan FL, Lam KSL (1998) Adrenal extramedullary haemopoiesis: diagnosis by a non invasive method. Br J Haematol 100:725\u2013727","journal-title":"Br J Haematol"},{"key":"2855_CR27","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1007\/s002470100011","volume":"31","author":"SK Calhoun","year":"2001","unstructured":"Calhoun SK, Murphy RC, Shariati N, Jacir N, Bergman K (2001) Extramedullary hematopoiesis in a child with hereditary spherocytosis: an uncommon cause of an adrenal mass. Pediatr Radiol 31:879\u2013881","journal-title":"Pediatr Radiol"},{"key":"2855_CR28","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1002\/jmri.10401","volume":"18","author":"NL Kelekis","year":"2003","unstructured":"Kelekis NL, Alexopoulou E, Brountzos EL, Ladis V, Boussiotou A, Kelekis DA (2003) Giant adrenal myelolipoma with minimal fat content in a patient with homozygous beta-thalassemia: appearance on MRI. J Magn Reson Imaging 18:608\u2013611","journal-title":"J Magn Reson Imaging"},{"key":"2855_CR29","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1007\/BF02013515","volume":"22","author":"C Hadjigeorgi","year":"1992","unstructured":"Hadjigeorgi C, Lafoyanni S, Pontikis Y, Van Vliet-Constantinidou C (1992) Asymptomatic myelolipoma of the adrenal. Pediatr Radiol 22:465\u2013466","journal-title":"Pediatr Radiol"},{"key":"2855_CR30","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1002\/1096-8652(200011)65:3<265::AID-AJH18>3.0.CO;2-H","volume":"65","author":"WT Au","year":"2000","unstructured":"Au WT, Tam PC, Ma SK, Lam KY (2000) Giant myelolipoma in a patient with thalassemia intermedia. Am J Hematol 65:265\u2013266","journal-title":"Am J Hematol"},{"key":"2855_CR31","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/S0009-9260(05)81739-8","volume":"49","author":"JM Vincent","year":"1994","unstructured":"Vincent JM, Morrison ID, Armstrong P, Reznek RA (1994) The size of normal adrenal glands on computed tomography. Clin Radiol 49:453\u2013455","journal-title":"Clin Radiol"},{"key":"2855_CR32","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1097\/00004728-198004000-00005","volume":"4","author":"JA Long","year":"1980","unstructured":"Long JA, Doppman JL, Nienhus AW, Mills SR (1980) Computed tomographic analysis of beta-thalassemic syndromes with hemochromatosis: pathologic findings with clinical and laboratory correlations. J Comput Assist Tomogr 4:159\u2013165","journal-title":"J Comput Assist Tomogr"},{"issue":"6","key":"2855_CR33","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1007\/s00330-004-2241-4","volume":"14","author":"T Allkemper","year":"2004","unstructured":"Allkemper T, Schwindt W, Maintz D, Heindel W, Tombach B (2004) Sensitivity of T2-weighted FSE sequences towards physiological iron depositions in normal brains at 1.5 and 3.0\u00a0T. Eur Radiol 14(6):1000\u20131004","journal-title":"Eur Radiol"},{"key":"2855_CR34","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1007\/s00330-002-1774-7","volume":"13","author":"MI Argyropoulou","year":"2003","unstructured":"Argyropoulou MI, Kiortsis DN, Efremidis SC (2003) MRI of the liver and the pituitary gland in patients with beta-thalassemia major: does hepatic siderosis predict pituitary iron deposition? Eur Radiol 13:12\u201316","journal-title":"Eur Radiol"},{"key":"2855_CR35","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.2214\/ajr.175.6.1751567","volume":"175","author":"MI Argyropoulou","year":"2000","unstructured":"Argyropoulou MI, Metafratzi Z, Kiortsis DN, Bitsis S, Tsatsoulis A, Efremidis S (2000) T2 relaxation rate as an index of pituitary iron overload in patients with beta-thalassemia major. Am J Roentgenol 175:1567\u20131569","journal-title":"Am J Roentgenol"},{"issue":"3","key":"2855_CR36","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1148\/radiology.215.3.r00jn10818","volume":"215","author":"G Sparacia","year":"2000","unstructured":"Sparacia G, Iaia A, Banco A, D\u2019Angelo P, Lagalla R (2000) Transfusional hemochromatosis: quantitative relation of MR imaging pituitary signal intensity reduction to hypogonadotropic hypogonadism. Radiology 215(3):818\u2013823","journal-title":"Radiology"},{"key":"2855_CR37","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1148\/radiographics.21.4.g01jl21995","volume":"21","author":"WW Mayo Smith","year":"2001","unstructured":"Mayo Smith WW, Boland GW, Noto RB, Lee MJ (2001) State of the art adrenal imaging. Radiographics 21:995\u20131012","journal-title":"Radiographics"},{"key":"2855_CR38","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/S0140-6736(71)90838-5","volume":"1","author":"M Barry","year":"1971","unstructured":"Barry M, Sherlock S (1971) Measurement of liver iron concentration in needle biopsy specimens. Lancet 1:100\u2013103","journal-title":"Lancet"}],"container-title":["European Radiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00330-005-2855-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00330-005-2855-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00330-005-2855-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T07:52:27Z","timestamp":1559029947000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00330-005-2855-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,8,16]]},"references-count":38,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2005,12]]}},"alternative-id":["2855"],"URL":"https:\/\/doi.org\/10.1007\/s00330-005-2855-1","relation":{},"ISSN":["0938-7994","1432-1084"],"issn-type":[{"value":"0938-7994","type":"print"},{"value":"1432-1084","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,8,16]]}}}