{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T23:50:31Z","timestamp":1781653831504,"version":"3.54.5"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T00:00:00Z","timestamp":1599004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T00:00:00Z","timestamp":1599004800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100004569","name":"Ministerstwo Nauki i Szkolnictwa Wy\u017cszego","doi-asserted-by":"publisher","award":["IP 2014 0477 73"],"award-info":[{"award-number":["IP 2014 0477 73"]}],"id":[{"id":"10.13039\/501100004569","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Institute of Cardiology","award":["4.5\/V\/17"],"award-info":[{"award-number":["4.5\/V\/17"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Radiol"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Objectives<\/jats:title>\n                <jats:p>To assess the value of cardiac MRI in comparison to echocardiography in consecutive patients with previously diagnosed and new suspected hypertrophic cardiomyopathy (HCM).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>All MRI studies of patients with HCM or suspected disease performed at our centre within a 10-year time period were evaluated. Initial diagnoses (echocardiography-based) and final (MRI-based) diagnoses were compared in subgroups, and the discrepancies were recorded.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>A total of 1006 subjects with HCM or suspected HCM were identified (61% males, 39% females; median age, 49.1 years; interquartile range, 34.9\u201360.4). In 12 (2.2%) out of 550 patients with known HCM, MRI indicated a diagnosis other than HCM, including but not limited to the subaortic membrane (<jats:italic>n<\/jats:italic>\u2009=\u20091, 8.3%) or mild left ventricular hypertrophy (<jats:italic>n<\/jats:italic>\u2009=\u20095, 41.7%). Among all patients with suspected HCM (<jats:italic>n<\/jats:italic>\u2009=\u2009456), MRI diagnosis was different from HCM in 5.3% (<jats:italic>n<\/jats:italic>\u2009=\u200924) of patients. In an additional 20.4% of patients (<jats:italic>n<\/jats:italic>\u2009=\u200993), no significant hypertrophy was present. In total, among patients with suspected HCM, MRI led to clear HCM diagnosis in 204 (44.7%) patients. Among patients with a history of uncontrolled hypertension suspected of having HCM, MRI aided in identifying cardiomyopathy in 47.9% of patients. This subgroup contained the largest proportion of patients with an ambiguous diagnosis, namely, 29.6% compared with 13.8% in the remaining groups of patients with suspected HCM (<jats:italic>p<\/jats:italic>\u2009=\u20090.0001).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>In a small but important group of patients with ultrasound-based HCM, cardiac MRI can diagnose previously unknown conditions and\/or refute suspected cardiomyopathy. The diagnostic yield of MRI when compared to echocardiography in patients suspected of having HCM is 44.7%.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Key Points<\/jats:title>\n                <jats:p><jats:italic>\u2022 Out of 550 patients previously diagnosed with echocardiography but without magnetic resonance imaging (MRI) as having hypertrophic cardiomyopathy (HCM), we diagnosed a different disease in 12 (2.2%) patients using MRI.<\/jats:italic><\/jats:p>\n                <jats:p><jats:italic>\u2022 Among patients with suspected HCM based on echocardiography, MRI led to clear HCM diagnosis in 44.7% of patients.<\/jats:italic><\/jats:p>\n                <jats:p><jats:italic>\u2022 In patients with a history of uncontrolled hypertension suspected, based on an echocardiogram, of having HCM, MRI aided in identifying cardiomyopathy in 47.9% of patients. This subgroup contained the largest proportion of patients with an ambiguous diagnosis.<\/jats:italic><\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00330-020-07207-8","type":"journal-article","created":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T13:03:48Z","timestamp":1599051828000},"page":"1194-1205","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Impact of cardiac magnetic resonance on the diagnosis of hypertrophic cardiomyopathy - a 10-year experience with over 1000 patients"],"prefix":"10.1007","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2393-4194","authenticated-orcid":false,"given":"Mateusz","family":"\u015apiewak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariusz","family":"K\u0142opotowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Ojrzy\u0144ska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Petryka-Mazurkiewicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Mi\u0142osz-Wieczorek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0141ukasz","family":"Mazurkiewicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacek","family":"Grzybowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zofia","family":"Bili\u0144ska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Witkowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Marczak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,9,2]]},"reference":[{"key":"7207_CR1","doi-asserted-by":"publisher","first-page":"2733","DOI":"10.1093\/eurheartj\/ehu199","volume":"35","author":"PM Elliott","year":"2014","unstructured":"Elliott PM, Anastasakis A, Borger MA et al (2014) 2014 ESC guidelines on diagnosis and management of hypertrophic cardiomyopathy: the Task Force for the Diagnosis and Management of Hypertrophic Cardiomyopathy of the European Society of Cardiology (ESC). 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No complex statistical methods were necessary for this paper.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Statistics and biometry"}},{"value":"Written informed consent was obtained from all subjects (patients) included prospectively in this study. Written informed consent for retrospective analysis was waived by the Institutional Review Board.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"Approval was granted by the local ethics committee of the National Institute of Cardiology, Warsaw, Poland (Reference number: 1656).","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Some study subjects or cohorts have been previously reported. The current analysis encompasses all patients with HCM who underwent cardiac MRI at our centre, thus including selected data that had been previously analysed in studies with smaller samples (\u015apiewak et al <i>Eur J Radiol<\/i> 2010; \u015apiewak et al <i>Int J Cardiovasc Imaging<\/i> 2010; \u015apiewak et al <i>Kardiol Pol<\/i> 2010; D\u0105browski et al <i>Kardiol Pol<\/i> 2012; Ma\u0142ek et al <i>Magn Reson Imaging<\/i> 2015; K\u0142opotowski et al <i>J Cardiol<\/i> 2016; Mazurkiewicz et al <i>Clin Radiol<\/i> 2017; Gawor et al <i>Kardiol Pol<\/i> 2017; \u015apiewak et al <i>J Cardiovasc Magn Reson<\/i> 2017; Gawor et al <i>Biomarkers<\/i> 2018; D\u0105browski et al <i>Kardiol Pol<\/i> 2019). The current analysis does not duplicate the results from previous studies. This manuscript differs substantially from our recent reports as follows: (1) the previous studies addressed different issues in patients with HCM (e.g. methods of late gadolinium enhancement quantification discrepancies between left ventricular mass and maximal wall thickness, the prognostic value of late gadolinium enhancement, the relation between late gadolinium enhancement and selected serum biomarkers, the value of native T1 mapping in patients with HCM and changes following alcohol septal ablation), and (2) the current study included a much larger population (<i>n<\/i>\u2009=\u20091006).","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Study subjects or cohorts overlap"}},{"value":"\u2022 retrospective\u2022 observational\u2022 performed at one institution","order":8,"name":"Ethics","group":{"name":"EthicsHeading","label":"Methodology"}}]}}