{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T12:17:08Z","timestamp":1789301828255,"version":"build-2803163510"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2021,4,18]],"date-time":"2021-04-18T00:00:00Z","timestamp":1618704000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,4,18]],"date-time":"2021-04-18T00:00:00Z","timestamp":1618704000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"name":"VHS Medical Center Research Grant","award":["VHSMC 20012"],"award-info":[{"award-number":["VHSMC 20012"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Radiol"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1007\/s00330-021-07954-2","type":"journal-article","created":{"date-parts":[[2021,4,18]],"date-time":"2021-04-18T01:02:37Z","timestamp":1618707757000},"page":"7684-7695","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["MRI features of symptomatic amputation neuromas"],"prefix":"10.1007","volume":"31","author":[{"given":"Bo Mi","family":"Chung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guen Young","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan Tae","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Injoong","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4155-9260","authenticated-orcid":false,"given":"Sung Bin","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,4,18]]},"reference":[{"key":"7954_CR1","doi-asserted-by":"publisher","first-page":"20160572","DOI":"10.1259\/bjr.20160572","volume":"89","author":"N Subedi","year":"2016","unstructured":"Subedi N, Heire P, Parmer V et al (2016) Multimodality imaging review of the post-amputation stump pain. Br J Radiol 89:20160572","journal-title":"Br J Radiol"},{"key":"7954_CR2","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1097\/j.pain.0000000000001705","volume":"161","author":"NS Buch","year":"2020","unstructured":"Buch NS, Qerama E, Brix Finnerup N, Nikolajsen L (2020) Neuromas and postamputation pain. Pain 161:147\u2013155","journal-title":"Pain"},{"key":"7954_CR3","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1097\/AJP.0b013e318261c9f9","volume":"29","author":"C Clarke","year":"2013","unstructured":"Clarke C, Lindsay DR, Pyati S, Buchheit T (2013) Residual limb pain is not a diagnosis: a proposed algorithm to classify postamputation pain. Clin J Pain 29:551\u2013562","journal-title":"Clin J Pain"},{"key":"7954_CR4","first-page":"1068.e1061","volume":"71","author":"MA O\u2019Reilly","year":"2016","unstructured":"O\u2019Reilly MA, O\u2019Reilly PM, Sheahan JN, Sullivan J, O\u2019Reilly HM, O'Reilly MJ (2016) Neuromas as the cause of pain in the residual limbs of amputees. An ultrasound study. Clin Radiol 71:1068.e1061\u20131068.e1066","journal-title":"Clin Radiol"},{"key":"7954_CR5","doi-asserted-by":"publisher","first-page":"e0200548","DOI":"10.1371\/journal.pone.0200548","volume":"13","author":"KMC Oliveira","year":"2018","unstructured":"Oliveira KMC, Pindur L, Han Z, Bhavsar MB, Barker JH, Leppik L (2018) Time course of traumatic neuroma development. PLoS One 13:e0200548","journal-title":"PLoS One"},{"key":"7954_CR6","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1007\/BF00191667","volume":"19","author":"RD Singson","year":"1990","unstructured":"Singson RD, Feldman F, Staron R, Fechtner D, Gonzalez E, Stein J (1990) MRI of postamputation neuromas. Skeletal Radiol 19:259\u2013262","journal-title":"Skeletal Radiol"},{"key":"7954_CR7","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1097\/AJP.0b013e31823d30a2","volume":"28","author":"K Rajput","year":"2012","unstructured":"Rajput K, Reddy S, Shankar H (2012) Painful neuromas. Clin J Pain 28:639\u2013645","journal-title":"Clin J Pain"},{"key":"7954_CR8","doi-asserted-by":"publisher","first-page":"1204","DOI":"10.1007\/s00330-015-3907-9","volume":"26","author":"S Ahlawat","year":"2016","unstructured":"Ahlawat S, Belzberg AJ, Montgomery EA, Fayad LM (2016) MRI features of peripheral traumatic neuromas. Eur Radiol 26:1204\u20131212","journal-title":"Eur Radiol"},{"key":"7954_CR9","doi-asserted-by":"crossref","unstructured":"Henrot P, Stines J, Walter F, Martinet N, Paysant J, Blum A (2000) Imaging of the painful lower limb stump. Radiographics 20(SpecNo):S219\u2013S235","DOI":"10.1148\/radiographics.20.suppl_1.g00oc14s219"},{"key":"7954_CR10","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.3174\/ajnr.A2002","volume":"31","author":"A Chhabra","year":"2010","unstructured":"Chhabra A, Williams EH, Wang KC, Dellon AL, Carrino JA (2010) MR neurography of neuromas related to nerve injury and entrapment with surgical correlation. AJNR Am J Neuroradiol 31:1363\u20131368","journal-title":"AJNR Am J Neuroradiol"},{"key":"7954_CR11","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1007\/s13244-013-0255-7","volume":"4","author":"FR Van den Bergh","year":"2013","unstructured":"Van den Bergh FR, Vanhoenacker FM, De Smet E, Huysse W, Verstraete KL (2013) Peroneal nerve: normal anatomy and pathologic findings on routine MRI of the knee. Insights Imaging 4:287\u2013299","journal-title":"Insights Imaging"},{"key":"7954_CR12","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1177\/0284185113494983","volume":"55","author":"V Wadhwa","year":"2014","unstructured":"Wadhwa V, Lee PP, Strome GM, Suh KJ, Carrino JA, Chhabra A (2014) Spectrum of superficial nerve-related tumor and tumor-like lesions: MRI features. Acta Radiol 55:345\u2013358","journal-title":"Acta Radiol"},{"key":"7954_CR13","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1177\/1534734616657964","volume":"15","author":"M Buntragulpoontawee","year":"2016","unstructured":"Buntragulpoontawee M, Pattamapaspong N, Tongprasert S (2016) Multiple neuromas cause painful \u201cjumping stump\u201d in a transfemoral amputee: a case report. Int J Low Extrem Wounds 15:271\u2013273","journal-title":"Int J Low Extrem Wounds"},{"key":"7954_CR14","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1097\/00004728-199007000-00028","volume":"14","author":"JF Donnal","year":"1990","unstructured":"Donnal JF, Blinder RA, Coblentz CL, Moylan JA, Fitzpatrick KP (1990) MR imaging of stump neuroma. J Comput Assist Tomogr 14:656\u2013657","journal-title":"J Comput Assist Tomogr"},{"key":"7954_CR15","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1515\/revneuro-2017-0077","volume":"29","author":"C Lu","year":"2018","unstructured":"Lu C, Sun X, Wang C, Wang Y, Peng J (2018) Mechanisms and treatment of painful neuromas. Rev Neurosci 29:557\u2013566","journal-title":"Rev Neurosci"},{"key":"7954_CR16","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1097\/SAP.0000000000001796","volume":"82","author":"DMJ Arnold","year":"2019","unstructured":"Arnold DMJ, Wilkens SC, Coert JH, Chen NC, Ducic I, Eberlin KR (2019) Diagnostic criteria for symptomatic neuroma. Ann Plast Surg 82:420\u2013427","journal-title":"Ann Plast Surg"},{"key":"7954_CR17","unstructured":"Manaster BJ (2016) Diagnostic imaging musculoskeletal non-traumatic disease, 2nd edn. Elsevier"},{"key":"7954_CR18","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1016\/j.mehy.2008.05.010","volume":"71","author":"R Foltan","year":"2008","unstructured":"Foltan R, Klima K, Spackova J, Sedy J (2008) Mechanism of traumatic neuroma development. Med Hypotheses 71:572\u2013576","journal-title":"Med Hypotheses"},{"key":"7954_CR19","unstructured":"Avneesh C, Gustav A (2012) Magnetic resonance neurography, 1st edn. Jaypee brothers medical Pub"},{"key":"7954_CR20","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.ejrad.2011.04.036","volume":"82","author":"E Abreu","year":"2013","unstructured":"Abreu E, Aubert S, Wavreille G, Gheno R, Canella C, Cotten A (2013) Peripheral tumor and tumor-like neurogenic lesions. Eur J Radiol 82:38\u201350","journal-title":"Eur J Radiol"},{"key":"7954_CR21","doi-asserted-by":"publisher","first-page":"60","DOI":"10.5292\/jkbjts.2014.20.2.60","volume":"20","author":"JI Kim","year":"2014","unstructured":"Kim JI, Kim UJ, Moon TY, Lee IS, Song YS, Choi KU (2014) Diagnostic value of MRI in Schwannoma. J Korean Bone Joint Tumor Soc 20:60\u201365","journal-title":"J Korean Bone Joint Tumor Soc"},{"key":"7954_CR22","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1227\/01.NEU.0000069534.43067.28","volume":"53","author":"BD Aagaard","year":"2003","unstructured":"Aagaard BD, Lazar DA, Lankerovich L et al (2003) High-resolution magnetic resonance imaging is a noninvasive method of observing injury and recovery in the peripheral nervous system. Neurosurgery 53:199\u2013203 discussion 203-194","journal-title":"Neurosurgery"},{"key":"7954_CR23","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1148\/radiol.11110911","volume":"262","author":"CD Liao","year":"2012","unstructured":"Liao CD, Zhang F, Guo RM et al (2012) Peripheral nerve repair: monitoring by using gadofluorine M-enhanced MR imaging with chitosan nerve conduits with cultured mesenchymal stem cells in rat model of neurotmesis. Radiology 262:161\u2013171","journal-title":"Radiology"},{"key":"7954_CR24","doi-asserted-by":"publisher","first-page":"177","DOI":"10.3174\/ajnr.A5437","volume":"39","author":"BJ Hill","year":"2018","unstructured":"Hill BJ, Padgett KR, Kalra V et al (2018) Gadolinium DTPA enhancement characteristics of the rat sciatic nerve after crush injury at 4.7T. AJNR Am J Neuroradiol 39:177\u2013183","journal-title":"AJNR Am J Neuroradiol"},{"key":"7954_CR25","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.retram.2016.09.003","volume":"64","author":"B Hinz","year":"2016","unstructured":"Hinz B (2016) The role of myofibroblasts in wound healing. Curr Res Transl Med 64:171\u2013177","journal-title":"Curr Res Transl Med"},{"key":"7954_CR26","doi-asserted-by":"publisher","first-page":"2730","DOI":"10.1091\/mbc.12.9.2730","volume":"12","author":"B Hinz","year":"2001","unstructured":"Hinz B, Celetta G, Tomasek JJ, Gabbiani G, Chaponnier C (2001) Alpha-smooth muscle actin expression upregulates fibroblast contractile activity. Mol Biol Cell 12:2730\u20132741","journal-title":"Mol Biol Cell"},{"key":"7954_CR27","doi-asserted-by":"publisher","first-page":"2791","DOI":"10.1089\/neu.2012.2502","volume":"29","author":"H Yan","year":"2012","unstructured":"Yan H, Gao W, Pan Z, Zhang F, Fan C (2012) The expression of alpha-SMA in the painful traumatic neuroma: potential role in the pathobiology of neuropathic pain. J Neurotrauma 29:2791\u20132797","journal-title":"J Neurotrauma"},{"key":"7954_CR28","doi-asserted-by":"publisher","first-page":"23828","DOI":"10.1038\/srep23828","volume":"6","author":"W Weng","year":"2016","unstructured":"Weng W, Zhao B, Lin D, Gao W, Li Z, Yan H (2016) Significance of alpha smooth muscle actin expression in traumatic painful neuromas: a pilot study in rats. Sci Rep 6:23828","journal-title":"Sci Rep"},{"issue":"Suppl 3","key":"7954_CR29","doi-asserted-by":"publisher","first-page":"S43","DOI":"10.1016\/j.injury.2008.05.015","volume":"39","author":"AF Mavrogenis","year":"2008","unstructured":"Mavrogenis AF, Pavlakis K, Stamatoukou A et al (2008) Current treatment concepts for neuromas-in-continuity. Injury 39(Suppl 3):S43\u2013S48","journal-title":"Injury"},{"key":"7954_CR30","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1097\/AJP.0b013e31818b2b12","volume":"25","author":"H Shankar","year":"2009","unstructured":"Shankar H (2009) Ultrasound demonstration of vascularity changes with changes in pain perception in a stump neuroma. Clin J Pain 25:253\u2013255","journal-title":"Clin J Pain"},{"key":"7954_CR31","doi-asserted-by":"publisher","first-page":"369","DOI":"10.2106\/00004623-197658030-00013","volume":"58","author":"JH Herndon","year":"1976","unstructured":"Herndon JH, Eaton RG, Littler JW (1976) Management of painful neuromas in the hand. J Bone Joint Surg Am 58:369\u2013373","journal-title":"J Bone Joint Surg Am"},{"key":"7954_CR32","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1097\/01.prs.0000299281.57480.77","volume":"121","author":"I Ducic","year":"2008","unstructured":"Ducic I, Mesbahi AN, Attinger CE, Graw K (2008) The role of peripheral nerve surgery in the treatment of chronic pain associated with amputation stumps. Plast Reconstr Surg 121:908\u2013914 discussion 915-907","journal-title":"Plast Reconstr Surg"},{"key":"7954_CR33","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1097\/01.SAP.0000054187.72439.57","volume":"51","author":"H Koch","year":"2003","unstructured":"Koch H, Haas F, Hubmer M, Rappl T, Scharnagl E (2003) Treatment of painful neuroma by resection and nerve stump transplantation into a vein. Ann Plast Surg 51:45\u201350","journal-title":"Ann Plast Surg"},{"key":"7954_CR34","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1177\/107110070402500706","volume":"25","author":"H Koch","year":"2004","unstructured":"Koch H, Hubmer M, Welkerling H, Sandner-Kiesling A, Scharnagl E (2004) The treatment of painful neuroma on the lower extremity by resection and nerve stump transplantation into a vein. Foot Ankle Int 25:476\u2013481","journal-title":"Foot Ankle Int"}],"container-title":["European Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00330-021-07954-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00330-021-07954-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00330-021-07954-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,20]],"date-time":"2021-09-20T19:00:38Z","timestamp":1632164438000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00330-021-07954-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,18]]},"references-count":34,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["7954"],"URL":"https:\/\/doi.org\/10.1007\/s00330-021-07954-2","relation":{},"ISSN":["0938-7994","1432-1084"],"issn-type":[{"value":"0938-7994","type":"print"},{"value":"1432-1084","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,18]]},"assertion":[{"value":"30 January 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 March 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 March 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 April 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The scientific guarantor of this publication is Sung Bin Park.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Guarantor"}},{"value":"The authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"One of the authors has significant statistical expertise. (Young Lee, Veterans Medical Research Institute).","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Statistics and biometry"}},{"value":"Written informed consent was waived by the Institutional Review Board.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"Institutional Review Board approval was obtained.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"\u2022 Retrospective\u2022 Observational\u2022 Performed at one institution","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Methodology"}}]}}