{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T22:29:22Z","timestamp":1790461762993,"version":"4.1.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2022,3,12]],"date-time":"2022-03-12T00:00:00Z","timestamp":1647043200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,3,12]],"date-time":"2022-03-12T00:00:00Z","timestamp":1647043200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81730048"],"award-info":[{"award-number":["81730048"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82151309"],"award-info":[{"award-number":["82151309"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014717","name":"National Outstanding Youth Science Fund Project of National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81825012"],"award-info":[{"award-number":["81825012"]}],"id":[{"id":"10.13039\/100014717","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Radiol"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1007\/s00330-022-08661-2","type":"journal-article","created":{"date-parts":[[2022,3,12]],"date-time":"2022-03-12T02:03:01Z","timestamp":1647050581000},"page":"5436-5445","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["FLAIR vessel hyperintensities predict functional outcomes in patients with acute ischemic stroke treated with medical therapy"],"prefix":"10.1007","volume":"32","author":[{"given":"Jin-hao","family":"Lyu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sen-hao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-yang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-hua","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-yan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo-hua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing-liang","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-tong","family":"Bian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-ting","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng-ting","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting-yang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cao-hui","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang-bing","family":"Bian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-lin","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2980-5171","authenticated-orcid":false,"given":"Xin","family":"Lou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,3,12]]},"reference":[{"key":"8661_CR1","doi-asserted-by":"publisher","first-page":"1453","DOI":"10.1161\/STROKEAHA.115.009160","volume":"46","author":"BK Menon","year":"2015","unstructured":"Menon BK, Campbell BCV, Levi C, Goyal M (2015) Role of imaging in current acute ischemic stroke workflow for endovascular therapy. Stroke 46:1453\u20131461","journal-title":"Stroke"},{"key":"8661_CR2","doi-asserted-by":"publisher","first-page":"1279","DOI":"10.1001\/jama.2016.13647","volume":"316","author":"JL Saver","year":"2016","unstructured":"Saver JL, Goyal M, van der Lugt A et al (2016) Time to treatment with endovascular thrombectomy and outcomes from ischemic stroke: a meta-analysis. JAMA 316:1279\u20131288","journal-title":"JAMA"},{"key":"8661_CR3","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1056\/NEJMoa1713973","volume":"378","author":"GW Albers","year":"2018","unstructured":"Albers GW, Marks MP, Kemp S et al (2018) Thrombectomy for stroke at 6 to 16 hours with selection by perfusion imaging. N Engl J Med 378:708\u2013718","journal-title":"N Engl J Med"},{"key":"8661_CR4","doi-asserted-by":"crossref","unstructured":"Han Y, Qiao H, Chen S et al (2018) Intracranial artery stenosis magnetic resonance imaging aetiology and progression study: Rationale and design. Brain Behav 8:e01154","DOI":"10.1002\/brb3.1154"},{"key":"8661_CR5","doi-asserted-by":"publisher","first-page":"1771","DOI":"10.3174\/ajnr.A2265","volume":"32","author":"A Azizyan","year":"2011","unstructured":"Azizyan A, Sanossian N, Mogensen MA, Liebeskind DS (2011) Fluid-attenuated inversion recovery vascular hyperintensities: an important imaging marker for cerebrovascular disease. AJNR Am J Neuroradiol 32:1771\u20131775","journal-title":"AJNR Am J Neuroradiol"},{"key":"8661_CR6","doi-asserted-by":"publisher","first-page":"2240","DOI":"10.1161\/STROKEAHA.119.028550","volume":"51","author":"Z Zhou","year":"2020","unstructured":"Zhou Z, Yoshimura S, Delcourt C et al (2020) Thrombolysis outcomes in acute ischemic stroke by fluid-attenuated inversion recovery hyperintense arteries. Stroke 51:2240\u20132243","journal-title":"Stroke"},{"key":"8661_CR7","doi-asserted-by":"publisher","first-page":"2957","DOI":"10.1161\/STROKEAHA.112.658906","volume":"43","author":"B Cheng","year":"2012","unstructured":"Cheng B, Ebinger M, Kufner A et al (2012) Hyperintense vessels on acute stroke fluid-attenuated inversion recovery imaging: associations with clinical and other MRI findings. Stroke 43:2957\u20132961","journal-title":"Stroke"},{"key":"8661_CR8","doi-asserted-by":"crossref","unstructured":"P\u00e9rez de la Ossa N, Hern\u00e1ndez-P\u00e9rez M, Dom\u00e8nech S et al (2012) Hyperintensity of distal vessels on FLAIR is associated with slow progression of the infarction in acute ischemic stroke. Cerebrovasc Dis 34:376\u2013384","DOI":"10.1159\/000343658"},{"key":"8661_CR9","doi-asserted-by":"publisher","first-page":"1134","DOI":"10.1212\/01.wnl.0000345360.80382.69","volume":"72","author":"KY Lee","year":"2009","unstructured":"Lee KY, Latour LL, Luby M, Hsia AW, Merino JG, Warach S (2009) Distal hyperintense vessels on FLAIR: an MRI marker for collateral circulation in acute stroke? Neurology 72:1134\u20131139","journal-title":"Neurology"},{"key":"8661_CR10","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1161\/STROKEAHA.111.632026","volume":"43","author":"M Ebinger","year":"2012","unstructured":"Ebinger M, Kufner A, Galinovic I et al (2012) Fluid-attenuated inversion recovery images and stroke outcome after thrombolysis. Stroke 43:539\u2013542","journal-title":"Stroke"},{"key":"8661_CR11","doi-asserted-by":"publisher","first-page":"1426","DOI":"10.3174\/ajnr.A4320","volume":"36","author":"A Kufner","year":"2015","unstructured":"Kufner A, Galinovic I, Ambrosi V et al (2015) Hyperintense vessels on FLAIR: hemodynamic correlates and response to thrombolysis. AJNR Am J Neuroradiol 36:1426\u20131430","journal-title":"AJNR Am J Neuroradiol"},{"key":"8661_CR12","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1111\/ene.13259","volume":"24","author":"KW Nam","year":"2017","unstructured":"Nam KW, Kwon HM, Park SW, Lim JS, Han MK, Lee YS (2017) Distal hyperintense vessel sign is associated with neurological deterioration in acute ischaemic stroke. Eur J Neurol 24:617\u2013623","journal-title":"Eur J Neurol"},{"key":"8661_CR13","doi-asserted-by":"publisher","first-page":"77","DOI":"10.3174\/ajnr.A5431","volume":"39","author":"E Mahdjoub","year":"2018","unstructured":"Mahdjoub E, Turc G, Legrand L et al (2018) Do fluid-attenuated inversion recovery vascular hyperintensities represent good collaterals before reperfusion therapy? AJNR Am J Neuroradiol 39:77\u201383","journal-title":"AJNR Am J Neuroradiol"},{"key":"8661_CR14","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1161\/STROKEAHA.117.019588","volume":"49","author":"AH Nave","year":"2018","unstructured":"Nave AH, Kufner A, Bucke P et al (2018) Hyperintense vessels, collateralization, and functional outcome in patients with stroke receiving endovascular treatment. Stroke 49:675\u2013681","journal-title":"Stroke"},{"key":"8661_CR15","doi-asserted-by":"publisher","first-page":"e344","DOI":"10.1161\/STROKEAHA.118.022606","volume":"50","author":"WJ Powers","year":"2019","unstructured":"Powers WJ, Rabinstein AA, Ackerson T et al (2019) Guidelines for the early management of patients with acute ischemic stroke: 2019 update to the 2018 guidelines for the early management of acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association\/American Stroke Association. Stroke 50:e344\u2013e418","journal-title":"Stroke"},{"key":"8661_CR16","doi-asserted-by":"publisher","first-page":"2042","DOI":"10.3174\/ajnr.A4423","volume":"36","author":"SJ Ahn","year":"2015","unstructured":"Ahn SJ, Suh SH, Lee KY, Kim JH, Seo KD, Lee S (2015) Hyperintense vessels on T2-PROPELLER-FLAIR in patients with acute MCA stroke: prediction of arterial stenosis and perfusion abnormality. AJNR Am J Neuroradiol 36:2042\u20132047","journal-title":"AJNR Am J Neuroradiol"},{"key":"8661_CR17","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1159\/000339012","volume":"34","author":"M Hohenhaus","year":"2012","unstructured":"Hohenhaus M, Schmidt WU, Brunecker P et al (2012) FLAIR vascular hyperintensities in acute ICA and MCA infarction: a marker for mismatch and stroke severity? Cerebrovasc Dis 34:63\u201369","journal-title":"Cerebrovasc Dis"},{"key":"8661_CR18","first-page":"1534","volume":"22","author":"JH Pexman","year":"2001","unstructured":"Pexman JH, Barber PA, Hill MD et al (2001) Use of the Alberta Stroke Program Early CT Score (ASPECTS) for assessing CT scans in patients with acute stroke. AJNR Am J Neuroradiol 22:1534\u20131542","journal-title":"AJNR Am J Neuroradiol"},{"key":"8661_CR19","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/S1474-4422(18)30314-4","volume":"18","author":"BCV Campbell","year":"2019","unstructured":"Campbell BCV, Majoie C, Albers GW et al (2019) Penumbral imaging and functional outcome in patients with anterior circulation ischaemic stroke treated with endovascular thrombectomy versus medical therapy: a meta-analysis of individual patient-level data. Lancet Neurol 18:46\u201355","journal-title":"Lancet Neurol"},{"key":"8661_CR20","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/S1474-4422(08)70044-9","volume":"7","author":"SM Davis","year":"2008","unstructured":"Davis SM, Donnan GA, Parsons MW et al (2008) Effects of alteplase beyond 3 h after stroke in the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET): a placebo-controlled randomised trial. Lancet Neurol 7:299\u2013309","journal-title":"Lancet Neurol"},{"key":"8661_CR21","doi-asserted-by":"publisher","first-page":"1561","DOI":"10.1161\/STROKEAHA.111.642322","volume":"43","author":"JB Fiebach","year":"2012","unstructured":"Fiebach JB, Al-Rawi Y, Wintermark M et al (2012) Vascular occlusion enables selecting acute ischemic stroke patients for treatment with desmoteplase. Stroke 43:1561\u20131566","journal-title":"Stroke"},{"key":"8661_CR22","doi-asserted-by":"publisher","first-page":"1548","DOI":"10.1161\/STROKEAHA.115.012285","volume":"47","author":"SE Kim","year":"2016","unstructured":"Kim SE, Lee BI, Kim SE et al (2016) Clinical significance of fluid-attenuated inversion recovery vascular hyperintensities in borderzone infarcts. Stroke 47:1548\u20131554","journal-title":"Stroke"},{"key":"8661_CR23","doi-asserted-by":"publisher","first-page":"564","DOI":"10.3174\/ajnr.A1388","volume":"30","author":"N Sanossian","year":"2009","unstructured":"Sanossian N, Saver JL, Alger JR et al (2009) Angiography reveals that fluid-attenuated inversion recovery vascular hyperintensities are due to slow flow, not thrombus. AJNR Am J Neuroradiol 30:564\u2013568","journal-title":"AJNR Am J Neuroradiol"},{"key":"8661_CR24","doi-asserted-by":"publisher","unstructured":"Lee K-Y, Kim JW, Park M, Suh SH, Ahn SJ (2021) Interpretation of fluid-attenuated inversion recovery vascular hyperintensity in stroke. J neuroradiol https:\/\/doi.org\/10.1016\/j.neurad.2021.01.009","DOI":"10.1016\/j.neurad.2021.01.009"},{"key":"8661_CR25","doi-asserted-by":"publisher","first-page":"5567","DOI":"10.1007\/s00330-019-06094-y","volume":"29","author":"L Legrand","year":"2019","unstructured":"Legrand L, Turc G, Edjlali M et al (2019) Benefit from revascularization after thrombectomy according to FLAIR vascular hyperintensities-DWI mismatch. Eur Radiol 29:5567\u20135576","journal-title":"Eur Radiol"},{"key":"8661_CR26","doi-asserted-by":"publisher","first-page":"4879","DOI":"10.1007\/s00330-019-06022-0","volume":"29","author":"L Jiang","year":"2019","unstructured":"Jiang L, Chen YC, Zhang H et al (2019) FLAIR vascular hyperintensity in acute stroke is associated with collateralization and functional outcome. Eur Radiol 29:4879\u20134888","journal-title":"Eur Radiol"},{"key":"8661_CR27","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1161\/STROKEAHA.115.011057","volume":"47","author":"J Lyu","year":"2016","unstructured":"Lyu J, Ma N, Liebeskind DS et al (2016) Arterial spin labeling magnetic resonance imaging estimation of antegrade and collateral flow in unilateral middle cerebral artery stenosis. Stroke 47:428\u2013433","journal-title":"Stroke"},{"key":"8661_CR28","doi-asserted-by":"publisher","unstructured":"Derraz I, Ahmed R, Benali A et al (2021) FLAIR vascular hyperintensities and functional outcome in nonagenarians with anterior circulation large-vessel ischemic stroke treated with endovascular thrombectomy. Eur Radiol. https:\/\/doi.org\/10.1007\/s00330-021-07866-1","DOI":"10.1007\/s00330-021-07866-1"},{"key":"8661_CR29","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1016\/S1474-4422(09)70173-5","volume":"8","author":"WJ Schonewille","year":"2009","unstructured":"Schonewille WJ, Wijman CA, Michel P et al (2009) Treatment and outcomes of acute basilar artery occlusion in the Basilar Artery International Cooperation Study (BASICS): a prospective registry study. Lancet Neurol 8:724\u2013730","journal-title":"Lancet Neurol"},{"key":"8661_CR30","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1148\/radiol.2016151827","volume":"280","author":"WJ Lee","year":"2016","unstructured":"Lee WJ, Jung KH, Ryu YJ et al (2016) Acute symptomatic basilar artery stenosis: MR imaging predictors of early neurologic deterioration and long-term outcomes. Radiology 280:193\u2013201","journal-title":"Radiology"},{"key":"8661_CR31","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1016\/j.ejrad.2010.09.043","volume":"80","author":"W Liu","year":"2011","unstructured":"Liu W, Xu G, Yue X et al (2011) Hyperintense vessels on FLAIR: a useful non-invasive method for assessing intracerebral collaterals. Eur J Radiol 80:786\u2013791","journal-title":"Eur J Radiol"},{"key":"8661_CR32","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1093\/brain\/awu374","volume":"138","author":"GW Harston","year":"2015","unstructured":"Harston GW, Tee YK, Blockley N et al (2015) Identifying the ischaemic penumbra using pH-weighted magnetic resonance imaging. Brain. 138:36\u201342","journal-title":"Brain."},{"key":"8661_CR33","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1186\/s12938-015-0064-y","volume":"14","author":"X Sun","year":"2015","unstructured":"Sun X, Shi L, Luo Y et al (2015) Histogram-based normalization technique on human brain magnetic resonance images from different acquisitions. Biomed Eng Online. 14:73","journal-title":"Biomed Eng Online."},{"key":"8661_CR34","doi-asserted-by":"publisher","first-page":"593","DOI":"10.3389\/fneur.2017.00593","volume":"8","author":"L Shi","year":"2017","unstructured":"Shi L, Miao X, Lou W et al (2017) The spatial associations of cerebral blood flow and spontaneous brain activities with white matter hyperintensities-an exploratory study using multimodal magnetic resonance imaging. Front Neurol. 8:593","journal-title":"Front Neurol."},{"key":"8661_CR35","doi-asserted-by":"publisher","first-page":"2149","DOI":"10.1109\/TMI.2018.2821244","volume":"37","author":"R Zhang","year":"2018","unstructured":"Zhang R, Zhao L, Lou W et al (2018) Automatic segmentation of acute ischemic stroke from DWI using 3-D fully convolutional DenseNets. IEEE Trans Med Imaging. 37:2149\u20132160","journal-title":"IEEE Trans Med Imaging."}],"container-title":["European Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00330-022-08661-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00330-022-08661-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00330-022-08661-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,13]],"date-time":"2022-07-13T17:43:16Z","timestamp":1657734196000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00330-022-08661-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,12]]},"references-count":35,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["8661"],"URL":"https:\/\/doi.org\/10.1007\/s00330-022-08661-2","relation":{},"ISSN":["1432-1084"],"issn-type":[{"value":"1432-1084","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,12]]},"assertion":[{"value":"11 November 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 February 2022","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 February 2022","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 March 2022","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The scientific guarantor of this publication is Xin Lou.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Guarantor"}},{"value":"The authors of this manuscript declare no relationships with any companies whose products or services may be related to the subject matter of the article.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"No complex statistical methods were necessary for this paper.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Statistics and biometry"}},{"value":"Written informed consent was obtained from all subjects (patients) in this study.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"Institutional Review Board approval was obtained.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"\u2022 prospective\u2022 prognostic study\u2022 multicenter study","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Methodology"}}]}}