{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T13:43:18Z","timestamp":1790430198263,"version":"4.1.0"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2018,7,4]],"date-time":"2018-07-04T00:00:00Z","timestamp":1530662400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Radiol"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1007\/s00330-018-5594-9","type":"journal-article","created":{"date-parts":[[2018,7,4]],"date-time":"2018-07-04T10:36:41Z","timestamp":1530700601000},"page":"716-724","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Abnormalities of white and grey matter in early multiple system atrophy: comparison of parkinsonian and cerebellar variants"],"prefix":"10.1007","volume":"29","author":[{"given":"Santosh Kumar","family":"Dash","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Stezin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tejashree","family":"Takalkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lija","family":"George","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nitish L","family":"Kamble","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Netravathi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi","family":"Yadav","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keshav J.","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhura","family":"Ingalhalikar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jitender","family":"Saini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4085-2377","authenticated-orcid":false,"given":"Pramod Kumar","family":"Pal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,7,4]]},"reference":[{"key":"5594_CR1","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1056\/NEJMra1311488","volume":"372","author":"A Fanciulli","year":"2015","unstructured":"Fanciulli A, Wenning GK (2015) Multiple-System Atrophy. N Engl J Med 372:249\u2013263. \n                    https:\/\/doi.org\/10.1056\/NEJMra1311488","journal-title":"N Engl J Med"},{"key":"5594_CR2","doi-asserted-by":"publisher","first-page":"1172","DOI":"10.1016\/S1474-4422(09)70288-1","volume":"8","author":"N Stefanova","year":"2009","unstructured":"Stefanova N, B\u00fccke P, Duerr S, Wenning GK (2009) Multiple system atrophy: an update. Lancet Neurol. 8:1172\u20131178","journal-title":"Lancet Neurol."},{"key":"5594_CR3","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1136\/jnnp.68.4.434","volume":"68","author":"GK Wenning","year":"2000","unstructured":"Wenning GK, Ben-Shlomo Y, Hughes A et al (2000) What clinical features are most useful to distinguish definite multiple system atrophy from Parkinson\u2019s disease? J Neurol Neurosurg Psychiatry 68:434\u2013440. \n                    https:\/\/doi.org\/10.1136\/jnnp.68.4.434","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"5594_CR4","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1212\/01.wnl.0000324625.00404.15","volume":"71","author":"S Gilman","year":"2008","unstructured":"Gilman S, Wenning GK, Low PA et al (2008) Second consensus statement on the diagnosis of multiple system atrophy. Neurology 71:670\u2013676. \n                    https:\/\/doi.org\/10.1212\/01.wnl.0000324625.00404.15","journal-title":"Neurology"},{"key":"5594_CR5","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1016\/j.tins.2011.08.003","volume":"34","author":"K Ubhi","year":"2011","unstructured":"Ubhi K, Low P, Masliah E (2011) Multiple system atrophy: A clinical and neuropathological perspective. Trends Neurosci 34:581\u2013590. \n                    https:\/\/doi.org\/10.1016\/j.tins.2011.08.003","journal-title":"Trends Neurosci"},{"key":"5594_CR6","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1002\/mds.22413","volume":"24","author":"DJ Brooks","year":"2009","unstructured":"Brooks DJ, Seppi K (2009) Proposed neuroimaging criteria for the diagnosis of multiple system atrophy. Mov Disord 24:949\u2013964. \n                    https:\/\/doi.org\/10.1002\/mds.22413","journal-title":"Mov Disord"},{"key":"5594_CR7","doi-asserted-by":"publisher","unstructured":"Kim H-J, Jeon BS, Kim YE et al (2013) Clinical and imaging characteristics of dementia in multiple system atrophy. Parkinsonism Relat Disord 19:617\u201321. doi: \n                    https:\/\/doi.org\/10.1016\/j.parkreldis.2013.02.012","DOI":"10.1016\/j.parkreldis.2013.02.012"},{"key":"5594_CR8","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1002\/mds.20656","volume":"21","author":"C Brenneis","year":"2006","unstructured":"Brenneis C, Boesch SM, Egger KE et al (2006) Cortical atrophy in the cerebellar variant of multiple system atrophy: A voxel-based morphometry study. Mov Disord 21:159\u2013165. \n                    https:\/\/doi.org\/10.1002\/mds.20656","journal-title":"Mov Disord"},{"key":"5594_CR9","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.1111\/j.1468-1331.2009.02661.x","volume":"16","author":"CC Chang","year":"2009","unstructured":"Chang CC, Chang YY, Chang WN et al (2009) Cognitive deficits in multiple system atrophy correlate with frontal atrophy and disease duration. Eur J Neurol 16:1144\u20131150. \n                    https:\/\/doi.org\/10.1111\/j.1468-1331.2009.02661.x","journal-title":"Eur J Neurol"},{"key":"5594_CR10","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1111\/j.1552-6569.2008.00343.x","volume":"20","author":"LC Tzarouchi","year":"2010","unstructured":"Tzarouchi LC, Astrakas LG, Konitsiotis S et al (2010) Voxel-based morphometry and voxel-based relaxometry in parkinsonian variant of multiple system atrophy. J Neuroimaging 20:260\u2013266. \n                    https:\/\/doi.org\/10.1111\/j.1552-6569.2008.00343.x","journal-title":"J Neuroimaging"},{"key":"5594_CR11","doi-asserted-by":"publisher","first-page":"1674","DOI":"10.1002\/mds.21032","volume":"21","author":"T-K Hauser","year":"2006","unstructured":"Hauser T-K, Luft A, Skalej M et al (2006) Visualization and quantification of disease progression in multiple system atrophy. Mov Disord 21:1674\u20131681. \n                    https:\/\/doi.org\/10.1002\/mds.21032","journal-title":"Mov Disord"},{"key":"5594_CR12","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1111\/ene.12796","volume":"23","author":"MJ Lee","year":"2016","unstructured":"Lee MJ, Shin J-H, Seoung J-K et al (2016) Cognitive impairments associated with morphological changes in cortical and subcortical structures in multiple system atrophy of the cerebellar type. Eur J Neurol 23:92\u2013100. \n                    https:\/\/doi.org\/10.1111\/ene.12796","journal-title":"Eur J Neurol"},{"key":"5594_CR13","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1111\/j.1552-6569.2008.00262.x","volume":"19","author":"K Oishi","year":"2009","unstructured":"Oishi K, Konishi J, Mori S et al (2009) Reduced fractional anisotropy in early-stage cerebellar variant of multiple system atrophy. J Neuroimaging 19:127\u2013131. \n                    https:\/\/doi.org\/10.1111\/j.1552-6569.2008.00262.x","journal-title":"J Neuroimaging"},{"key":"5594_CR14","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.parkreldis.2017.03.001","volume":"39","author":"S Zanigni","year":"2017","unstructured":"Zanigni S, Evangelisti S, Testa C et al (2017) White matter and cortical changes in atypical parkinsonisms: A multimodal quantitative MR study. Parkinsonism Relat Disord 39:44\u201351. \n                    https:\/\/doi.org\/10.1016\/j.parkreldis.2017.03.001","journal-title":"Parkinsonism Relat Disord"},{"key":"5594_CR15","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1002\/jmri.22229","volume":"32","author":"J Wang","year":"2010","unstructured":"Wang J, Wai Y, Lin W-Y et al (2010) Microstructural changes in patients with progressive supranuclear palsy: a diffusion tensor imaging study. J Magn Reson Imaging 32:69\u201375. \n                    https:\/\/doi.org\/10.1002\/jmri.22229","journal-title":"J Magn Reson Imaging"},{"key":"5594_CR16","doi-asserted-by":"publisher","first-page":"2199","DOI":"10.1212\/01.wnl.0000249307.59950.f8","volume":"67","author":"CRV Blain","year":"2006","unstructured":"Blain CRV, Barker GJ, Jarosz JM et al (2006) Measuring brain stem and cerebellar damage in parkinsonian syndromes using diffusion tensor MRI. Neurology 67:2199\u20132205. \n                    https:\/\/doi.org\/10.1212\/01.wnl.0000249307.59950.f8","journal-title":"Neurology"},{"key":"5594_CR17","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1007\/s00234-010-0757-7","volume":"53","author":"PS Wang","year":"2011","unstructured":"Wang PS, Wu HM, Lin CP, Soong BW (2011) Use of diffusion tensor imaging to identify similarities and differences between cerebellar and Parkinsonism forms of multiple system atrophy. Neuroradiology 53:471\u2013481. \n                    https:\/\/doi.org\/10.1007\/s00234-010-0757-7","journal-title":"Neuroradiology"},{"key":"5594_CR18","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1007\/s13760-016-0724-0","volume":"117","author":"P-S Wang","year":"2016","unstructured":"Wang P-S, Yeh C-L, Lu C-F et al (2016) The involvement of supratentorial white matter in multiple system atrophy: a diffusion tensor imaging tractography study. Acta Neurol Belg 117:213\u2013220. \n                    https:\/\/doi.org\/10.1007\/s13760-016-0724-0","journal-title":"Acta Neurol Belg"},{"key":"5594_CR19","doi-asserted-by":"publisher","first-page":"1050","DOI":"10.1016\/j.parkreldis.2014.06.017","volume":"20","author":"L Ji","year":"2014","unstructured":"Ji L, Zhu D, Xiao C, Shi J (2014) Tract based spatial statistics in multiple system atrophy: A comparison between clinical subtypes. Parkinsonism Relat Disord 20:1050\u20131055. \n                    https:\/\/doi.org\/10.1016\/j.parkreldis.2014.06.017","journal-title":"Parkinsonism Relat Disord"},{"key":"5594_CR20","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1007\/s00234-008-0447-x","volume":"50","author":"S Ito","year":"2008","unstructured":"Ito S, Makino T, Shirai W, Hattori T (2008) Diffusion tensor analysis of corpus callosum in progressive supranuclear palsy. Neuroradiology 50:981\u2013985. \n                    https:\/\/doi.org\/10.1007\/s00234-008-0447-x","journal-title":"Neuroradiology"},{"key":"5594_CR21","doi-asserted-by":"publisher","first-page":"2181","DOI":"10.2147\/NDT.S109094","volume":"12","author":"AM Rulseh","year":"2016","unstructured":"Rulseh AM, Keller J, Rusz J et al (2016) Diffusion tensor imaging in the characterization of multiple system atrophy. Neuropsychiatr Dis Treat 12:2181\u20132187. \n                    https:\/\/doi.org\/10.2147\/NDT.S109094","journal-title":"Neuropsychiatr Dis Treat"},{"key":"5594_CR22","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1016\/S1474-4422(12)70327-7","volume":"12","author":"GK Wenning","year":"2013","unstructured":"Wenning GK, Geser F, Krismer F et al (2013) The natural history of multiple system atrophy: A prospective European cohort study. Lancet Neurol. 12:264\u2013274. \n                    https:\/\/doi.org\/10.1016\/S1474-4422(12)70327-7","journal-title":"Lancet Neurol."},{"key":"5594_CR23","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1016\/s1474-4422(15)00058-7","volume":"14","author":"PA Low","year":"2015","unstructured":"Low PA, Reich SG, Jankovic J et al (2015) Natural history of multiple system atrophy in the USA: a prospective cohort study. Lancet Neurol. 14:710\u2013719. \n                    https:\/\/doi.org\/10.1016\/s1474-4422(15)00058-7","journal-title":"Lancet Neurol."},{"key":"5594_CR24","doi-asserted-by":"publisher","first-page":"1484","DOI":"10.1016\/j.neuroimage.2012.03.074","volume":"61","author":"V Popescu","year":"2012","unstructured":"Popescu V, Battaglini M, Hoogstrate WS et al (2012) Optimizing parameter choice for FSL-Brain Extraction Tool (BET) on 3D T1 images in multiple sclerosis. Neuroimage 61:1484\u20131494. \n                    https:\/\/doi.org\/10.1016\/j.neuroimage.2012.03.074","journal-title":"Neuroimage"},{"key":"5594_CR25","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.media.2009.11.001","volume":"14","author":"A Trist\u00e1n-Vega","year":"2010","unstructured":"Trist\u00e1n-Vega A, Aja-Fern\u00e1ndez S (2010) DWI filtering using joint information for DTI and HARDI. Med Image Anal. 14:205\u2013218. \n                    https:\/\/doi.org\/10.1016\/j.media.2009.11.001","journal-title":"Med Image Anal."},{"key":"5594_CR26","doi-asserted-by":"crossref","unstructured":"Mestre TA, Gupta A, Lang A E (2016) MRI signs of multiple system atrophy preceding the clinical diagnosis: the case for an imaging-supported probable MSA diagnostic category. J Neurol Neurosurg Psychiatry. 87 443\u20134.","DOI":"10.1136\/jnnp-2014-309645"},{"key":"5594_CR27","doi-asserted-by":"publisher","unstructured":"Laurens B, Vergnet S, Lopez MC et al (2017) Multiple System Atrophy - State of the Art. Curr Neurol Neurosci Rep 17. \n                    https:\/\/doi.org\/10.1007\/s11910-017-0751-0","DOI":"10.1007\/s11910-017-0751-0"},{"key":"5594_CR28","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1007\/s00702-013-1133-7","volume":"121","author":"D Roncevic","year":"2014","unstructured":"Roncevic D, Palma JA, Martinez J et al (2014) Cerebellar and parkinsonian phenotypes in multiple system atrophy: similarities, differences and survival. J Neural Transm (Vienna). 121:507\u2013512","journal-title":"J Neural Transm (Vienna)."},{"key":"5594_CR29","doi-asserted-by":"publisher","first-page":"e112638","DOI":"10.1371\/journal.pone.0112638","volume":"9","author":"A Worker","year":"2014","unstructured":"Worker A, Blain C, Jarosz J et al (2014) Diffusion Tensor Imaging of Parkinson\u2019s Disease, Multiple System Atrophy and Progressive Supranuclear Palsy: A Tract-Based Spatial Statistics Study. PLoS One. 9:e112638. \n                    https:\/\/doi.org\/10.1371\/journal.pone.0112638","journal-title":"PLoS One."},{"key":"5594_CR30","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1148\/radiol.10090988","volume":"255","author":"KK Tha","year":"2010","unstructured":"Tha KK, Terae S, Yabe I et al (2010) Microstructural white matter abnormalities of multiple system atrophy: in vivo topographic illustration by using diffusion-tensor MR imaging. Radiology. 255:563\u2013569. \n                    https:\/\/doi.org\/10.1148\/radiol.10090988","journal-title":"Radiology."},{"key":"5594_CR31","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1002\/mds.22463","volume":"24","author":"M Tir","year":"2009","unstructured":"Tir M, Delmaire C, Le Thuc V et al (2009) Motor-related circuit dysfunction in MSA-P: Usefulness of combined whole-brain imaging analysis. Mov Disord 24:863\u2013870","journal-title":"Mov Disord."},{"key":"5594_CR32","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1159\/000430953","volume":"15","author":"JS Kim","year":"2015","unstructured":"Kim JS, Yang JJ, Lee DK et al (2015) Cognitive impairment and its structural correlates in the parkinsonian subtype of multiple system atrophy. Neurodegener Dis 15:294\u2013300. \n                    https:\/\/doi.org\/10.1159\/000430953","journal-title":"Neurodegener Dis"},{"key":"5594_CR33","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1016\/j.nicl.2013.03.017","volume":"2","author":"Y Shigemoto","year":"2013","unstructured":"Shigemoto Y, Matsuda H, Kamiya K et al (2013) In vivo evaluation of gray and white matter volume loss in the parkinsonian variant of multiple system atrophy using SPM8 plus DARTEL for VBM. NeuroImage Clin 2:491\u2013496. \n                    https:\/\/doi.org\/10.1016\/j.nicl.2013.03.017","journal-title":"NeuroImage Clin"},{"key":"5594_CR34","doi-asserted-by":"publisher","first-page":"1086","DOI":"10.1016\/j.neuroimage.2007.04.028","volume":"36","author":"M Minnerop","year":"2007","unstructured":"Minnerop M, Specht K, Ruhlmann J et al (2007) Voxel-based morphometry and voxel-based relaxometry in multiple system atrophy-A comparison between clinical subtypes and correlations with clinical parameters. Neuroimage. 36:1086\u20131095. \n                    https:\/\/doi.org\/10.1016\/j.neuroimage.2007.04.028","journal-title":"Neuroimage."},{"key":"5594_CR35","doi-asserted-by":"publisher","first-page":"2613","DOI":"10.1002\/mds.23318","volume":"25","author":"M Minnerop","year":"2010","unstructured":"Minnerop M, L\u00fcders E, Specht K et al (2010) Callosal tissue loss in multiple system atrophy-A one-year follow-up study. Mov Disord 25:2613\u20132620. \n                    https:\/\/doi.org\/10.1002\/mds.23318","journal-title":"Mov Disord"},{"key":"5594_CR36","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.neuroimage.2004.11.022","volume":"25","author":"K Specht","year":"2005","unstructured":"Specht K, Minnerop M, M\u00fcller-H\u00fcbenthal J et al (2005) Complementary results by combining voxel-based morphometry and voxel-based relaxometry. Neuroimage. 25:287\u2013293. \n                    https:\/\/doi.org\/10.1016\/j.neuroimage.2004.11.022","journal-title":"Neuroimage."},{"key":"5594_CR37","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1007\/s00415-006-0325-6","volume":"254","author":"C Brenneis","year":"2007","unstructured":"Brenneis C, Egger K, Scherfler C et al (2007) Progression of brain atrophy in multiple system atrophy: A longitudinal VBM study. J Neurol 254:191\u2013196. \n                    https:\/\/doi.org\/10.1007\/s00415-006-0325-6","journal-title":"J Neurol"},{"key":"5594_CR38","doi-asserted-by":"crossref","unstructured":"Yang H, Wang X, Liao W et al (2015) Application of diffusion tensor imaging in multiple system atrophy: the involvement of pontine transverse and longitudinal fibers. Int J Neurosci 125: 18\u201324.","DOI":"10.3109\/00207454.2014.896914"}],"container-title":["European Radiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00330-018-5594-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00330-018-5594-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00330-018-5594-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,3]],"date-time":"2019-07-03T19:10:42Z","timestamp":1562181042000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00330-018-5594-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,4]]},"references-count":38,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["5594"],"URL":"https:\/\/doi.org\/10.1007\/s00330-018-5594-9","relation":{},"ISSN":["0938-7994","1432-1084"],"issn-type":[{"value":"0938-7994","type":"print"},{"value":"1432-1084","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,4]]},"assertion":[{"value":"24 February 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 May 2018","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 June 2018","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 July 2018","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The scientific guarantor of this publication is Dr. Pramod Kumar Pal.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Guarantor"}},{"value":"The authors of this manuscript declare no relationships with any companies whose products or services may be related to the subject matter of the article.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The authors report no financial interests or conflicts of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Financial disclosure"}},{"value":"No complex statistical methods were necessary for this paper.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Statistics and biometry"}},{"value":"Written informed consent was obtained from all subjects in this study.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"Institutional review board approval was obtained.","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"\u2022 prospective\u2022 case-control study\u2022 performed at one institution","order":8,"name":"Ethics","group":{"name":"EthicsHeading","label":"Methodology"}}]}}