{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T21:35:45Z","timestamp":1791495345010,"version":"4.3.4"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2020,11,19]],"date-time":"2020-11-19T00:00:00Z","timestamp":1605744000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,11,19]],"date-time":"2020-11-19T00:00:00Z","timestamp":1605744000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Radiol"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1007\/s00330-020-07483-4","type":"journal-article","created":{"date-parts":[[2020,11,19]],"date-time":"2020-11-19T06:02:52Z","timestamp":1605765772000},"page":"4042-4052","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":78,"title":["MRI-Based radiomics nomogram for differentiation of benign and malignant lesions of the parotid gland"],"prefix":"10.1007","volume":"31","author":[{"given":"Ying-mei","family":"Zheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiu-fa","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-feng","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Pang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui-zhi","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-li","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1903-2291","authenticated-orcid":false,"given":"Cheng","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,11,19]]},"reference":[{"key":"7483_CR1","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1007\/s00405-008-0882-7","volume":"266","author":"M Stenner","year":"2009","unstructured":"Stenner M, Klussmann JP (2009) Current update on established and novel biomarkers in salivary gland carcinoma pathology and the molecular pathways involved. Eur Arch Otorhinolaryngol 266:333\u2013341","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"7483_CR2","first-page":"135","volume":"31","author":"F Bussu","year":"2011","unstructured":"Bussu F, Parrilla C, Rizzo D, Almadori G, Paludetti G, Galli J (2011) Clinical approach and treatment of benign and malignant parotid masses, personal experience. Acta Otorhinolaryngol Ital 31:135\u2013143","journal-title":"Acta Otorhinolaryngol Ital"},{"key":"7483_CR3","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1016\/j.jcms.2004.05.004","volume":"32","author":"N Papadogeorgakis","year":"2004","unstructured":"Papadogeorgakis N, Skouteris CA, Mylonas AI, Angelopoulos AP (2004) Superficial parotidectomy: technical modifications based on tumour characteristics. J Craniomaxillofac Surg 32:350\u2013353","journal-title":"J Craniomaxillofac Surg"},{"key":"7483_CR4","doi-asserted-by":"publisher","first-page":"1989","DOI":"10.1097\/00005537-200111000-00023","volume":"111","author":"P Zbaren","year":"2001","unstructured":"Zbaren P, Schar C, Hotz MA, Loosli H (2001) Value of fine-needle aspiration cytology of parotid gland masses. Laryngoscope 111:1989\u20131992","journal-title":"Laryngoscope"},{"key":"7483_CR5","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1097\/00005537-200404000-00041","volume":"114","author":"B Sergi","year":"2004","unstructured":"Sergi B, Contucci AM, Corina L, Paludetti G (2004) Value of fine-needle aspiration cytology of parotid gland masses. Laryngoscope 114:789","journal-title":"Laryngoscope"},{"key":"7483_CR6","doi-asserted-by":"publisher","first-page":"1958","DOI":"10.1007\/s00330-010-1756-0","volume":"20","author":"KS Bhatia","year":"2010","unstructured":"Bhatia KS, Rasalkar DD, Lee YP et al (2010) Evaluation of real-time qualitative sonoelastography of focal lesions in the parotid and submandibular glands: applications and limitations. Eur Radiol 20:1958\u20131964","journal-title":"Eur Radiol"},{"key":"7483_CR7","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/j.ejrad.2008.01.027","volume":"66","author":"YY Lee","year":"2008","unstructured":"Lee YY, Wong KT, King AD, Ahuja AT (2008) Imaging of salivary gland tumours. Eur J Radiol 66:419\u2013436","journal-title":"Eur J Radiol"},{"key":"7483_CR8","doi-asserted-by":"publisher","first-page":"591","DOI":"10.3174\/ajnr.A1412","volume":"30","author":"CR Habermann","year":"2009","unstructured":"Habermann CR, Arndt C, Graessner J et al (2009) Diffusion-weighted echo-planar MR imaging of primary parotid gland tumors: is a prediction of different histologic subtypes possible? AJNR Am J Neuroradiol 30:591\u2013596","journal-title":"AJNR Am J Neuroradiol"},{"key":"7483_CR9","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1148\/radiol.2015151169","volume":"278","author":"RJ Gillies","year":"2016","unstructured":"Gillies RJ, Kinahan PE, Hricak H (2016) Radiomics: images are more than pictures, they are data. Radiology 278:563\u2013577","journal-title":"Radiology"},{"key":"7483_CR10","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1016\/j.ejca.2011.11.036","volume":"48","author":"P Lambin","year":"2012","unstructured":"Lambin P, Rios-Velazquez E, Leijenaar R et al (2012) Radiomics: extracting more information from medical images using advanced feature analysis. Eur J Cancer 48:441\u2013446","journal-title":"Eur J Cancer"},{"key":"7483_CR11","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.3174\/ajnr.A4285","volume":"36","author":"K Buch","year":"2015","unstructured":"Buch K, Fujita A, Li B, Kawashima Y, Qureshi MM, Sakai O (2015) Using texture analysis to determine human papillomavirus status of oropharyngeal squamous cell carcinomas on CT. AJNR Am J Neuroradiol 36:1343\u20131348","journal-title":"AJNR Am J Neuroradiol"},{"key":"7483_CR12","doi-asserted-by":"publisher","first-page":"2604","DOI":"10.1007\/s00330-017-5214-0","volume":"28","author":"E Al Ajmi","year":"2018","unstructured":"Al Ajmi E, Forghani B, Reinhold C, Bayat M, Forghani R (2018) Spectral multi-energy CT texture analysis with machine learning for tissue classification: an investigation using classification of benign parotid tumours as a testing paradigm. Eur Radiol 28:2604\u20132611","journal-title":"Eur Radiol"},{"key":"7483_CR13","doi-asserted-by":"publisher","first-page":"1372","DOI":"10.1002\/nbm.2962","volume":"26","author":"J Fruehwald-Pallamar","year":"2013","unstructured":"Fruehwald-Pallamar J, Czerny C, Holzer-Fruehwald L et al (2013) Texture-based and diffusion-weighted discrimination of parotid gland lesions on MR images at 3.0 Tesla. NMR Biomed 26:1372\u20131379","journal-title":"NMR Biomed"},{"key":"7483_CR14","doi-asserted-by":"publisher","first-page":"1202","DOI":"10.3174\/ajnr.A2520","volume":"32","author":"A Christe","year":"2011","unstructured":"Christe A, Waldherr C, Hallett R, Zbaeren P, Thoeny H (2011) MR imaging of parotid tumors: typical lesion characteristics in MR imaging improve discrimination between benign and malignant disease. AJNR Am J Neuroradiol 32:1202\u20131207","journal-title":"AJNR Am J Neuroradiol"},{"key":"7483_CR15","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.mri.2003.09.001","volume":"22","author":"G Collewet","year":"2004","unstructured":"Collewet G, Strzelecki M, Mariette F (2004) Influence of MRI acquisition protocols and image intensity normalization methods on texture classification. Magn Reson Imaging 22:81\u201391","journal-title":"Magn Reson Imaging"},{"key":"7483_CR16","doi-asserted-by":"publisher","first-page":"1310","DOI":"10.1109\/TMI.2010.2046908","volume":"29","author":"NJ Tustison","year":"2010","unstructured":"Tustison NJ, Avants BB, Cook PA et al (2010) N4ITK: improved N3 bias correction. IEEE Trans Med Imaging 29:1310\u20131320","journal-title":"IEEE Trans Med Imaging"},{"key":"7483_CR17","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.media.2013.10.005","volume":"18","author":"A Depeursinge","year":"2014","unstructured":"Depeursinge A, Foncubierta-Rodriguez A, Van De Ville D, Muller H (2014) Three-dimensional solid texture analysis in biomedical imaging: review and opportunities. Med Image Anal 18:176\u2013196","journal-title":"Med Image Anal"},{"key":"7483_CR18","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.mbs.2018.06.004","volume":"303","author":"R Alhamzawi","year":"2018","unstructured":"Alhamzawi R, Ali HTM (2018) The Bayesian adaptive lasso regression. Math Biosci 303:75\u201382","journal-title":"Math Biosci"},{"issue":"Suppl 4","key":"7483_CR19","doi-asserted-by":"publisher","first-page":"L25","DOI":"10.1007\/s00330-003-1999-0","volume":"13","author":"M Okahara","year":"2003","unstructured":"Okahara M, Kiyosue H, Hori Y, Matsumoto A, Mori H, Yokoyama S (2003) Parotid tumors: MR imaging with pathological correlation. Eur Radiol 13(Suppl 4):L25\u2013L33","journal-title":"Eur Radiol"},{"key":"7483_CR20","doi-asserted-by":"publisher","first-page":"1577","DOI":"10.2214\/ajr.176.6.1761577","volume":"176","author":"S Takashima","year":"2001","unstructured":"Takashima S, Wang J, Takayama F et al (2001) Parotid masses: prediction of malignancy using magnetization transfer and MR imaging findings. AJR Am J Roentgenol 176:1577\u20131584","journal-title":"AJR Am J Roentgenol"},{"key":"7483_CR21","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1007\/s00330-018-5609-6","volume":"29","author":"YF Zhang","year":"2019","unstructured":"Zhang YF, Li H, Wang XM, Cai YF (2019) Sonoelastography for differential diagnosis between malignant and benign parotid lesions: a meta-analysis. Eur Radiol 29:725\u2013735","journal-title":"Eur Radiol"},{"key":"7483_CR22","doi-asserted-by":"publisher","first-page":"e17042","DOI":"10.1097\/MD.0000000000017042","volume":"98","author":"JH Hwang","year":"2019","unstructured":"Hwang JH, Kim DW, Kim KS, Lee SY (2019) Mucosa-associated lymphoid tissue lymphoma of the accessory parotid gland presenting as a simple cheek mass: a case report. Medicine (Baltimore) 98:e17042","journal-title":"Medicine (Baltimore)"},{"key":"7483_CR23","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1309\/AJCPOIE0CZNAT6SQ","volume":"136","author":"RL Schmidt","year":"2011","unstructured":"Schmidt RL, Hall BJ, Wilson AR, Layfield LJ (2011) A systematic review and meta-analysis of the diagnostic accuracy of fine-needle aspiration cytology for parotid gland lesions. Am J Clin Pathol 136:45\u201359","journal-title":"Am J Clin Pathol"},{"key":"7483_CR24","doi-asserted-by":"publisher","first-page":"32","DOI":"10.11152\/mu-923","volume":"19","author":"V Cantisani","year":"2017","unstructured":"Cantisani V, David E, De Virgilio A et al (2017) Prospective evaluation of quasistatic ultrasound elastography (USE) compared with baseline US for parotid gland lesions: preliminary results of elasticity contrast index (ECI) evaluation. Med Ultrason 19:32\u201338","journal-title":"Med Ultrason"},{"key":"7483_CR25","first-page":"166","volume":"38","author":"N Mansour","year":"2017","unstructured":"Mansour N, Bas M, Stock KF, Strassen U, Hofauer B, Knopf A (2017) Multimodal ultrasonographic pathway of parotid gland lesions. Ultraschall Med 38:166\u2013173","journal-title":"Ultraschall Med"},{"key":"7483_CR26","doi-asserted-by":"publisher","first-page":"77","DOI":"10.7863\/ultra.16.02038","volume":"36","author":"NK Altinbas","year":"2017","unstructured":"Altinbas NK, Gundogdu Anamurluoglu E, Oz II et al (2017) Real-time sonoelastography of parotid gland tumors. J Ultrasound Med 36:77\u201387","journal-title":"J Ultrasound Med"},{"key":"7483_CR27","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1148\/radiol.2262011486","volume":"226","author":"H Yabuuchi","year":"2003","unstructured":"Yabuuchi H, Fukuya T, Tajima T, Hachitanda Y, Tomita K, Koga M (2003) Salivary gland tumors: diagnostic value of gadolinium-enhanced dynamic MR imaging with histopathologic correlation. Radiology 226:345\u2013354","journal-title":"Radiology"},{"key":"7483_CR28","doi-asserted-by":"publisher","first-page":"e160","DOI":"10.1055\/s-0039-1697005","volume":"24","author":"M Niazi","year":"2020","unstructured":"Niazi M, Mohammadzadeh M, Aghazadeh K et al (2020) Perfusion computed tomography scan imaging in differentiation of benign from malignant parotid lesions. Int Arch Otorhinolaryngol 24:e160\u2013e169","journal-title":"Int Arch Otorhinolaryngol"},{"key":"7483_CR29","doi-asserted-by":"publisher","first-page":"1692","DOI":"10.1007\/s00330-011-2101-y","volume":"21","author":"GQ Jin","year":"2011","unstructured":"Jin GQ, Su DK, Xie D, Zhao W, Liu LD, Zhu XN (2011) Distinguishing benign from malignant parotid gland tumours: low-dose multi-phasic CT protocol with 5-minute delay. Eur Radiol 21:1692\u20131698","journal-title":"Eur Radiol"},{"key":"7483_CR30","doi-asserted-by":"publisher","first-page":"1602","DOI":"10.1007\/s003300050894","volume":"9","author":"SK Morcos","year":"1999","unstructured":"Morcos SK, Thomsen HS, Webb JA (1999) Contrast-media-induced nephrotoxicity: a consensus report. Contrast Media Safety Committee, European Society of Urogenital Radiology (ESUR). Eur Radiol 9:1602\u20131613","journal-title":"Eur Radiol"},{"key":"7483_CR31","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1007\/s00330-012-2597-9","volume":"23","author":"HS Thomsen","year":"2013","unstructured":"Thomsen HS, Morcos SK, Almen T et al (2013) Nephrogenic systemic fibrosis and gadolinium-based contrast media: updated ESUR Contrast Medium Safety Committee guidelines. Eur Radiol 23:307\u2013318","journal-title":"Eur Radiol"},{"key":"7483_CR32","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.ejrad.2017.08.013","volume":"95","author":"K Takumi","year":"2017","unstructured":"Takumi K, Fukukura Y, Hakamada H, Ideue J, Kumagae Y, Yoshiura T (2017) Value of diffusion tensor imaging in differentiating malignant from benign parotid gland tumors. Eur J Radiol 95:249\u2013256","journal-title":"Eur J Radiol"},{"key":"7483_CR33","doi-asserted-by":"publisher","first-page":"20190100","DOI":"10.1259\/dmfr.20190100","volume":"48","author":"Z Zhang","year":"2019","unstructured":"Zhang Z, Song C, Zhang Y, Wen B, Zhu J, Cheng J (2019) Apparent diffusion coefficient (ADC) histogram analysis: differentiation of benign from malignant parotid gland tumors using readout-segmented diffusion-weighted imaging. Dentomaxillofac Radiol 48:20190100","journal-title":"Dentomaxillofac Radiol"},{"key":"7483_CR34","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1148\/radiol.2493072045","volume":"249","author":"H Yabuuchi","year":"2008","unstructured":"Yabuuchi H, Matsuo Y, Kamitani T et al (2008) Parotid gland tumors: can addition of diffusion-weighted MR imaging to dynamic contrast-enhanced MR imaging improve diagnostic accuracy in characterization? Radiology 249:909\u2013916","journal-title":"Radiology"},{"key":"7483_CR35","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.amjoto.2016.09.002","volume":"38","author":"P Milad","year":"2017","unstructured":"Milad P, Elbegiermy M, Shokry T et al (2017) The added value of pretreatment DW MRI in characterization of salivary glands pathologies. Am J Otolaryngol 38:13\u201320","journal-title":"Am J Otolaryngol"},{"key":"7483_CR36","doi-asserted-by":"publisher","first-page":"1274","DOI":"10.1007\/s00330-019-06427-x","volume":"30","author":"P Nie","year":"2020","unstructured":"Nie P, Yang G, Wang Z et al (2020) A CT-based radiomics nomogram for differentiation of renal angiomyolipoma without visible fat from homogeneous clear cell renal cell carcinoma. Eur Radiol 30:1274\u20131284","journal-title":"Eur Radiol"},{"key":"7483_CR37","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1002\/jmri.26818","volume":"51","author":"H Wang","year":"2020","unstructured":"Wang H, Nie P, Wang Y et al (2020) Radiomics nomogram for differentiating between benign and malignant soft-tissue masses of the extremities. J Magn Reson Imaging 51:155\u2013163","journal-title":"J Magn Reson Imaging"},{"key":"7483_CR38","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1002\/jmri.26901","volume":"51","author":"H Wang","year":"2020","unstructured":"Wang H, Chen H, Duan S, Hao D, Liu J (2020) Radiomics and machine learning with multiparametric preoperative MRI may accurately predict the histopathological grades of soft tissue sarcomas. J Magn Reson Imaging 51:791\u2013797","journal-title":"J Magn Reson Imaging"},{"key":"7483_CR39","first-page":"195","volume":"188","author":"J Fruehwald-Pallamar","year":"2016","unstructured":"Fruehwald-Pallamar J, Hesselink JR, Mafee MF, Holzer-Fruehwald L, Czerny C, Mayerhoefer ME (2016) Texture-based analysis of 100 MR examinations of head and neck tumors - is it possible to discriminate between benign and malignant masses in a multicenter trial? Rofo 188:195\u2013202","journal-title":"Rofo"}],"container-title":["European Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00330-020-07483-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00330-020-07483-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00330-020-07483-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,17]],"date-time":"2021-05-17T15:06:55Z","timestamp":1621264015000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00330-020-07483-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,19]]},"references-count":39,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["7483"],"URL":"https:\/\/doi.org\/10.1007\/s00330-020-07483-4","relation":{},"ISSN":["0938-7994","1432-1084"],"issn-type":[{"value":"0938-7994","type":"print"},{"value":"1432-1084","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,19]]},"assertion":[{"value":"13 July 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 August 2020","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 November 2020","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 November 2020","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The scientific guarantor of this publication is Wen-jian Xu.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Guarantor"}},{"value":"The authors declare that they have no conflict of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"One of the authors (Jian Li) has significant statistical expertise.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Statistics and biometry"}},{"value":"Written informed consent was obtained from all subjects (patients) in this study.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"Institutional Review Board approval was obtained.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"\u2022 retrospective\u2022 diagnostic study\/observational\u2022 multicenter study","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Methodology"}}]}}