{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T04:11:55Z","timestamp":1777522315432,"version":"3.51.4"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2020,10,6]],"date-time":"2020-10-06T00:00:00Z","timestamp":1601942400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,10,6]],"date-time":"2020-10-06T00:00:00Z","timestamp":1601942400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100003785","name":"Medical Scientific Research Foundation of Guangdong Province of China","doi-asserted-by":"crossref","award":["A2019528"],"award-info":[{"award-number":["A2019528"]}],"id":[{"id":"10.13039\/501100003785","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2019A1515010845"],"award-info":[{"award-number":["2019A1515010845"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Radiol"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1007\/s00330-020-07342-2","type":"journal-article","created":{"date-parts":[[2020,10,6]],"date-time":"2020-10-06T15:02:48Z","timestamp":1601996568000},"page":"2414-2421","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Diagnostic efficiency of 68Ga-DOTANOC PET\/CT in patients with suspected tumour-induced osteomalacia"],"prefix":"10.1007","volume":"31","author":[{"given":"Qiao","family":"He","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linqi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhifeng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinchong","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang","family":"Yi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangsong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,10,6]]},"reference":[{"key":"7342_CR1","doi-asserted-by":"publisher","first-page":"1260","DOI":"10.1001\/jama.294.10.1260","volume":"294","author":"SM Jan de Beur","year":"2005","unstructured":"Jan de Beur SM (2005) Tumor-induced osteomalacia. JAMA 294:1260\u20131267","journal-title":"JAMA"},{"key":"7342_CR2","doi-asserted-by":"publisher","first-page":"17044","DOI":"10.1038\/nrdp.2017.44","volume":"3","author":"S Minisola","year":"2017","unstructured":"Minisola S, Peacock M, Fukumoto S et al (2017) Tumour-induced osteomalacia. Nat Rev Dis Primers 3:17044","journal-title":"Nat Rev Dis Primers"},{"key":"7342_CR3","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1172\/JCI18399","volume":"112","author":"M Riminucci","year":"2003","unstructured":"Riminucci M, Collins MT, Fedarko NS et al (2003) FGF-23 in fibrous dysplasia of bone and its relationship to renal phosphate wasting. J Clin Invest 112:683\u2013692","journal-title":"J Clin Invest"},{"key":"7342_CR4","first-page":"33","volume":"16","author":"CR Mc","year":"1947","unstructured":"Mc CR (1947) Osteomalacia with Looser\u2019s nodes (Milkman\u2019s syndrome) due to a raised resistance to vitamin D acquired about the age of 15 years. Q J Med 16:33\u201346","journal-title":"Q J Med"},{"key":"7342_CR5","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1053\/j.semdp.2019.07.002","volume":"36","author":"AL Folpe","year":"2019","unstructured":"Folpe AL (2019) Phosphaturic mesenchymal tumors: a review and update. Semin Diagn Pathol 36:260\u2013268","journal-title":"Semin Diagn Pathol"},{"key":"7342_CR6","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1186\/s12891-015-0496-3","volume":"16","author":"ZJ Sun","year":"2015","unstructured":"Sun ZJ, Jin J, Qiu GX, Gao P, Liu Y (2015) Surgical treatment of tumor-induced osteomalacia: a retrospective review of 40 cases with extremity tumors. BMC Musculoskelet Disord 16:43","journal-title":"BMC Musculoskelet Disord"},{"key":"7342_CR7","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1186\/s12891-017-1756-1","volume":"18","author":"QY Zuo","year":"2017","unstructured":"Zuo QY, Wang H, Li W et al (2017) Treatment and outcomes of tumor-induced osteomalacia associated with phosphaturic mesenchymal tumors: retrospective review of 12 patients. BMC Musculoskelet Disord 18:403","journal-title":"BMC Musculoskelet Disord"},{"key":"7342_CR8","doi-asserted-by":"publisher","first-page":"3049","DOI":"10.1210\/jc.2013-4515","volume":"99","author":"S Jadhav","year":"2014","unstructured":"Jadhav S, Kasaliwal R, Shetty NS et al (2014) Radiofrequency ablation, an effective modality of treatment in tumor-induced osteomalacia: a case series of three patients. J Clin Endocrinol Metab 99:3049\u20133054","journal-title":"J Clin Endocrinol Metab"},{"key":"7342_CR9","doi-asserted-by":"publisher","first-page":"R53","DOI":"10.1530\/ERC-11-0006","volume":"18","author":"WH Chong","year":"2011","unstructured":"Chong WH, Molinolo AA, Chen CC, Collins MT (2011) Tumor-induced osteomalacia. Endocr Relat Cancer 18:R53\u2013R77","journal-title":"Endocr Relat Cancer"},{"key":"7342_CR10","doi-asserted-by":"publisher","first-page":"e2018011","DOI":"10.4084\/mjhid.2018.011","volume":"10","author":"R Ria","year":"2018","unstructured":"Ria R, Dammacco F, Vacca A (2018) Heavy-chain diseases and myeloma-associated Fanconi syndrome: an update. Mediterr J Hematol Infect Dis 10:e2018011","journal-title":"Mediterr J Hematol Infect Dis"},{"key":"7342_CR11","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1097\/MCG.0b013e3181e12ed3","volume":"45","author":"CM Girgis","year":"2011","unstructured":"Girgis CM, Wong T, Ngu MC et al (2011) Hypophosphataemic osteomalacia in patients on adefovir dipivoxil. J Clin Gastroenterol 45:468\u2013473","journal-title":"J Clin Gastroenterol"},{"key":"7342_CR12","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/j.ejim.2005.07.003","volume":"16","author":"JL Dupond","year":"2005","unstructured":"Dupond JL, Mahammedi H, Magy N, Blagosklonov O, Meaux-Ruault N, Kantelip B (2005) Detection of a mesenchymal tumor responsible for hypophosphatemic osteomalacia using FDG-PET. Eur J Intern Med 16:445\u2013446","journal-title":"Eur J Intern Med"},{"key":"7342_CR13","doi-asserted-by":"publisher","first-page":"177","DOI":"10.4158\/EP10151.OR","volume":"17","author":"VS Jagtap","year":"2011","unstructured":"Jagtap VS, Sarathi V, Lila AR et al (2011) Tumor-induced osteomalacia: a single center experience. Endocr Pract 17:177\u2013184","journal-title":"Endocr Pract"},{"key":"7342_CR14","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1007\/s13139-011-0095-7","volume":"45","author":"HJ Seo","year":"2011","unstructured":"Seo HJ, Choi YJ, Kim HJ et al (2011) Using (18)F-FDG PET\/CT to detect an occult mesenchymal tumor causing oncogenic osteomalacia. Nucl Med Mol Imaging 45:233\u2013237","journal-title":"Nucl Med Mol Imaging"},{"key":"7342_CR15","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1097\/RLU.0b013e31818866bf","volume":"33","author":"M Duet","year":"2008","unstructured":"Duet M, Kerkeni S, Sfar R, Bazille C, Liote F, Orcel P (2008) Clinical impact of somatostatin receptor scintigraphy in the management of tumor-induced osteomalacia. Clin Nucl Med 33:752\u2013756","journal-title":"Clin Nucl Med"},{"key":"7342_CR16","doi-asserted-by":"publisher","first-page":"2711","DOI":"10.1016\/j.humpath.2013.07.016","volume":"44","author":"M Houang","year":"2013","unstructured":"Houang M, Clarkson A, Sioson L et al (2013) Phosphaturic mesenchymal tumors show positive staining for somatostatin receptor 2A (SSTR2A). Hum Pathol 44:2711\u20132718","journal-title":"Hum Pathol"},{"key":"7342_CR17","doi-asserted-by":"publisher","first-page":"2028","DOI":"10.1016\/j.ejrad.2013.04.006","volume":"82","author":"H Jing","year":"2013","unstructured":"Jing H, Li F, Zhuang H et al (2013) Effective detection of the tumors causing osteomalacia using [Tc-99m]-HYNIC-octreotide (99mTc-HYNIC-TOC) whole body scan. Eur J Radiol 82:2028\u20132034","journal-title":"Eur J Radiol"},{"key":"7342_CR18","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1016\/j.bone.2014.04.016","volume":"64","author":"S Breer","year":"2014","unstructured":"Breer S, Brunkhorst T, Beil FT et al (2014) Ga-68 DOTA-TATE PET\/CT allows tumor localization in patients with tumor-induced osteomalacia but negative In-111-octreotide SPECT\/CT. Bone 64:222\u2013227","journal-title":"Bone"},{"key":"7342_CR19","doi-asserted-by":"publisher","first-page":"3575","DOI":"10.1210\/jc.2016-2052","volume":"101","author":"D El-Maouche","year":"2016","unstructured":"El-Maouche D, Sadowski SM, Papadakis GZ et al (2016) (68)Ga-DOTATATE for tumor localization in tumor-induced osteomalacia. J Clin Endocrinol Metab 101:3575\u20133581","journal-title":"J Clin Endocrinol Metab"},{"key":"7342_CR20","doi-asserted-by":"publisher","first-page":"1710","DOI":"10.1007\/s00259-018-3971-x","volume":"45","author":"M Paquet","year":"2018","unstructured":"Paquet M, Gauthe M, Zhang Yin J et al (2018) Diagnostic performance and impact on patient management of (68)Ga-DOTA-TOC PET\/CT for detecting osteomalacia-associated tumours. Eur J Nucl Med Mol Imaging 45:1710\u20131720","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"7342_CR21","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.1007\/s00259-008-0755-8","volume":"35","author":"C von Falck","year":"2008","unstructured":"von Falck C, Rodt T, Rosenthal H et al (2008) (68)Ga-DOTANOC PET\/CT for the detection of a mesenchymal tumor causing oncogenic osteomalacia. Eur J Nucl Med Mol Imaging 35:1034","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"7342_CR22","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1007\/s13139-015-0328-2","volume":"49","author":"CL Ho","year":"2015","unstructured":"Ho CL (2015) Ga68-DOTA Peptide PET\/CT to detect occult mesenchymal tumor-inducing osteomalacia: a case series of three patients. Nucl Med Mol Imaging 49:231\u2013236","journal-title":"Nucl Med Mol Imaging"},{"key":"7342_CR23","doi-asserted-by":"publisher","first-page":"1271","DOI":"10.1007\/s00259-012-2123-y","volume":"39","author":"L Kabasakal","year":"2012","unstructured":"Kabasakal L, Demirci E, Ocak M et al (2012) Comparison of (6)(8)Ga-DOTATATE and (6)(8)Ga-DOTANOC PET\/CT imaging in the same patient group with neuroendocrine tumours. Eur J Nucl Med Mol Imaging 39:1271\u20131277","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"7342_CR24","doi-asserted-by":"publisher","first-page":"364","DOI":"10.2967\/jnumed.112.111724","volume":"54","author":"D Wild","year":"2013","unstructured":"Wild D, Bomanji JB, Benkert P et al (2013) Comparison of 68Ga-DOTANOC and 68Ga-DOTATATE PET\/CT within patients with gastroenteropancreatic neuroendocrine tumors. J Nucl Med 54:364\u2013372","journal-title":"J Nucl Med"},{"key":"7342_CR25","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1097\/RLU.0000000000000854","volume":"40","author":"J Zhang","year":"2015","unstructured":"Zhang J, Zhu Z, Zhong D et al (2015) 68Ga DOTATATE PET\/CT is an accurate imaging modality in the detection of culprit tumors causing osteomalacia. Clin Nucl Med 40:642\u2013646","journal-title":"Clin Nucl Med"},{"key":"7342_CR26","doi-asserted-by":"publisher","first-page":"188","DOI":"10.4103\/ijnm.IJNM_14_19","volume":"34","author":"JR John","year":"2019","unstructured":"John JR, Hephzibah J, Oommen R, Shanthly N, Mathew D (2019) Ga-68 DOTATATE positron emission tomography-computed tomography imaging in oncogenic osteomalacia: experience from a tertiary level hospital in South India. Indian J Nucl Med 34:188\u2013193","journal-title":"Indian J Nucl Med"},{"key":"7342_CR27","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1210\/jc.2012-3642","volume":"98","author":"RJ Clifton-Bligh","year":"2013","unstructured":"Clifton-Bligh RJ, Hofman MS, Duncan E et al (2013) Improving diagnosis of tumor-induced osteomalacia with Gallium-68 DOTATATE PET\/CT. J Clin Endocrinol Metab 98:687\u2013694","journal-title":"J Clin Endocrinol Metab"},{"key":"7342_CR28","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1111\/cen.12822","volume":"84","author":"N Bhavani","year":"2016","unstructured":"Bhavani N, Reena Asirvatham A, Kallur K et al (2016) Utility of gallium-68 DOTANOC PET\/CT in the localization of tumour-induced osteomalacia. Clin Endocrinol (Oxf) 84:134\u2013140","journal-title":"Clin Endocrinol (Oxf)"},{"key":"7342_CR29","doi-asserted-by":"publisher","first-page":"20160811","DOI":"10.1259\/bjr.20160811","volume":"90","author":"D Singh","year":"2017","unstructured":"Singh D, Chopra A, Ravina M et al (2017) Oncogenic osteomalacia: role of Ga-68 DOTANOC PET\/CT scan in identifying the culprit lesion and its management. Br J Radiol 90:20160811","journal-title":"Br J Radiol"},{"key":"7342_CR30","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1097\/MNM.0000000000001163","volume":"41","author":"Y Jiang","year":"2020","unstructured":"Jiang Y, Hou G, Cheng W (2020) Performance of 68Ga-DOTA-SST PET\/CT, octreoscan SPECT\/CT and 18F-FDG PET\/CT in the detection of culprit tumors causing osteomalacia: a meta-analysis. Nucl Med Commun 41:370\u2013376","journal-title":"Nucl Med Commun"},{"key":"7342_CR31","doi-asserted-by":"publisher","first-page":"e6","DOI":"10.1097\/RLU.0000000000000460","volume":"40","author":"K Agrawal","year":"2015","unstructured":"Agrawal K, Bhadada S, Mittal BR et al (2015) Comparison of 18F-FDG and 68Ga DOTATATE PET\/CT in localization of tumor causing oncogenic osteomalacia. Clin Nucl Med 40:e6\u2013e10","journal-title":"Clin Nucl Med"},{"key":"7342_CR32","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1097\/RLU.0000000000002290","volume":"43","author":"J Ding","year":"2018","unstructured":"Ding J, Hu G, Wang L, Li F, Huo L (2018) Increased activity due to fractures does not significantly affect the accuracy of 68Ga-DOTATATE PET\/CT in the detection of culprit tumor in the evaluation of tumor-induced osteomalacia. Clin Nucl Med 43:880\u2013886","journal-title":"Clin Nucl Med"},{"key":"7342_CR33","doi-asserted-by":"publisher","first-page":"317","DOI":"10.3109\/01913129109016242","volume":"15","author":"N Weidner","year":"1991","unstructured":"Weidner N (1991) Review and update: oncogenic osteomalacia-rickets. Ultrastruct Pathol 15:317\u2013333","journal-title":"Ultrastruct Pathol"},{"key":"7342_CR34","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/00000478-200401000-00001","volume":"28","author":"AL Folpe","year":"2004","unstructured":"Folpe AL, Fanburg-Smith JC, Billings SD et al (2004) Most osteomalacia-associated mesenchymal tumors are a single histopathologic entity: an analysis of 32 cases and a comprehensive review of the literature. Am J Surg Pathol 28:1\u201330","journal-title":"Am J Surg Pathol"}],"container-title":["European Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00330-020-07342-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00330-020-07342-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00330-020-07342-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,6]],"date-time":"2021-10-06T06:09:13Z","timestamp":1633500553000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00330-020-07342-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,6]]},"references-count":34,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["7342"],"URL":"https:\/\/doi.org\/10.1007\/s00330-020-07342-2","relation":{},"ISSN":["0938-7994","1432-1084"],"issn-type":[{"value":"0938-7994","type":"print"},{"value":"1432-1084","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,6]]},"assertion":[{"value":"9 July 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 August 2020","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 September 2020","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 October 2020","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The scientific guarantor of this publication is Xiangsong Zhang.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Guarantor"}},{"value":"The authors of this manuscript declare no relationships with any companies whose products or services may be related to the subject matter of the article.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"No complex statistical methods were necessary for this paper.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Statistics and biometry"}},{"value":"Written informed consent was waived by the Institutional Review Board.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"Institutional Review Board approval was obtained.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"One study subject has been previously reported in <i>Clin Nucl Med<\/i>. 2018 Jun;43(6):e198\u2013e199.","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Study subjects or cohorts overlap"}},{"value":"\u2022 retrospective\u2022 diagnostic or prognostic study\u2022 performed at one institution","order":8,"name":"Ethics","group":{"name":"EthicsHeading","label":"Methodology"}}]}}