{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T18:53:16Z","timestamp":1784227996229,"version":"3.55.0"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2020,3,12]],"date-time":"2020-03-12T00:00:00Z","timestamp":1583971200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,3,12]],"date-time":"2020-03-12T00:00:00Z","timestamp":1583971200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Radiol"],"published-print":{"date-parts":[[2020,7]]},"DOI":"10.1007\/s00330-020-06765-1","type":"journal-article","created":{"date-parts":[[2020,3,12]],"date-time":"2020-03-12T20:02:32Z","timestamp":1584043352000},"page":"3702-3710","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Prognostic value of cardiovascular magnetic resonance in patients with biopsy-proven systemic sarcoidosis"],"prefix":"10.1007","volume":"30","author":[{"given":"Louis","family":"Flam\u00e9e","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolf","family":"Symons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ganna","family":"Degtiarova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Dresselaers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Gheysens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wim","family":"Wuyts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Van Cleemput","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7495-9183","authenticated-orcid":false,"given":"Jan","family":"Bogaert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,3,12]]},"reference":[{"key":"6765_CR1","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1177\/2040622318790197","volume":"9","author":"EV Arkema","year":"2018","unstructured":"Arkema EV, Cozier YC (2018) Epidemiology of sarcoidosis: current findings and future directions. Ther Adv Chronic Dis 9:227\u2013240","journal-title":"Ther Adv Chronic Dis"},{"key":"6765_CR2","doi-asserted-by":"crossref","unstructured":"Valeyre D, Prasse A, Nunes H, Uzunhan Y, Brillet PY, M\u00fcller-Quernheim J (2014) Sarcoidosis. Lancet 383:1155\u20131167","DOI":"10.1016\/S0140-6736(13)60680-7"},{"key":"6765_CR3","unstructured":"(1999) Statement on sarcoidosis. Joint Statement of the American Thoracic Society (ATS), the European Respiratory Society (ERS) and the World Association of Sarcoidosis and Other Granulomatous Disorders (WASOG) Adopted by the ATS Board of Directors and by the ERS Executive Committee, February 1999. Am J Respir Crit Care Med 160:736\u2013755"},{"key":"6765_CR4","doi-asserted-by":"publisher","first-page":"2153","DOI":"10.1056\/NEJMra071714","volume":"357","author":"MC Iannuzzi","year":"2007","unstructured":"Iannuzzi MC, Rybicki BA, Teirstein AS (2007) Sarcoidosis. N Engl J Med 357:2153\u20132165","journal-title":"N Engl J Med"},{"key":"6765_CR5","doi-asserted-by":"crossref","unstructured":"Iwai K, Tachibana T, Takemura T, Matsui Y, Kitaichi M, Kawabata Y (1993) Pathological studies on sarcoidosis autopsy. Epidemiological features of 320 cases in Japan. Acta Pathol Jpn 43:372\u2013376","DOI":"10.1111\/j.1440-1827.1993.tb01148.x"},{"key":"6765_CR6","first-page":"167","volume":"119","author":"A Perry","year":"1995","unstructured":"Perry A, Vuitch F (1995) Causes of death in patients with sarcoidosis. A morphologic study of 38 autopsies with clinicopathologic correlations. Arch Pathol Lab Med 119:167\u2013172","journal-title":"Arch Pathol Lab Med"},{"key":"6765_CR7","doi-asserted-by":"crossref","unstructured":"Birnie DH, Nery PB, Ha AC, Beanlands RSB (2016) Cardiac Sarcoidosis. J Am Coll Cardiol 68:411\u2013421","DOI":"10.1016\/j.jacc.2016.03.605"},{"key":"6765_CR8","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.ahj.2008.09.009","volume":"157","author":"JS Kim","year":"2009","unstructured":"Kim JS, Judson MA, Donnino R et al (2009) Cardiac sarcoidosis. Am Heart J 157:9\u201321","journal-title":"Am Heart J"},{"key":"6765_CR9","doi-asserted-by":"publisher","first-page":"1437","DOI":"10.1016\/j.jcmg.2016.11.019","volume":"10","author":"V Kouranos","year":"2017","unstructured":"Kouranos V, Tzelepis GE, Rapti A et al (2017) Complementary role of CMR to conventional screening in the diagnosis and prognosis of cardiac sarcoidosis. JACC Cardiovasc Imaging 10:1437\u20131447","journal-title":"JACC Cardiovasc Imaging"},{"key":"6765_CR10","doi-asserted-by":"publisher","first-page":"1683","DOI":"10.1016\/j.jacc.2005.01.047","volume":"45","author":"JP Smedema","year":"2005","unstructured":"Smedema JP, Snoep G, van Kroonenburgh MP et al (2005) Evaluation of the accuracy of gadolinium-enhanced cardiovascular magnetic resonance in the diagnosis of cardiac sarcoidosis. J Am Coll Cardiol 45:1683\u20131690","journal-title":"J Am Coll Cardiol"},{"key":"6765_CR11","doi-asserted-by":"publisher","first-page":"1969","DOI":"10.1161\/CIRCULATIONAHA.109.851352","volume":"120","author":"MR Patel","year":"2009","unstructured":"Patel MR, Cawley PJ, Heitner JF et al (2009) Detection of myocardial damage in patients with sarcoidosis. Circulation 120:1969\u20131977","journal-title":"Circulation"},{"key":"6765_CR12","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1016\/j.jcmg.2016.05.009","volume":"10","author":"GC Coleman","year":"2017","unstructured":"Coleman GC, Shaw PW, Balfour PC et al (2017) Prognostic value of myocardial scarring on CMR in patients with cardiac sarcoidosis: a systematic review and meta-analysis. JACC Cardiovasc Imaging 10:411\u2013420","journal-title":"JACC Cardiovasc Imaging"},{"key":"6765_CR13","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1186\/1532-429X-10-35","volume":"10","author":"CM Kramer","year":"2008","unstructured":"Kramer CM, Barkhausen J, Flamm SD, Kim RJ, Nagel E, Society for Cardiovascular Magnetic Resonance Board of Trustees Task Force on Standardized Protocols (2008) Standardized cardiovascular magnetic resonance (CMR) protocols, society for cardiovascular magnetic resonance: board of trustee\u2019s task force for standardized protocols. J Cardiovasc Magn Reson 10:35","journal-title":"J Cardiovasc Magn Reson"},{"key":"6765_CR14","doi-asserted-by":"publisher","first-page":"H1200","DOI":"10.1152\/ajpheart.01294.2008","volume":"296","author":"S Bohl","year":"2009","unstructured":"Bohl S, Lygate CA, Barnes H et al (2009) Advanced methods for quantification of infarct size in mice using three-dimensional high-field late gadolinium enhancement MRI. Am J Physiol Heart Circ Physiol 296:H1200\u2013H1208","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"6765_CR15","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1186\/1471-2261-13-110","volume":"13","author":"R Jablonowski","year":"2013","unstructured":"Jablonowski R, Nordlund D, Kanski M et al (2013) Infarct quantification using 3D inversion recovery and 2D phase sensitive inversion recovery; validation in patients and ex vivo. BMC Cardiovasc Disord 13:110\u2013117","journal-title":"BMC Cardiovasc Disord"},{"key":"6765_CR16","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1161\/hc0402.102975","volume":"105","author":"MD Cerqueira","year":"2002","unstructured":"Cerqueira MD, Weissman NJ, Dilsizian V et al (2002) Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart: a statement for healthcare professionals from the cardiac imaging committee of the council on clinical cardiology of the American Heart Association. Circulation 105:539\u2013542","journal-title":"Circulation"},{"key":"6765_CR17","doi-asserted-by":"publisher","first-page":"1405","DOI":"10.1161\/CIRCULATIONAHA.110.940254","volume":"122","author":"PG Masci","year":"2010","unstructured":"Masci PG, Francone M, Desmet W et al (2010) Right ventricular ischemic injury in patients with acute ST-segment elevation myocardial infarction. Characterization with cardiovascular magnetic resonance. Circulation 122:1405\u20131412","journal-title":"Circulation"},{"issue":"20","key":"6765_CR18","doi-asserted-by":"publisher","first-page":"3940","DOI":"10.1093\/bioinformatics\/bti623","volume":"21","author":"T Sing","year":"2005","unstructured":"Sing T, Sander O, Beerenwinkel N, Lengauer T (2005) ROCR: visualizing classifier performance in R. Bioinformatics 21(20):3940\u20133941","journal-title":"Bioinformatics"},{"issue":"8","key":"6765_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.18637\/jss.v061.i08","volume":"61","author":"M L\u00f3pez-Rat\u00f3n","year":"2014","unstructured":"L\u00f3pez-Rat\u00f3n M, Rodr\u00edguez-\u00c1lvarez MX, Cadarso-Su\u00e1rez C, Gude-Sampedro F (2014) OptimalCutpoints: an R package for selecting optimal cutpoints in diagnostic tests. J Stat Softw 61(8):1\u201336","journal-title":"J Stat Softw"},{"issue":"1","key":"6765_CR20","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1002\/1097-0142(1950)3:1<32::AID-CNCR2820030106>3.0.CO;2-3","volume":"3","author":"WJ Youden","year":"1950","unstructured":"Youden WJ (1950) Index for rating diagnostic tests. Cancer 3(1):32\u201335","journal-title":"Cancer"},{"key":"6765_CR21","doi-asserted-by":"crossref","unstructured":"Fluss R, Faraggi D, Reiser B (2005) Estimation of the Youden index and its associated cutoff point. Biom J 47(4):458\u2013472","DOI":"10.1002\/bimj.200410135"},{"key":"6765_CR22","unstructured":"Therneau T (2015) A package for survival analysis in S. version 2.38"},{"key":"6765_CR23","doi-asserted-by":"publisher","first-page":"3158","DOI":"10.1016\/j.jacc.2018.09.072","volume":"72","author":"VM Ferreira","year":"2018","unstructured":"Ferreira VM, Schulz-Menger J, Holmvang G et al (2018) Cardiovascular magnetic resonance in nonischemic myocardial inflammation: expert recommendations. J Am Coll Cardiol 72:3158\u20133176","journal-title":"J Am Coll Cardiol"},{"key":"6765_CR24","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.jcmg.2017.01.025","volume":"11","author":"JA Lurz","year":"2018","unstructured":"Lurz JA, Luecke C, Lang D et al (2018) CMR-derived extracellular volume fraction as a marker for myocardial fibrosis: the importance of coexisting myocardial inflammation. JACC Cardiovasc Imaging 11:38\u201345","journal-title":"JACC Cardiovasc Imaging"},{"key":"6765_CR25","doi-asserted-by":"publisher","first-page":"1800","DOI":"10.1016\/j.jacc.2016.02.013","volume":"67","author":"P Lurz","year":"2016","unstructured":"Lurz P, Luecke C, Eitel I et al (2016) Comprehensive cardiac magnetic resonance imaging in patients with suspected myocarditis: the MyoRacer-Trial. J Am Coll Cardiol 67:1800\u20131811","journal-title":"J Am Coll Cardiol"},{"key":"6765_CR26","doi-asserted-by":"publisher","first-page":"3686","DOI":"10.1007\/s00330-019-06171-2","volume":"29","author":"J Uhlig","year":"2019","unstructured":"Uhlig J, L\u00fccke C, Vliegenthart R et al (2019) Acute adverse events in cardiac MR imaging with gadolinium-based contrast agents: results from the European Society of Cardiovascular Radiology (ESCR) MRCT Registry in 72,839 patients. Eur Radiol 29:3686\u20133695","journal-title":"Eur Radiol"},{"key":"6765_CR27","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1016\/j.jcmg.2012.10.021","volume":"6","author":"S Greulich","year":"2013","unstructured":"Greulich S, Deluigi CC, Gloekler S et al (2013) CMR imaging predicts death and other adverse events in suspected cardiac sarcoidosis. JACC Cardiovasc Imaging 6:501\u2013511","journal-title":"JACC Cardiovasc Imaging"},{"key":"6765_CR28","first-page":"634","volume":"16","author":"J Nadel","year":"2015","unstructured":"Nadel J, Lancefield T, Voskoboinik A, Taylor AJ (2015) Late gadolinium enhancement identified with cardiac magnetic resonance imaging in sarcoidosis patients is associated with long-term ventricular arrhythmia and sudden cardiac death. Eur Heart J Cardiovasc Imaging 16:634\u2013641","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"6765_CR29","doi-asserted-by":"publisher","first-page":"e003738","DOI":"10.1161\/CIRCIMAGING.115.003738","volume":"9","author":"G Murtagh","year":"2016","unstructured":"Murtagh G, Laffin LJ, Beshai JF et al (2016) Prognosis of myocardial damage in sarcoidosis patients with preserved left ventricular ejection fraction: risk stratification using cardiovascular magnetic resonance. Circ Cardiovasc Imaging 9:e003738","journal-title":"Circ Cardiovasc Imaging"},{"key":"6765_CR30","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1016\/j.jjcc.2012.08.002","volume":"60","author":"MA Shafee","year":"2012","unstructured":"Shafee MA, Fukuda K, Wakayama Y et al (2012) Delayed enhancement on cardiac magnetic resonance imaging is a poor prognostic factor in patients with cardiac sarcoidosis. J Cardiol 60:448\u2013453","journal-title":"J Cardiol"},{"key":"6765_CR31","doi-asserted-by":"crossref","unstructured":"Dawson DK, Hawlisch K, Prescott G et al (2013) Prognostic role of CMR in patients presenting with ventricular arrhythmias. JACC Cardiovasc Imaging 6:335\u2013344","DOI":"10.1016\/j.jcmg.2012.09.012"},{"key":"6765_CR32","doi-asserted-by":"publisher","first-page":"1604","DOI":"10.1016\/j.jacc.2012.01.007","volume":"59","author":"S Gr\u00fcn","year":"2012","unstructured":"Gr\u00fcn S, Schumm J, Greulich S et al (2012) Long-term follow-up of biopsy proven viral myocarditis: predictors of mortality and incomplete recovery. J Am Coll Cardiol 59:1604\u20131615","journal-title":"J Am Coll Cardiol"},{"key":"6765_CR33","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1016\/j.jacc.2010.05.007","volume":"56","author":"O Bruder","year":"2010","unstructured":"Bruder O, Wagner A, Jensen CJ et al (2010) Myocardial scar visualized by cardiovascular magnetic resonance imaging predicts major adverse events in patients with hypertrophic cardiomyopathy. J Am Coll Cardiol 56:875\u2013887","journal-title":"J Am Coll Cardiol"},{"key":"6765_CR34","doi-asserted-by":"publisher","first-page":"950","DOI":"10.1016\/j.ijcard.2016.07.233","volume":"222","author":"L Agoston-Coldea","year":"2016","unstructured":"Agoston-Coldea L, Kouaho S, Sacre K et al (2016) High mass (18 g) of late gadolinium enhancement on CMR imaging is associated with major cardiac events on long-term outcome in patients with biopsy-proven extracardiac sarcoidosis. Int J Cardiol 222:950\u2013656","journal-title":"Int J Cardiol"},{"key":"6765_CR35","doi-asserted-by":"publisher","unstructured":"Degtiarova G, Gheysens O, Van Cleemput J, Wuyts W, Bogaert J (2019) Natural evolution of cardiac sarcoidosis in an asymptomatic patient: a case report. Eur Heart J Case Rep. https:\/\/doi.org\/10.1093\/ehjcr\/ytz099","DOI":"10.1093\/ehjcr\/ytz099"},{"key":"6765_CR36","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1148\/radiol.2017162732","volume":"285","author":"VO Puntmann","year":"2017","unstructured":"Puntmann VO, Isted A, Hinojar R, Foote L, Carr-White G, Nagel E (2017) T1 and T2 mapping in recognition of early cardiac involvement in systemic sarcoidosis. Radiology 285:63\u201372","journal-title":"Radiology"},{"key":"6765_CR37","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1148\/radiol.2493080340","volume":"250","author":"PG Masci","year":"2009","unstructured":"Masci PG, Dymarkowski S, Rademakers FE, Bogaert J (2009) Determination of regional fraction in patients with myocardial infarction by using merged late gadolinium enhancement and cine MR: feasibility study. Radiology 250:50\u201360","journal-title":"Radiology"},{"issue":"1","key":"6765_CR38","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.jcmg.2017.02.021","volume":"11","author":"MR Dweck","year":"2018","unstructured":"Dweck MR, Abgral R, Trivieri MG et al (2018) Hybrid magnetic resonance imaging and positron emission tomography with fluorodeoxyglucose to diagnose active cardiac sarcoidosis. JACC Cardiovasc Imaging 11(1):94\u2013107","journal-title":"JACC Cardiovasc Imaging"}],"container-title":["European Radiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00330-020-06765-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00330-020-06765-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00330-020-06765-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,12]],"date-time":"2021-03-12T00:26:15Z","timestamp":1615508775000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00330-020-06765-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,12]]},"references-count":38,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["6765"],"URL":"https:\/\/doi.org\/10.1007\/s00330-020-06765-1","relation":{},"ISSN":["0938-7994","1432-1084"],"issn-type":[{"value":"0938-7994","type":"print"},{"value":"1432-1084","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,12]]},"assertion":[{"value":"7 October 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 February 2020","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 February 2020","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 March 2020","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The scientific guarantor of this publication is Jan Bogaert.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Guarantor"}},{"value":"The authors of this manuscript declare no relationships with any companies whose products or services may be related to the subject matter of the article.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"One of the authors has significant statistical expertise.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Statistics and biometry"}},{"value":"Written informed consent was waived by the Institutional Review Board.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"Institutional Review Board approval was obtained.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"One case report has been published on an asymptomatic patient showing progressive disease at repeated CMR follow-up. This case report has no influence of the results of this study. Degtiarova G et al EHJ case reports Doi:","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Study subjects or cohorts overlap"}},{"value":"\u2022 Retrospective\u2022 Observational\u2022 Performed at one institution","order":8,"name":"Ethics","group":{"name":"EthicsHeading","label":"Methodology"}}]}}