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In all coronary segments, we assessed lumen and wall volumes and segmental length, calculated volume-length ratio (VLR) (volumes indexed by segmental length; mm<jats:sup>3<\/jats:sup>\/mm), wall burden (WB) (wall\/wall + lumen volumes; %), and assessed proportions of calcified, fibrotic, fibro-fatty, and low-attenuation tissue (%) in coronary wall<jats:italic>.<\/jats:italic> We rendered independent CTA measures associated with CAV by ICA, tested their discriminatory capacity, and assessed concordance between CTA and ICA.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>Among 50 patients (84% men; 53.6\u2009\u00b1\u200911.9\u00a0years), we analyzed 632 coronary segments. Mean interval between HTX and CTA was 6.7\u2009\u00b1\u20094.7\u00a0years and between ICA and CTA 1 (0\u20131) day. Segmental VLR, WB, and proportion of fibrotic tissue were independently associated with CAV (OR\u2009=\u20091.06\u20131.27; <jats:italic>p<\/jats:italic>\u2009\u2264\u20090.002), reaching a high discriminatory capacity (combination of all three: AUC\u2009=\u20090.84; 95%CI, 0.75\u20130.90). Concordance between CTA and ICA was higher in advanced CAV (88%) compared with that in none (37%) and mild (19%) CAV. Discordance was primarily driven by a large number of segments with coronary wall changes on CTA but without luminal stenoses on ICA (177\/591; 25%).<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusion<\/jats:title>\n<jats:p>CTA-derived coronary wall VLR, WB, and the proportion of fibrotic tissue are independent markers of CAV. Combination of these three parameters may aid the detection of early CAV not detected by ICA, the current standard of care.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Key Points<\/jats:title>\n<jats:p><jats:italic>\u2022 Coronary CTA detects CAV in HTX patients.<\/jats:italic><\/jats:p>\n<jats:p><jats:italic>\u2022 Coronary wall volume-length ratio, wall burden, and proportion of fibrotic tissue are independently associated with CAV.<\/jats:italic><\/jats:p>\n<jats:p><jats:italic>\u2022 In contrast to ICA, coronary CTA may identify the early stages of CAV.<\/jats:italic><\/jats:p>\n<\/jats:sec>","DOI":"10.1007\/s00330-019-06653-3","type":"journal-article","created":{"date-parts":[[2020,3,16]],"date-time":"2020-03-16T16:03:41Z","timestamp":1584374621000},"page":"4317-4326","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Quantitative coronary computed tomography angiography for the detection of cardiac allograft vasculopathy"],"prefix":"10.1007","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2466-4827","authenticated-orcid":false,"given":"Borek","family":"Foldyna","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"Sandri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Luecke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Garbade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin","family":"Gohmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jochen","family":"Hahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Fischer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Gutberlet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"Lehmkuhl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,3,16]]},"reference":[{"key":"6653_CR1","doi-asserted-by":"publisher","first-page":"1244","DOI":"10.1016\/j.healun.2015.08.003","volume":"34","author":"LH Lund","year":"2015","unstructured":"Lund LH, Edwards LB, Kucheryavaya AY et al (2015) The registry of the International Society for Heart and Lung Transplantation: thirty-second official adult heart transplantation report\u20142015; focus theme: early graft failure. 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