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Consequently, feedback to the radiologist about concurrent focal abnormalities (e.g., palpable lesions) is lost. To enable marking of patient- or physician-reported focal abnormalities, we aimed to develop skin markers that can be used without disturbing the interpretability of the image.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>Disk-shaped markers were casted out of silicone. In this IRB-approved prospective study, 16 patients were included with a mean age of 57 (39\u201385). In all patients, the same volume was imaged twice using an automated breast ultrasound system, once with and once without a marker in place. Nine radiologists from two medical centers filled scoring forms regarding image quality, image interpretation, and confidence in providing a diagnosis based on the images.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>Marker adhesion was sufficient for automated scanning. Observer scores showed a significant shift in scores from excellent to good regarding diagnostic yield\/image quality (<jats:italic>\u03c7<\/jats:italic><jats:sup>2<\/jats:sup>, 15.99, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01), and image noise (<jats:italic>\u03c7<\/jats:italic><jats:sup>2<\/jats:sup>, 21.20, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) due to marker presence. In 93% of cases, the median score of observers \u201cagree\u201d with the statement that marker-induced noise did not influence image interpretability. Marker presence did not interfere with confidence in diagnosis (<jats:italic>\u03c7<\/jats:italic><jats:sup>2<\/jats:sup>, 6.00, <jats:italic>p<\/jats:italic>\u2009=\u20090.20).<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusion<\/jats:title>\n<jats:p>Inexpensive, easy producible skin markers can be used for accurate lesion marking in automated ultrasound examinations of the breast while image interpretability is preserved. Any marker-induced noise and decreased image quality did not affect confidence in providing a diagnosis.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Key Points<\/jats:title>\n<jats:p><jats:italic>\u2022 The use of a skin marker enables the reporting radiologist to identify a location which a patient is concerned about.<\/jats:italic><\/jats:p>\n<jats:p><jats:italic>\u2022 The developed skin marker can be used for accurate breast lesion marking in ultrasound examinations.<\/jats:italic><\/jats:p>\n<\/jats:sec>","DOI":"10.1007\/s00330-020-06695-y","type":"journal-article","created":{"date-parts":[[2020,2,14]],"date-time":"2020-02-14T18:03:36Z","timestamp":1581703416000},"page":"3356-3362","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Production and clinical evaluation of breast lesion skin markers for automated three-dimensional ultrasonography of the breast: a pilot study"],"prefix":"10.1007","volume":"30","author":[{"given":"Leon","family":"de Jong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcel K.","family":"Welleweerd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan C.M.","family":"van Zelst","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francoise J.","family":"Siepel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Stramigioli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ritse M.","family":"Mann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris L.","family":"de Korte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jurgen J.","family":"F\u00fctterer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,2,14]]},"reference":[{"issue":"10","key":"6695_CR1","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1016\/j.diii.2019.03.012","volume":"100","author":"A. 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