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Konstantin Nikolaou received institutional research funds and speaker\u2019s honorarium from Siemens Healthineers and is a scientific advisor of Siemens Healthcare, Germany. Jan Fritz received institutional research support from Siemens Healthcare, USA, DePuy, Zimmer, Microsoft, and BTG International; is a scientific advisor of Siemens Healthcare USA, Alexion Pharmaceuticals, and BTG International; received speaker\u2019s honorarium from Siemens Healthcare, USA; and has shared patents with Siemens Healthcare and Johns Hopkins University. 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