{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:19:35Z","timestamp":1786979975151,"version":"build-2736575974"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2013,3,15]],"date-time":"2013-03-15T00:00:00Z","timestamp":1363305600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Radiol"],"published-print":{"date-parts":[[2013,7]]},"DOI":"10.1007\/s00330-013-2794-1","type":"journal-article","created":{"date-parts":[[2013,3,14]],"date-time":"2013-03-14T11:24:03Z","timestamp":1363260243000},"page":"1773-1784","source":"Crossref","is-referenced-by-count":36,"title":["Assessment of therapeutic response in ankylosing spondylitis patients undergoing anti-tumour necrosis factor therapy by whole-body magnetic resonance imaging"],"prefix":"10.1007","volume":"23","author":[{"given":"Martina","family":"Karpitschka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"Godau-Kellner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herbert","family":"Kellner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annie","family":"Horng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Theisen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Glaser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Brandlhuber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilian","family":"Reiser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Weckbach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,3,15]]},"reference":[{"key":"2794_CR1","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1136\/ard.2008.097931","volume":"68","author":"H Marzo-Ortega","year":"2009","unstructured":"Marzo-Ortega H, McGonagle D, O\u2019Connor P, Hensor EM, Bennett AN, Green MJ (2009) Baseline and 1-year magnetic resonance imaging of the sacroiliac joint and lumbar spine in very early inflammatory back pain. Relationship between symptoms, HLA-B27 and disease extent and persistence. Ann Rheum Dis 68:1721\u20131727","journal-title":"Ann Rheum Dis"},{"key":"2794_CR2","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1136\/ard.60.4.353","volume":"60","author":"A Boonen","year":"2001","unstructured":"Boonen A, Chorus A, Midema H, van der Heijde D, van der Tempel H, van der Linden S (2001) Employment, work disability and work days lost in patients with ankylosing spondylitis: a cross sectional study of Dutch patients. Ann Rheum Dis 60:353\u2013358","journal-title":"Ann Rheum Dis"},{"key":"2794_CR3","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1002\/art.1780270401","volume":"27","author":"S Linden van der","year":"1984","unstructured":"van der Linden S, Valkenburg HA, Cats A (1984) Evaluation of diagnostic criteria for ankylosing spondylitis. A proposal for modification of the New York criteria. Arthritis Rheum 27:361\u2013368","journal-title":"Arthritis Rheum"},{"key":"2794_CR4","first-page":"1109","volume":"15","author":"W Mau","year":"1988","unstructured":"Mau W, Zeidler H, Mau R, Majewski A, Freyschmidt J, Stangel W (1988) Clinical features and prognosis of patients with possible ankylosing spondylitis. Results of a 10-year followup. J Rheumatol 15:1109\u20131114","journal-title":"J Rheumatol"},{"key":"2794_CR5","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1002\/1529-0131(199801)41:1<58::AID-ART8>3.0.CO;2-G","volume":"41","author":"J Braun","year":"1998","unstructured":"Braun J, Bollow M, Remlinger G et al (1998) Prevalence of spondylarthropathies in HLA-B27 positive and negative blood donors. Arthritis Rheum 41:58\u201367","journal-title":"Arthritis Rheum"},{"key":"2794_CR6","doi-asserted-by":"crossref","first-page":"ii55","DOI":"10.1136\/ard.2004.033928","volume":"64","author":"PA Ory","year":"2005","unstructured":"Ory PA, Gladman DD, Mease PJ (2005) Psoriatic arthritis and imaging. Ann Rheum Dis 64:ii55\u2013ii57","journal-title":"Ann Rheum Dis"},{"key":"2794_CR7","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1136\/ard.59.2.135","volume":"59","author":"M Bollow","year":"2000","unstructured":"Bollow M, Fischer T, Reisshauer H et al (2000) Quantitative analyses of sacroiliac biopsies in spondyloarthropathies: T cells and macrophages predominate in early and active sacroiliitis\u2014cellularity correlates with the degree of enhancement detected by magnetic resonance imaging. Ann Rheum Dis 59:135\u2013140","journal-title":"Ann Rheum Dis"},{"key":"2794_CR8","doi-asserted-by":"crossref","first-page":"3413","DOI":"10.1002\/art.24024","volume":"58","author":"AN Bennett","year":"2008","unstructured":"Bennett AN, McGonagle D, O\u2019Connor P, Hensor EM, Sivera F, Coates LC (2008) Severity of baseline magnetic resonance imaging-evident sacroiliitis and HLA-B27 status in early inflammatory back pain predict radiographically evident ankylosing spondylitis at eight years. Arthritis Rheum 58:3413\u20133418","journal-title":"Arthritis Rheum"},{"key":"2794_CR9","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1136\/ard.2009.108233","volume":"68","author":"M Rudwaleit","year":"2009","unstructured":"Rudwaleit M, van der Heijde D, Landewe R, Listing J, Akkoc N, Brandt J (2009) The development of Assessment of SpondyloArthritis International Society classification criteria for axial spondyloarthritis (part II): validation and final selection. Ann Rheum Dis 68:777\u2013783","journal-title":"Ann Rheum Dis"},{"key":"2794_CR10","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/1471-2474-8-20","volume":"8","author":"U Weber","year":"2007","unstructured":"Weber U, Pfirrmann CW, Kissling RO, Hodler J, Zanetti M (2007) Whole body MR imaging ankylosing spondylitis: a descriptive pilot study in patients with suspected early and active confirmed ankylosing spondylitis. BMC Musculoskelet Disord 8:20","journal-title":"BMC Musculoskelet Disord"},{"key":"2794_CR11","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.ejrad.2009.03.047","volume":"70","author":"S Weckbach","year":"2009","unstructured":"Weckbach S (2009) Whole-body MR imaging for patients with rheumatism. Eur J Radiol 70:431\u2013441","journal-title":"Eur J Radiol"},{"key":"2794_CR12","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1002\/art.21054","volume":"52","author":"A Wanders","year":"2005","unstructured":"Wanders A, Heijde D, Landewe R, Behier JM, Calin A, Olivieri I (2005) Nonsteroidal anti inflammatory drugs reduce radiographic progression in patients with ankylosing spondylitis: a randomized clinical trial. Arthritis Rheum 52:1756\u20131765","journal-title":"Arthritis Rheum"},{"key":"2794_CR13","unstructured":"National Institute for Health and Clinical Excellence (2008) Adalimumab, Etanercept and Infliximab for Ankylosing Spondylitis. NICE, London. Available via http:\/\/guidance.nice.org.uk\/TA143"},{"key":"2794_CR14","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1136\/ard.2005.041137","volume":"65","author":"J Zochling","year":"2006","unstructured":"Zochling J, van der Heijde D, Burgos-Vargas R, Collantes E, Davis JC Jr, Dijkmans B (2006) ASAS\/EULAR recommendations for the management of ankylosing spondylitis. Ann Rheum Dis 65:442\u2013452","journal-title":"Ann Rheum Dis"},{"key":"2794_CR15","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1002\/art.24001","volume":"59","author":"J Braun","year":"2008","unstructured":"Braun J, Deodhar A, Dijkmans B et al (2008) Efficacy and safety of infliximab in patients with ankylosing spondylitis over a two-year period. Arthritis Rheum 59:1270\u20131278","journal-title":"Arthritis Rheum"},{"key":"2794_CR16","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.3899\/jrheum.081033","volume":"36","author":"B Dijkmans","year":"2009","unstructured":"Dijkmans B, Emery P, Hakala M et al (2009) Etanercept in the longterm treatment of patients with ankylosing spondylitis. J Rheumatol 36:1256\u20131264","journal-title":"J Rheumatol"},{"key":"2794_CR17","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1136\/ard.2007.087270","volume":"68","author":"D Heijde van der","year":"2009","unstructured":"van der Heijde D, Schiff MH, Sieper J et al (2009) Adalimumab effectiveness for the treatment of ankylosing spondylitis is maintained for up to 2\u00a0years: long-term results from the ATLAS trial. Ann Rheum Dis 68:922\u2013929","journal-title":"Ann Rheum Dis"},{"key":"2794_CR18","first-page":"2281","volume":"21","author":"A Calin","year":"1994","unstructured":"Calin A, Garrel S, Whitelock H et al (1994) A new approach to defining functional ability in ankylosing spondylitis: the development of the Bath ankylosing spondylitis functional index. J Rheumatol 21:2281\u20132285","journal-title":"J Rheumatol"},{"key":"2794_CR19","first-page":"2286","volume":"21","author":"S Garrett","year":"1994","unstructured":"Garrett S, Ienkinson T, Kennedy G, Whitelock H, Gaisford P, Calin A (1994) A new approach to defining disease status in ankylosing spondylitis: the Bath ankylosing spondylitis disease activity index. J Rheumatol 21:2286\u20132291","journal-title":"J Rheumatol"},{"key":"2794_CR20","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1002\/art.20790","volume":"52","author":"D Heijde Van der","year":"2005","unstructured":"Van der Heijde D, Dougados M, Davis J et al (2005) Assessment in Ankylosing Spondylitis International Working Group\/Spondylitis Association of America recommendation for conducting clinical trials in ankylosing spondylitis. Arthritis Rheum 52:386\u2013394","journal-title":"Arthritis Rheum"},{"key":"2794_CR21","first-page":"951","volume":"26","author":"D Heijde Van der","year":"1999","unstructured":"Van der Heijde D, Calin A, Dougados M et al (1999) Selection of instruments in the core set for DC-ART, SMARD, physical therapy and clinical record keeping in ankylosing spondylitis: progress report of the ASAS Working Group. J Rheumatol 26:951\u2013954","journal-title":"J Rheumatol"},{"key":"2794_CR22","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1093\/rheumatology\/25.2.171","volume":"25","author":"NJ Sheehan","year":"1986","unstructured":"Sheehan NJ, Slavin BM, Donovan MP, Mount JN, Mathews JA (1986) Lack of correlation between clinical disease activity and erythrocyte sedimentation rate, acute phase proteins or protease inhibitors in ankylosing spondylitis. Br J Rheumatol 25:171\u2013174","journal-title":"Br J Rheumatol"},{"key":"2794_CR23","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s00296-009-1313-9","volume":"31","author":"Z Lin","year":"2001","unstructured":"Lin Z, Gu J, He P et al (2001) Multicenter validation of the value of BASFI and BASDAI in Chinese ankylosing spondylitis and undifferentiated spondyloarthropathy patients. Rheumatol Int 31:233\u2013238","journal-title":"Rheumatol Int"},{"key":"2794_CR24","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1002\/art.24408","volume":"60","author":"N Barkham","year":"2009","unstructured":"Barkham N, Keen HI, Coates LC et al (2009) Clinical and imaging efficacy of infliximab in HLA-B27-positive patients with magnetic resonance imaging-determined early sacroiliitis. Arthritis Rheum 60:946\u2013954","journal-title":"Arthritis Rheum"},{"key":"2794_CR25","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1002\/art.21790","volume":"54","author":"J Braun","year":"2006","unstructured":"Braun J, Landewe R, Hermann KG et al (2006) Major reduction in spinal inflammation in patients with ankylosing spondylitis after treatment with infliximab: results of a multicenter, randomized, double-blind, placebo-controlled magnetic resonance imaging study. Arthritis Rheum 54:1646\u20131652","journal-title":"Arthritis Rheum"},{"key":"2794_CR26","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1136\/ard.2007.069948","volume":"66","author":"CE Althoff","year":"2007","unstructured":"Althoff CE, Appel H, Rudwaleit M et al (2007) Whole-body MRI as a new screening tool for detecting axial and peripheral manifestations of spondyloarthritis. Ann Rheum Dis 66:983\u2013985","journal-title":"Ann Rheum Dis"},{"key":"2794_CR27","first-page":"2497","volume":"34","author":"H Appel","year":"2007","unstructured":"Appel H, Hermann KG, Althoff CE, Rudwaleit M, Sieper J (2007) Whole-body magnetic resonance imaging evaluation of widespread inflammatory lesions in a patient with ankylosing spondylitis before and after 1\u00a0year of treatment with infliximab. J Rheumatol 34:2497\u20132498","journal-title":"J Rheumatol"},{"key":"2794_CR28","doi-asserted-by":"crossref","first-page":"2613","DOI":"10.1001\/jama.1977.03270510035017","volume":"237","author":"A Calin","year":"2009","unstructured":"Calin A, Porta J, Fries JF, Schurmann DJ (2009) Clinical history as a screening test for ankylosing spondylitis. JAMA 237:2613\u20132614","journal-title":"JAMA"},{"key":"2794_CR29","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1136\/ard.2009.110767","volume":"68","author":"M Rudwaleit","year":"2009","unstructured":"Rudwaleit M, Jurik AG, Hermann KG et al (2009) Defining active sacroiliitis on magnetic resonance imaging (MRI) for classification of axial spondyloarthritis: a consensual approach by the ASAS\/OMERACT MRI group. Ann Rheum Dis 68:1520\u20131527","journal-title":"Ann Rheum Dis"},{"key":"2794_CR30","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1002\/art.1780341003","volume":"34","author":"M Dougados","year":"1991","unstructured":"Dougados M, van der Linden S, Juhlin R et al (1991) The European Spondylarthropathy Study Group preliminary criteria for the classification of spondylarthropathy. Arthritis Rheum 34:1218\u20131227","journal-title":"Arthritis Rheum"},{"key":"2794_CR31","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s00117-003-0992-6","volume":"44","author":"KG Hermann","year":"2004","unstructured":"Hermann KG, Braun J, Fischer T, Reisshauer H, Bollow M (2004) Magnetic resonance tomography of sacroiliitis: anatomy, histological pathology, MR-morphology, and grading]. Radiologe 44:217\u2013228","journal-title":"Radiologe"},{"key":"2794_CR32","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1002\/acr.20007","volume":"62","author":"WP Maksymowych","year":"2010","unstructured":"Maksymowych WP, Crowther SM, Dhillon SS, Conner-Spady B, Lambert RG (2010) Systematic assessment of inflammation by magnetic resonance imaging in the posterior elements of the spine in ankylosing spondylitis. Arthritis Care Res 62:4\u201310","journal-title":"Arthritis Care Res"},{"key":"2794_CR33","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1093\/rheumatology\/kep419","volume":"49","author":"AG Bochkova","year":"2010","unstructured":"Bochkova AG, Levshakova AV, Bunchuk NV, Braun J (2010) Spinal inflammation lesions as detected by magnetic resonance imaging in patients with early ankylosing spondylitis are more often observed in posterior structures of the spine. Rheumatology 49:749\u2013755","journal-title":"Rheumatology"},{"key":"2794_CR34","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1136\/ard.2010.139667","volume":"70","author":"IH Song","year":"2011","unstructured":"Song IH, Hermann K, Haibel H et al (2011) Effects of etanercept versus sulfalazine in early axial spondyloarthritis on active inflammatory lesions as detected by whole-body MRI (ESTHER): a 48-week randomised controlled trial. Ann Rheum Dis 70:590\u2013596","journal-title":"Ann Rheum Dis"},{"key":"2794_CR35","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1136\/ard.2009.121533","volume":"69","author":"M Dougados","year":"2010","unstructured":"Dougados M, Combe B, Braun J et al (2010) A randomised, multicentre, double-blind, placebo-controlled trial of etanercept in adults with refractory heel enthesitis in spondyloarthritis: the HEEL trial. Ann Rheum Dis 69:1430\u20131435","journal-title":"Ann Rheum Dis"},{"key":"2794_CR36","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1136\/ard.61.6.534","volume":"61","author":"D McGonagle","year":"2002","unstructured":"McGonagle D, Marzo-Ortega H, O\u2019Connor P et al (2002) Histological assessment of the early enthesitis lesion in spondyloarthropathy. Ann Rheum Dis 61:534\u2013537","journal-title":"Ann Rheum Dis"},{"key":"2794_CR37","first-page":"2295","volume":"27","author":"WP Maksymowych","year":"2000","unstructured":"Maksymowych WP (2000) Ankylosing spondylitis\u2014at the interface of bone and cartilage. J Rheumatol 27:2295\u20132301","journal-title":"J Rheumatol"},{"key":"2794_CR38","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S0140-6736(08)61000-4","volume":"372","author":"P Emery","year":"2008","unstructured":"Emery P, Breedveld FC, Hall S et al (2008) Comparison of methotrexate monotherapy with a combination of methotrexate and etanercept in active, early, moderate to severe rheumatoid arthritis (COMET): a randomised, double-blind, parallel treatment trial. Lancet 372:375\u2013382","journal-title":"Lancet"},{"key":"2794_CR39","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1002\/art.23260","volume":"58","author":"J Sieper","year":"2008","unstructured":"Sieper J, Appel H, Braun J, Rudwaleit M (2008) Critical appraisal of assessment of structural damage in ankylosing spondylitis: implications for treatment outcomes. Arthritis Rheum 58:649\u2013656","journal-title":"Arthritis Rheum"},{"key":"2794_CR40","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1136\/ard.2003.016386","volume":"63","author":"M Rudwaleit","year":"2004","unstructured":"Rudwaleit M, Listing J, Brandt J, Sieper J (2004) Prediction of a major clinical response (BASDAI 50) to tumour necrosis factor alpha blockers in ankylosing spondylitis. Ann Rheum Dis 63:665\u2013670","journal-title":"Ann Rheum Dis"},{"key":"2794_CR41","doi-asserted-by":"crossref","first-page":"801","DOI":"10.3899\/jrheum.081048","volume":"36","author":"M Rudwaleit","year":"2009","unstructured":"Rudwaleit M, Claudepierre P, Wordsworth P et al (2009) Effectiveness, safety, and predictors of good clinical response in 1250 patients treated with adalimumab for active ankylosing spondylitis. J Rheumatol 36:801\u2013808","journal-title":"J Rheumatol"}],"container-title":["European Radiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00330-013-2794-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00330-013-2794-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00330-013-2794-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T08:01:55Z","timestamp":1559030515000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00330-013-2794-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3,15]]},"references-count":41,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["2794"],"URL":"https:\/\/doi.org\/10.1007\/s00330-013-2794-1","relation":{},"ISSN":["0938-7994","1432-1084"],"issn-type":[{"value":"0938-7994","type":"print"},{"value":"1432-1084","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,15]]}}}