{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T08:55:27Z","timestamp":1790326527313,"version":"4.1.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2021,4,21]],"date-time":"2021-04-21T00:00:00Z","timestamp":1618963200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,4,21]],"date-time":"2021-04-21T00:00:00Z","timestamp":1618963200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Radiol"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1007\/s00330-021-07955-1","type":"journal-article","created":{"date-parts":[[2021,4,21]],"date-time":"2021-04-21T09:06:11Z","timestamp":1618995971000},"page":"8606-8614","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Validation of functional liver imaging scores (FLIS) derived from gadoxetic acid\u2013enhanced MRI in patients with chronic liver disease and liver cirrhosis: the relationship between Child-Pugh score and FLIS"],"prefix":"10.1007","volume":"31","author":[{"given":"Ho Jun","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1731-0430","authenticated-orcid":false,"given":"Seung Baek","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nam Kyung","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suk","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyung Il","family":"Seo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Uk","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Yong","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ki Suk","family":"Choo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,4,21]]},"reference":[{"key":"7955_CR1","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1586\/17474124.2014.876359","volume":"8","author":"A Ba-Ssalamah","year":"2014","unstructured":"Ba-Ssalamah A, Qayyum A, Bastati N, Fakhrai N, Herold CJ, Caseiro Alves F (2014) P4 radiology of hepatobiliary diseases with gadoxetic acid-enhanced MRI as a biomarker. Expert Rev Gastroenterol Hepatol 8:147\u2013160","journal-title":"Expert Rev Gastroenterol Hepatol"},{"key":"7955_CR2","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.1007\/s00535-012-0571-6","volume":"47","author":"T Inoue","year":"2012","unstructured":"Inoue T, Kudo M, Komuta M et al (2012) Assessment of Gd-EOB-DTPA-enhanced MRI for HCC and dysplastic nodules and comparison of detection sensitivity versus MDCT. J Gastroenterol 47:1036\u20131047","journal-title":"J Gastroenterol"},{"key":"7955_CR3","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1111\/apt.12166","volume":"37","author":"A Granito","year":"2013","unstructured":"Granito A, Galassi M, Piscaglia F et al (2013) Impact of gadoxetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance on the non-invasive diagnosis of small hepatocellular carcinoma: a prospective study. Aliment Pharmacol Ther 37:355\u2013363","journal-title":"Aliment Pharmacol Ther"},{"key":"7955_CR4","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1016\/j.jhep.2012.01.031","volume":"57","author":"BE Van Beers","year":"2012","unstructured":"Van Beers BE, Pastor CM, Hussain HK (2012) Primovist, Eovist: what to expect? J Hepatol 57:421\u2013429","journal-title":"J Hepatol"},{"key":"7955_CR5","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1148\/radiol.11100586","volume":"260","author":"A Yamada","year":"2011","unstructured":"Yamada A, Hara T, Li F et al (2011) Quantitative evaluation of liver function with use of gadoxetate disodium-enhanced MR imaging. Radiology 260:727\u2013733","journal-title":"Radiology"},{"key":"7955_CR6","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1148\/radiol.13130210","volume":"269","author":"A Wibmer","year":"2013","unstructured":"Wibmer A, Prusa AM, Nolz R, Gruenberger T, Schindl M, Ba-Ssalamah A (2013) Liver failure after major liver resection: risk assessment by using preoperative gadoxetic acid-enhanced 3-T MR imaging. Radiology 269:777\u2013786","journal-title":"Radiology"},{"key":"7955_CR7","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1007\/s00330-014-3108-y","volume":"24","author":"N Verloh","year":"2014","unstructured":"Verloh N, Haimerl M, Zeman F et al (2014) Assessing liver function by liver enhancement during the hepatobiliary phase with Gd-EOB-DTPA-enhanced MRI at 3 Tesla. Eur Radiol 24:1013\u20131019","journal-title":"Eur Radiol"},{"key":"7955_CR8","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1002\/jmri.25518","volume":"45","author":"A Ba-Ssalamah","year":"2017","unstructured":"Ba-Ssalamah A, Bastati N, Wibmer A et al (2017) Hepatic gadoxetic acid uptake as a measure of diffuse liver disease: where are we? J Magn Reson Imaging 45:646\u2013659","journal-title":"J Magn Reson Imaging"},{"key":"7955_CR9","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1097\/RLI.0000000000000286","volume":"51","author":"N Bastati","year":"2016","unstructured":"Bastati N, Wibmer A, Tamandl D et al (2016) Assessment of orthotopic liver transplant graft survival on gadoxetic acid-enhanced magnetic resonance imaging using qualitative and quantitative parameters. Invest Radiol 51:728\u2013734","journal-title":"Invest Radiol"},{"key":"7955_CR10","doi-asserted-by":"publisher","first-page":"1775","DOI":"10.1007\/s00330-015-3994-7","volume":"26","author":"JH Yoon","year":"2016","unstructured":"Yoon JH, Lee JM, Paek M, Han JK, Choi BI (2016) Quantitative assessment of hepatic function: modified look-locker inversion recovery (MOLLI) sequence for T1 mapping on Gd-EOB-DTPA-enhanced liver MR imaging. Eur Radiol 26:1775\u20131782","journal-title":"Eur Radiol"},{"key":"7955_CR11","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1148\/radiol.2016152800","volume":"282","author":"JH Yoon","year":"2017","unstructured":"Yoon JH, Lee JM, Kim E, Okuaki T, Han JK (2017) Quantitative liver function analysis: volumetric T1 mapping with fast multisection B1 inhomogeneity correction in hepatocyte-specific contrast-enhanced liver MR imaging. Radiology 282:408\u2013417","journal-title":"Radiology"},{"key":"7955_CR12","doi-asserted-by":"publisher","first-page":"3584","DOI":"10.1007\/s00330-018-5947-4","volume":"29","author":"JE Kim","year":"2019","unstructured":"Kim JE, Kim HO, Bae K, Choi DS, Nickel D (2019) T1 mapping for liver function evaluation in gadoxetic acid-enhanced MR imaging: comparison of look-locker inversion recovery and B1 inhomogeneity-corrected variable flip angle method. Eur Radiol 29:3584\u20133594","journal-title":"Eur Radiol"},{"key":"7955_CR13","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1016\/j.mri.2015.06.013","volume":"33","author":"C Besa","year":"2015","unstructured":"Besa C, Bane O, Jajamovich G, Marchione J, Taouli B (2015) 3D T1 relaxometry pre and post gadoxetic acid injection for the assessment of liver cirrhosis and liver function. Magn Reson Imaging 33:1075\u20131082","journal-title":"Magn Reson Imaging"},{"key":"7955_CR14","doi-asserted-by":"publisher","first-page":"1186","DOI":"10.1002\/jmri.25440","volume":"45","author":"L Yang","year":"2017","unstructured":"Yang L, Ding Y, Rao S et al (2017) Staging liver fibrosis in chronic hepatitis B with T1 relaxation time index on gadoxetic acid-enhanced MRI: comparison with aspartate aminotransferase-to-platelet ratio index and FIB-4. J Magn Reson Imaging 45:1186\u20131194","journal-title":"J Magn Reson Imaging"},{"key":"7955_CR15","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1148\/radiol.2019190734","volume":"294","author":"N Bastati","year":"2020","unstructured":"Bastati N, Beer L, Mandorfer M et al (2020) Does the functional liver imaging score derived from gadoxetic acid-enhanced MRI predict outcomes in chronic liver disease? Radiology 294:98\u2013107","journal-title":"Radiology"},{"key":"7955_CR16","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1002\/hep.21178","volume":"43","author":"RK Sterling","year":"2006","unstructured":"Sterling RK, Lissen E, Clumeck N et al (2006) Development of a simple noninvasive index to predict significant fibrosis in patients with HIV\/HCV coinfection. Hepatology 43:1317\u20131325","journal-title":"Hepatology"},{"key":"7955_CR17","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1053\/j.gastro.2007.05.024","volume":"133","author":"C Ripoll","year":"2007","unstructured":"Ripoll C, Groszmann R, Garcia-Tsao G et al (2007) Hepatic venous pressure gradient predicts clinical decompensation in patients with compensated cirrhosis. Gastroenterology 133:481\u2013488","journal-title":"Gastroenterology"},{"key":"7955_CR18","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1002\/hep.24418","volume":"54","author":"A Berzigotti","year":"2011","unstructured":"Berzigotti A, Garcia-Tsao G, Bosch J et al (2011) Obesity is an independent risk factor for clinical decompensation in patients with cirrhosis. Hepatology 54:555\u2013561","journal-title":"Hepatology"},{"key":"7955_CR19","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1002\/hep.30885","volume":"71","author":"M Mandorfer","year":"2020","unstructured":"Mandorfer M, Kozbial K, Schwabl P et al (2020) Changes in hepatic venous pressure gradient predict hepatic decompensation in patients who achieved sustained virologic response to interferon-free therapy. Hepatology 71:1023\u20131036","journal-title":"Hepatology"},{"key":"7955_CR20","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1111\/liv.13943","volume":"39","author":"B Scheiner","year":"2019","unstructured":"Scheiner B, Steininger L, Semmler G et al (2019) Controlled attenuation parameter does not predict hepatic decompensation in patients with advanced chronic liver disease. Liver Int 39:127\u2013135","journal-title":"Liver Int"},{"key":"7955_CR21","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1111\/j.1365-2036.2005.02691.x","volume":"22","author":"E Cholongitas","year":"2005","unstructured":"Cholongitas E, Papatheodoridis GV, Vangeli M, Terreni N, Patch D, Burroughs AK (2005) Systematic review: the model for end-stage liver disease--Should it replace Child-Pugh\u2019s classification for assessing prognosis in cirrhosis? Aliment Pharmacol Ther 22:1079\u20131089","journal-title":"Aliment Pharmacol Ther"},{"key":"7955_CR22","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1148\/radiol.2431051823","volume":"243","author":"S Halligan","year":"2007","unstructured":"Halligan S, Altman DG (2007) Evidence-based practice in radiology: steps 3 and 4--Appraise and apply systematic reviews and meta-analyses. Radiology 243:13\u201327","journal-title":"Radiology"},{"key":"7955_CR23","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1007\/s00428-011-1099-5","volume":"459","author":"F Vasuri","year":"2011","unstructured":"Vasuri F, Golfieri R, Fiorentino M et al (2011) OATP 1B1\/1B3 expression in hepatocellular carcinomas treated with orthotopic liver transplantation. Virchows Arch 459:141\u2013146","journal-title":"Virchows Arch"},{"key":"7955_CR24","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.1002\/jmri.21956","volume":"30","author":"U Motosugi","year":"2009","unstructured":"Motosugi U, Ichikawa T, Sou H et al (2009) Liver parenchymal enhancement of hepatocyte-phase images in Gd-EOB-DTPA-enhanced MR imaging: which biological markers of the liver function affect the enhancement? J Magn Reson Imaging 30:1042\u20131046","journal-title":"J Magn Reson Imaging"},{"key":"7955_CR25","doi-asserted-by":"publisher","first-page":"231","DOI":"10.3348\/kjr.2004.5.4.231","volume":"5","author":"HK Ryeom","year":"2004","unstructured":"Ryeom HK, Kim SH, Kim JY et al (2004) Quantitative evaluation of liver function with MRI using Gd-EOB-DTPA. Korean J Radiol 5:231\u2013239","journal-title":"Korean J Radiol"},{"key":"7955_CR26","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1002\/jmri.23700","volume":"36","author":"NK Lee","year":"2012","unstructured":"Lee NK, Kim S, Kim GH et al (2012) Significance of the \u201cdelayed hyperintense portal vein sign\u201d in the hepatobiliary phase MRI obtained with Gd-EOB-DTPA. J Magn Reson Imaging 36:678\u2013685","journal-title":"J Magn Reson Imaging"},{"key":"7955_CR27","doi-asserted-by":"publisher","first-page":"e101","DOI":"10.1016\/S1470-2045(16)30569-1","volume":"18","author":"A Granito","year":"2017","unstructured":"Granito A, Bolondi L (2017) Non-transplant therapies for patients with hepatocellular carcinoma and Child-Pugh-Turcotte class B cirrhosis. Lancet Oncol 18:e101\u2013e112","journal-title":"Lancet Oncol"},{"key":"7955_CR28","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/S0895-4356(02)00531-0","volume":"56","author":"HT Sorensen","year":"2003","unstructured":"Sorensen HT, Thulstrup AM, Mellemkjar L et al (2003) Long-term survival and cause-specific mortality in patients with cirrhosis of the liver: a nationwide cohort study in Denmark. J Clin Epidemiol 56:88\u201393","journal-title":"J Clin Epidemiol"},{"key":"7955_CR29","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1200\/JCO.2014.57.9151","volume":"33","author":"PJ Johnson","year":"2015","unstructured":"Johnson PJ, Berhane S, Kagebayashi C et al (2015) Assessment of liver function in patients with hepatocellular carcinoma: a new evidence-based approach-The ALBI grade. J Clin Oncol 33:550\u2013558","journal-title":"J Clin Oncol"}],"container-title":["European Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00330-021-07955-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00330-021-07955-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00330-021-07955-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,18]],"date-time":"2021-10-18T20:02:20Z","timestamp":1634587340000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00330-021-07955-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,21]]},"references-count":29,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["7955"],"URL":"https:\/\/doi.org\/10.1007\/s00330-021-07955-1","relation":{},"ISSN":["0938-7994","1432-1084"],"issn-type":[{"value":"0938-7994","type":"print"},{"value":"1432-1084","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,21]]},"assertion":[{"value":"5 October 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 March 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 March 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 April 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The scientific guarantor of this publication is Seung Baek Hong.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Guarantor"}},{"value":"The authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"No complex statistical methods were necessary for this paper.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Statistics and biometry"}},{"value":"Written informed consent was waived by the Institutional Review Board.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"Institutional Review Board approval was obtained.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"\u2022 retrospective\u2022 observational\u2022 performed at one institution","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Methodology"}}]}}