{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:56:33Z","timestamp":1790816193311,"version":"4.1.0"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2018,2,15]],"date-time":"2018-02-15T00:00:00Z","timestamp":1518652800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"the National Nature Science Foundation of China","doi-asserted-by":"crossref","award":["No. 81525014"],"award-info":[{"award-number":["No. 81525014"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the Jiangsu Provincial Special Program of Medical Science","award":["BL2013029"],"award-info":[{"award-number":["BL2013029"]}]},{"name":"The Key Research and Development Program of Jiangsu Province","award":["BE2016782"],"award-info":[{"award-number":["BE2016782"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Radiol"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1007\/s00330-017-5298-6","type":"journal-article","created":{"date-parts":[[2018,2,15]],"date-time":"2018-02-15T04:22:05Z","timestamp":1518668525000},"page":"3326-3334","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["Renal fat fraction and diffusion tensor imaging in patients with early-stage diabetic nephropathy"],"prefix":"10.1007","volume":"28","author":[{"given":"Yuan-Cheng","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinglian","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Qiang","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5041-7865","authenticated-orcid":false,"given":"Shenghong","family":"Ju","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,2,15]]},"reference":[{"key":"5298_CR1","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1016\/S0140-6736(13)60687-X","volume":"382","author":"V Jha","year":"2013","unstructured":"Jha V, Garcia-Garcia G, Iseki K et al (2013) Chronic kidney disease: global dimension and perspectives. Lancet 382:260\u2013272","journal-title":"Lancet"},{"key":"5298_CR2","doi-asserted-by":"publisher","first-page":"1684","DOI":"10.1111\/j.1523-1755.2005.00265.x","volume":"67","author":"CA Jones","year":"2005","unstructured":"Jones CA, Krolewski AS, Rogus J, Xue JL, Collins A, Warram JH (2005) Epidemic of end-stage renal disease in people with diabetes in the United States population: do we know the cause? Kidney Int 67:1684\u20131691","journal-title":"Kidney Int"},{"key":"5298_CR3","doi-asserted-by":"publisher","first-page":"S39","DOI":"10.1053\/j.ajkd.2013.10.048","volume":"63","author":"RJ Macisaac","year":"2014","unstructured":"Macisaac RJ, Ekinci EI, Jerums G (2014) Markers of and risk factors for the development and progression of diabetic kidney disease. Am J Kidney Dis 63:S39\u2013S62","journal-title":"Am J Kidney Dis"},{"key":"5298_CR4","doi-asserted-by":"publisher","first-page":"550","DOI":"10.2215\/CJN.04071206","volume":"2","author":"IM Wahba","year":"2007","unstructured":"Wahba IM, Mak RH (2007) Obesity and obesity-initiated metabolic syndrome: mechanistic links to chronic kidney disease. Clin J Am Soc Nephrol 2:550\u2013562","journal-title":"Clin J Am Soc Nephrol"},{"key":"5298_CR5","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1148\/radiol.13122860","volume":"269","author":"XG Peng","year":"2013","unstructured":"Peng XG, Bai YY, Fang F et al (2013) Renal lipids and oxygenation in diabetic mice: noninvasive quantification with MR imaging. Radiology 269:748\u2013757","journal-title":"Radiology"},{"key":"5298_CR6","doi-asserted-by":"publisher","first-page":"2328","DOI":"10.2337\/diabetes.54.8.2328","volume":"54","author":"Z Wang","year":"2005","unstructured":"Wang Z, Jiang T, Li J et al (2005) Regulation of renal lipid metabolism, lipid accumulation, and glomerulosclerosis in FVBdb\/db mice with type 2 diabetes. Diabetes 54:2328\u20132335","journal-title":"Diabetes"},{"key":"5298_CR7","doi-asserted-by":"publisher","first-page":"1312","DOI":"10.1002\/jmri.25252","volume":"44","author":"T Yokoo","year":"2016","unstructured":"Yokoo T, Clark HR, Pedrosa I et al (2016) Quantification of renal steatosis in type II diabetes mellitus using Dixon-based MRI. J Magn Reson Imaging 44:1312\u20131319","journal-title":"J Magn Reson Imaging"},{"key":"5298_CR8","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1194\/jlr.P040501","volume":"55","author":"M Herman-Edelstein","year":"2014","unstructured":"Herman-Edelstein M, Scherzer P, Tobar A, Levi M, Gafter U (2014) Altered renal lipid metabolism and renal lipid accumulation in human diabetic nephropathy. J Lipid Res 55:561\u2013572","journal-title":"J Lipid Res"},{"key":"5298_CR9","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1046\/j.1523-1755.2000.00814.x","volume":"57","author":"JH Dominguez","year":"2000","unstructured":"Dominguez JH, Tang N, Xu W et al (2000) Studies of renal injury III: lipid-induced nephropathy in type II diabetes. Kidney Int 57:92\u2013104","journal-title":"Kidney Int"},{"key":"5298_CR10","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1097\/MNH.0b013e32833aa4ac","volume":"19","author":"IA Bobulescu","year":"2010","unstructured":"Bobulescu IA (2010) Renal lipid metabolism and lipotoxicity. Curr Opin Nephrol Hypertens 19:393\u2013402","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"5298_CR11","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1159\/000075925","volume":"24","author":"CK Abrass","year":"2004","unstructured":"Abrass CK (2004) Cellular lipid metabolism and the role of lipids in progressive renal disease. Am J Nephrol 24:46\u201353","journal-title":"Am J Nephrol"},{"key":"5298_CR12","doi-asserted-by":"publisher","first-page":"2775","DOI":"10.1097\/01.ASN.0000141965.28037.EE","volume":"15","author":"SP Bagby","year":"2004","unstructured":"Bagby SP (2004) Obesity-initiated metabolic syndrome and the kidney: a recipe for chronic kidney disease? J Am Soc Nephrol 15:2775\u20132791","journal-title":"J Am Soc Nephrol"},{"key":"5298_CR13","doi-asserted-by":"publisher","first-page":"1309","DOI":"10.1016\/S0140-6736(82)91513-6","volume":"2","author":"JF Moorhead","year":"1982","unstructured":"Moorhead JF, Chan MK, El-Nahas M, Varghese Z (1982) Lipid nephrotoxicity in chronic progressive glomerular and tubulo-interstitial disease. Lancet 2:1309\u20131311","journal-title":"Lancet"},{"key":"5298_CR14","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.3390\/jcm4051010","volume":"4","author":"R Hojs","year":"2015","unstructured":"Hojs R, Ekart R, Bevc S, Hojs N (2015) Biomarkers of renal disease and progression in patients with diabetes. J Clin Med 4:1010\u20131024","journal-title":"J Clin Med"},{"key":"5298_CR15","doi-asserted-by":"publisher","first-page":"348","DOI":"10.2215\/CJN.02870707","volume":"3","author":"AC Baxmann","year":"2008","unstructured":"Baxmann AC, Ahmed MS, Marques NC et al (2008) Influence of muscle mass and physical activity on serum and urinary creatinine and serum cystatin C. Clin J Am Soc Nephrol 3:348\u2013354","journal-title":"Clin J Am Soc Nephrol"},{"key":"5298_CR16","doi-asserted-by":"publisher","first-page":"1847","DOI":"10.1194\/jlr.D016691","volume":"52","author":"XG Peng","year":"2011","unstructured":"Peng XG, Ju S, Qin Y et al (2011) Quantification of liver fat in mice: comparing dual-echo Dixon imaging, chemical shift imaging, and 1H-MR spectroscopy. J Lipid Res 52:1847\u20131855","journal-title":"J Lipid Res"},{"key":"5298_CR17","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1002\/jmri.23741","volume":"36","author":"SB Reeder","year":"2012","unstructured":"Reeder SB, Hu HH, Sirlin CB (2012) Proton density fat-fraction: a standardized MR-based biomarker of tissue fat concentration. J Magn Reson Imaging 36:1011\u20131014","journal-title":"J Magn Reson Imaging"},{"key":"5298_CR18","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.1097\/GME.0000000000000721","volume":"23","author":"G Li","year":"2016","unstructured":"Li G, Xu Z, Chen Y et al (2016) Longitudinal assessment of marrow fat content using three-point Dixon technique in osteoporotic rabbits. Menopause 23:1339\u20131344","journal-title":"Menopause"},{"key":"5298_CR19","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1148\/radiol.2015150320","volume":"278","author":"LW Mann","year":"2016","unstructured":"Mann LW, Higgins DM, Peters CN et al (2016) Accelerating MR imaging liver steatosis measurement using combined compressed sensing and parallel imaging: a quantitative evaluation. Radiology 278:247\u2013256","journal-title":"Radiology"},{"key":"5298_CR20","doi-asserted-by":"publisher","first-page":"1678","DOI":"10.1007\/s00330-012-2749-y","volume":"23","author":"C Gaudiano","year":"2013","unstructured":"Gaudiano C, Clementi V, Busato F et al (2013) Diffusion tensor imaging and tractography of the kidneys: assessment of chronic parenchymal diseases. Eur Radiol 23:1678\u20131685","journal-title":"Eur Radiol"},{"key":"5298_CR21","doi-asserted-by":"publisher","first-page":"2427","DOI":"10.1007\/s00330-011-2189-0","volume":"21","author":"K Hueper","year":"2011","unstructured":"Hueper K, Gutberlet M, Rodt T et al (2011) Diffusion tensor imaging and tractography for assessment of renal allograft dysfunction-initial results. Eur Radiol 21:2427\u20132433","journal-title":"Eur Radiol"},{"key":"5298_CR22","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1097\/RLI.0b013e31824f272d","volume":"47","author":"K Hueper","year":"2012","unstructured":"Hueper K, Hartung D, Gutberlet M et al (2012) Magnetic resonance diffusion tensor imaging for evaluation of histopathological changes in a rat model of diabetic nephropathy. Invest Radiol 47:430\u2013437","journal-title":"Invest Radiol"},{"key":"5298_CR23","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1007\/s00330-014-3461-x","volume":"25","author":"Z Liu","year":"2015","unstructured":"Liu Z, Xu Y, Zhang J et al (2015) Chronic kidney disease: pathological and functional assessment with diffusion tensor imaging at 3T MR. Eur Radiol 25:652\u2013660","journal-title":"Eur Radiol"},{"key":"5298_CR24","doi-asserted-by":"publisher","first-page":"e113469","DOI":"10.1371\/journal.pone.0113469","volume":"9","author":"Z Zheng","year":"2014","unstructured":"Zheng Z, Shi H, Zhang J, Zhang Y (2014) Renal water molecular diffusion characteristics in healthy native kidneys: assessment with diffusion tensor MR imaging. PLoS One 9:e113469","journal-title":"PLoS One"},{"key":"5298_CR25","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1148\/radiol.12111327","volume":"263","author":"EE Sigmund","year":"2012","unstructured":"Sigmund EE, Vivier PH, Sui D et al (2012) Intravoxel incoherent motion and diffusion-tensor imaging in renal tissue under hydration and furosemide flow challenges. Radiology 263:758\u2013769","journal-title":"Radiology"},{"key":"5298_CR26","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1148\/radiol.10092419","volume":"259","author":"HC Thoeny","year":"2011","unstructured":"Thoeny HC, De Keyzer F (2011) Diffusion-weighted MR imaging of native and transplanted kidneys. Radiology 259:25\u201338","journal-title":"Radiology"},{"key":"5298_CR27","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1148\/radiol.2015150244","volume":"278","author":"M Iima","year":"2016","unstructured":"Iima M, Le Bihan D (2016) Clinical intravoxel incoherent motion and diffusion MR imaging: past, present, and future. Radiology 278:13\u201332","journal-title":"Radiology"},{"key":"5298_CR28","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.lfs.2016.10.015","volume":"166","author":"WK Leung","year":"2016","unstructured":"Leung WK, Gao L, Siu PM, Lai CW (2016) Diabetic nephropathy and endothelial dysfunction: current and future therapies, and emerging of vascular imaging for preclinical renal-kinetic study. Life Sci 166:121\u2013130","journal-title":"Life Sci"},{"key":"5298_CR29","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1097\/RLI.0b013e31817d14e6","volume":"43","author":"M Notohamiprodjo","year":"2008","unstructured":"Notohamiprodjo M, Glaser C, Herrmann KA et al (2008) Diffusion tensor imaging of the kidney with parallel imaging: initial clinical experience. Invest Radiol 43:677\u2013685","journal-title":"Invest Radiol"},{"key":"5298_CR30","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1148\/radiology.153.1.6089263","volume":"153","author":"WT Dixon","year":"1984","unstructured":"Dixon WT (1984) Simple proton spectroscopic imaging. Radiology 153:189\u2013194","journal-title":"Radiology"},{"key":"5298_CR31","doi-asserted-by":"publisher","first-page":"1562","DOI":"10.1007\/s00125-002-0962-y","volume":"45","author":"DH Atchley","year":"2002","unstructured":"Atchley DH, Lopes-Virella MF, Zheng D, Kenny D, Virella G (2002) Oxidized LDL-anti-oxidized LDL immune complexes and diabetic nephropathy. Diabetologia 45:1562\u20131571","journal-title":"Diabetologia"},{"key":"5298_CR32","doi-asserted-by":"publisher","first-page":"F1587","DOI":"10.1152\/ajprenal.00404.2009","volume":"297","author":"XX Wang","year":"2009","unstructured":"Wang XX, Jiang T, Shen Y et al (2009) The farnesoid X receptor modulates renal lipid metabolism and diet-induced renal inflammation, fibrosis, and proteinuria. Am J Physiol Renal Physiol 297:F1587\u2013F1596","journal-title":"Am J Physiol Renal Physiol"},{"key":"5298_CR33","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1002\/jmri.22501","volume":"33","author":"ZJ Wang","year":"2011","unstructured":"Wang ZJ, Kumar R, Banerjee S, Hsu CY (2011) Blood oxygen level-dependent (BOLD) MRI of diabetic nephropathy: preliminary experience. J Magn Reson Imaging 33:655\u2013660","journal-title":"J Magn Reson Imaging"},{"key":"5298_CR34","doi-asserted-by":"publisher","first-page":"113","DOI":"10.2214\/AJR.11.8052","volume":"200","author":"Q Li","year":"2013","unstructured":"Li Q, Wu X, Qiu L, Zhang P, Zhang M, Yan F (2013) Diffusion-weighted MRI in the assessment of split renal function: comparison of navigator-triggered prospective acquisition correction and breath-hold acquisition. AJR Am J Roentgenol 200:113\u2013119","journal-title":"AJR Am J Roentgenol"},{"key":"5298_CR35","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1097\/RLI.0000000000000073","volume":"49","author":"YC Wang","year":"2014","unstructured":"Wang YC, Tang A, Chang D, Zhang SJ, Ju S (2014) Significant perturbation in renal functional magnetic resonance imaging parameters and contrast retention for iodixanol compared with iopromide: an experimental study using blood-oxygen-level-dependent\/diffusion-weighted magnetic resonance imaging and computed tomography in rats. Invest Radiol 49:699\u2013706","journal-title":"Invest Radiol"},{"key":"5298_CR36","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1681\/ASN.2016060666","volume":"28","author":"L Tonneijck","year":"2017","unstructured":"Tonneijck L, Muskiet MH, Smits MM et al (2017) Glomerular hyperfiltration in diabetes: mechanisms, clinical significance, and treatment. J Am Soc Nephrol 28:1023\u20131039","journal-title":"J Am Soc Nephrol"},{"key":"5298_CR37","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1038\/nrneph.2012.19","volume":"8","author":"I Helal","year":"2012","unstructured":"Helal I, Fick-Brosnahan GM, Reed-Gitomer B, Schrier RW (2012) Glomerular hyperfiltration: definitions, mechanisms and clinical implications. Nat Rev Nephrol 8:293\u2013300","journal-title":"Nat Rev Nephrol"},{"key":"5298_CR38","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1172\/JCI12066","volume":"107","author":"TH Hostetter","year":"2001","unstructured":"Hostetter TH (2001) Hypertrophy and hyperfunction of the diabetic kidney. J Clin Invest 107:161\u2013162","journal-title":"J Clin Invest"},{"key":"5298_CR39","doi-asserted-by":"publisher","first-page":"1429","DOI":"10.1681\/ASN.2010111143","volume":"22","author":"T Inoue","year":"2011","unstructured":"Inoue T, Kozawa E, Okada H et al (2011) Noninvasive evaluation of kidney hypoxia and fibrosis using magnetic resonance imaging. J Am Soc Nephrol 22:1429\u20131434","journal-title":"J Am Soc Nephrol"}],"container-title":["European Radiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00330-017-5298-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00330-017-5298-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00330-017-5298-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,2,14]],"date-time":"2019-02-14T20:20:32Z","timestamp":1550175632000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00330-017-5298-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,15]]},"references-count":39,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["5298"],"URL":"https:\/\/doi.org\/10.1007\/s00330-017-5298-6","relation":{},"ISSN":["0938-7994","1432-1084"],"issn-type":[{"value":"0938-7994","type":"print"},{"value":"1432-1084","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,15]]},"assertion":[{"value":"25 October 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 December 2017","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 December 2017","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 February 2018","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The scientific guarantor of this publication is Shenghong Ju.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Guarantor"}},{"value":"The authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"No complex statistical methods were necessary for this paper.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Statistics and biometry"}},{"value":"Written informed consent was obtained from all subjects (patients) in this study.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"Institutional Review Board approval was obtained.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"\u2022 observational\u2022 performed at one institution","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Methodology"}}]}}