{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T13:18:51Z","timestamp":1760015931859},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2018,4,30]],"date-time":"2018-04-30T00:00:00Z","timestamp":1525046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"the National Normal Science Foundation of China under Grant","award":["81671666"],"award-info":[{"award-number":["81671666"]}]},{"name":"the National Normal Science Foundation of China under Grant","award":["8117130"],"award-info":[{"award-number":["8117130"]}]},{"name":"the Medicine Scientific key Research Project of Chongqing Health Bureau Grant of China","award":["2016ZDXM002"],"award-info":[{"award-number":["2016ZDXM002"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Radiol"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1007\/s00330-018-5461-8","type":"journal-article","created":{"date-parts":[[2018,4,30]],"date-time":"2018-04-30T13:42:32Z","timestamp":1525095752000},"page":"4447-4454","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Optic radiations are thinner and show signs of iron deposition in patients with long-standing remitting-relapsing multiple sclerosis: an enhanced T2*-weighted angiography imaging study"],"prefix":"10.1007","volume":"28","author":[{"given":"Chun","family":"Zeng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silin","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongliang","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jialiang","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yayun","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoya","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianyou","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongmei","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yineng","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,4,30]]},"reference":[{"key":"5461_CR1","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1111\/ene.13224","volume":"24","author":"JW Hyun","year":"2017","unstructured":"Hyun JW, Park G, Kwak K et al (2017) Deep gray matter atrophy in neuromyelitis optica spectrum disorder and\u2002multiple sclerosis. Eur J Neurol 24:437\u2013445","journal-title":"Eur J Neurol"},{"key":"5461_CR2","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1111\/ene.13200","volume":"24","author":"T Uher","year":"2017","unstructured":"Uher T, Vaneckova M, Sormani MP et al (2017) Identification of multiple sclerosis patients at highest risk of cognitive impairment using an integrated brain magnetic resonance imaging assessment approach. Eur J Neurol 24:292\u2013301","journal-title":"Eur J Neurol"},{"issue":"11","key":"5461_CR3","doi-asserted-by":"publisher","first-page":"1561","DOI":"10.1177\/1352458517705002","volume":"23","author":"Maria Pia Amato","year":"2017","unstructured":"Amato MP (2017) The diagnostic dilemma of multiple sclerosis presenting with isolated cognitive and behavioral disorders. Mult Scler. \n                    https:\/\/doi.org\/10.1177\/1352458517705002","journal-title":"Multiple Sclerosis Journal"},{"key":"5461_CR4","doi-asserted-by":"publisher","first-page":"1610","DOI":"10.1177\/1352458513485146","volume":"19","author":"MA Rocca","year":"2013","unstructured":"Rocca MA, Mesaros S, Preziosa P et al (2013) Wallerian and trans-synaptic degeneration contribute to optic radiation damage in multiple sclerosis: a diffusion tensor MRI study. Mult Scler 19:1610\u20131617","journal-title":"Mult Scler"},{"issue":"5","key":"5461_CR5","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1177\/1352458517704077","volume":"24","author":"Giulia Bommarito","year":"2017","unstructured":"Bommarito G, Bellini A, Pardini M et al (2017) Composite MRI measures and short-term disability in patients with clinically isolated syndrome suggestive of MS. Mult Scler. \n                    https:\/\/doi.org\/10.1177\/1352458517704077","journal-title":"Multiple Sclerosis Journal"},{"key":"5461_CR6","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.mri.2016.04.011","volume":"39","author":"MY Takemura","year":"2016","unstructured":"Takemura MY, Hori M, Yokoyama K et al (2016) Alterations of the optic pathway betweenunilateral and bilateral optic nerve damage in multiple sclerosis as revealed by the combined use of advanced diffusion kurtosis imaging and visual evoked potentials. Magn Reson Imaging 39:24\u201330","journal-title":"Magn Reson Imaging"},{"key":"5461_CR7","doi-asserted-by":"publisher","first-page":"e0122114","DOI":"10.1371\/journal.pone.0122114","volume":"10","author":"A Klistorner","year":"2015","unstructured":"Klistorner A, Vootakuru N, Wang C et al (2015) Decoding diffusivity in multiple sclerosis: analysis of optic radiation lesional and non-lesional white matter. PLoS One 10:e0122114","journal-title":"PLoS One"},{"key":"5461_CR8","doi-asserted-by":"publisher","first-page":"2165","DOI":"10.1212\/WNL.0000000000000522","volume":"82","author":"A Klistorner","year":"2014","unstructured":"Klistorner A, Sriram P, Vootakuru N et al (2014) Axonal loss of retinal neurons in multiple sclerosis associated with optic radiation lesions. Neurology 82:2165\u20132172","journal-title":"Neurology"},{"key":"5461_CR9","first-page":"1379","volume":"17","author":"M Kitajima","year":"1996","unstructured":"Kitajima M, Korogi Y, Takahashi M, Eto K (1996) MR signal intensity of the optic radiation. AJNR Am J Neuroradiol 17:1379\u20131383","journal-title":"AJNR Am J Neuroradiol"},{"key":"5461_CR10","doi-asserted-by":"publisher","first-page":"2505","DOI":"10.3892\/etm.2016.3635","volume":"12","author":"J Chen","year":"2016","unstructured":"Chen J, Zhu L, Li H, Lu Z, Chen X, Fang S (2016) Diffusion tensor imaging of occult injury of optic radiation following optic neuritis in multiple sclerosis. Exp Ther Med 12:2505\u20132510","journal-title":"Exp Ther Med"},{"key":"5461_CR11","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1167\/iovs.11-8864","volume":"53","author":"SC Kolbe","year":"2012","unstructured":"Kolbe SC, Marriott M, Av W et al (2012) Diffusion tensor imaging correlates of visual impairment in multiple sclerosis and chronic optic neuritis. Invest Ophthalmol Vis Sci 53:825\u2013832","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"5461_CR12","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1097\/RLI.0b013e318193ff25","volume":"44","author":"N Mori","year":"2009","unstructured":"Mori N, Miki Y, Kasahara S et al (2009) Susceptibility-weighted imaging at 3 Tesla delineates the optic radiation. Invest Radiol 44:140\u2013145","journal-title":"Invest Radiol"},{"key":"5461_CR13","doi-asserted-by":"publisher","first-page":"1283","DOI":"10.1016\/j.acra.2012.05.018","volume":"19","author":"S Ide","year":"2012","unstructured":"Ide S, Kakeda S, Korogi Y et al (2012) Delineation of optic radiation and stria of Gennari on high-resolution phase difference enhanced imaging. Acad Radiol 19:1283\u20131289","journal-title":"Acad Radiol"},{"key":"5461_CR14","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1007\/s00330-014-3358-8","volume":"25","author":"T Sinnecker","year":"2015","unstructured":"Sinnecker T, Oberwahrenbrock T, Metz I et al (2015) Optic radiation damage in multiple sclerosis is associated with visual dysfunction and retinal thinning-an ultrahigh-field MR pilot study. Eur Radiol 25:122\u2013131","journal-title":"Eur Radiol"},{"key":"5461_CR15","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1007\/s00330-012-2637-5","volume":"23","author":"C Zeng","year":"2013","unstructured":"Zeng C, Chen X, Li Y et al (2013) Cerebral vein changes in relapsing-remitting multiple sclerosis demonstrated by three-dimensional enhanced T2-weighted angiography at 3.0 T. Eur Radiol 23:869\u2013878","journal-title":"Eur Radiol"},{"key":"5461_CR16","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1016\/S1474-4422(15)00393-2","volume":"15","author":"M Filippi","year":"2016","unstructured":"Filippi M, Rocca MA, Ciccarelli O et al (2016) MRI criteria for the diagnosis of multiple sclerosis: MAGNIMS consensus guidelines. Lancet Neurol 15:292\u2013303","journal-title":"Lancet Neurol"},{"issue":"4","key":"5461_CR17","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1177\/1352458517703801","volume":"24","author":"Benjamin V Ineichen","year":"2017","unstructured":"Ineichen BV, Schneider MP, Hlavica M, Hagenbuch N, Linnebank M, Kessler TM (2017) High EDSS can predict risk for upper urinary tract damage in patients with multiple sclerosis. Mult Scler. \n                    https:\/\/doi.org\/10.1177\/1352458517703801","journal-title":"Multiple Sclerosis Journal"},{"key":"5461_CR18","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1177\/1352458512447870","volume":"19","author":"W Bian","year":"2013","unstructured":"Bian W, Harter K, Hammond-Rosenbluth KE et al (2013) A serial in vivo 7T magnetic resonance phase imaging study of white matter lesions in multiple sclerosis. Mult Scler 19:69\u201375","journal-title":"Mult Scler"},{"key":"5461_CR19","doi-asserted-by":"publisher","first-page":"e633","DOI":"10.1016\/j.ejrad.2012.01.003","volume":"81","author":"X Chen","year":"2012","unstructured":"Chen X, Zeng C, Luo T et al (2012) Iron deposition of the deep grey matter in patients with multiple sclerosis and neuromyelitis optica: a control quantitative study by 3D-enhanced susceptibility-weighted angiography (ESWAN). Eur J Radiol 81:e633\u2013e639","journal-title":"Eur J Radiol"},{"key":"5461_CR20","doi-asserted-by":"publisher","first-page":"1325","DOI":"10.1016\/j.ejrad.2015.04.013","volume":"84","author":"S Du","year":"2015","unstructured":"Du S, Sah SK, Zeng C et al (2015) Iron deposition in the gray matter in patients with relapse-remitting multiple sclerosis: A longitudinal study using three-dimensional (3D)-enhanced T2\n                           *-weighted angiography (ESWAN). Eur J Radiol 84:1325\u20131332","journal-title":"Eur J Radiol"},{"key":"5461_CR21","doi-asserted-by":"publisher","first-page":"e95","DOI":"10.1016\/j.ejrad.2012.09.006","volume":"82","author":"R Rumzan","year":"2013","unstructured":"Rumzan R, Wang JJ, Zeng C et al (2013) Iron deposition in the precentral grey matter in patients with multiple sclerosis: a quantitative study using susceptibility-weighted imaging. Eur J Radiol 82:e95\u2013e99","journal-title":"Eur J Radiol"},{"key":"5461_CR22","doi-asserted-by":"publisher","first-page":"439","DOI":"10.3174\/ajnr.A4599","volume":"37","author":"P Schmalbrock","year":"2016","unstructured":"Schmalbrock P, Prakash RS, Schirda B et al (2016) Basal ganglia iron in patients with multiple sclerosis measured with 7T quantitative susceptibility mapping correlates with inhibitory control. AJNR Am J Neuroradiol 37:439\u2013446","journal-title":"AJNR Am J Neuroradiol"},{"key":"5461_CR23","doi-asserted-by":"publisher","first-page":"2396","DOI":"10.1212\/WNL.0000000000001679","volume":"84","author":"M Khalil","year":"2015","unstructured":"Khalil M, Langkammer C, Pichler A et al (2015) Dynamics of brain iron levels in multiple sclerosis: A longitudinal 3T MRI study. Neurology 84:2396\u20132402","journal-title":"Neurology"},{"key":"5461_CR24","doi-asserted-by":"publisher","first-page":"2597","DOI":"10.1172\/JCI86198","volume":"126","author":"M Absinta","year":"2016","unstructured":"Absinta M, Sati P, Schindler M et al (2016) Persistent 7-tesla phase rim predicts poor outcome in new multiple sclerosis patient lesions. J Clin Invest 126:2597\u20132609","journal-title":"J Clin Invest"},{"key":"5461_CR25","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1002\/nbm.922","volume":"17","author":"JF Schenck","year":"2004","unstructured":"Schenck JF, Zimmerman EA (2004) High-field magnetic resonance imaging of brain iron: birth of a biomarker? NMR Biomed 17:433\u2013445","journal-title":"NMR Biomed"},{"key":"5461_CR26","doi-asserted-by":"publisher","first-page":"1691","DOI":"10.1212\/WNL.0b013e318236ef0e","volume":"77","author":"M Khalil","year":"2011","unstructured":"Khalil M, Langkammer C, Ropele S et al (2011) Determinants of brain iron in multiple sclerosis: a quantitative 3T MRI study. Neurology 77:1691\u20131697","journal-title":"Neurology"},{"key":"5461_CR27","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1002\/ana.21582","volume":"64","author":"KE Hammond","year":"2008","unstructured":"Hammond KE, Metcalf M, Carvajal L et al (2008) Quantitative in vivo magnetic resonance imaging of multiple sclerosis at 7 Tesla with sensitivity to iron. Ann Neurol 64:707\u2013713","journal-title":"Ann Neurol"},{"key":"5461_CR28","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1148\/radiol.14132475","volume":"272","author":"DA Rudko","year":"2014","unstructured":"Rudko DA, Solovey I, Gati JS, Kremenchutzky M, Menon RS (2014) Multiple sclerosis: improved identification of disease-relevant changes in gray and white matter by using susceptibility-based MR imaging. Radiology 272:851\u2013864","journal-title":"Radiology"},{"key":"5461_CR29","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1001\/archneurol.2011.2450","volume":"69","author":"T Sinnecker","year":"2012","unstructured":"Sinnecker T, Mittelstaedt P, D\u00f6rr J et al (2012) Multiple sclerosis lesions and irreversible brain tissue damage: a comparative ultrahigh-field strength magnetic resonance imaging study. Arch Neurol 69:739\u2013745","journal-title":"Arch Neurol"},{"key":"5461_CR30","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1001\/archneurol.2009.107","volume":"66","author":"DS Reich","year":"2009","unstructured":"Reich DS, Smith SA, Gordon-Lipkin EM et al (2009) Damage to the optic radiation in multiple sclerosis is associated with retinal injury and visual disability. Arch Neurol 66:998\u20131006","journal-title":"Arch Neurol"}],"container-title":["European Radiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00330-018-5461-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00330-018-5461-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00330-018-5461-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,30]],"date-time":"2019-04-30T12:58:19Z","timestamp":1556629099000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00330-018-5461-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,30]]},"references-count":30,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["5461"],"URL":"https:\/\/doi.org\/10.1007\/s00330-018-5461-8","relation":{},"ISSN":["0938-7994","1432-1084"],"issn-type":[{"value":"0938-7994","type":"print"},{"value":"1432-1084","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,30]]},"assertion":[{"value":"1 November 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 March 2018","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 April 2018","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 April 2018","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The scientific guarantor of this publication is Chun Zeng.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Guarantor"}},{"value":"The authors of this manuscript declare no relationships with any companies whose products or services may be related to the subject matter of the article.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"No complex statistical methods were necessary for this paper.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Statistics and biometry"}},{"value":"Written informed consent was obtained from all subjects (patients) in this study.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"Institutional Review Board approval was obtained.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"\u2022 retrospective\u2022 case-control study\u2022 performed at one institution","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Methodology"}}]}}