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The role of anatomical variations in different subtypes of hydropic ear disease was investigated.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Twenty-eight patients with ipsilateral DEH, 76 patients with unilateral MD, and 59 control subjects were enrolled. The radiological indices included the distance between the vertical part of the posterior semicircular canal and the posterior fossa (MRI-PP distance) and the visibility of vestibular aqueduct (MRI-VA). These variations among patients with DEH, MD, and control subjects were compared. The correlation between radiological anatomical variations and clinical features or audio-vestibular findings was also examined.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>(1) MRI-PP distance in the affected side of unilateral MD was shorter than that in ipsilateral DEH (<jats:italic>Z<\/jats:italic>\u2009=\u2009\u2009\u2212\u20092.481, <jats:italic>p<\/jats:italic>\u2009=\u20090.013) and control subjects (<jats:italic>Z<\/jats:italic>\u2009=\u2009\u2009\u2212\u20092.983, <jats:italic>p<\/jats:italic>\u2009=\u20090.003), while the difference of MRI-PP distance between the affected side of ipsilateral DEH and control subjects was not statistically significant (<jats:italic>Z<\/jats:italic>\u2009=\u2009\u2009\u2212\u20090.859, <jats:italic>p<\/jats:italic>\u2009=\u20090.391). (2) There was no significant interaural difference of MRI-PP distance in patients with unilateral MD (<jats:italic>Z<\/jats:italic>\u2009=\u2009\u2009\u2212\u20090.041, <jats:italic>p<\/jats:italic>\u2009=\u20090.968) and ipsilateral DEH (<jats:italic>t<\/jats:italic>\u2009=\u2009\u2009\u2212\u20090.107, <jats:italic>p<\/jats:italic>\u2009=\u20090.915) respectively. (3) No significant interaural difference of MRI-VA visibility was observed in patients with unilateral MD (\u03c7<jats:sup>2<\/jats:sup>\u2009=\u20090.742, <jats:italic>p<\/jats:italic>\u2009=\u20090.389) and ipsilateral DEH (\u03c7<jats:sup>2<\/jats:sup>\u2009=\u20090.327, <jats:italic>p<\/jats:italic>\u2009=\u20090.567) respectively. (4) No correlation was found between these anatomical variables and clinical features or audio-vestibular findings in patients with unilateral MD and ipsilateral DEH respectively (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Anatomical variations of inner ear may be a predisposing factor in the pathogenesis of unilateral MD rather than ipsilateral DEH.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Key Points<\/jats:title>\n                <jats:p><jats:italic>\u2022 Patients with ipsilateral delayed endolymphatic hydrops showed normal distance between the vertical part of the posterior semicircular canal and the posterior fossa.<\/jats:italic><\/jats:p>\n                <jats:p><jats:italic>\u2022 Compared to patients with ipsilateral delayed endolymphatic hydrops and control subjects, patients with unilateral M\u00e9ni\u00e8re\u2019s disease exhibited shorter distance between the vertical part of the posterior semicircular canal and the posterior fossa.<\/jats:italic><\/jats:p>\n                <jats:p><jats:italic>\u2022 Anatomical variations of inner ear may be a predisposing factor in the pathogenesis of unilateral M\u00e9ni\u00e8re\u2019s disease rather than ipsilateral delayed endolymphatic hydrops.<\/jats:italic><\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00330-021-08430-7","type":"journal-article","created":{"date-parts":[[2022,1,3]],"date-time":"2022-01-03T13:07:19Z","timestamp":1641215239000},"page":"3553-3564","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Anatomical variation of inner ear may be a predisposing factor for unilateral M\u00e9ni\u00e8re\u2019s disease rather than for ipsilateral delayed endolymphatic hydrops"],"prefix":"10.1007","volume":"32","author":[{"given":"Ping","family":"Lei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangming","family":"Leng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renhong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1642-9867","authenticated-orcid":false,"given":"Bo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,1,3]]},"reference":[{"key":"8430_CR1","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1097\/00129492-200501000-00013","volume":"26","author":"SN Merchant","year":"2005","unstructured":"Merchant SN, Adams JC, Nadol JB Jr (2005) Pathophysiology of Meniere\u2019s syndrome: are symptoms caused by endolymphatic hydrops? 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