{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T17:02:17Z","timestamp":1792083737896,"version":"4.4.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2018,3,14]],"date-time":"2018-03-14T00:00:00Z","timestamp":1520985600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Radiol"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1007\/s00330-018-5339-9","type":"journal-article","created":{"date-parts":[[2018,3,14]],"date-time":"2018-03-14T12:49:17Z","timestamp":1521031757000},"page":"3601-3610","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":72,"title":["Diagnostic prediction of complicated appendicitis by combined clinical and radiological appendicitis severity index (APSI)"],"prefix":"10.1007","volume":"28","author":[{"given":"Maxim","family":"Avanesov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nis Jesper","family":"Wiese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murat","family":"Karul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena","family":"Guerreiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Keller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Busch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Jacobsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Adam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Yamamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,3,14]]},"reference":[{"key":"5339_CR1","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.ijsu.2012.02.006","volume":"10","author":"A Petroianu","year":"2012","unstructured":"Petroianu A (2012) Diagnosis of acute appendicitis. Int J Surg 10:115\u2013119","journal-title":"Int J Surg"},{"key":"5339_CR2","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1186\/s12876-015-0277-3","volume":"15","author":"T Jaschinski","year":"2015","unstructured":"Jaschinski T, Mosch C, Eikermann M, Neugebauer EAM (2015) Laparoscopic versus open appendectomy in patients with suspected appendicitis: a systematic review of meta-analyses of randomised controlled trials. BMC Gastroenterol 15:48","journal-title":"BMC Gastroenterol"},{"key":"5339_CR3","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1097\/SLE.0000000000000394","volume":"27","author":"C Hobeika","year":"2017","unstructured":"Hobeika C, Hor T, Chereau N et al (2017) Day surgery for acute appendicitis in adults: a prospective series of 102 patients. Surg Laparosc Endosc Percutan Tech 27:158\u2013162","journal-title":"Surg Laparosc Endosc Percutan Tech"},{"key":"5339_CR4","doi-asserted-by":"publisher","first-page":"e2156","DOI":"10.1136\/bmj.e2156","volume":"344","author":"KK Varadhan","year":"2012","unstructured":"Varadhan KK, Neal KR, Lobo DN (2012) Safety and efficacy of antibiotics compared with appendicectomy for treatment of uncomplicated acute appendicitis: meta-analysis of randomised controlled trials. BMJ 344:e2156","journal-title":"BMJ"},{"key":"5339_CR5","doi-asserted-by":"publisher","first-page":"2305","DOI":"10.1007\/s00268-016-3561-7","volume":"40","author":"KE Rollins","year":"2016","unstructured":"Rollins KE, Varadhan KK, Neal KR, Lobo DN (2016) Antibiotics versus appendicectomy for the treatment of uncomplicated acute appendicitis: an updated meta-analysis of randomised controlled trials. World J Surg 40:2305\u20132318","journal-title":"World J Surg"},{"key":"5339_CR6","doi-asserted-by":"publisher","first-page":"2028","DOI":"10.1007\/s00268-012-1641-x","volume":"36","author":"J Hansson","year":"2012","unstructured":"Hansson J, K\u00f6rner U, Ludwigs K et al (2012) Antibiotics as first-line therapy for acute appendicitis: evidence for a change in clinical practice. World J Surg 36:2028\u20132036","journal-title":"World J Surg"},{"key":"5339_CR7","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1002\/bjs.10147","volume":"103","author":"V Sallinen","year":"2016","unstructured":"Sallinen V, Akl EA, You JJ et al (2016) Meta-analysis of antibiotics versus appendicectomy for non-perforated acute appendicitis. Br J Surg 103:656\u2013667","journal-title":"Br J Surg"},{"key":"5339_CR8","doi-asserted-by":"publisher","first-page":"2340","DOI":"10.1001\/jama.2015.6154","volume":"313","author":"P Salminen","year":"2015","unstructured":"Salminen P, Paajanen H, Rautio T et al (2015) Antibiotic therapy vs appendectomy for treatment of uncomplicated acute appendicitis. The APPAC Randomized Clinical Trial. JAMA 313:2340\u20132348","journal-title":"JAMA"},{"key":"5339_CR9","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1148\/radiol.2483071652","volume":"249","author":"RA Van","year":"2008","unstructured":"Van RA, Bipat S, Zwinderman AH, Ubbink DT, Stoker J, Boermeester MA (2008) Acute appendicitis: meta-analysis of diagnostic performance of CT and graded compression us related to prevalence of disease. Radiology 249:97\u2013106","journal-title":"Radiology"},{"key":"5339_CR10","first-page":"1304","volume":"139","author":"AJ Hansen","year":"2004","unstructured":"Hansen AJ, Young SW, De Petris G, Tessier DJ, Hernandez JL, Johnson DJ (2004) Histologic severity of appendicitis can be predicted by computed tomography. ArchSurg 139:1304\u20131308","journal-title":"ArchSurg"},{"key":"5339_CR11","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1148\/radiol.2413051896","volume":"241","author":"SD Bixby","year":"2006","unstructured":"Bixby SD, Lucey BC, Soto JA, Theyson JM, Ozonoff A, Varghese JC (2006) Perforated versus nonperforated acute appendicitis: accuracy of multidetector CT detection. Radiology 241:780\u2013786","journal-title":"Radiology"},{"key":"5339_CR12","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1007\/s00261-014-0117-x","volume":"39","author":"MS Kim","year":"2014","unstructured":"Kim MS, Park HW, Park JY et al (2014) Differentiation of early perforated from nonperforated appendicitis: MDCT findings, MDCT diagnostic performance, and clinical outcome. Abdominal Imaging 39:459\u2013466","journal-title":"Abdominal Imaging"},{"key":"5339_CR13","first-page":"72","volume":"19","author":"P Antonopoulos","year":"2006","unstructured":"Antonopoulos P, Konstantinidis F, Dalamarinis K et al (2006) Acute gangrenous appendicitis-diagnosis by spiral CT. Ann Gastroenterol 19:72\u201376","journal-title":"Ann Gastroenterol"},{"key":"5339_CR14","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1148\/radiol.2351040310","volume":"235","author":"TA Foley","year":"2005","unstructured":"Foley TA, Earnest F IV, Nathan MA, Hough DM, Schiller HJ, Hoskin TL (2005) Differentiation of nonperforated from perforated appendicitis\u00a0: accuracy of CT diagnosis and relationship of CT findings to length of hospital stay 1. Radiology 235:89\u201396","journal-title":"Radiology"},{"key":"5339_CR15","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1016\/j.surg.2016.04.021","volume":"160","author":"E Lietz\u00e9n","year":"2016","unstructured":"Lietz\u00e9n E, M\u00e4llinen J, Gr\u00f6nroos MJ et al (2016) Is preoperative distinction between complicated and uncomplicated acute appendicitis feasible without imaging\u00a0? Surgery 160:789\u2013795","journal-title":"Surgery"},{"key":"5339_CR16","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1002\/bjs.9008","volume":"100","author":"CW Yu","year":"2013","unstructured":"Yu CW, Juan LI, Wu MH, Shen CJ, Wu JY, Lee CC (2013) Systematic review and meta-analysis of the diagnostic accuracy of procalcitonin, C-reactive protein and white blood cell count for suspected acute appendicitis. Br J Surg 100:322\u2013329","journal-title":"Br J Surg"},{"key":"5339_CR17","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1186\/s13017-016-0107-0","volume":"11","author":"Y Imaoka","year":"2016","unstructured":"Imaoka Y, Itamoto T, Takakura Y, Suzuki T, Ikeda S, Urushihara T (2016) Validity of predictive factors of acute complicated appendicitis. World J Emerg Surg 11:48","journal-title":"World J Emerg Surg"},{"key":"5339_CR18","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1186\/1749-7922-9-62","volume":"9","author":"K Kitaoka","year":"2014","unstructured":"Kitaoka K, Saito K, Tokuuye K (2014) Important CT findings for prediction of severe appendicitis: involvement of retroperitoneal space. World J Emerg Surg 9:62","journal-title":"World J Emerg Surg"},{"key":"5339_CR19","doi-asserted-by":"publisher","first-page":"e111144","DOI":"10.1371\/journal.pone.0111144","volume":"9","author":"HG Jeon","year":"2014","unstructured":"Jeon HG, Ju HU, Kim GY et al (2014) Bacteriology and changes in antibiotic susceptibility in adults with community-acquired perforated appendicitis. PLoS One 9:e111144","journal-title":"PLoS One"},{"key":"5339_CR20","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1148\/radiology.174.2.2296641","volume":"174","author":"EJ Balthazar","year":"1990","unstructured":"Balthazar EJ, Robinson DL, Megibow AJ, Ranson JH (1990) Acute pancreatitis: value of CT in establishing prognosis. Radiology 174:331\u2013336","journal-title":"Radiology"},{"key":"5339_CR21","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.2214\/ajr.183.5.1831261","volume":"183","author":"KJ Mortele","year":"2004","unstructured":"Mortele KJ, Wiesner W, Intriere L et al (2004) A modified CT severity index for evaluating acute pancreatitis: improved correlation with patient outcome. AJR Am J Roentgenol 183:1261\u20131265","journal-title":"AJR Am J Roentgenol"},{"key":"5339_CR22","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1097\/mpa.0b013e31802d4136","volume":"34","author":"JJ Waele De","year":"2007","unstructured":"De Waele JJ, Delrue L, Hoste EA, De Vos M, Duyck P, Colardyn FA (2007) Extrapancreatic inflammation on abdominal computed tomography as an early predictor of disease severity in acute pancreatitis: evaluation of a new scoring system. Pancreas 34:185\u2013190","journal-title":"Pancreas"},{"key":"5339_CR23","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1002\/bjs.9835","volume":"102","author":"JJ Atema","year":"2015","unstructured":"Atema JJ, van Rossem CC, Leeuwenburgh MM, Stoker J, Boermeester MA (2015) Scoring system to distinguish uncomplicated from complicated acute appendicitis. Br J Surg 102:979\u2013990","journal-title":"Br J Surg"},{"key":"5339_CR24","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1002\/bjs.4464","volume":"91","author":"REB Andersson","year":"2004","unstructured":"Andersson REB (2004) Meta-analysis of the clinical and laboratory diagnosis of appendicitis. Br J Surg 91:28\u201337","journal-title":"Br J Surg"},{"key":"5339_CR25","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.jss.2011.09.049","volume":"83","author":"MEE Br\u00f6ker","year":"2012","unstructured":"Br\u00f6ker MEE, Van Lieshout EMM, van der Elst M et al (2012) Discriminating between simple and perforated appendicitis. J Surg Res 83:79\u201383","journal-title":"J Surg Res"},{"key":"5339_CR26","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1007\/s11605-011-1486-x","volume":"15","author":"T Augustin","year":"2011","unstructured":"Augustin T, Cagir B, Vandermeer TJ (2011) Characteristics of perforated appendicitis: effect of delay is confounded by age and gender. J Gastrointest Surg 15:1223\u20131231","journal-title":"J Gastrointest Surg"},{"key":"5339_CR27","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/S1092-9134(00)90011-X","volume":"4","author":"NJ Carr","year":"2000","unstructured":"Carr NJ (2000) The pathology of acute appendicitis. Ann Diagn Pathol 4:46\u201358","journal-title":"Ann Diagn Pathol"},{"key":"5339_CR28","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.1111\/1469-0691.12717","volume":"20","author":"LA Vught van","year":"2014","unstructured":"van Vught LA, Endeman H, Meijvis SC et al (2014) The effect of age on the systemic inflammatory response in patients with community-acquired pneumonia. Clin Microbiol Infect 20:1183\u20131188","journal-title":"Clin Microbiol Infect"},{"key":"5339_CR29","first-page":"242","volume":"23","author":"T Miki","year":"2005","unstructured":"Miki T, Ogata S, Uto M et al (2005) Enhanced multidetector-row computed tomography (MDCT) in the diagnosis of acute appendicitis and its severity. Radiat Med 23:242\u2013255","journal-title":"Radiat Med"}],"container-title":["European Radiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00330-018-5339-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00330-018-5339-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00330-018-5339-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,3,14]],"date-time":"2019-03-14T00:19:25Z","timestamp":1552522765000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00330-018-5339-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,14]]},"references-count":29,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["5339"],"URL":"https:\/\/doi.org\/10.1007\/s00330-018-5339-9","relation":{},"ISSN":["0938-7994","1432-1084"],"issn-type":[{"value":"0938-7994","type":"print"},{"value":"1432-1084","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,14]]},"assertion":[{"value":"13 December 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 January 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 March 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The scientific guarantor of this publication is Dr. Maxim Avanesov.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Guarantor"}},{"value":"The authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"One of the authors has significant statistical expertise.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Statistics and biometry"}},{"value":"Written informed consent was waived by the Institutional Review Board.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"Institutional Review Board approval was obtained.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"\u2022 retrospective\u2022 diagnostic study\u2022 observational\u2022 performed at one institution","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Methodology"}}]}}