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In this study, occurrence of remote intramedullary signal changes, consistent with WD, and its correlation with clinical and neurophysiological impairment were assessed after traumatic spinal cord injury (tSCI).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>In 35 patients with tSCI, WD was evaluated by two radiologists on T2-weighted images of serial routine MRI examinations of the cervical spine. Dorsal column (DC), lateral corticospinal tract (CS), and lateral spinothalamic tract (ST) were the analyzed anatomical regions. Impairment scoring according to the American Spinal Injury Association Impairment Scale (AIS, A\u2013D) as well as a scoring system (0\u20134 points) for motor evoked potential (MEP) and sensory evoked potential (SEP) was included. Mann-Whitney <jats:italic>U<\/jats:italic> test was used to test for differences.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>WD in the DC occurred in 71.4% (<jats:italic>n<\/jats:italic>\u2009=\u200925), in the CS in 57.1% (<jats:italic>n<\/jats:italic>\u2009=\u200920), and in 37.1% (<jats:italic>n<\/jats:italic>\u2009=\u200913) in the ST. With WD present, AIS grades were worse for all tracts. DC: median AIS B vs D, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001; CS: B vs D, <jats:italic>p<\/jats:italic>\u2009=\u20090.016; and ST: B vs D, <jats:italic>p<\/jats:italic>\u2009=\u20090.015. More pathological MEP scores correlated with WD in the DC (median score 0 vs 3, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and in the CS (0 vs 2, <jats:italic>p<\/jats:italic>\u2009=\u20090.032). SEP scores were lower with WD in the DC only (1 vs 2, <jats:italic>p<\/jats:italic>\u2009=\u20090.031).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>WD can be detected on T2-weighted scans in the majority of cervical spinal cord injury patients and should be considered as a direct effect of the trauma. When observed, it is associated with higher degree of impairment.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Key Points<\/jats:title>\n                <jats:p><jats:italic>\u2022 Wallerian degeneration is commonly seen in routine MRI after traumatic spinal cord injury.<\/jats:italic><\/jats:p>\n                <jats:p><jats:italic>\u2022 Wallerian degeneration is visible in the anatomical regions of the dorsal column, the lateral corticospinal tract, and the lateral spinothalamic tract.<\/jats:italic><\/jats:p>\n                <jats:p><jats:italic>\u2022 Presence of Wallerian degeneration is associated with higher degree of impairment.<\/jats:italic><\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00330-020-07388-2","type":"journal-article","created":{"date-parts":[[2020,10,30]],"date-time":"2020-10-30T14:02:45Z","timestamp":1604066565000},"page":"2923-2932","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Wallerian degeneration in cervical spinal cord tracts is commonly seen in routine T2-weighted MRI after traumatic spinal cord injury and is associated with impairment in a retrospective study"],"prefix":"10.1007","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1807-9146","authenticated-orcid":false,"given":"Tim","family":"Fischer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Stern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Freund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Schubert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reto","family":"Sutter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,10,30]]},"reference":[{"key":"7388_CR1","doi-asserted-by":"publisher","first-page":"e51729","DOI":"10.1371\/journal.pone.0051729","volume":"7","author":"P Freund","year":"2012","unstructured":"Freund P, Schneider T, Nagy Z et al (2012) Degeneration of the injured cervical cord is associated with remote changes in corticospinal tract integrity and upper limb impairment. 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