{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T04:31:11Z","timestamp":1775277071938,"version":"3.50.1"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,7,29]],"date-time":"2019-07-29T00:00:00Z","timestamp":1564358400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2019,7,29]],"date-time":"2019-07-29T00:00:00Z","timestamp":1564358400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"VTR","award":["5063542"],"award-info":[{"award-number":["5063542"]}]},{"name":"VTR","award":["5063542"],"award-info":[{"award-number":["5063542"]}]},{"name":"VTR","award":["5654132"],"award-info":[{"award-number":["5654132"]}]},{"DOI":"10.13039\/501100006383","name":"Sy\u00f6p\u00e4j\u00e4rjest\u00f6t","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006383","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008723","name":"Finnish Medical Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100008723","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Paavo Koistinen Foundation","award":["NA"],"award-info":[{"award-number":["NA"]}]},{"name":"Japanese Scandinavian Radiological Society Scholarship","award":["NA"],"award-info":[{"award-number":["NA"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Radiol"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1007\/s00330-019-06361-y","type":"journal-article","created":{"date-parts":[[2019,7,29]],"date-time":"2019-07-29T16:02:46Z","timestamp":1564416166000},"page":"38-46","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Peritumoral ADC values in breast cancer: region of interest selection, associations with hyaluronan intensity, and prognostic significance"],"prefix":"10.1007","volume":"30","author":[{"given":"Tiia","family":"Kettunen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidemi","family":"Okuma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u00e4ivi","family":"Auvinen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mazen","family":"Sudah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satu","family":"Tiainen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Sutela","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amro","family":"Masarwah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markku","family":"Tammi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raija","family":"Tammi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanna","family":"Oikari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ritva","family":"Vanninen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,7,29]]},"reference":[{"key":"6361_CR1","doi-asserted-by":"publisher","first-page":"87","DOI":"10.3322\/caac.21262","volume":"65","author":"LA Torre","year":"2015","unstructured":"Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A (2015) Global cancer statistics, 2012. CA Cancer J Clin 65:87\u2013108","journal-title":"CA Cancer J Clin"},{"key":"6361_CR2","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1038\/bjc.2017.497","volume":"118","author":"J Remsik","year":"2018","unstructured":"Remsik J, Fedr R, Navratil J et al (2018) Plasticity and intratumoural heterogeneity of cell surface antigen expression in breast cancer. Br J Cancer 118:813\u2013819","journal-title":"Br J Cancer"},{"key":"6361_CR3","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1038\/nrclinonc.2015.73","volume":"12","author":"D Zardavas","year":"2015","unstructured":"Zardavas D, Irrthum A, Swanton C, Piccart M (2015) Clinical management of breast cancer heterogeneity. Nat Rev Clin Oncol 12:381\u2013394","journal-title":"Nat Rev Clin Oncol"},{"key":"6361_CR4","doi-asserted-by":"publisher","first-page":"2095","DOI":"10.1101\/gad.1204904","volume":"18","author":"DA Nelson","year":"2004","unstructured":"Nelson DA, Tan TT, Rabson AB, Anderson D, Degenhardt K, White E (2004) Hypoxia and defective apoptosis drive genomic instability and tumorigenesis. Genes Dev 18:2095\u20132107","journal-title":"Genes Dev"},{"key":"6361_CR5","doi-asserted-by":"publisher","first-page":"a003244","DOI":"10.1101\/cshperspect.a003244","volume":"2","author":"K Polyak","year":"2010","unstructured":"Polyak K, Kalluri R (2010) The role of the microenvironment in mammary gland development and cancer. Cold Spring Harb Perspect Biol 2:a003244","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"6361_CR6","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1159\/000430499","volume":"82","author":"SD Soysal","year":"2015","unstructured":"Soysal SD, Tzankov A, Muenst SE (2015) Role of the tumor microenvironment in breast cancer. Pathobiology 82:142\u2013152","journal-title":"Pathobiology"},{"key":"6361_CR7","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.matbio.2018.04.012","volume":"78-79","author":"MI Tammi","year":"2019","unstructured":"Tammi MI, Oikari S, Pasonen-Seppanen S, Rilla K, Auvinen P, Tammi RH (2019) Activated hyaluronan metabolism in the tumor matrix - causes and consequences. Matrix Biol 78-79:147\u2013164","journal-title":"Matrix Biol"},{"key":"6361_CR8","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/j.yexcr.2010.11.017","volume":"317","author":"RK Sironen","year":"2011","unstructured":"Sironen RK, Tammi M, Tammi R, Auvinen PK, Anttila M, Kosma VM (2011) Hyaluronan in human malignancies. Exp Cell Res 317:383\u2013391","journal-title":"Exp Cell Res"},{"key":"6361_CR9","doi-asserted-by":"publisher","first-page":"L10","DOI":"10.1016\/j.bpj.2012.05.028","volume":"103","author":"J Hunger","year":"2012","unstructured":"Hunger J, Bernecker A, Bakker HJ, Bonn M, Richter RP (2012) Hydration dynamics of hyaluronan and dextran. Biophys J 103:L10\u2013L12","journal-title":"Biophys J"},{"key":"6361_CR10","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1016\/j.semcancer.2008.03.005","volume":"18","author":"RH Tammi","year":"2008","unstructured":"Tammi RH, Kultti A, Kosma VM, Pirinen R, Auvinen P, Tammi MI (2008) Hyaluronan in human tumors: pathobiological and prognostic messages from cell-associated and stromal hyaluronan. Semin Cancer Biol 18:288\u2013295","journal-title":"Semin Cancer Biol"},{"key":"6361_CR11","doi-asserted-by":"publisher","unstructured":"Tammi MI, Oikari S, Pasonen-Seppanen S, Rilla K, Auvinen P, Tammi RH (2018) Activated hyaluronan metabolism in the tumor matrix - causes and consequences. Matrix Biol. \nhttps:\/\/doi.org\/10.1016\/j.matbio.2018.04.012","DOI":"10.1016\/j.matbio.2018.04.012"},{"key":"6361_CR12","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1002\/ijc.27707","volume":"132","author":"P Auvinen","year":"2013","unstructured":"Auvinen P, Tammi R, Kosma VM et al (2013) Increased hyaluronan content and stromal cell CD44 associate with HER2 positivity and poor prognosis in human breast cancer. Int J Cancer 132:531\u2013539","journal-title":"Int J Cancer"},{"key":"6361_CR13","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/S0002-9440(10)64757-8","volume":"156","author":"P Auvinen","year":"2000","unstructured":"Auvinen P, Tammi R, Parkkinen J et al (2000) Hyaluronan in peritumoral stroma and malignant cells associates with breast cancer spreading and predicts survival. Am J Pathol 156:529\u2013536","journal-title":"Am J Pathol"},{"key":"6361_CR14","doi-asserted-by":"publisher","first-page":"4361","DOI":"10.1007\/s00330-016-4326-2","volume":"26","author":"O Arponen","year":"2016","unstructured":"Arponen O, Masarwah A, Sutela A et al (2016) Incidentally detected enhancing lesions found in breast MRI: analysis of apparent diffusion coefficient and T2 signal intensity significantly improves specificity. Eur Radiol 26:4361\u20134370","journal-title":"Eur Radiol"},{"key":"6361_CR15","doi-asserted-by":"publisher","first-page":"e0138702","DOI":"10.1371\/journal.pone.0138702","volume":"10","author":"O Arponen","year":"2015","unstructured":"Arponen O, Sudah M, Masarwah A et al (2015) Diffusion-weighted imaging in 3.0 tesla breast MRI: diagnostic performance and tumor characterization using small subregions vs. whole tumor regions of interest. PLoS One 10:e0138702","journal-title":"PLoS One"},{"key":"6361_CR16","doi-asserted-by":"publisher","first-page":"4104","DOI":"10.1200\/JCO.2007.11.9610","volume":"25","author":"DA Hamstra","year":"2007","unstructured":"Hamstra DA, Rehemtulla A, Ross BD (2007) Diffusion magnetic resonance imaging: a biomarker for treatment response in oncology. J Clin Oncol 25:4104\u20134109","journal-title":"J Clin Oncol"},{"key":"6361_CR17","doi-asserted-by":"publisher","first-page":"1622","DOI":"10.2214\/AJR.06.1403","volume":"188","author":"DM Koh","year":"2007","unstructured":"Koh DM, Collins DJ (2007) Diffusion-weighted MRI in the body: applications and challenges in oncology. AJR Am J Roentgenol 188:1622\u20131635","journal-title":"AJR Am J Roentgenol"},{"key":"6361_CR18","doi-asserted-by":"publisher","first-page":"2875","DOI":"10.1038\/s41598-017-03122-z","volume":"7","author":"M Fan","year":"2017","unstructured":"Fan M, He T, Zhang P, Zhang J, Li L (2017) Heterogeneity of diffusion-weighted imaging in tumours and the surrounding stroma for prediction of Ki-67 proliferation status in breast cancer. Sci Rep 7:2875","journal-title":"Sci Rep"},{"key":"6361_CR19","doi-asserted-by":"publisher","first-page":"1308","DOI":"10.1002\/jmri.24283","volume":"39","author":"RL McLaughlin","year":"2014","unstructured":"McLaughlin RL, Newitt DC, Wilmes LJ et al (2014) High resolution in vivo characterization of apparent diffusion coefficient at the tumor-stromal boundary of breast carcinomas: a pilot study to assess treatment response using proximity-dependent diffusion-weighted imaging. J Magn Reson Imaging 39:1308\u20131313","journal-title":"J Magn Reson Imaging"},{"key":"6361_CR20","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1007\/s00330-015-3847-4","volume":"26","author":"N Mori","year":"2016","unstructured":"Mori N, Mugikura S, Takasawa C et al (2016) Peritumoral apparent diffusion coefficients for prediction of lymphovascular invasion in clinically node-negative invasive breast cancer. Eur Radiol 26:331\u2013339","journal-title":"Eur Radiol"},{"key":"6361_CR21","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1016\/j.ejrad.2016.02.017","volume":"85","author":"HJ Shin","year":"2016","unstructured":"Shin HJ, Park JY, Shin KC et al (2016) Characterization of tumor and adjacent peritumoral stroma in patients with breast cancer using high-resolution diffusion-weighted imaging: correlation with pathologic biomarkers. Eur J Radiol 85:1004\u20131011","journal-title":"Eur J Radiol"},{"key":"6361_CR22","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.matbio.2017.12.015","volume":"67","author":"S Oikari","year":"2018","unstructured":"Oikari S, Kettunen T, Tiainen S et al (2018) UDP-sugar accumulation drives hyaluronan synthesis in breast cancer. Matrix Biol 67:63\u201374","journal-title":"Matrix Biol"},{"key":"6361_CR23","first-page":"6410","volume":"62","author":"EL Hiltunen","year":"2002","unstructured":"Hiltunen EL, Anttila M, Kultti A et al (2002) Elevated hyaluronan concentration without hyaluronidase activation in malignant epithelial ovarian tumors. Cancer Res 62:6410\u20136413","journal-title":"Cancer Res"},{"key":"6361_CR24","doi-asserted-by":"publisher","first-page":"159","DOI":"10.2307\/2529310","volume":"33","author":"JR Landis","year":"1977","unstructured":"Landis JR, Koch GG (1977) The measurement of observer agreement for categorical data. Biometrics 33:159\u2013174","journal-title":"Biometrics"},{"key":"6361_CR25","doi-asserted-by":"crossref","unstructured":"Fan M, He T, Zhang P et al (2018) Diffusion-weighted imaging features of breast tumours and the surrounding stroma reflect intrinsic heterogeneous characteristics of molecular subtypes in breast cancer. NMR Biomed 31","DOI":"10.1002\/nbm.3869"},{"key":"6361_CR26","first-page":"9674565","volume":"2018","author":"M Huang","year":"2018","unstructured":"Huang M, Liao B, Xu P et al (2018) Prediction of microvascular invasion in hepatocellular carcinoma: preoperative Gd-EOB-DTPA-dynamic enhanced MRI and histopathological correlation. Contrast Media Mol Imaging 2018:9674565","journal-title":"Contrast Media Mol Imaging"},{"key":"6361_CR27","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/s40644-018-0156-6","volume":"18","author":"L Deng","year":"2018","unstructured":"Deng L, Wang QP, Yan R et al (2018) The utility of measuring the apparent diffusion coefficient for peritumoral zone in assessing infiltration depth of endometrial cancer. Cancer Imaging 18:23","journal-title":"Cancer Imaging"},{"key":"6361_CR28","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1038\/s41598-017-18035-0","volume":"8","author":"O Arponen","year":"2018","unstructured":"Arponen O, Sudah M, Sutela A et al (2018) Gadoterate meglumine decreases ADC values of breast lesions depending on the b value combination. Sci Rep 8:87","journal-title":"Sci Rep"},{"key":"6361_CR29","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1593\/neo.81328","volume":"11","author":"AR Padhani","year":"2009","unstructured":"Padhani AR, Liu G, Koh DM et al (2009) Diffusion-weighted magnetic resonance imaging as a cancer biomarker: consensus and recommendations. Neoplasia 11:102\u2013125","journal-title":"Neoplasia"},{"key":"6361_CR30","doi-asserted-by":"publisher","first-page":"2243","DOI":"10.1007\/s00330-018-5866-4","volume":"29","author":"FC Schmeel","year":"2019","unstructured":"Schmeel FC (2019) Variability in quantitative diffusion-weighted MR imaging (DWI) across different scanners and imaging sites: is there a potential consensus that can help reducing the limits of expected bias? Eur Radiol 29:2243\u20132245","journal-title":"Eur Radiol"},{"key":"6361_CR31","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1111\/j.1524-4741.2010.00915.x","volume":"16","author":"PA Baltzer","year":"2010","unstructured":"Baltzer PA, Yang F, Dietzel M et al (2010) Sensitivity and specificity of unilateral edema on T2w-TSE sequences in MR-mammography considering 974 histologically verified lesions. Breast J 16:233\u2013239","journal-title":"Breast J"},{"key":"6361_CR32","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1148\/radiol.2017171157","volume":"287","author":"H Cheon","year":"2018","unstructured":"Cheon H, Kim HJ, Kim TH et al (2018) Invasive breast cancer: prognostic value of peritumoral edema identified at preoperative MR imaging. Radiology 287:68\u201375","journal-title":"Radiology"},{"key":"6361_CR33","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.clbc.2012.07.002","volume":"12","author":"M Costantini","year":"2012","unstructured":"Costantini M, Belli P, Distefano D et al (2012) Magnetic resonance imaging features in triple-negative breast cancer: comparison with luminal and HER2-overexpressing tumors. Clin Breast Cancer 12:331\u2013339","journal-title":"Clin Breast Cancer"}],"container-title":["European Radiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00330-019-06361-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00330-019-06361-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00330-019-06361-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,27]],"date-time":"2020-07-27T23:10:03Z","timestamp":1595891403000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00330-019-06361-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,29]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["6361"],"URL":"https:\/\/doi.org\/10.1007\/s00330-019-06361-y","relation":{},"ISSN":["0938-7994","1432-1084"],"issn-type":[{"value":"0938-7994","type":"print"},{"value":"1432-1084","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,29]]},"assertion":[{"value":"22 February 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 June 2019","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 July 2019","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 July 2019","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The scientific guarantor of this publication is Ritva Vanninen.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Guarantor"}},{"value":"The authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Tuomas Selander kindly provided statistical advice for this manuscript.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Statistics and biometry"}},{"value":"Written informed consent was obtained from all subjects (patients) in this study.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"Institutional Review Board approval was obtained.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"\u2022 prospective\u2022 diagnostic or prognostic study\/observational\u2022 performed at one institution","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Methodology"}}]}}