{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:19:06Z","timestamp":1791296346063,"version":"4.1.0"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2018,8,7]],"date-time":"2018-08-07T00:00:00Z","timestamp":1533600000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Radiol"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1007\/s00330-018-5634-5","type":"journal-article","created":{"date-parts":[[2018,8,7]],"date-time":"2018-08-07T12:19:14Z","timestamp":1533644354000},"page":"1546-1554","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Cardiac magnetic resonance in patients with mitral valve prolapse: Focus on late gadolinium enhancement and T1 mapping"],"prefix":"10.1007","volume":"29","author":[{"given":"Silvia","family":"Pradella","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Grazzini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Brandani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Calistri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cosimo","family":"Nardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Mori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vittorio","family":"Miele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Colagrande","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,8,7]]},"reference":[{"key":"5634_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1056\/NEJM199907013410101","volume":"341","author":"LA Freed","year":"1999","unstructured":"Freed LA, Levy D, Levine RA et al (1999) Prevalence and Clinical Outcome of Mitral-Valve Prolapse. N Engl J Med 341:1\u20137","journal-title":"N Engl J Med"},{"issue":"7","key":"5634_CR2","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1161\/CIRCULATIONAHA.115.016291","volume":"132","author":"C Basso","year":"2015","unstructured":"Basso C, Perazzolo Marra M, Rizzo S et al (2015) Arrhythmic mitral valve prolapse and sudden cardiac death clinical perspective. Circulation 132(7):556\u2013566","journal-title":"Circulation"},{"key":"5634_CR3","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1016\/j.jcmg.2008.01.013","volume":"1","author":"Y Han","year":"2008","unstructured":"Han Y, Peters DC, Salton CJ et al (2008) Cardiovascular Magnetic Resonance Characterization of Mitral Valve Prolapse. JACC Cardiovasc Imaging 1:294\u2013303","journal-title":"JACC Cardiovasc Imaging"},{"key":"5634_CR4","doi-asserted-by":"publisher","first-page":"2289","DOI":"10.1016\/j.jacc.2016.02.065","volume":"67","author":"RA Nishimura","year":"2016","unstructured":"Nishimura RA, Carabello B (2016) Operationalizing the 2014 ACC\/AHA guidelines for valvular heart disease. J Am Coll Cardiol 67:2289\u20132294","journal-title":"J Am Coll Cardiol"},{"key":"5634_CR5","doi-asserted-by":"publisher","first-page":"613","DOI":"10.2147\/CEOR.S112691","volume":"8","author":"M Moore","year":"2016","unstructured":"Moore M, Chen J (2016) The direct health-care burden of valvular heart disease: evidence from US national survey data. Clinicoecon Outcomes Res 8:613\u2013627","journal-title":"Clinicoecon Outcomes Res"},{"key":"5634_CR6","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1161\/CIRCRESAHA.116.307972","volume":"119","author":"RT Hahn","year":"2016","unstructured":"Hahn RT (2016) Transcathether valve replacement and valve repair: review of procedures and intraprocedural echocardiographic imaging. Circ Res 119:341\u2013356","journal-title":"Circ Res"},{"issue":"6","key":"5634_CR7","doi-asserted-by":"publisher","first-page":"1594","DOI":"10.1148\/rg.346140030","volume":"34","author":"SA Hamlin","year":"2014","unstructured":"Hamlin SA, Henry TS, Little BP et al (2014) Mapping the future of cardiac MR imaging: case-based review of T1 and T2 mapping techniques. Radiographics 34(6):1594\u20131611","journal-title":"Radiographics"},{"key":"5634_CR8","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1016\/j.jacc.2010.11.013","volume":"57","author":"N Mewton","year":"2011","unstructured":"Mewton N, Liu CY, Croisille P et al (2011) Assessment of myocardial fibrosis with cardiovascular magnetic resonance. J Am Coll Cardiol 57:891\u2013903","journal-title":"J Am Coll Cardiol"},{"key":"5634_CR9","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1161\/CIRCULATIONAHA.108.847772","volume":"120","author":"F Weidemann","year":"2009","unstructured":"Weidemann F, Herrmann S, St\u00f6rk S et al (2009) Impact of myocardial fibrosis in patients with symptomatic severe aortic stenosis. Circulation 120:577\u2013584","journal-title":"Circulation"},{"key":"5634_CR10","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.jacc.2010.02.047","volume":"56","author":"C Jellis","year":"2010","unstructured":"Jellis C, Martin J, Narula J et al (2010) Assessment of nonischemic myocardial fibrosis. J Am Coll Cardiol 56:89\u201397","journal-title":"J Am Coll Cardiol"},{"key":"5634_CR11","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1161\/CIRCIMAGING.112.000192","volume":"6","author":"CA Miller","year":"2013","unstructured":"Miller CA, Naish JH, Bishop P et al (2013) Comprehensive validation of cardiovascular magnetic resonance techniques for the assessment of myocardial extracellular volume. Circ Cardiovasc Imaging 6:373\u2013383","journal-title":"Circ Cardiovasc Imaging"},{"key":"5634_CR12","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1016\/j.jacc.2014.12.047","volume":"65","author":"S Uretsky","year":"2015","unstructured":"Uretsky S, Gillam L, Lang R et al (2015) Discordance between echocardiography and MRI in the assessment of mitral regurgitation severity: A prospective multicenter trial. J Am Coll Cardiol 65:1078\u20131088","journal-title":"J Am Coll Cardiol"},{"key":"5634_CR13","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1016\/j.jtcvs.2014.05.014","volume":"148","author":"RA Nishimura","year":"2014","unstructured":"Nishimura RA, Otto CM, Bonow RO et al (2014) 2014 AHA\/ACC guideline for the management of patients with valvular heart disease: a report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines. J Thorac Cardiovasc Surg 148:e1\u2013e132","journal-title":"J Thorac Cardiovasc Surg"},{"key":"5634_CR14","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1111\/j.1540-8159.1993.tb01599.x","volume":"16","author":"J Vohra","year":"1993","unstructured":"Vohra J, Sathe S, Warren R et al (1993) Malignant ventricular arrhythmias in patients with mitral valve prolapse and mild mitral regurgitation. Pacing Clin Electrophysiol 16:387\u2013393","journal-title":"Pacing Clin Electrophysiol"},{"key":"5634_CR15","doi-asserted-by":"publisher","first-page":"E827","DOI":"10.21037\/jtd.2016.07.58","volume":"8","author":"Z Niu","year":"2016","unstructured":"Niu Z, Chan V, Mesana T, Ruel M (2016) The evolution of mitral valve prolapse: Insights from the Framingham Heart Study. J Thorac Dis 8:E827\u2013E828","journal-title":"J Thorac Dis"},{"issue":"3","key":"5634_CR16","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1136\/heartjnl-2016-309303","volume":"103","author":"AH Bui","year":"2017","unstructured":"Bui AH, Roujol S, Foppa M et al (2017) Diffuse myocardial fibrosis in patients with mitral valve prolapse and ventricular arrhythmia. Heart 103(3):204\u2013209","journal-title":"Heart"},{"key":"5634_CR17","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1016\/j.hrthm.2015.09.026","volume":"13","author":"K Narayanan","year":"2016","unstructured":"Narayanan K, Uy-evanado A, Teodorescu C et al (2016) Mitral valve prolapse and sudden cardiac arrest in the community. Heart Rhythm 13:498\u2013503","journal-title":"Heart Rhythm"},{"key":"5634_CR18","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1161\/01.CIR.44.1.130","volume":"44","author":"B Lown","year":"1971","unstructured":"Lown B, Wolf M (1971) Approaches to sudden death from coronary heart disease. Circulation 44:130\u2013142","journal-title":"Circulation"},{"key":"5634_CR19","first-page":"600","volume":"13","author":"MWS Kon","year":"2004","unstructured":"Kon MWS, Myerson SG, Moat NE, Pennell DJ (2004) Quantification of regurgitant fraction in mitral regurgitation by cardiovascular magnetic resonance: comparison of techniques. J Heart Valve Dis 13:600\u2013607","journal-title":"J Heart Valve Dis"},{"issue":"3","key":"5634_CR20","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1080\/10976640600604856","volume":"8","author":"EV Gelfand","year":"2006","unstructured":"Gelfand EV, Hughes S, Hauser TH et al (2006) Severity of mitral and aortic regurgitation as assessed by cardiovascular magnetic resonance: optimizing correlation with Doppler echocardiography. J Cardiovasc Magn Reson 8(3):503\u2013507","journal-title":"J Cardiovasc Magn Reson"},{"key":"5634_CR21","doi-asserted-by":"crossref","unstructured":"Cerqueira MD, Weissman NJ, Dilsizian V et al (2002) Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart. A statement for healthcare professionals from the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association. Int J Cardiovasc Imaging 18(1):539\u2013542","DOI":"10.1081\/JCMR-120003946"},{"key":"5634_CR22","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.jcmg.2015.11.008","volume":"9","author":"TA Treibel","year":"2016","unstructured":"Treibel TA, Fontana M, Maestrini V et al (2016) Automatic measurement of the myocardial interstitium: synthetic extracellular volume quantification without hematocrit sampling. JACC Cardiovasc Imaging 9:54\u201363","journal-title":"JACC Cardiovasc Imaging"},{"key":"5634_CR23","doi-asserted-by":"publisher","first-page":"1268","DOI":"10.1093\/eurheartj\/ehr481","volume":"33","author":"M Ugander","year":"2012","unstructured":"Ugander M, Oki AJ, Hsu LY et al (2012) Extracellular volume imaging by magnetic resonance imaging provides insights into overt and sub-clinical myocardial pathology. Eur Heart J 33:1268\u20131278","journal-title":"Eur Heart J"},{"issue":"9","key":"5634_CR24","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1111\/eci.12306","volume":"44","author":"CM Heyning Van De","year":"2014","unstructured":"Van De Heyning CM, Magne J, Pi\u00e9rard LA et al (2014) Late gadolinium enhancement CMR in primary mitral regurgitation. Eur J Clin Invest 44(9):840\u2013847","journal-title":"Eur J Clin Invest"},{"key":"5634_CR25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s12410-015-9363-8","volume":"9","author":"MP Marra","year":"2016","unstructured":"Marra MP, Basso C, De Lazzari M et al (2016) Morphofunctional abnormalities of mitral annulus and arrhythmic mitral valve prolapse. Circ Cardiovasc Imaging 9:1\u201310","journal-title":"Circ Cardiovasc Imaging"},{"key":"5634_CR26","doi-asserted-by":"publisher","first-page":"e458","DOI":"10.1161\/CIRCULATIONAHA.115.018775","volume":"133","author":"MN Sheppard","year":"2016","unstructured":"Sheppard MN, Steriotis AK, Sharma S (2016) Letter by Sheppard at al regarding article \"Arrhythmic mitral valve prolapse and sudden cardiac death\". Circulation 133:e458","journal-title":"Circulation"},{"key":"5634_CR27","doi-asserted-by":"publisher","first-page":"5390","DOI":"10.21037\/jtd.2017.11.14","volume":"9","author":"M Spartalis","year":"2017","unstructured":"Spartalis M, Tzatzaki E, Spartalis E et al (2017) Mitral valve prolapse: an underestimated cause of sudden cardiac death - a current review of the literature. J Thorac Dis 9:5390\u20135398","journal-title":"J Thorac Dis"},{"key":"5634_CR28","doi-asserted-by":"crossref","unstructured":"Fujita N, Chazouilleres AF, Hartiala JJ et al (1994) Quantification of mitral regurgitation by velocity-encoded cine nuclear magnetic resonance imaging. J Am Coll Cardiol 23:951\u2013958","DOI":"10.1016\/0735-1097(94)90642-4"},{"key":"5634_CR29","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1016\/S0002-9149(97)01024-2","volume":"81","author":"AM Kizilbash","year":"1998","unstructured":"Kizilbash AM, Hundley WG, Willett DL et al (1998) Comparison of quantitative Doppler with magnetic resonance imaging for assessment of the severity of mitral regurgitation. Am J Cardiol 81:792\u2013795","journal-title":"Am J Cardiol"},{"key":"5634_CR30","doi-asserted-by":"publisher","first-page":"142","DOI":"10.14797\/mdcj-9-3-142","volume":"9","author":"JC Lopez-Mattei","year":"2013","unstructured":"Lopez-Mattei JC, Shah DJ (2013) The role of cardiac magnetic resonance in valvular heart disease. Methodist Debakey Cardiovasc J 9:142\u2013148","journal-title":"Methodist Debakey Cardiovasc J"},{"issue":"6","key":"5634_CR31","doi-asserted-by":"publisher","first-page":"946","DOI":"10.1161\/CIRCIMAGING.114.002397","volume":"7","author":"NC Edwards","year":"2014","unstructured":"Edwards NC, Moody WE, Yuan M et al (2014) Quantification of left ventricular interstitial fibrosis in asymptomatic chronic primary degenerative mitral regurgitation. Circ Cardiovasc Imaging 7(6):946\u2013953","journal-title":"Circ Cardiovasc Imaging"}],"container-title":["European Radiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00330-018-5634-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00330-018-5634-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00330-018-5634-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,27]],"date-time":"2019-08-27T19:04:49Z","timestamp":1566932689000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00330-018-5634-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,7]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["5634"],"URL":"https:\/\/doi.org\/10.1007\/s00330-018-5634-5","relation":{},"ISSN":["0938-7994","1432-1084"],"issn-type":[{"value":"0938-7994","type":"print"},{"value":"1432-1084","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,7]]},"assertion":[{"value":"11 March 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 June 2018","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 June 2018","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 August 2018","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The scientific guarantor of this publication is Prof. Stefano Colagrande.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Guarantor"}},{"value":"The authors of this manuscript declare no relationships with any companies whose products or services may be related to the subject matter of the article.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"No complex statistical methods were necessary for this paper.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Statistics and biometry"}},{"value":"Written informed consent was obtained from all subjects (patients) in this study.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"Institutional Review Board approval was obtained.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"\u2022 Retrospective\u2022 Observational\u2022 Performed at one institution","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Methodology"}}]}}