{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T06:35:22Z","timestamp":1790145322838,"version":"4.0.1"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2018,5,7]],"date-time":"2018-05-07T00:00:00Z","timestamp":1525651200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2018,5,7]],"date-time":"2018-05-07T00:00:00Z","timestamp":1525651200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000051","name":"National Human Genome Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000051","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000098","name":"NIH Clinical Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000098","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Radiol"],"published-print":{"date-parts":[[2018,11]]},"DOI":"10.1007\/s00330-018-5421-3","type":"journal-article","created":{"date-parts":[[2018,5,7]],"date-time":"2018-05-07T17:12:58Z","timestamp":1525713178000},"page":"4635-4642","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Thoracic involvement in Erdheim-Chester disease: computed tomography imaging findings and their association with the BRAFV600E mutation"],"prefix":"10.1007","volume":"28","author":[{"given":"S. Mojdeh","family":"Mirmomen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arlene","family":"Sirajuddin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moozhan","family":"Nikpanah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolf","family":"Symons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna K.","family":"Paschall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis","family":"Papageorgiou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William A.","family":"Gahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"O\u2019Brien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juvianee I.","family":"Estrada-Veras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashkan A.","family":"Malayeri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,5,7]]},"reference":[{"issue":"1","key":"5421_CR1","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1097\/BOR.0b013e32834d861d","volume":"24","author":"J Haroche","year":"2012","unstructured":"Haroche J, Arnaud L, Amoura Z (2012) Erdheim\u2013Chester disease. Curr Opin Rheumatol 24(1):53\u201359","journal-title":"Curr Opin Rheumatol"},{"issue":"7","key":"5421_CR2","first-page":"3257","volume":"34","author":"AM Abdelfattah","year":"2014","unstructured":"Abdelfattah AM, Arnaout K, Tabbara IA (2014) Erdheim-Chester disease: a comprehensive review. Anticancer Res 34(7):3257\u20133261","journal-title":"Anticancer Res"},{"issue":"2","key":"5421_CR3","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/j.rdc.2013.02.011","volume":"39","author":"J Haroche","year":"2013","unstructured":"Haroche J, Arnaud L, Cohen-Aubart F et al (2013) Erdheim-Chester disease. Rheum Dis Clin N Am 39(2):299\u2013311","journal-title":"Rheum Dis Clin N Am"},{"issue":"4","key":"5421_CR4","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.ejim.2015.03.004","volume":"26","author":"C Campochiaro","year":"2015","unstructured":"Campochiaro C, Tomelleri A, Cavalli G, Berti A, Dagna L (2015) Erdheim-Chester disease. Eur J int Med 26(4):223\u2013229","journal-title":"Eur J int Med"},{"issue":"20","key":"5421_CR5","doi-asserted-by":"publisher","first-page":"2375","DOI":"10.1182\/blood-2016-01-643569","volume":"127","author":"SH Swerdlow","year":"2016","unstructured":"Swerdlow SH, Campo E, Pileri SA et al (2016) The 2016 revision of the World Health Organization classification of lymphoid neoplasms. Blood 127(20):2375\u20132390","journal-title":"Blood"},{"issue":"1","key":"5421_CR6","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1186\/1750-1172-8-137","volume":"8","author":"RD Mazor","year":"2013","unstructured":"Mazor RD, Manevich-Mazor M, Shoenfeld Y (2013) Erdheim-Chester Disease: a comprehensive review of the literature. Orphanet J Rare Dis 8(1):137","journal-title":"Orphanet J Rare Dis"},{"issue":"6","key":"5421_CR7","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1182\/bloodadvances.2016001784","volume":"1","author":"JI Estrada-Veras","year":"2017","unstructured":"Estrada-Veras JI, O\u2019Brien KJ, Boyd LC et al (2017) The clinical spectrum of Erdheim-Chester disease: an observational cohort study. Blood Adv 1(6):357\u2013366. \n                    https:\/\/doi.org\/10.1182\/bloodadvances.2016001784","journal-title":"Blood Adv"},{"issue":"4","key":"5421_CR8","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1182\/blood-2014-03-561381","volume":"124","author":"EL Diamond","year":"2014","unstructured":"Diamond EL, Dagna L, Hyman DM et al (2014) Consensus guidelines for the diagnosis and clinical management of Erdheim-Chester disease. Blood 124(4):483\u2013492","journal-title":"Blood"},{"issue":"13","key":"5421_CR9","doi-asserted-by":"publisher","first-page":"2700","DOI":"10.1182\/blood-2012-05-430140","volume":"120","author":"J Haroche","year":"2012","unstructured":"Haroche J, Charlotte F, Arnaud L et al (2012) High prevalence of BRAF V600E mutations in Erdheim-Chester disease but not in other non-Langerhans cell histiocytoses. Blood 120(13):2700\u20132703. \n                    https:\/\/doi.org\/10.1182\/blood-2012-05-430140","journal-title":"Blood"},{"issue":"11","key":"5421_CR10","doi-asserted-by":"publisher","first-page":"3607","DOI":"10.18632\/oncotarget.1964","volume":"5","author":"F Janku","year":"2014","unstructured":"Janku F, Vibat CRT, Kosco K et al (2014) BRAF V600E mutations in urine and plasma cell-free DNA from patients with Erdheim-Chester disease. Oncotarget 5(11):3607","journal-title":"Oncotarget"},{"key":"5421_CR11","doi-asserted-by":"crossref","unstructured":"Cohen Aubart F, Emile JF, Maksud P, et al (2016) Efficacy of the MEK inhibitor cobimetinib for wild-type BRAF Erdheim-Chester disease. B J Haematol","DOI":"10.1111\/bjh.14284"},{"issue":"8","key":"5421_CR12","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1056\/NEJMoa1502309","volume":"373","author":"DM Hyman","year":"2015","unstructured":"Hyman DM, Puzanov I, Subbiah V et al (2015) Vemurafenib in multiple nonmelanoma cancers with BRAF V600 mutations. N Engl J Med 373(8):726\u2013736","journal-title":"N Engl J Med"},{"issue":"5","key":"5421_CR13","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1200\/JCO.2014.57.1950","volume":"33","author":"Julien Haroche","year":"2015","unstructured":"Haroche J, Cohen-Aubart F, Emile J-F et al (2014) Reproducible and sustained efficacy of targeted therapy with vemurafenib in patients with BRAF(V600E)-mutated Erdheim-Chester disease. J Clin Oncol 33(5):411\u2013418","journal-title":"Journal of Clinical Oncology"},{"issue":"11","key":"5421_CR14","doi-asserted-by":"publisher","first-page":"2579","DOI":"10.1007\/s00330-010-1830-7","volume":"20","author":"A-L Brun","year":"2010","unstructured":"Brun A-L, Touitou-Gottenberg D, Haroche J et al (2010) Erdheim-Chester disease: CT findings of thoracic involvement. Eur Radiol 20(11):2579\u20132587","journal-title":"Eur Radiol"},{"issue":"4","key":"5421_CR15","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1007\/s13244-014-0331-7","volume":"5","author":"C Antunes","year":"2014","unstructured":"Antunes C, Gra\u00e7a B, Donato P (2014) Thoracic, abdominal and musculoskeletal involvement in Erdheim-Chester disease: CT, MR and PET imaging findings. Insights Into imaging 5(4):473\u2013482","journal-title":"Insights Into imaging"},{"issue":"11","key":"5421_CR16","doi-asserted-by":"publisher","first-page":"3504","DOI":"10.1002\/art.27672","volume":"62","author":"L Arnaud","year":"2010","unstructured":"Arnaud L, Pierre I, Beigelman-Aubry C et al (2010) Pulmonary involvement in Erdheim-Chester disease: A single-center study of thirty-four patients and a review of the literature. Arthritis Rheum 62(11):3504\u20133512","journal-title":"Arthritis Rheum"},{"issue":"5","key":"5421_CR17","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.2214\/ajr.183.5.1831253","volume":"183","author":"E Dion","year":"2004","unstructured":"Dion E, Graef C, Haroche J et al (2004) Imaging of thoracoabdominal involvement in Erdheim-Chester disease. AJR Am J Roentgenol 183(5):1253\u20131260","journal-title":"AJR Am J Roentgenol"},{"issue":"5","key":"5421_CR18","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.2214\/ajr.174.5.1741327","volume":"174","author":"KH Wittenberg","year":"2000","unstructured":"Wittenberg KH, Swensen SJ, Myers JL (2000) Pulmonary involvement with Erdheim-Chester disease: radiographic and CT findings. AJR Am J Roentgenol 174(5):1327\u20131331","journal-title":"AJR Am J Roentgenol"},{"issue":"7","key":"5421_CR19","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1038\/modpathol.3880130","volume":"13","author":"WL Rush","year":"2000","unstructured":"Rush WL, Andriko JAW, Galateau-Salle F et al (2000) Pulmonary pathology of Erdheim-Chester disease. Mod Pathol 13(7):747\u2013754","journal-title":"Mod Pathol"},{"issue":"20","key":"5421_CR20","doi-asserted-by":"publisher","first-page":"2468","DOI":"10.1182\/blood-2016-07-724815","volume":"128","author":"D Gianfreda","year":"2016","unstructured":"Gianfreda D, Palumbo AA, Rossi E et al (2016) Cardiac involvement in Erdheim-Chester disease: an MRI study. Blood 128(20):2468\u20132471","journal-title":"Blood"},{"issue":"6","key":"5421_CR21","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1097\/01.md.0000145368.17934.91","volume":"83","author":"J Haroche","year":"2004","unstructured":"Haroche J, Amoura Z, Dion E et al (2004) Cardiovascular involvement, an overlooked feature of Erdheim-Chester disease: report of 6 new cases and a literature review. Medicine 83(6):371\u2013392","journal-title":"Medicine"},{"issue":"6","key":"5421_CR22","first-page":"1550","volume":"27","author":"J Serratrice","year":"2000","unstructured":"Serratrice J, Granel B, De Roux C et al (2000) \"Coated aorta\": a new sign of Erdheim-Chester disease. J Rheumatol 27(6):1550\u20131553","journal-title":"J Rheumatol"},{"issue":"9","key":"5421_CR23","doi-asserted-by":"publisher","first-page":"3751","DOI":"10.1007\/s00330-018-5326-1","volume":"28","author":"Moozhan Nikpanah","year":"2018","unstructured":"Nikpanah M, Kim L, Mirmomen SM et al (2018) Abdominal involvement in Erdheim-Chester disease (ECD): MRI and CT imaging findings and their association with BRAFV600E mutation. Eur Radiol :1\u20139. \n                    https:\/\/doi.org\/10.1007\/s00330-018-5326-1","journal-title":"European Radiology"}],"container-title":["European Radiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00330-018-5421-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00330-018-5421-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00330-018-5421-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,16]],"date-time":"2020-05-16T12:01:04Z","timestamp":1589630464000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00330-018-5421-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,7]]},"references-count":23,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["5421"],"URL":"https:\/\/doi.org\/10.1007\/s00330-018-5421-3","relation":{},"ISSN":["0938-7994","1432-1084"],"issn-type":[{"value":"0938-7994","type":"print"},{"value":"1432-1084","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,7]]},"assertion":[{"value":"4 October 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 February 2018","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 March 2018","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 May 2018","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The scientific guarantor of this publication is Ashkan A. Malayeri.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Guarantor"}},{"value":"The authors of this manuscript declare no relationships with any companies whose products or services may be related to the subject matter of the article.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Rolf Symons, MD, one of the authors, has significant statistical expertise.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Statistics and biometry"}},{"value":"Written informed consent was obtained from all patients prior to their participation in the study.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"This was a prospective study approved by the institutional review board at the National Human Genome Research Institute (NHGRI).","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Clinical aspects of 60 patients of the present cohort were previously reviewed by Estrada-Veras et al. in the paper titled \u201cThe clinical spectrum of Erdheim-Chester disease: an observational cohort study\u201d [].","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Study subjects or cohorts overlap"}},{"value":"\u2022 observational\u2022 single-centre\u2022 prospective","order":8,"name":"Ethics","group":{"name":"EthicsHeading","label":"Methodology"}}]}}