{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T03:43:21Z","timestamp":1777434201609,"version":"3.51.4"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2017,3,14]],"date-time":"2017-03-14T00:00:00Z","timestamp":1489449600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Radiol"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1007\/s00330-017-4772-5","type":"journal-article","created":{"date-parts":[[2017,3,14]],"date-time":"2017-03-14T13:47:22Z","timestamp":1489499242000},"page":"4218-4236","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["HIV-associated neurodegeneration and neuroimmunity: multivoxel MR spectroscopy study in drug-na\u00efve and treated patients"],"prefix":"10.1007","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9701-5484","authenticated-orcid":false,"given":"Jasmina","family":"Boban","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dusko","family":"Kozic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vesna","family":"Turkulov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jelena","family":"Ostojic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Semnic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dajana","family":"Lendak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Snezana","family":"Brkic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,3,14]]},"reference":[{"key":"4772_CR1","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1186\/s12879-015-0969-x","volume":"15","author":"S Patterson","year":"2015","unstructured":"Patterson S, Cescon A, Samji H, Chan K, Zhang W, Raboud J et al (2015) Life expectancy of HIV-positive individuals on combination antiretroviral therapy in Canada. BMC Infect Dis 15:274","journal-title":"BMC Infect Dis"},{"key":"4772_CR2","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/S1473-3099(13)70269-X","volume":"13","author":"DB Clifford","year":"2013","unstructured":"Clifford DB, Ances BM (2013) HIV-associated neurocognitive disorder. Lancet Infect Dis 13:976\u2013986","journal-title":"Lancet Infect Dis"},{"key":"4772_CR3","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1007\/s13365-011-0033-6","volume":"17","author":"DF Tate","year":"2011","unstructured":"Tate DF, Sampat M, Harezlak J, Fiecas M, Hogan J, Dewey J et al (2011) Regional areas and widths of the midsagittal corpus callosum among HIV-infected patients on stable antiretroviral therapies. J Neurovirol 17:368\u2013379","journal-title":"J Neurovirol"},{"key":"4772_CR4","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3109\/13550280903552420","volume":"16","author":"RA Cohen","year":"2010","unstructured":"Cohen RA, Harezlak J, Schifitto G, Hana G, Clark U, Gongvatana A et al (2010) Effects of nadir CD4 count and duration of human immunodeficiency virus infection on brain volumes in the highly active antiretroviral therapy era. J Neurovirol 16:25\u201332","journal-title":"J Neurovirol"},{"key":"4772_CR5","doi-asserted-by":"crossref","first-page":"467154","DOI":"10.1155\/2012\/467154","volume":"2012","author":"M Airoldi","year":"2012","unstructured":"Airoldi M, Bandera A, Trabattoni D, Tagliabue B, Arosio B, Soria A et al (2012) Neurocognitive impairment in HIV-infected naive patients with advanced disease: the role of virus and intrathecal immune activation. Clin Dev Immunol 2012:467154","journal-title":"Clin Dev Immunol"},{"key":"4772_CR6","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s13195-015-0123-4","volume":"7","author":"RA Cohen","year":"2015","unstructured":"Cohen RA, Seider TR, Navia B (2015) HIV effects on age-associated neurocognitive dysfunction: premature cognitive aging or neurodegenerative disease? Alzheimers Res Ther 7:37","journal-title":"Alzheimers Res Ther"},{"key":"4772_CR7","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1093\/cid\/ciu862","volume":"60","author":"RK Heaton","year":"2015","unstructured":"Heaton RK, Franklin DR, Deutsch R, Letendre S, Ellis RJ, Casaletto K et al (2015) Neurocognitive change in the era of HIV combination antiretroviral therapy: the longitudinal CHARTER study. Clin Infect Dis 60:473\u2013480","journal-title":"Clin Infect Dis"},{"key":"4772_CR8","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1097\/COH.0000000000000112","volume":"9","author":"BM Ances","year":"2014","unstructured":"Ances BM, Hammoud DA (2014) Neuroimaging of HIV associated neurocognitive yadisorders (HAND). Curr Opin HIV AIDS 9:545\u2013551","journal-title":"Curr Opin HIV AIDS"},{"key":"4772_CR9","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0049272","volume":"7","author":"N Sailasuta","year":"2012","unstructured":"Sailasuta N, Ross W, Ananworanich J, Chalermchai T, DeGruttola V, Lerdlum S et al (2012) Change in brain magnetic resonance spectroscopy after treatment during acute HIV infection. PLoS One 7, e49272","journal-title":"PLoS One"},{"key":"4772_CR10","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1093\/infdis\/jis326","volume":"206","author":"V Valcour","year":"2012","unstructured":"Valcour V, Chalermchai T, Sailasuta N, Marovich M, Lerdlum S, Suttichom D et al (2012) Central nervous system viral invasion and inflammation during acute HIV infection. J Infect Dis 206:275\u2013282","journal-title":"J Infect Dis"},{"key":"4772_CR11","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1097\/QAD.0b013e3283427da7","volume":"25","author":"J Harezlak","year":"2011","unstructured":"Harezlak J, Buchtal S, Taylor M, Schifitto G, Zhong J, Daar E et al (2011) Persistence of HIV-associated cognitive impairment, inflammation and neuronal injury in era of highly active antiretroviral treatment. AIDS 25:625\u2013633","journal-title":"AIDS"},{"key":"4772_CR12","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1023\/A:1020609213664","volume":"13","author":"CD Marcus","year":"1998","unstructured":"Marcus CD, Taylor-Robinson SD, Sargentoni J, Ainsworth JG, Frize G, Easterbrook PJ et al (1998) 1H MR spectroscopy of the brain in HIV-1-seropositive subjects: evidence for diffuse metabolic abnormalities. Metab Brain Dis 13:123\u2013136","journal-title":"Metab Brain Dis"},{"key":"4772_CR13","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/hiv.12322","volume":"17","author":"L Ryom","year":"2016","unstructured":"Ryom L, Boesecke C, Gisler V, Manzardo C, Rockstroh JK, Puoti M et al (2016) Essentials from the 2015 European AIDS Clinical Society (EACS) guidelines for the treatment of adult HIV-positive persons. HIV Med 17:83\u201388","journal-title":"HIV Med"},{"key":"4772_CR14","first-page":"1367","volume":"19","author":"NC Sacktor","year":"2005","unstructured":"Sacktor NC, Wong M, Nakasujja N, Skolasky RL, Selnes OA, Musisi S et al (2005) The International HIV Dementia Scale: a new rapid screening test for HIV dementia. AIDS 19:1367\u20131374","journal-title":"AIDS"},{"key":"4772_CR15","doi-asserted-by":"crossref","first-page":"447","DOI":"10.3174\/ajnr.A4557","volume":"37","author":"VV Eylers","year":"2016","unstructured":"Eylers VV, Maudsley AA, Bronzlik P, Dellani PR, Lanfermann H, Ding XQ (2016) Detection of normal aging effects on human brain metabolite concentrations and microstructure with whole-brain MR spectroscopic imaging and quantitative MR imaging. Am J Neuroradiol 37:447\u2013454","journal-title":"Am J Neuroradiol"},{"key":"4772_CR16","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s13365-013-0162-1","volume":"19","author":"A Gongvatana","year":"2013","unstructured":"Gongvatana A, Harezlak J, Buchtal S, Daar E, Schifitto G, Campbell T et al (2013) Progressive cerebral injury in the setting of chronic HIV infection and antiretroviral therapy. J Neurovirol 19:209\u2013218","journal-title":"J Neurovirol"},{"key":"4772_CR17","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.nicl.2013.07.009","volume":"3","author":"X Hua","year":"2013","unstructured":"Hua X, Boyle CP, Harezlak J, Tate DF, Yiannoutsos CT, Cohen R et al (2013) Disrupted cerebral metabolite levels and lower nadir CD4+ counts are linked to brain volume deficits in 210 HIV-infected patients on stable treatment. Neuroimage Clin 3:132\u2013142","journal-title":"Neuroimage Clin"},{"key":"4772_CR18","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1007\/s13365-012-0135-9","volume":"19","author":"T Zhu","year":"2013","unstructured":"Zhu T, Zhong J, Hu R, Tivarus M, Ekholm S, Harezlak J et al (2013) Patterns of white matter injury in HIV infection after partial immune reconstitution: a DTI tract-based spatial statistics study. J Neurovirol 19:10\u201323","journal-title":"J Neurovirol"},{"key":"4772_CR19","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/j.ejrad.2012.11.029","volume":"82","author":"J Bladowska","year":"2013","unstructured":"Bladowska J, Zimny A, Koltowska A, Szewczyk P, Knysz B, Gasiorowski J et al (2013) Evaluation of metabolic changes within the normal appearing gray and white matters in neurologically asymptomatic HIV-1-positive and HCV-positive patients: magnetic resonance spectroscopy and immunologic correlation. Eur J Radiol 82:686\u2013692","journal-title":"Eur J Radiol"},{"key":"4772_CR20","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1093\/cercor\/11.7.598","volume":"11","author":"JC Brooks","year":"2001","unstructured":"Brooks JC, Roberts N, Kemp GJ, Gosney MA, Lye M, Whitehouse GH et al (2001) A proton magnetic resonance spectroscopy study of age-related changes in frontal lobe metabolite concentrations. Cereb Cortex 11:598\u2013605","journal-title":"Cereb Cortex"},{"key":"4772_CR21","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/0278-5846(94)90125-2","volume":"18","author":"HC Charles","year":"1994","unstructured":"Charles HC, Lazeyras F, Krishnan KR, Boyko OB, Patterson LJ, Doraiswamy PM et al (1994) Proton spectroscopy of human brain: effects of age and sex. Prog Neuropsychopharmacol Biol Psychiatry 18:995\u20131004","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"4772_CR22","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0061738","volume":"8","author":"LA Cysique","year":"2013","unstructured":"Cysique LA, Moffat K, Moore DM, Lane TA, Davies NW, Carr A et al (2013) HIV, vascular and aging injuries in the brain of clinically stable HIV-infected adults: a (1)H MRS study. PLoS One 8, e61738","journal-title":"PLoS One"},{"key":"4772_CR23","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1007\/s13365-014-0246-6","volume":"20","author":"J Harezlak","year":"2014","unstructured":"Harezlak J, Cohen R, Gongvatana A, Taylor M, Buchthal S, Schifitto G et al (2014) Predictors of CNS injury as measured by proton magnetic resonance spectroscopy in the setting of chronic HIV infection and CART. J Neurovirol 20:294\u2013303","journal-title":"J Neurovirol"},{"key":"4772_CR24","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1080\/09084282.2011.595601","volume":"19","author":"JM Foley","year":"2012","unstructured":"Foley JM, Ettenhofer ML, Kim MS, Behdin N, Castellon SA, Hinkin CH (2012) Cognitive reserve as a protective factor in older HIV-postive patients at risk for cognitive decline. Appl Neuropsychol Adult 19:16\u201325","journal-title":"Appl Neuropsychol Adult"},{"key":"4772_CR25","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.tics.2010.11.004","volume":"15","author":"A Etkin","year":"2011","unstructured":"Etkin A, Egner T, Kalisch R (2011) Emotional processing in anterior cingulate and medial prefrontal cortex. Trends Cogn Sci 15:85\u201393","journal-title":"Trends Cogn Sci"},{"key":"4772_CR26","doi-asserted-by":"crossref","first-page":"591","DOI":"10.3233\/JAD-2011-110254","volume":"27","author":"A Zimny","year":"2011","unstructured":"Zimny A, Szewczyk P, Trypka E, Wojtynska R, Noga L, Leszek J et al (2011) Multimodal imaging in diagnosis of Alzheimer\u2019s disease and amnestic mild cognitive impairment \u2013 value of magnetic resonance spectroscopy, perfusion and diffusion tensor imaging of the posterior cingulated region. J Alzheimers Dis 27:591\u2013601","journal-title":"J Alzheimers Dis"},{"key":"4772_CR27","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1212\/WNL.0000000000000932","volume":"83","author":"AC Young","year":"2014","unstructured":"Young AC, Yiannoutsos CT, Hegde M, Lee M, Peterson J, Walter R et al (2014) Cerebral metabolite changes prior to and after antiretroviral therapy in primary HIV infection. Neurology 83:1592\u20131600","journal-title":"Neurology"},{"key":"4772_CR28","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1097\/QAI.0000000000000779","volume":"71","author":"N Sailasuta","year":"2016","unstructured":"Sailasuta N, Ananworanich J, Lerdlum S, Sithinamsuwan P, Fletcher JL, Tipsuk S et al (2016) Neuronal-Glia markers by magnetic resonance spectroscopy in HIV before and after combination antiretroviral therapy. J Acquir Immune Defic Syndr 71:24\u201330","journal-title":"J Acquir Immune Defic Syndr"},{"key":"4772_CR29","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s004010000284","volume":"101","author":"M Mittelbronn","year":"2001","unstructured":"Mittelbronn M, Dietz K, Schluesener HJ, Meyermann R (2001) Local distribution of microglia in the normal adult human central nervous system differs by up to one order of magnitude. Acta Neuropathol 101:249\u2013255","journal-title":"Acta Neuropathol"},{"key":"4772_CR30","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1097\/QAD.0b013e32834a40cd","volume":"25","author":"RJ Ellis","year":"2011","unstructured":"Ellis RJ, Badiee J, Vajda F, Letendre S, Heaton RK, Clifford D et al (2011) CD4 nadir is a predictor of HIV neurocognitive impairment in the era of combination antiretroviral therapy. AIDS 25:1747\u20131751","journal-title":"AIDS"},{"key":"4772_CR31","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1002\/1522-2586(200012)12:6<859::AID-JMRI8>3.0.CO;2-T","volume":"12","author":"T Ernst","year":"2000","unstructured":"Ernst T, Itti E, Itti L, Chang L (2000) Changes in cerebral metabolism are detected prior to perfusion changes in early HIV-CMC: a coregistered (1)H MRS and SPECT study. J Magn Reson Imaging 12:859\u2013865","journal-title":"J Magn Reson Imaging"},{"key":"4772_CR32","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1007\/s11011-008-9109-2","volume":"23","author":"EL Streck","year":"2008","unstructured":"Streck EL, Scaini G, Rezin GT, Moreira J, Fochesato CM, Rom\u00e3o PR (2008) Effects of the HIV treatment drugs nevirapine and efavirenz on brain creatine kinase activity. Metab Brain Dis 23:485\u2013492","journal-title":"Metab Brain Dis"},{"key":"4772_CR33","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1080\/13550280591002342","volume":"11","author":"BC Schweinsburg","year":"2011","unstructured":"Schweinsburg BC, Taylor MJ, Alhassoon OM, Gonzalez R, Brown GG, Ellis RJ et al (2011) Brain mitochondrial injury in human immunodeficiency virus-seropositive (HIV+) individuals taking nucleoside reverse transcriptase inhibitors. J Neurovirol 11:356\u2013364","journal-title":"J Neurovirol"},{"key":"4772_CR34","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1002\/mrm.22821","volume":"66","author":"EM Ratai","year":"2011","unstructured":"Ratai EM, Annamalai L, Burdo T, Joo CG, Bombardier JP, Fell R et al (2011) Brain creatine elevation and n-acetylaspartate reduction indicates neuronal dysfunction in the setting of enhanced glial energy metabolism in a macaque model of neuroAIDS. Magn Reson Med 66:625\u2013634","journal-title":"Magn Reson Med"}],"container-title":["European Radiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00330-017-4772-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00330-017-4772-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00330-017-4772-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,3]],"date-time":"2020-10-03T21:09:53Z","timestamp":1601759393000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00330-017-4772-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,14]]},"references-count":34,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["4772"],"URL":"https:\/\/doi.org\/10.1007\/s00330-017-4772-5","relation":{},"ISSN":["0938-7994","1432-1084"],"issn-type":[{"value":"0938-7994","type":"print"},{"value":"1432-1084","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,14]]}}}