{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:17:02Z","timestamp":1790792222899,"version":"4.1.0"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2018,8,20]],"date-time":"2018-08-20T00:00:00Z","timestamp":1534723200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100000664","name":"Health Technology Assessment Programme","doi-asserted-by":"publisher","award":["11\/23\/01"],"award-info":[{"award-number":["11\/23\/01"]}],"id":[{"id":"10.13039\/501100000664","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Radiol"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1007\/s00330-018-5661-2","type":"journal-article","created":{"date-parts":[[2018,8,20]],"date-time":"2018-08-20T11:52:57Z","timestamp":1534765977000},"page":"1083-1093","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":71,"title":["Magnetic resonance enterography, small bowel ultrasound and colonoscopy to diagnose and stage Crohn\u2019s disease: patient acceptability and perceived burden"],"prefix":"10.1007","volume":"29","author":[{"name":"on behalf of the METRIC investigators","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Miles","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gauraang","family":"Bhatnagar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Halligan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damian","family":"Tolan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Zealley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6765-8806","authenticated-orcid":false,"given":"Stuart A.","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,8,20]]},"reference":[{"key":"5661_CR1","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1016\/j.crohns.2013.02.020","volume":"7","author":"J Panes","year":"2013","unstructured":"Panes J, Bouhnik Y, Reinisch W et al (2013) Imaging techniques for assessment of inflammatory bowel disease: joint ECCO and ESGAR evidence-based consensus guidelines. J Crohns Colitis 7:556\u2013585","journal-title":"J Crohns Colitis"},{"key":"5661_CR2","doi-asserted-by":"publisher","first-page":"1524","DOI":"10.1136\/gut.2008.151415","volume":"57","author":"AN Desmond","year":"2008","unstructured":"Desmond AN, O'Regan K, Curran C et al (2008) Crohn's disease: factors associated with exposure to high levels of diagnostic radiation. Gut 57:1524\u20131529","journal-title":"Gut"},{"key":"5661_CR3","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1007\/s00330-013-2973-0","volume":"24","author":"J Dong","year":"2014","unstructured":"Dong J, Wang H, Zhao J et al (2014) Ultrasound as a diagnostic tool in detecting active Crohn's disease: a meta-analysis of prospective studies. Eur Radiol 24:26\u201333","journal-title":"Eur Radiol"},{"key":"5661_CR4","doi-asserted-by":"publisher","first-page":"3295","DOI":"10.1007\/s00330-015-3737-9","volume":"25","author":"CA Puylaert","year":"2015","unstructured":"Puylaert CA, Tielbeek JA, Bipat S, Stoker J (2015) Grading of Crohn's disease activity using CT, MRI, US and scintigraphy: a meta-analysis. Eur Radiol 25:3295\u20133313","journal-title":"Eur Radiol"},{"key":"5661_CR5","doi-asserted-by":"publisher","first-page":"e4235","DOI":"10.1097\/MD.0000000000004235","volume":"95","author":"C Zhu","year":"2016","unstructured":"Zhu C, Ma X, Xue L et al (2016) Small intestine contrast ultrasonography for the detection and assessment of Crohn disease: a meta-analysis. Medicine (Baltimore) 95:e4235","journal-title":"Medicine (Baltimore)"},{"key":"5661_CR6","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1111\/j.1365-2036.2011.04710.x","volume":"34","author":"J Panes","year":"2011","unstructured":"Panes J, Bouzas R, Chaparro M et al (2011) Systematic review: the use of ultrasonography, computed tomography and magnetic resonance imaging for the diagnosis, assessment of activity and abdominal complications of Crohn's disease. Aliment Pharmacol Ther 34:125\u2013145","journal-title":"Aliment Pharmacol Ther"},{"key":"5661_CR7","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1259\/bjr\/65972479","volume":"84","author":"R Hafeez","year":"2011","unstructured":"Hafeez R, Greenhalgh R, Rajan J et al (2011) Use of small bowel imaging for the diagnosis and staging of Crohn's disease\u2013a survey of current UK practice. Br J Radiol 84:508\u2013517","journal-title":"Br J Radiol"},{"key":"5661_CR8","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1186\/1471-230X-14-142","volume":"14","author":"S Taylor","year":"2014","unstructured":"Taylor S, Mallett S, Bhatnagar G et al (2014) METRIC (MREnterography or ulTRasound in Crohn's disease): a study protocol for a multicentre, non-randomised, single-arm, prospective comparison study of magnetic resonance enterography and small bowel ultrasound compared to a reference standard in those aged 16 and over. BMC Gastroenterol 14:142","journal-title":"BMC Gastroenterol"},{"key":"5661_CR9","doi-asserted-by":"publisher","unstructured":"Taylor SA, Mallett S, Bhatnagar G et al (2018) Diagnostic accuracy of magnetic resonance enterography and small bowel ultrasound for the extent and activity of newly diagnosed and relapsed Crohn\u2019s disease (METRIC): a multicentre trial. Lancet Gastroenterol Hepatol S2468-1253(18)30161\u20134. \n                    https:\/\/doi.org\/10.1016\/S2468-1253(18)30161-4","DOI":"10.1016\/S2468-1253(18)30161-4"},{"key":"5661_CR10","doi-asserted-by":"crossref","unstructured":"Plumb AA, Ghanouni A, Rainbow S et al (2017) Patient factors associated with non-attendance at colonoscopy after a positive screening faecal occult blood test. J Med Screen 24:12-19","DOI":"10.1177\/0969141316645629"},{"key":"5661_CR11","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1023\/A:1005492806777","volume":"45","author":"J Casati","year":"2000","unstructured":"Casati J, Toner BB, de Rooy EC, Drossman DA, Maunder RG (2000) Concerns of patients with inflammatory bowel disease: a review of emerging themes. Dig Dis Sci 45:26\u201331","journal-title":"Dig Dis Sci"},{"key":"5661_CR12","volume-title":"A user's guide to the General Health Questionnaire","author":"D Goldberg","year":"1988","unstructured":"Goldberg D, Williams P (1988) A user's guide to the General Health Questionnaire. NFER-Nelson, Windsor"},{"key":"5661_CR13","unstructured":"Knott C (2013) General mental and physical health. In: Craig R, Mindell J (eds). Health survey for England 2012, health social care and lifestyle. NatCen Social Research, London. \n                    http:\/\/content.digital.nhs.uk\/catalogue\/PUB13218\/HSE2012-Ch4-Gen-health.pdf\n                    \n                  . Accessed 12 Feb 2018"},{"key":"5661_CR14","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1055\/s-2007-1008988","volume":"26","author":"P Salmon","year":"1994","unstructured":"Salmon P, Shah R, Berg S, Williams C (1994) Evaluating customer satisfaction with colonoscopy. Endoscopy 26:342\u2013346","journal-title":"Endoscopy"},{"key":"5661_CR15","doi-asserted-by":"publisher","first-page":"20170731","DOI":"10.1259\/bjr.20170731","volume":"91","author":"REC Evans","year":"2018","unstructured":"Evans REC, Taylor SA, Beare S et al (2018) Perceived patient burden and acceptability of whole body MRI for staging lung and colorectal cancer; comparison with standard staging investigations. Br J Radiol 91:20170731","journal-title":"Br J Radiol"},{"key":"5661_CR16","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1148\/radiol.2331031208","volume":"233","author":"RE Gelder van","year":"2004","unstructured":"van Gelder RE, Birnie E, Florie J et al (2004) CT colonography and colonoscopy: assessment of patient preference in a 5-week follow-up study. Radiology 233:328\u2013337","journal-title":"Radiology"},{"key":"5661_CR17","doi-asserted-by":"publisher","first-page":"e016391","DOI":"10.1136\/bmjopen-2017-016391","volume":"7","author":"R Evans","year":"2017","unstructured":"Evans R, Taylor S, Janes S et al (2017) Patient experience and perceived acceptability of whole-body magnetic resonance imaging for staging colorectal and lung cancer compared with current staging scans: a qualitative study. BMJ Open 7:e016391","journal-title":"BMJ Open"},{"key":"5661_CR18","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1016\/j.cgh.2016.05.012","volume":"15","author":"DJ Gracie","year":"2017","unstructured":"Gracie DJ, Williams CJ, Sood R et al (2017) Negative effects on psychological health and quality of life of genuine irritable bowel syndrome-type symptoms in patients with inflammatory bowel disease. Clin Gastroenterol Hepatol 15:376\u2013384","journal-title":"Clin Gastroenterol Hepatol"},{"key":"5661_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/pon.1929","volume":"21","author":"P Brocken","year":"2012","unstructured":"Brocken P, Prins JB, Dekhuijzen PN, van der Heijden HF (2012) The faster the better?\u2014A systematic review on distress in the diagnostic phase of suspected cancer, and the influence of rapid diagnostic pathways. Psychooncology 21:1\u201310","journal-title":"Psychooncology"},{"key":"5661_CR20","doi-asserted-by":"publisher","first-page":"20150121","DOI":"10.1259\/bjr.20150121","volume":"88","author":"RI Shortman","year":"2015","unstructured":"Shortman RI, Neriman D, Hoath J et al (2015) A comparison of the psychological burden of PET\/MRI and PET\/CT scans and association to initial state anxiety and previous imaging experiences. Br J Radiol 88:20150121","journal-title":"Br J Radiol"},{"key":"5661_CR21","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1111\/1754-9485.12296","volume":"59","author":"MM Hobbs","year":"2015","unstructured":"Hobbs MM, Taylor DB, Buzynski S, Peake RE (2015) Contrast-enhanced spectral mammography (CESM) and contrast enhanced MRI (CEMRI): patient preferences and tolerance. J Med Imaging Radiat Oncol 59:300\u2013305","journal-title":"J Med Imaging Radiat Oncol"},{"key":"5661_CR22","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1111\/j.1369-7625.2008.00520.x","volume":"12","author":"C Wagner von","year":"2009","unstructured":"von Wagner C, Halligan S, Atkin WS, Lilford RJ, Morton D, Wardle J (2009) Choosing between CT colonography and colonoscopy in the diagnostic context: a qualitative study of influences on patient preferences. Health Expect 12:18\u201326","journal-title":"Health Expect"},{"key":"5661_CR23","doi-asserted-by":"publisher","first-page":"4372","DOI":"10.1007\/s00330-017-4810-3","volume":"27","author":"G Conte","year":"2017","unstructured":"Conte G, Preda L, Cocorocchio E et al (2017) Signal intensity change on unenhanced T1-weighted images in dentate nucleus and globus pallidus after multiple administrations of gadoxetate disodium: an intraindividual comparative study. Eur Radiol 27:4372\u20134378","journal-title":"Eur Radiol"},{"key":"5661_CR24","doi-asserted-by":"publisher","first-page":"3353","DOI":"10.1007\/s00330-016-4724-5","volume":"27","author":"S Bae","year":"2017","unstructured":"Bae S, Lee HJ, Han K et al (2017) Gadolinium deposition in the brain: association with various GBCAs using a generalized additive model. Eur Radiol 27:3353\u20133361","journal-title":"Eur Radiol"},{"key":"5661_CR25","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1007\/s00330-015-3879-9","volume":"26","author":"DA Stojanov","year":"2016","unstructured":"Stojanov DA, Aracki-Trenkic A, Vojinovic S, Benedeto-Stojanov D, Ljubisavljevic S (2016) Increasing signal intensity within the dentate nucleus and globus pallidus on unenhanced T1W magnetic resonance images in patients with relapsing-remitting multiple sclerosis: correlation with cumulative dose of a macrocyclic gadolinium-based contrast agent. gadobutrol. Eur Radiol 26:807\u2013815","journal-title":"gadobutrol. Eur Radiol"},{"key":"5661_CR26","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/1471-2288-12-13","volume":"12","author":"OA Bjertnaes","year":"2012","unstructured":"Bjertnaes OA (2012) The association between survey timing and patient-reported experiences with hospitals: results of a national postal survey. BMC Med Res Methodol 12:13","journal-title":"BMC Med Res Methodol"},{"key":"5661_CR27","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1007\/s00330-009-1517-0","volume":"20","author":"S Jensch","year":"2010","unstructured":"Jensch S, Bipat S, Peringa J et al (2010) CT colonography with limited bowel preparation: prospective assessment of patient experience and preference in comparison to optical colonoscopy with cathartic bowel preparation. Eur Radiol 20:146\u2013156","journal-title":"Eur Radiol"},{"key":"5661_CR28","doi-asserted-by":"publisher","first-page":"1872","DOI":"10.1158\/1055-9965.EPI-08-0074","volume":"17","author":"A Miles","year":"2008","unstructured":"Miles A, Voorwinden S, Chapman S, Wardle J (2008) Psychologic predictors of cancer information avoidance among older adults: the role of cancer fear and fatalism. Cancer Epidemiol Biomarkers Prev 17:1872\u20131879","journal-title":"Cancer Epidemiol Biomarkers Prev"}],"container-title":["European Radiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00330-018-5661-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00330-018-5661-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00330-018-5661-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T21:41:33Z","timestamp":1569966093000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00330-018-5661-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,20]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["5661"],"URL":"https:\/\/doi.org\/10.1007\/s00330-018-5661-2","relation":{},"ISSN":["0938-7994","1432-1084"],"issn-type":[{"value":"0938-7994","type":"print"},{"value":"1432-1084","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,20]]},"assertion":[{"value":"11 May 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 July 2018","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 July 2018","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 August 2018","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The scientific guarantor of this publication is Professor Stuart Taylor.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Guarantor"}},{"value":"Stuart Taylor is a research consultant to Robarts.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"One of the authors has significant statistical expertise.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Statistics and biometry"}},{"value":"Written informed consent was obtained from all subjects (patients) in this study.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"Institutional review board approval was obtained.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Some study subjects or cohorts have been previously reported in the main METRIC trial results paper.","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Study subjects or cohorts overlap"}},{"value":"\u2022 prospective\u2022 cross-sectional study\u2022 multicentre study","order":8,"name":"Ethics","group":{"name":"EthicsHeading","label":"Methodology"}},{"value":"This report presents independent research commissioned by the National Institute for Health Research (NIHR). The views and opinions expressed by authors in this publication are those of the authors and do not necessarily reflect those of the NHS, the NIHR, NETSCC or the HTA programme or the Department of Health.","order":9,"name":"Ethics","group":{"name":"EthicsHeading","label":"Department of Health disclaimer"}}]}}