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Ratings were compared to a consensus rating by two experienced neuroradiologists for estimation of true positive and negative rates (TPR and TNR) and over- and underestimation of MTA. Inter-modality agreement expressed as Cohen\u2019s \u03ba (dichotomized data), Cohen\u2019s \u03ba<jats:sub>w<\/jats:sub>, and two-way mixed, single measures, consistency ICC (ordinal data) were determined. Adequate agreement was defined as \u03ba\/\u03ba<jats:sub>w<\/jats:sub> \u2265 0.80 and ICC \u2265 0.80 (significance level at 95% CI \u2265 0.65).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Forty-nine subjects (median age 72 years, 27% abnormal MTA) with cognitive impairment were included. Only junior radiologists achieved adequate agreement expressed as Cohen\u2019s \u03ba. All raters achieved adequate agreement expressed as Cohen\u2019s \u03ba<jats:sub>w<\/jats:sub> and ICC. True positive rates varied from 69 to 100% and TNR varied from 85 to 100%. No under- or overestimation of MTA was observed. Ratings did not differ between radiologists.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>We conclude that radiologists with varying experience achieve adequate inter-modality agreement and similar accuracy when Scheltens\u2019 MTA scale is used to rate MTA on a non-demented population. However, TPR varied between radiologists which could be attributed to rating style differences.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Key Points<\/jats:title>\n                <jats:p>\u2022 <jats:italic>Radiologists with varying experience achieve adequate inter-modality agreement with similar accuracy when Scheltens\u2019 MTA scale is used to rate MTA on a non-demented population<\/jats:italic>.<\/jats:p>\n                <jats:p>\u2022 <jats:italic>Differences in rating styles might affect accuracy, this was most evident for senior neuroradiologists, and only junior radiologists achieved adequate agreement on dichotomized (abnormal\/normal) ratings<\/jats:italic>.<\/jats:p>\n                <jats:p>\u2022 <jats:italic>The use of an MTA scale template might compensate for varying clinical experience which could make it applicable for clinical use<\/jats:italic>.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00330-021-08177-1","type":"journal-article","created":{"date-parts":[[2021,7,30]],"date-time":"2021-07-30T08:16:00Z","timestamp":1627632960000},"page":"1127-1134","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Inter-modality assessment of medial temporal lobe atrophy in a non-demented population: application of a visual rating scale template across radiologists with varying clinical experience"],"prefix":"10.1007","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6032-2445","authenticated-orcid":false,"given":"Claes","family":"H\u00e5kansson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashkan","family":"Tamaddon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik","family":"Andersson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustav","family":"Torisson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustav","family":"M\u00e5rtensson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"My","family":"Truong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e5rten","family":"Annertz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabet","family":"Londos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabella M.","family":"Bj\u00f6rkman-Burtscher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oskar","family":"Hansson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle","family":"van Westen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,7,30]]},"reference":[{"key":"8177_CR1","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/S1474-4422(02)00002-9","volume":"1","author":"P Scheltens","year":"2002","unstructured":"Scheltens P, Fox N, Barkhof F, De Carli C (2002) Structural magnetic resonance imaging in the practical assessment of dementia: beyond exclusion. 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In the past 2 years, he has received consultancy\/speaker fees from AC Immune, Alzpath, Biogen, Cerveau, and Roche. The other authors declare no conflicts of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"One of the authors has significant statistical expertise.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Statistics and biometry"}},{"value":"Written informed consent has been obtained from all subjects included in the BioFINDER study. Additional written informed consent was waived by the Institutional Review Board for this study.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"Institutional Review Board approval was obtained.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Some study subjects or cohorts have been previously reported in H\u00e5kansson et al <i>Neurology<\/i> 2019; 61:397-404, and H\u00e5kansson et al <i>Eur Radiol<\/i> 2021; 31:666-673.","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Study subjects or cohorts overlap"}},{"value":"\u2022 Retrospective\u2022 Observational\u2022 Performed at one institution","order":8,"name":"Ethics","group":{"name":"EthicsHeading","label":"Methodology"}}]}}