{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T23:39:42Z","timestamp":1784763582506,"version":"3.55.0"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2021,5,22]],"date-time":"2021-05-22T00:00:00Z","timestamp":1621641600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,5,22]],"date-time":"2021-05-22T00:00:00Z","timestamp":1621641600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100006244","name":"Stichting Kinderen Kankervrij","doi-asserted-by":"publisher","award":["87"],"award-info":[{"award-number":["87"]}],"id":[{"id":"10.13039\/501100006244","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Radiol"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Objectives<\/jats:title>\n                <jats:p>To compare WB-MRI with an [<jats:sup>18<\/jats:sup>F]FDG-PET\/CT-based reference for early response assessment and restaging in children with Hodgkin\u2019s lymphoma (HL).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Fifty-one children (ages 10\u201317) with HL were included in this prospective, multicentre study. All participants underwent WB-MRI and [<jats:sup>18<\/jats:sup>F]FDG-PET\/CT at early response assessment. Thirteen of the 51 patients also underwent both WB-MRI and [<jats:sup>18<\/jats:sup>F]FDG-PET\/CT at restaging. Two radiologists independently evaluated all WB-MR images in two separate readings: without and with DWI. The [<jats:sup>18<\/jats:sup>F]FDG-PET\/CT examinations were evaluated by a nuclear medicine physician. An expert panel assessed all discrepancies between WB-MRI and [<jats:sup>18<\/jats:sup>F]FDG-PET\/CT to derive the [<jats:sup>18<\/jats:sup>F]FDG-PET\/CT-based reference standard. Inter-observer agreement for WB-MRI was calculated using kappa statistics. Concordance, PPV, NPV, sensitivity and specificity for a correct assessment of the response between WB-MRI and the reference standard were calculated for both nodal and extra-nodal disease presence and total response evaluation.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Inter-observer agreement of WB-MRI including DWI between both readers was moderate (<jats:italic>\u03ba<\/jats:italic> 0.46\u20130.60). For early response assessment, WB-MRI DWI agreed with the reference standard in 33\/51 patients (65%, 95% CI 51\u201377%) versus 15\/51 (29%, 95% CI 19\u201343%) for WB-MRI without DWI. For restaging, WB-MRI including DWI agreed with the reference standard in 9\/13 patients (69%, 95% CI 42\u201387%) versus 5\/13 patients (38%, 95% CI 18\u201364%) for WB-MRI without DWI.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The addition of DWI to the WB-MRI protocol in early response assessment and restaging of paediatric HL improved agreement with the [<jats:sup>18<\/jats:sup>F]FDG-PET\/CT-based reference standard. However, WB-MRI remained discordant in 30% of the patients compared to standard imaging for assessing residual disease presence.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Key Points<\/jats:title>\n                <jats:p><jats:italic>\u2022 Inter-observer agreement of WB-MRI including DWI between both readers was moderate for (early) response assessment of paediatric Hodgkin\u2019s lymphoma.<\/jats:italic><\/jats:p>\n                <jats:p><jats:italic>\u2022 The addition of DWI to the WB-MRI protocol in early response assessment and restaging of paediatric Hodgkin\u2019s lymphoma improved agreement with the [18F]FDG-PET\/CT-based reference standard.<\/jats:italic><\/jats:p>\n                <jats:p><jats:italic>\u2022 WB-MRI including DWI agreed with the reference standard in respectively 65% and 69% of the patients for early response assessment and restaging.<\/jats:italic><\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00330-021-08026-1","type":"journal-article","created":{"date-parts":[[2021,5,21]],"date-time":"2021-05-21T23:10:53Z","timestamp":1621638653000},"page":"8925-8936","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Whole-body MRI versus an [18F]FDG-PET\/CT-based reference standard for early response assessment and restaging of paediatric Hodgkin\u2019s lymphoma: a prospective multicentre study"],"prefix":"10.1007","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9632-7002","authenticated-orcid":false,"given":"Suzanne","family":"Spijkers","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annemieke S.","family":"Littooij","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas C.","family":"Kwee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelleke","family":"Tolboom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Auke","family":"Beishuizen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marrie C. 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Nievelstein.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Guarantor"}},{"value":"The authors of this manuscript declare no relationships with any companies whose products or services may be related to the subject matter of the article.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"No complex statistical methods were necessary for this paper.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Statistics and biometry"}},{"value":"Written informed consent was obtained for all included children and\/or their parents or legal guardians","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"Institutional Review Board approval was obtained.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Staging results of the cohort described in this study were reported in our previous article: \u2018Whole-body MRI versus an FDG-PET\/CT-based reference standard for staging of paediatric Hodgkin lymphoma: a prospective multicentre study.\u2019","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Study subjects or cohorts overlap"}},{"value":"\u2022 prospective\u2022 cross-sectional study \/ diagnostic study\u2022 multicenter study","order":8,"name":"Ethics","group":{"name":"EthicsHeading","label":"Methodology"}}]}}