{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T06:34:57Z","timestamp":1790922897122,"version":"4.1.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2016,9,5]],"date-time":"2016-09-05T00:00:00Z","timestamp":1473033600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Radiol"],"published-print":{"date-parts":[[2017,5]]},"DOI":"10.1007\/s00330-016-4532-y","type":"journal-article","created":{"date-parts":[[2016,9,5]],"date-time":"2016-09-05T14:34:37Z","timestamp":1473086077000},"page":"1840-1847","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Prognostic aspects of dynamic contrast-enhanced magnetic resonance imaging in synchronous distant metastatic rectal cancer"],"prefix":"10.1007","volume":"27","author":[{"given":"Jing","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Ya","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Cheng","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu-Lu","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-Bin","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,9,5]]},"reference":[{"key":"4532_CR1","doi-asserted-by":"crossref","first-page":"2311","DOI":"10.1016\/j.ejca.2013.03.006","volume":"49","author":"SM Engelen","year":"2013","unstructured":"Engelen SM, Maas M, Lahaye MJ, Leijtens JW, van Berlo CL, Jansen RL et al (2013) Modern multidisciplinary treatment of rectal cancer based on staging with magnetic resonance imaging leads to excellent local control, but distant control remains a challenge. Eur J Cancer 49:2311\u20132320","journal-title":"Eur J Cancer"},{"key":"4532_CR2","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.amjsurg.2005.03.012","volume":"189","author":"AN Meguerditchian","year":"2005","unstructured":"Meguerditchian AN, Bairati I, Lagace R, Harel F, Kibrite A (2005) Prognostic significance of lymphovascular invasion in surgically cured rectal carcinoma. Am J Surg 189:707\u2013713","journal-title":"Am J Surg"},{"key":"4532_CR3","doi-asserted-by":"crossref","first-page":"123","DOI":"10.3349\/ymj.2013.54.1.123","volume":"54","author":"HS Hong","year":"2013","unstructured":"Hong HS, Kim SH, Park HJ, Park MS, Kim KW, Kim WH et al (2013) Correlations of dynamic contrast-enhanced magnetic resonance imaging with morphologic, angiogenic, and molecular prognostic factors in rectal cancer. Yonsei Med J 54:123\u2013130","journal-title":"Yonsei Med J"},{"key":"4532_CR4","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1007\/s00330-008-1184-6","volume":"19","author":"OC Shihab","year":"2009","unstructured":"Shihab OC, Moran BJ, Heald RJ, Quirke P, Brown G (2009) MRI staging of low rectal cancer. Eur Radiol 19:643\u2013650","journal-title":"Eur Radiol"},{"key":"4532_CR5","doi-asserted-by":"crossref","first-page":"376","DOI":"10.12659\/MSM.892534","volume":"21","author":"L Li","year":"2015","unstructured":"Li L, Wang K, Sun X, Wang K, Sun Y, Zhang G et al (2015) Parameters of dynamic contrast-enhanced MRI as imaging markers for angiogenesis and proliferation in human breast cancer. Med Sci Monit 21:376\u2013382","journal-title":"Med Sci Monit"},{"key":"4532_CR6","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1002\/jmri.24301","volume":"39","author":"A Lollert","year":"2014","unstructured":"Lollert A, Junginger T, Schimanski CC, Biesterfeld S, Gockel I, Duber C et al (2014) Rectal cancer: dynamic contrast-enhanced MRI correlates with lymph node status and epidermal growth factor receptor expression. J Magn Reson Imaging 39:1436\u20131442","journal-title":"J Magn Reson Imaging"},{"key":"4532_CR7","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1002\/jmri.10176","volume":"16","author":"AR Padhani","year":"2002","unstructured":"Padhani AR (2002) Dynamic contrast-enhanced MRI in clinical oncology: current status and future directions. J Magn Reson Imaging 16:407\u2013422","journal-title":"J Magn Reson Imaging"},{"key":"4532_CR8","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1002\/(SICI)1522-2586(199909)10:3<223::AID-JMRI2>3.0.CO;2-S","volume":"10","author":"PS Tofts","year":"1999","unstructured":"Tofts PS, Brix G, Buckley DL, Evelhoch JL, Henderson E, Knopp MV et al (1999) Estimating kinetic parameters from dynamic contrast-enhanced T(1)-weighted MRI of a diffusable tracer: standardized quantities and symbols. J Magn Reson Imaging 10:223\u2013232","journal-title":"J Magn Reson Imaging"},{"key":"4532_CR9","doi-asserted-by":"crossref","first-page":"837","DOI":"10.2307\/2531595","volume":"44","author":"ER DeLong","year":"1988","unstructured":"DeLong ER, DeLong DM, Clarke-Pearson DL (1988) Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. Biometrics 44:837\u2013845","journal-title":"Biometrics"},{"key":"4532_CR10","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1097\/01.ede.0000147512.81966.ba","volume":"16","author":"EF Schisterman","year":"2005","unstructured":"Schisterman EF, Perkins NJ, Liu A, Bondell H (2005) Optimal cut-point and its corresponding Youden Index to discriminate individual using pooled blood samples. Epidemiology 16:73\u201381","journal-title":"Epidemiology"},{"key":"4532_CR11","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/0092-8674(94)90187-2","volume":"79","author":"IJ Fidler","year":"1994","unstructured":"Fidler IJ, Ellis LM (1994) The implications of angiogenesis for the biology and therapy of cancer metastasis. Cell 79:185\u2013188","journal-title":"Cell"},{"key":"4532_CR12","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1002\/jmri.23635","volume":"36","author":"HR Koo","year":"2012","unstructured":"Koo HR, Cho N, Song IC, Kim H, Chang JM, Yi A et al (2012) Correlation of perfusion parameters on dynamic contrast-enhanced MRI with prognostic factors and subtypes of breast cancers. J Magn Reson Imaging 36:145\u2013151","journal-title":"J Magn Reson Imaging"},{"key":"4532_CR13","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.mri.2015.10.013","volume":"34","author":"J Chen","year":"2016","unstructured":"Chen J, Qian T, Zhang H, Wei C, Meng F, Yin H (2016) Combining dynamic contrast enhanced magnetic resonance imaging and microvessel density to assess the angiogenesis after PEI in a rabbit VX2 liver tumor model. Magn Reson Imaging 34:177\u2013182","journal-title":"Magn Reson Imaging"},{"key":"4532_CR14","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1002\/jmri.24541","volume":"41","author":"DM Yeo","year":"2015","unstructured":"Yeo DM, Oh SN, Jung CK, Lee MA, Oh ST, Rha SE et al (2015) Correlation of dynamic contrast-enhanced MRI perfusion parameters with angiogenesis and biologic aggressiveness of rectal cancer: preliminary results. J Magn Reson Imaging 41:474\u2013480","journal-title":"J Magn Reson Imaging"},{"key":"4532_CR15","doi-asserted-by":"crossref","first-page":"3336","DOI":"10.1007\/s00330-013-2984-x","volume":"23","author":"MJ Gollub","year":"2013","unstructured":"Gollub MJ, Cao K, Gultekin DH, Kuk D, Gonen M, Sohn M et al (2013) Prognostic aspects of DCE-MRI in recurrent rectal cancer. Eur Radiol 23:3336\u20133344","journal-title":"Eur Radiol"},{"key":"4532_CR16","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0092-8674(00)81683-9","volume":"100","author":"D Hanahan","year":"2000","unstructured":"Hanahan D, Weinberg RA (2000) The hallmarks of cancer. Cell 100:57\u201370","journal-title":"Cell"},{"key":"4532_CR17","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0968-0004(98)01343-7","volume":"24","author":"G Christofori","year":"1999","unstructured":"Christofori G, Semb H (1999) The role of the cell-adhesion molecule E-cadherin as a tumour-suppressor gene. Trends Biochem Sci 24:73\u201376","journal-title":"Trends Biochem Sci"},{"key":"4532_CR18","doi-asserted-by":"crossref","first-page":"2290","DOI":"10.1038\/sj.onc.1210029","volume":"26","author":"M Herzig","year":"2007","unstructured":"Herzig M, Savarese F, Novatchkova M, Semb H, Christofori G (2007) Tumor progression induced by the loss of E-cadherin independent of beta-catenin\/Tcf-mediated Wnt signaling. Oncogene 26:2290\u20132298","journal-title":"Oncogene"},{"key":"4532_CR19","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s00234-011-0874-y","volume":"54","author":"R Awasthi","year":"2012","unstructured":"Awasthi R, Rathore RK, Soni P, Sahoo P, Awasthi A, Husain N et al (2012) Discriminant analysis to classify glioma grading using dynamic contrast-enhanced MRI and immunohistochemical markers. Neuroradiology 54:205\u2013213","journal-title":"Neuroradiology"},{"key":"4532_CR20","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/j.jocn.2011.08.030","volume":"19","author":"Z Jia","year":"2012","unstructured":"Jia Z, Geng D, Xie T, Zhang J, Liu Y (2012) Quantitative analysis of neovascular permeability in glioma by dynamic contrast-enhanced MR imaging. J Clin Neurosci 19:820\u2013823","journal-title":"J Clin Neurosci"},{"key":"4532_CR21","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1007\/s00384-013-1675-z","volume":"28","author":"JW Huh","year":"2013","unstructured":"Huh JW, Kim CH, Lim SW, Kim HR, Kim YJ (2013) Early recurrence in patients undergoing curative surgery for colorectal cancer: is it a predictor for poor overall survival? Int J Colorectal Dis 28:1143\u20131149","journal-title":"Int J Colorectal Dis"},{"key":"4532_CR22","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/codi.12354","volume":"16","author":"L Wang","year":"2014","unstructured":"Wang L, Zhong XG, Peng YF, Li ZW, Gu J (2014) Prognostic value of pretreatment level of carcinoembryonic antigen on tumour downstaging and early occurring metastasis in locally advanced rectal cancer following neoadjuvant radiotherapy (30 Gy in 10 fractions). Colorectal Dis 16:33\u201339","journal-title":"Colorectal Dis"},{"key":"4532_CR23","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1055\/s-0029-1242463","volume":"22","author":"PJ Villeneuve","year":"2009","unstructured":"Villeneuve PJ, Sundaresan RS (2009) Surgical management of colorectal lung metastasis. Clin Colon Rectal Surg 22:233\u2013241","journal-title":"Clin Colon Rectal Surg"},{"key":"4532_CR24","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1002\/jmri.23974","volume":"38","author":"MS Davenport","year":"2013","unstructured":"Davenport MS, Heye T, Dale BM, Horvath JJ, Breault SR, Feuerlein S et al (2013) Inter- and intra-rater reproducibility of quantitative dynamic contrast enhanced MRI using TWIST perfusion data in a uterine fibroid model. J Magn Reson Imaging 38:329\u2013335","journal-title":"J Magn Reson Imaging"},{"key":"4532_CR25","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1007\/s00330-014-3527-9","volume":"25","author":"B Sohn","year":"2015","unstructured":"Sohn B, Lim JS, Kim H, Myoung S, Choi J, Kim NK et al (2015) MRI-detected extramural vascular invasion is an independent prognostic factor for synchronous metastasis in patients with rectal cancer. Eur Radiol 25:1347\u20131355","journal-title":"Eur Radiol"},{"key":"4532_CR26","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/s00330-015-3837-6","volume":"26","author":"YC Kim","year":"2016","unstructured":"Kim YC, Kim JK, Kim MJ, Lee JH, Kim YB, Shin SJ (2016) Feasibility of mesorectal vascular invasion in predicting early distant metastasis in patients with stage T3 rectal cancer based on rectal MRI. Eur Radiol 26:297\u2013305","journal-title":"Eur Radiol"},{"key":"4532_CR27","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1002\/cncr.26310","volume":"118","author":"J Betge","year":"2012","unstructured":"Betge J, Pollheimer MJ, Lindtner RA, Kornprat P, Schlemmer A, Rehak P et al (2012) Intramural and extramural vascular invasion in colorectal cancer: prognostic significance and quality of pathology reporting. Cancer 118:628\u2013638","journal-title":"Cancer"},{"key":"4532_CR28","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1006\/jsre.2001.6312","volume":"103","author":"K Gunther","year":"2002","unstructured":"Gunther K, Dworak O, Remke S, Pfluger R, Merkel S, Hohenberger W et al (2002) Prediction of distant metastases after curative surgery for rectal cancer. J Surg Res 103:68\u201378","journal-title":"J Surg Res"},{"key":"4532_CR29","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/DCR.0b013e3181cf8ae5","volume":"53","author":"SB Lim","year":"2010","unstructured":"Lim SB, Yu CS, Jang SJ, Kim TW, Kim JH, Kim JC (2010) Prognostic significance of lymphovascular invasion in sporadic colorectal cancer. Dis Colon Rectum 53:377\u2013384","journal-title":"Dis Colon Rectum"},{"key":"4532_CR30","doi-asserted-by":"crossref","first-page":"2517","DOI":"10.1093\/annonc\/mds010","volume":"23","author":"R Glynne-Jones","year":"2012","unstructured":"Glynne-Jones R, Anyamene N, Moran B, Harrison M (2012) Neoadjuvant chemotherapy in MRI-staged high-risk rectal cancer in addition to or as an alternative to preoperative chemoradiation? Ann Oncol 23:2517\u20132526","journal-title":"Ann Oncol"},{"key":"4532_CR31","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S1470-2045(09)70381-X","volume":"11","author":"YJ Chua","year":"2010","unstructured":"Chua YJ, Barbachano Y, Cunningham D, Oates JR, Brown G, Wotherspoon A et al (2010) Neoadjuvant capecitabine and oxaliplatin before chemoradiotherapy and total mesorectal excision in MRI-defined poor-risk rectal cancer: a phase 2 trial. Lancet Oncol 11:241\u2013248","journal-title":"Lancet Oncol"},{"key":"4532_CR32","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1007\/s00330-013-2824-z","volume":"23","author":"M Scharitzer","year":"2013","unstructured":"Scharitzer M, Ba-Ssalamah A, Ringl H, Kolblinger C, Grunberger T, Weber M et al (2013) Preoperative evaluation of colorectal liver metastases: comparison between gadoxetic acid-enhanced 3.0-T MRI and contrast-enhanced MDCT with histopathological correlation. Eur Radiol 23:2187\u20132196","journal-title":"Eur Radiol"}],"container-title":["European Radiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00330-016-4532-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00330-016-4532-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00330-016-4532-y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00330-016-4532-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,24]],"date-time":"2017-06-24T22:01:48Z","timestamp":1498341708000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00330-016-4532-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,5]]},"references-count":32,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["4532"],"URL":"https:\/\/doi.org\/10.1007\/s00330-016-4532-y","relation":{},"ISSN":["0938-7994","1432-1084"],"issn-type":[{"value":"0938-7994","type":"print"},{"value":"1432-1084","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,5]]}}}