{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T05:32:09Z","timestamp":1791178329544,"version":"4.1.0"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2014,8,17]],"date-time":"2014-08-17T00:00:00Z","timestamp":1408233600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Radiol"],"published-print":{"date-parts":[[2015,1]]},"DOI":"10.1007\/s00330-014-3358-8","type":"journal-article","created":{"date-parts":[[2014,8,16]],"date-time":"2014-08-16T10:47:33Z","timestamp":1408186053000},"page":"122-131","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":84,"title":["Optic radiation damage in multiple sclerosis is associated with visual dysfunction and retinal thinning \u2013 an ultrahigh-field MR pilot study"],"prefix":"10.1007","volume":"25","author":[{"given":"Tim","family":"Sinnecker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timm","family":"Oberwahrenbrock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imke","family":"Metz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna","family":"Zimmermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caspar F.","family":"Pfueller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lutz","family":"Harms","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klemens","family":"Ruprecht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caren","family":"Ramien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrin","family":"Hahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Br\u00fcck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thoralf","family":"Niendorf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friedemann","family":"Paul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander U.","family":"Brandt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"D\u00f6rr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Wuerfel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,8,17]]},"reference":[{"key":"3358_CR1","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1002\/ana.22366","volume":"69","author":"CH Polman","year":"2011","unstructured":"Polman CH, Reingold SC, Banwell B et al (2011) Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria. Ann Neurol 69:292\u2013302","journal-title":"Ann Neurol"},{"key":"3358_CR2","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1093\/brain\/awg038","volume":"126","author":"M Filippi","year":"2003","unstructured":"Filippi M, Bozzali M, Rovaris M et al (2003) Evidence for widespread axonal damage at the earliest clinical stage of multiple sclerosis. Brain 126:433\u2013437","journal-title":"Brain"},{"key":"3358_CR3","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1177\/1352458513489757","volume":"19","author":"T Oberwahrenbrock","year":"2013","unstructured":"Oberwahrenbrock T, Ringelstein M, Jentschke S et al (2013) Retinal ganglion cell and inner plexiform layer thinning in clinically isolated syndrome. Mult Scler 19:1887\u20131895","journal-title":"Mult Scler"},{"key":"3358_CR4","first-page":"1379","volume":"17","author":"M Kitajima","year":"1996","unstructured":"Kitajima M, Korogi Y, Takahashi M, Eto K (1996) MR signal intensity of the optic radiation. AJNR Am J Neuroradiol 17:1379\u20131383","journal-title":"AJNR Am J Neuroradiol"},{"key":"3358_CR5","first-page":"397","volume":"38","author":"U B\u00fcrgel","year":"1997","unstructured":"B\u00fcrgel U, Mecklenburg I, Blohm U, Zilles K (1997) Histological visualization of long fiber tracts in the white matter of adult human brains. J Hirnforsch 38:397\u2013404","journal-title":"J Hirnforsch"},{"key":"3358_CR6","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1001\/archneurol.2011.2450","volume":"69","author":"T Sinnecker","year":"2012","unstructured":"Sinnecker T, Mittelstaedt P, D\u00f6rr J et al (2012) Multiple sclerosis lesions and irreversible brain tissue damage: a comparative ultrahigh-field strength magnetic resonance imaging study. Arch Neurol 69:739\u2013745","journal-title":"Arch Neurol"},{"key":"3358_CR7","doi-asserted-by":"crossref","first-page":"699","DOI":"10.3174\/ajnr.A1434","volume":"30","author":"K Kollia","year":"2009","unstructured":"Kollia K, Maderwald S, Putzki N et al (2009) First clinical study on ultra-high-field MR imaging in patients with multiple sclerosis: comparison of 1.5T and 7T. AJNR Am J Neuroradiol 30:699\u2013702","journal-title":"AJNR Am J Neuroradiol"},{"key":"3358_CR8","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1007\/s00330-013-3080-y","volume":"24","author":"ID Kilsdonk","year":"2014","unstructured":"Kilsdonk ID, Wattjes MP, Lopez-Soriano A et al (2014) Improved differentiation between MS and vascular brain lesions using FLAIR* at 7 Tesla. Eur Radiol 24:841\u2013849","journal-title":"Eur Radiol"},{"key":"3358_CR9","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.nic.2012.02.010","volume":"22","author":"ID Kilsdonk","year":"2012","unstructured":"Kilsdonk ID, de Graaf WL, Barkhof F, Wattjes MP (2012) Inflammation high-field magnetic resonance imaging. Neuroimaging Clin N Am 22:135\u2013157","journal-title":"Neuroimaging Clin N Am"},{"key":"3358_CR10","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1212\/WNL.0b013e31820b7630","volume":"76","author":"EC Tallantyre","year":"2011","unstructured":"Tallantyre EC, Dixon JE, Donaldson I et al (2011) Ultra-high-field imaging distinguishes MS lesions from asymptomatic white matter lesions. Neurology 76:534\u2013539","journal-title":"Neurology"},{"key":"3358_CR11","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1177\/1352458512441270","volume":"18","author":"J Wuerfel","year":"2012","unstructured":"Wuerfel J, Sinnecker T, Ringelstein EB et al (2012) Lesion morphology at 7 Tesla MRI differentiates Susac syndrome from multiple sclerosis. Mult Scler 18:1592\u20131599","journal-title":"Mult Scler"},{"key":"3358_CR12","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/nrneurol.2013.82","volume":"9","author":"J D\u00f6rr","year":"2013","unstructured":"D\u00f6rr J, Krautwald S, Wildemann B et al (2013) Characteristics of Susac syndrome: a review of all reported cases. Nat Rev Neurol 9:307\u2013316","journal-title":"Nat Rev Neurol"},{"key":"3358_CR13","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1212\/WNL.0b013e3182648bc8","volume":"79","author":"T Sinnecker","year":"2012","unstructured":"Sinnecker T, D\u00f6rr J, Pfueller CF et al (2012) Distinct lesion morphology at 7-T MRI differentiates neuromyelitis optica from multiple sclerosis. Neurology 79:708\u2013714","journal-title":"Neurology"},{"key":"3358_CR14","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/S1474-4422(10)70168-X","volume":"9","author":"A Petzold","year":"2010","unstructured":"Petzold A, de Boer JF, Schippling S et al (2010) Optical coherence tomography in multiple sclerosis: a systematic review and meta-analysis. Lancet Neurol 9:921\u2013932","journal-title":"Lancet Neurol"},{"key":"3358_CR15","first-page":"530305","volume":"2012","author":"T Oberwahrenbrock","year":"2012","unstructured":"Oberwahrenbrock T, Schippling S, Ringelstein M et al (2012) Retinal damage in multiple sclerosis disease subtypes measured by high-resolution optical coherence tomography. Mult Scler Int 2012:530305","journal-title":"Mult Scler Int"},{"key":"3358_CR16","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1002\/ana.20575","volume":"58","author":"SA Trip","year":"2005","unstructured":"Trip SA, Schlottmann PG, Jones SJ et al (2005) Retinal nerve fiber layer axonal loss and visual dysfunction in optic neuritis. Ann Neurol 58:383\u2013391","journal-title":"Ann Neurol"},{"key":"3358_CR17","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1177\/1352458507087326","volume":"14","author":"V Pueyo","year":"2008","unstructured":"Pueyo V, Martin J, Fernandez J et al (2008) Axonal loss in the retinal nerve fiber layer in patients with multiple sclerosis. Mult Scler 14:609\u2013614","journal-title":"Mult Scler"},{"key":"3358_CR18","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.1212\/01.wnl.0000278387.15090.5a","volume":"69","author":"GF Wu","year":"2007","unstructured":"Wu GF, Schwartz ED, Lei T et al (2007) Relation of vision to global and regional brain MRI in multiple sclerosis. Neurology 69:2128\u20132135","journal-title":"Neurology"},{"key":"3358_CR19","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1212\/WNL.33.11.1444","volume":"33","author":"JF Kurtzke","year":"1983","unstructured":"Kurtzke JF (1983) Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology 33:1444\u20131452","journal-title":"Neurology"},{"key":"3358_CR20","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1001\/archneur.59.2.275","volume":"59","author":"RA Bermel","year":"2002","unstructured":"Bermel RA, Bakshi R, Tjoa C et al (2002) Bicaudate ratio as a magnetic resonance imaging marker of brain atrophy in multiple sclerosis. Arch Neurol 59:275\u2013280","journal-title":"Arch Neurol"},{"key":"3358_CR21","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1001\/archneur.63.9.1301","volume":"63","author":"RHB Benedict","year":"2006","unstructured":"Benedict RHB, Bruce JM, Dwyer MG et al (2006) Neocortical atrophy, third ventricular width, and cognitive dysfunction in multiple sclerosis. Arch Neurol 63:1301\u20131306","journal-title":"Arch Neurol"},{"key":"3358_CR22","doi-asserted-by":"crossref","first-page":"e34823","DOI":"10.1371\/journal.pone.0034823","volume":"7","author":"P Tewarie","year":"2012","unstructured":"Tewarie P, Balk L, Costello F et al (2012) The OSCAR-IB consensus criteria for retinal OCT quality assessment. PLoS One 7:e34823","journal-title":"PLoS One"},{"key":"3358_CR23","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1136\/bjo.2010.193581","volume":"96","author":"M Bock","year":"2012","unstructured":"Bock M, Brandt AU, Kuchenbecker J et al (2012) Impairment of contrast visual acuity as a functional correlate of retinal nerve fibre layer thinning and total macular volume reduction in multiple sclerosis. Br J Ophthalmol 96:62\u201367","journal-title":"Br J Ophthalmol"},{"key":"3358_CR24","doi-asserted-by":"crossref","first-page":"3018","DOI":"10.1167\/iovs.08-1775","volume":"49","author":"A Ferreras","year":"2008","unstructured":"Ferreras A, Pablo LE, Garway-Heath DF et al (2008) Mapping standard automated perimetry to the peripapillary retinal nerve fiber layer in glaucoma. Invest Ophthalmol Vis Sci 49:3018\u20133025","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"3358_CR25","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1212\/01.wnl.0000313377.49555.2e","volume":"70","author":"EC Tallantyre","year":"2008","unstructured":"Tallantyre EC, Brookes MJ, Dixon JE et al (2008) Demonstrating the perivascular distribution of MS lesions in vivo with 7-Tesla MRI. Neurology 70:2076\u20132078","journal-title":"Neurology"},{"key":"3358_CR26","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1016\/j.acra.2012.05.018","volume":"19","author":"S Ide","year":"2012","unstructured":"Ide S, Kakeda S, Korogi Y et al (2012) Delineation of optic radiation and stria of Gennari on high-resolution phase difference enhanced imaging. Acad Radiol 19:1283\u20131289","journal-title":"Acad Radiol"},{"key":"3358_CR27","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1002\/mrm.24629","volume":"71","author":"AL Sukstanskii","year":"2014","unstructured":"Sukstanskii AL, Yablonskiy DA (2014) On the role of neuronal magnetic susceptibility and structure symmetry on gradient echo MR signal formation. Magn Reson Med 71:345\u2013353","journal-title":"Magn Reson Med"},{"key":"3358_CR28","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1056\/NEJM199801293380502","volume":"338","author":"BD Trapp","year":"1998","unstructured":"Trapp BD, Peterson J, Ransohoff RM et al (1998) Axonal transection in the lesions of multiple sclerosis. N Engl J Med 338:278\u2013285","journal-title":"N Engl J Med"},{"key":"3358_CR29","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1093\/brain\/awq346","volume":"134","author":"S Saidha","year":"2011","unstructured":"Saidha S, Syc SB, Ibrahim MA et al (2011) Primary retinal pathology in multiple sclerosis as detected by optical coherence tomography. Brain 134:518\u2013533","journal-title":"Brain"},{"key":"3358_CR30","doi-asserted-by":"crossref","first-page":"e193","DOI":"10.1093\/brain\/awr095","volume":"134","author":"AU Brandt","year":"2011","unstructured":"Brandt AU, Oberwahrenbrock T, Ringelstein M et al (2011) Primary retinal pathology in multiple sclerosis as detected by optical coherence tomography. Brain 134:e193","journal-title":"Brain"},{"key":"3358_CR31","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.1093\/brain\/awr125","volume":"134","author":"A Cowey","year":"2011","unstructured":"Cowey A, Alexander I, Stoerig P (2011) Transneuronal retrograde degeneration of retinal ganglion cells and optic tract in hemianopic monkeys and humans. Brain 134:2149\u20132157","journal-title":"Brain"},{"key":"3358_CR32","doi-asserted-by":"crossref","first-page":"e41","DOI":"10.1111\/j.1552-6569.2010.00468.x","volume":"21","author":"HH Dasenbrock","year":"2011","unstructured":"Dasenbrock HH, Smith SA, Ozturk A et al (2011) Diffusion tensor imaging of the optic tracts in multiple sclerosis: association with retinal thinning and visual disability. J Neuroimaging 21:e41\u2013e49","journal-title":"J Neuroimaging"},{"key":"3358_CR33","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1093\/brain\/awp001","volume":"132","author":"P Jindahra","year":"2009","unstructured":"Jindahra P, Petrie A, Plant GT (2009) Retrograde trans-synaptic retinal ganglion cell loss identified by optical coherence tomography. Brain 132:628\u2013634","journal-title":"Brain"},{"key":"3358_CR34","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1093\/brain\/124.9.1813","volume":"124","author":"N Evangelou","year":"2001","unstructured":"Evangelou N, Konz D, Esiri MM et al (2001) Size-selective neuronal changes in the anterior optic pathways suggest a differential susceptibility to injury in multiple sclerosis. Brain 124:1813\u20131820","journal-title":"Brain"},{"key":"3358_CR35","first-page":"145","volume":"94","author":"MR Matthews","year":"1960","unstructured":"Matthews MR, Cowan WM, Powell TP (1960) Transneuronal cell degeneration in the lateral geniculate nucleus of the macaque monkey. J Anat 94:145\u2013169","journal-title":"J Anat"},{"key":"3358_CR36","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1167\/iovs.10-5708","volume":"52","author":"H Bridge","year":"2011","unstructured":"Bridge H, Jindahra P, Barbur J, Plant GT (2011) Imaging reveals optic tract degeneration in hemianopia. Invest Ophthalmol Vis Sci 52:382\u2013388","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"3358_CR37","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1001\/archneurol.2008.562","volume":"66","author":"J Sepulcre","year":"2009","unstructured":"Sepulcre J, Go\u00f1i J, Masdeu JC et al (2009) Contribution of white matter lesions to gray matter atrophy in multiple sclerosis: evidence from voxel-based analysis of T1 lesions in the visual pathway. Arch Neurol 66:173\u2013179","journal-title":"Arch Neurol"},{"key":"3358_CR38","doi-asserted-by":"crossref","first-page":"e18019","DOI":"10.1371\/journal.pone.0018019","volume":"6","author":"CF Pfueller","year":"2011","unstructured":"Pfueller CF, Brandt AU, Schubert F et al (2011) Metabolic changes in the visual cortex are linked to retinal nerve fiber layer thinning in multiple sclerosis. PLoS One 6:e18019","journal-title":"PLoS One"},{"key":"3358_CR39","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1002\/ana.24030","volume":"75","author":"I Gabilondo","year":"2014","unstructured":"Gabilondo I, Mart\u00ednez-Lapiscina EH, Mart\u00ednez-Heras E et al (2014) Trans-synaptic axonal degeneration in the visual pathway in multiple sclerosis. Ann Neurol 75:98\u2013107","journal-title":"Ann Neurol"},{"key":"3358_CR40","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1167\/iovs.11-8732","volume":"53","author":"P Sriram","year":"2012","unstructured":"Sriram P, Graham SL, Wang C et al (2012) Transsynaptic retinal degeneration in optic neuropathies: optical coherence tomography study. Invest Ophthalmol Vis Sci 53:1271\u20131275","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"3358_CR41","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1212\/WNL.0b013e31827deb39","volume":"80","author":"A Klistorner","year":"2013","unstructured":"Klistorner A, Garrick R, Barnett MH et al (2013) Axonal loss in non-optic neuritis eyes of patients with multiple sclerosis linked to delayed visual evoked potential. Neurology 80:242\u2013245","journal-title":"Neurology"},{"key":"3358_CR42","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1177\/1352458512457844","volume":"19","author":"H Zimmermann","year":"2013","unstructured":"Zimmermann H, Freing A, Kaufhold F et al (2013) Optic neuritis interferes with optical coherence tomography and magnetic resonance imaging correlations. Mult Scler 19:443\u2013450","journal-title":"Mult Scler"},{"key":"3358_CR43","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1212\/01.wnl.0000295995.46586.ae","volume":"69","author":"E Gordon-Lipkin","year":"2007","unstructured":"Gordon-Lipkin E, Chodkowski B, Reich DS et al (2007) Retinal nerve fiber layer is associated with brain atrophy in multiple sclerosis. Neurology 69:1603\u20131609","journal-title":"Neurology"},{"key":"3358_CR44","doi-asserted-by":"crossref","first-page":"e18132","DOI":"10.1371\/journal.pone.0018132","volume":"6","author":"J D\u00f6rr","year":"2011","unstructured":"D\u00f6rr J, Wernecke KD, Bock M et al (2011) Association of retinal and macular damage with brain atrophy in multiple sclerosis. PLoS One 6:e18132","journal-title":"PLoS One"},{"key":"3358_CR45","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1001\/archneurol.2009.107","volume":"66","author":"DS Reich","year":"2009","unstructured":"Reich DS, Smith SA, Gordon-Lipkin EM et al (2009) Damage to the optic radiation in multiple sclerosis is associated with retinal injury and visual disability. Arch Neurol 66:998\u20131006","journal-title":"Arch Neurol"},{"key":"3358_CR46","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1167\/iovs.11-8864","volume":"53","author":"SC Kolbe","year":"2012","unstructured":"Kolbe SC, Marriott M, van der Walt A et al (2012) Diffusion tensor imaging correlates of visual impairment in multiple sclerosis and chronic optic neuritis. Invest Ophthalmol Vis Sci 53:825\u2013832","journal-title":"Invest Ophthalmol Vis Sci"}],"container-title":["European Radiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00330-014-3358-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00330-014-3358-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00330-014-3358-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T08:02:15Z","timestamp":1559030535000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00330-014-3358-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,17]]},"references-count":46,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["3358"],"URL":"https:\/\/doi.org\/10.1007\/s00330-014-3358-8","relation":{},"ISSN":["0938-7994","1432-1084"],"issn-type":[{"value":"0938-7994","type":"print"},{"value":"1432-1084","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,17]]}}}