{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T23:22:39Z","timestamp":1787613759383,"version":"build-2736575974"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Radiol"],"DOI":"10.1007\/s00330-022-08758-8","type":"journal-article","created":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T02:25:27Z","timestamp":1648779927000},"page":"6008-6016","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Impact of machine-learning-based coronary computed tomography angiography\u2013derived fractional flow reserve on decision-making in patients with severe aortic stenosis undergoing transcatheter aortic valve replacement"],"prefix":"10.1007","volume":"32","author":[{"given":"Verena","family":"Brandt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6164-5641","authenticated-orcid":false,"given":"U. Joseph","family":"Schoepf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilberto J.","family":"Aquino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffi","family":"Bekeredjian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akos","family":"Varga-Szemes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tilman","family":"Emrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"II","given":"Richard R.","family":"Bayer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Schwarz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J.","family":"Kroencke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Tesche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josua A.","family":"Decker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,4,1]]},"reference":[{"key":"8758_CR1","doi-asserted-by":"crossref","unstructured":"Smith CR, Leon MB, Mack MJ et al (2011) Transcatheter versus surgical aortic-valve replacement in high-risk patients. N Engl J Med 364(23):2187\u20132198","DOI":"10.1056\/NEJMoa1103510"},{"key":"8758_CR2","doi-asserted-by":"crossref","unstructured":"Moat NE, Ludman P, de Belder MA et al (2011) Long-term outcomes after transcatheter aortic valve implantation in high-risk patients with severe aortic stenosis: the U.K. TAVI (United Kingdom Transcatheter Aortic Valve Implantation) Registry. J Am Coll Cardiol 58(20):2130\u20132138","DOI":"10.1016\/j.jacc.2011.08.050"},{"issue":"2","key":"8758_CR3","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1093\/eurheartj\/ehq427","volume":"32","author":"T Lefevre","year":"2011","unstructured":"Lefevre T, Kappetein AP, Wolner E, Nataf P, Thomas M, Schachinger V et al (2011) One year follow-up of the multi-centre European PARTNER transcatheter heart valve study. Eur Heart J 32(2):148\u2013157","journal-title":"Eur Heart J"},{"issue":"2","key":"8758_CR4","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1093\/eurheartj\/ehq261","volume":"32","author":"H Eltchaninoff","year":"2011","unstructured":"Eltchaninoff H, Prat A, Gilard M, Leguerrier A, Blanchard D, Fournial G et al (2011) Transcatheter aortic valve implantation: early results of the FRANCE (FRench Aortic National CoreValve and Edwards) registry. Eur Heart J 32(2):191\u2013197","journal-title":"Eur Heart J"},{"issue":"5","key":"8758_CR5","first-page":"e35","volume":"143","author":"CM Otto","year":"2021","unstructured":"Otto CM, Nishimura RA, Bonow RO, Carabello BA, Erwin JP 3rd, Gentile F et al (2021) 2020 ACC\/AHA Guideline for the management of patients with valvular heart disease: executive summary: a report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation. 143(5):e35\u2013e71","journal-title":"Circulation."},{"key":"8758_CR6","doi-asserted-by":"crossref","unstructured":"Vahanian A, Beyersdorf F, Praz F, Milojevic M, Baldus S, Bauersachs J et al (2021) ESC\/EACTS Guidelines for the management of valvular heart disease. Eur Heart J 43:561\u2013632","DOI":"10.1093\/eurheartj\/ehab395"},{"issue":"1","key":"8758_CR7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jcmg.2018.12.003","volume":"12","author":"P Blanke","year":"2019","unstructured":"Blanke P, Weir-McCall JR, Achenbach S, Delgado V, Hausleiter J, Jilaihawi H et al (2019) Computed tomography imaging in the context of transcatheter aortic valve implantation (TAVI)\/transcatheter aortic valve replacement (TAVR): an expert consensus document of the Society of Cardiovascular Computed Tomography. JACC Cardiovasc Imaging 12(1):1\u201324","journal-title":"JACC Cardiovasc Imaging"},{"issue":"1","key":"8758_CR8","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1097\/RTI.0000000000000357","volume":"34","author":"CD Maroules","year":"2019","unstructured":"Maroules CD, Rajiah P, Bhasin M, Abbara S (2019) Current evidence in cardiothoracic imaging: growing evidence for coronary computed tomography angiography as a first-line test in stable chest pain. J Thorac Imaging 34(1):4\u201311","journal-title":"J Thorac Imaging"},{"issue":"5","key":"8758_CR9","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1161\/CIRCIMAGING.111.964155","volume":"4","author":"BJ Chow","year":"2011","unstructured":"Chow BJ, Small G, Yam Y, Chen L, Achenbach S, Al-Mallah M et al (2011) Incremental prognostic value of cardiac computed tomography in coronary artery disease using CONFIRM: COroNary computed tomography angiography evaluation for clinical outcomes: an InteRnational Multicenter registry. Circ Cardiovasc Imaging 4(5):463\u2013472","journal-title":"Circ Cardiovasc Imaging"},{"key":"8758_CR10","doi-asserted-by":"crossref","unstructured":"Francone M, Budde RP, Bremerich J, Dacher JN, Loewe C, Wolf F et al (2019) CT and MR imaging prior to transcatheter aortic valve implantation: standardisation of scanning protocols, measurements and reporting\u2014a consensus document by the European Society of Cardiovascular Radiology (ESCR). Eur Radiol:1\u201324","DOI":"10.1007\/s00330-019-06357-8"},{"issue":"1","key":"8758_CR11","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.jcmg.2013.07.013","volume":"7","author":"M Kruk","year":"2014","unstructured":"Kruk M, Noll D, Achenbach S, Mintz GS, Pregowski J, Kaczmarska E et al (2014) Impact of coronary artery calcium characteristics on accuracy of CT angiography. JACC Cardiovasc Imaging 7(1):49\u201358","journal-title":"JACC Cardiovasc Imaging"},{"issue":"4","key":"8758_CR12","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1007\/s10554-011-9902-6","volume":"28","author":"J Abdulla","year":"2012","unstructured":"Abdulla J, Pedersen KS, Budoff M, Kofoed KF (2012) Influence of coronary calcification on the diagnostic accuracy of 64-slice computed tomography coronary angiography: a systematic review and meta-analysis. Int J Card Imaging 28(4):943\u2013953","journal-title":"Int J Card Imaging"},{"issue":"3","key":"8758_CR13","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1056\/NEJMoa0807611","volume":"360","author":"PA Tonino","year":"2009","unstructured":"Tonino PA, De Bruyne B, Pijls NH, Siebert U, Ikeno F, van\u2019t Veer M et al (2009) Fractional flow reserve versus angiography for guiding percutaneous coronary intervention. N Engl J Med 360(3):213\u2013224","journal-title":"N Engl J Med"},{"issue":"8","key":"8758_CR14","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1016\/j.jcin.2010.06.006","volume":"3","author":"A Ntalianis","year":"2010","unstructured":"Ntalianis A, Trana C, Muller O, Mangiacapra F, Peace A, De Backer C et al (2010) Effective radiation dose, time, and contrast medium to measure fractional flow reserve. J Am Coll Cardiol Intv 3(8):821\u2013827","journal-title":"J Am Coll Cardiol Intv"},{"issue":"12","key":"8758_CR15","doi-asserted-by":"publisher","first-page":"2121","DOI":"10.1016\/j.amjcard.2017.08.034","volume":"120","author":"C Tesche","year":"2017","unstructured":"Tesche C, Vliegenthart R, Duguay TM, De Cecco CN, Albrecht MH, De Santis D et al (2017) Coronary computed tomographic angiography-derived fractional flow reserve for therapeutic decision making. Am J Cardiol 120(12):2121\u20132127","journal-title":"Am J Cardiol"},{"issue":"1","key":"8758_CR16","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.120.009586","volume":"14","author":"M Michail","year":"2021","unstructured":"Michail M, Ihdayhid AR, Comella A, Thakur U, Cameron JD, McCormick LM et al (2021) Feasibility and validity of computed tomography-derived fractional flow reserve in patients with severe aortic stenosis: the CAST-FFR study. Circ Cardiovasc Interv 14(1):e009586","journal-title":"Circ Cardiovasc Interv"},{"issue":"1","key":"8758_CR17","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1148\/radiol.2021210160","volume":"302","author":"GJ Aquino","year":"2022","unstructured":"Aquino GJ, Abadia AF, Schoepf UJ, Emrich T, Yacoub B, Kabakus I et al (2022) Coronary CT fractional flow reserve before transcatheter aortic valve replacement: clinical outcomes. Radiology. 302(1):50\u201358","journal-title":"Radiology."},{"key":"8758_CR18","doi-asserted-by":"crossref","unstructured":"Gohmann RF, Pawelka K, Seitz P, Majunke N, Heiser L, Renatus K et al (2021) Combined coronary CT-angiography and TAVR planning for ruling out significant coronary artery disease: added value of machine-learning-based CT-FFR. JACC Cardiovasc Imaging","DOI":"10.1016\/j.jcct.2021.06.202"},{"issue":"2","key":"8758_CR19","doi-asserted-by":"publisher","first-page":"211","DOI":"10.4065\/79.2.211","volume":"79","author":"AS Gami","year":"2004","unstructured":"Gami AS, Garovic VD (2004) Contrast nephropathy after coronary angiography. Mayo Clin Proc 79(2):211\u2013219","journal-title":"Mayo Clin Proc"},{"issue":"6","key":"8758_CR20","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1053\/pcad.2003.YPCAD16","volume":"45","author":"C Briguori","year":"2003","unstructured":"Briguori C, Tavano D, Colombo A (2003) Contrast agent--associated nephrotoxicity. Prog Cardiovasc Dis 45(6):493\u2013503","journal-title":"Prog Cardiovasc Dis"},{"issue":"12","key":"8758_CR21","doi-asserted-by":"publisher","first-page":"1410","DOI":"10.1016\/j.jacc.2020.07.048","volume":"76","author":"RJ Cubeddu","year":"2020","unstructured":"Cubeddu RJ, Asher CR, Lowry AM, Blackstone EH, Kapadia SR, Alu MC et al (2020) Impact of transcatheter aortic valve replacement on severity of chronic kidney disease. J Am Coll Cardiol 76(12):1410\u20131421","journal-title":"J Am Coll Cardiol"},{"issue":"1","key":"8758_CR22","first-page":"65","volume":"4","author":"M Tavakol","year":"2012","unstructured":"Tavakol M, Ashraf S, Brener SJ (2012) Risks and complications of coronary angiography: a comprehensive review. Global J Health Sci 4(1):65\u201393","journal-title":"Global J Health Sci"},{"issue":"20","key":"8758_CR23","doi-asserted-by":"publisher","first-page":"2017","DOI":"10.1016\/j.jacc.2012.08.966","volume":"60","author":"GJ Dehmer","year":"2012","unstructured":"Dehmer GJ, Weaver D, Roe MT, Milford-Beland S, Fitzgerald S, Hermann A et al (2012) A contemporary view of diagnostic cardiac catheterization and percutaneous coronary intervention in the United States: a report from the CathPCI Registry of the National Cardiovascular Data Registry, 2010 through June 2011. J Am Coll Cardiol 60(20):2017\u20132031","journal-title":"J Am Coll Cardiol"},{"issue":"7","key":"8758_CR24","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.119.007791","volume":"12","author":"MA Al-Hijji","year":"2019","unstructured":"Al-Hijji MA, Lennon RJ, Gulati R, El Sabbagh A, Park JY, Crusan D et al (2019) Safety and risk of major complications with diagnostic cardiac catheterization. Circ Cardiovasc Interv 12(7):e007791","journal-title":"Circ Cardiovasc Interv"},{"issue":"9","key":"8758_CR25","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1056\/NEJMoa0901249","volume":"361","author":"R Fazel","year":"2009","unstructured":"Fazel R, Krumholz HM, Wang Y, Ross JS, Chen J, Ting HH et al (2009) Exposure to low-dose ionizing radiation from medical imaging procedures. N Engl J Med 361(9):849\u2013857","journal-title":"N Engl J Med"},{"issue":"17","key":"8758_CR26","doi-asserted-by":"publisher","first-page":"1609","DOI":"10.1056\/NEJMoa1514616","volume":"374","author":"MB Leon","year":"2016","unstructured":"Leon MB, Smith CR, Mack MJ, Makkar RR, Svensson LG, Kodali SK et al (2016) Transcatheter or Surgical aortic-valve replacement in intermediate-risk patients. N Engl J Med 374(17):1609\u20131620","journal-title":"N Engl J Med"},{"issue":"18","key":"8758_CR27","doi-asserted-by":"publisher","first-page":"1695","DOI":"10.1056\/NEJMoa1814052","volume":"380","author":"MJ Mack","year":"2019","unstructured":"Mack MJ, Leon MB, Thourani VH, Makkar R, Kodali SK, Russo M et al (2019) Transcatheter aortic-valve replacement with a balloon-expandable valve in low-risk patients. N Engl J Med 380(18):1695\u20131705","journal-title":"N Engl J Med"},{"issue":"2","key":"8758_CR28","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1016\/j.jacc.2017.03.011","volume":"70","author":"RA Nishimura","year":"2017","unstructured":"Nishimura RA, Otto CM, Bonow RO, Carabello BA, Erwin JP 3rd, Fleisher LA et al (2017) 2017 AHA\/ACC Focused Update of the 2014 AHA\/ACC Guideline for the management of patients with valvular heart disease: a report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines. J Am Coll Cardiol 70(2):252\u2013289","journal-title":"J Am Coll Cardiol"},{"key":"8758_CR29","unstructured":"Cury RC, Abbara S, Achenbach S, Agatston A, Berman DS, Budoff MJ et al (2016) CAD-RADS: Coronary Artery Disease - Reporting and Data System: an expert consensus document of the Society of Cardiovascular Computed Tomography (SCCT), the American College of Radiology (ACR) and the North American Society for Cardiovascular Imaging (NASCI). Endorsed by the American College of Cardiology. J Am Coll Radiol 13(12 Pt A):1458-66 e9"},{"issue":"9","key":"8758_CR30","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1016\/j.amjcard.2014.07.064","volume":"114","author":"M Renker","year":"2014","unstructured":"Renker M, Schoepf UJ, Wang R, Meinel FG, Rier JD, Bayer RR 2nd et al (2014) Comparison of diagnostic value of a novel noninvasive coronary computed tomography angiography method versus standard coronary angiography for assessing fractional flow reserve. Am J Cardiol 114(9):1303\u20131308","journal-title":"Am J Cardiol"},{"issue":"3","key":"8758_CR31","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1148\/radiol.14140992","volume":"274","author":"A Coenen","year":"2015","unstructured":"Coenen A, Lubbers MM, Kurata A, Kono A, Dedic A, Chelu RG et al (2015) Fractional flow reserve computed from noninvasive CT angiography data: diagnostic performance of an on-site clinician-operated computational fluid dynamics algorithm. Radiology. 274(3):674\u2013683","journal-title":"Radiology."},{"issue":"2","key":"8758_CR32","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1093\/eurheartj\/ehy394","volume":"40","author":"FJ Neumann","year":"2019","unstructured":"Neumann FJ, Sousa-Uva M, Ahlsson A, Alfonso F, Banning AP, Benedetto U et al (2019) 2018 ESC\/EACTS Guidelines on myocardial revascularization. Eur Heart J 40(2):87\u2013165","journal-title":"Eur Heart J"},{"issue":"3","key":"8758_CR33","doi-asserted-by":"publisher","first-page":"276","DOI":"10.11613\/BM.2012.031","volume":"22","author":"ML McHugh","year":"2012","unstructured":"McHugh ML (2012) Interrater reliability: the kappa statistic. Biochem Med (Zagreb) 22(3):276\u2013282","journal-title":"Biochem Med (Zagreb)"},{"issue":"23","key":"8758_CR34","first-page":"e521","volume":"129","author":"RA Nishimura","year":"2014","unstructured":"Nishimura RA, Otto CM, Bonow RO, Carabello BA, Erwin JP 3rd, Guyton RA et al (2014) 2014 AHA\/ACC Guideline for the management of patients with valvular heart disease: a report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines. Circulation. 129(23):e521\u2013e643","journal-title":"Circulation."},{"issue":"21","key":"8758_CR35","doi-asserted-by":"publisher","first-page":"2492","DOI":"10.1016\/j.jacc.2020.09.595","volume":"76","author":"JD Carroll","year":"2020","unstructured":"Carroll JD, Mack MJ, Vemulapalli S, Herrmann HC, Gleason TG, Hanzel G et al (2020) STS-ACC TVT registry of transcatheter aortic valve replacement. J Am Coll Cardiol 76(21):2492\u20132516","journal-title":"J Am Coll Cardiol"},{"key":"8758_CR36","doi-asserted-by":"crossref","unstructured":"D\u2019Souza MS, Howell EN, Ray SD (2019) Radiological contrast agents and radiopharmaceuticals. Side Effects of Drugs Annual. 41: Elsevier, pp 531-47","DOI":"10.1016\/bs.seda.2019.07.009"},{"issue":"11","key":"8758_CR37","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1136\/heartjnl-2013-304708","volume":"101","author":"H Mollmann","year":"2015","unstructured":"Mollmann H, Kim WK, Kempfert J, Walther T, Hamm C (2015) Complications of transcatheter aortic valve implantation (TAVI): how to avoid and treat them. Heart. 101(11):900\u2013908","journal-title":"Heart."},{"issue":"11","key":"8758_CR38","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1016\/j.jcin.2010.09.009","volume":"3","author":"JM Sinning","year":"2010","unstructured":"Sinning JM, Ghanem A, Steinhauser H, Adenauer V, Hammerstingl C, Nickenig G et al (2010) Renal function as predictor of mortality in patients after percutaneous transcatheter aortic valve implantation. JACC Cardiovasc Interv 3(11):1141\u20131149","journal-title":"JACC Cardiovasc Interv"},{"issue":"Suppl 1","key":"8758_CR39","doi-asserted-by":"publisher","first-page":"S66","DOI":"10.1097\/RTI.0000000000000483","volume":"35","author":"C Tesche","year":"2020","unstructured":"Tesche C, Gray HN (2020) Machine learning and deep neural networks applications in coronary flow assessment: the case of computed tomography fractional flow reserve. J Thorac Imaging 35(Suppl 1):S66\u2013S71","journal-title":"J Thorac Imaging"},{"issue":"1","key":"8758_CR40","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1148\/radiol.2017162641","volume":"285","author":"C Tesche","year":"2017","unstructured":"Tesche C, De Cecco CN, Albrecht MH, Duguay TM, Bayer RR 2nd, Litwin SE et al (2017) Coronary CT Angiography-derived Fractional Flow Reserve. Radiology. 285(1):17\u201333","journal-title":"Radiology."},{"issue":"6","key":"8758_CR41","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.117.007217","volume":"11","author":"A Coenen","year":"2018","unstructured":"Coenen A, Kim YH, Kruk M, Tesche C, De Geer J, Kurata A et al (2018) Diagnostic accuracy of a machine-learning approach to coronary computed tomographic angiography-based fractional flow reserve: result from the MACHINE consortium. Circ Cardiovasc Imaging 11(6):e007217","journal-title":"Circ Cardiovasc Imaging"},{"issue":"12","key":"8758_CR42","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.1001\/2012.jama.11274","volume":"308","author":"JK Min","year":"2012","unstructured":"Min JK, Leipsic J, Pencina MJ, Berman DS, Koo BK, van Mieghem C et al (2012) Diagnostic accuracy of fractional flow reserve from anatomic CT angiography. JAMA. 308(12):1237\u20131245","journal-title":"JAMA."},{"issue":"12","key":"8758_CR43","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1016\/j.jacc.2013.11.043","volume":"63","author":"BL Norgaard","year":"2014","unstructured":"Norgaard BL, Leipsic J, Gaur S, Seneviratne S, Ko BS, Ito H et al (2014) Diagnostic performance of noninvasive fractional flow reserve derived from coronary computed tomography angiography in suspected coronary artery disease: the NXT trial (Analysis of Coronary Blood Flow Using CT Angiography: Next Steps). J Am Coll Cardiol 63(12):1145\u20131155","journal-title":"J Am Coll Cardiol"},{"issue":"19","key":"8758_CR44","doi-asserted-by":"publisher","first-page":"1989","DOI":"10.1016\/j.jacc.2011.06.066","volume":"58","author":"BK Koo","year":"2011","unstructured":"Koo BK, Erglis A, Doh JH, Daniels DV, Jegere S, Kim HS et al (2011) Diagnosis of ischemia-causing coronary stenoses by noninvasive fractional flow reserve computed from coronary computed tomographic angiograms. Results from the prospective multicenter DISCOVER-FLOW (Diagnosis of Ischemia-Causing Stenoses Obtained Via Noninvasive Fractional Flow Reserve) study. J Am Coll Cardiol 58(19):1989\u20131997","journal-title":"J Am Coll Cardiol"},{"issue":"2","key":"8758_CR45","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.jacc.2018.10.056","volume":"73","author":"RS Driessen","year":"2019","unstructured":"Driessen RS, Danad I, Stuijfzand WJ, Raijmakers PG, Schumacher SP, van Diemen PA et al (2019) Comparison of coronary computed tomography angiography, fractional flow reserve, and perfusion imaging for ischemia diagnosis. J Am Coll Cardiol 73(2):161\u2013173","journal-title":"J Am Coll Cardiol"},{"issue":"47","key":"8758_CR46","doi-asserted-by":"publisher","first-page":"3359","DOI":"10.1093\/eurheartj\/ehv444","volume":"36","author":"PS Douglas","year":"2015","unstructured":"Douglas PS, Pontone G, Hlatky MA, Patel MR, Norgaard BL, Byrne RA et al (2015) Clinical outcomes of fractional flow reserve by computed tomographic angiography-guided diagnostic strategies vs. usual care in patients with suspected coronary artery disease: the prospective longitudinal trial of FFR(CT): outcome and resource impacts study. Eur Heart J 36(47):3359\u20133367","journal-title":"Eur Heart J"},{"issue":"41","key":"8758_CR47","doi-asserted-by":"publisher","first-page":"3701","DOI":"10.1093\/eurheartj\/ehy530","volume":"39","author":"TA Fairbairn","year":"2018","unstructured":"Fairbairn TA, Nieman K, Akasaka T, Norgaard BL, Berman DS, Raff G et al (2018) Real-world clinical utility and impact on clinical decision-making of coronary computed tomography angiography-derived fractional flow reserve: lessons from the ADVANCE Registry. Eur Heart J 39(41):3701\u20133711","journal-title":"Eur Heart J"},{"issue":"1 Pt 1","key":"8758_CR48","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/S0002-8703(00)90316-8","volume":"139","author":"LL Leape","year":"2000","unstructured":"Leape LL, Park RE, Bashore TM, Harrison JK, Davidson CJ, Brook RH (2000) Effect of variability in the interpretation of coronary angiograms on the appropriateness of use of coronary revascularization procedures. Am Heart J 139(1 Pt 1):106\u2013113","journal-title":"Am Heart J"},{"issue":"5","key":"8758_CR49","doi-asserted-by":"publisher","first-page":"1445","DOI":"10.21037\/cdt-20-226","volume":"10","author":"J Nogic","year":"2020","unstructured":"Nogic J, Prosser H, O'Brien J, Thakur U, Soon K, Proimos G et al (2020) The assessment of intermediate coronary lesions using intracoronary imaging. Cardiovasc Diagn Ther 10(5):1445\u20131460","journal-title":"Cardiovasc Diagn Ther"},{"issue":"2","key":"8758_CR50","doi-asserted-by":"publisher","first-page":"97","DOI":"10.15420\/icr.2017:13:2","volume":"12","author":"S Achenbach","year":"2017","unstructured":"Achenbach S, Rudolph T, Rieber J, Eggebrecht H, Richardt G, Schmitz T et al (2017) Performing and interpreting fractional flow reserve measurements in clinical practice: an expert consensus document. Interv Cardiol 12(2):97\u2013109","journal-title":"Interv Cardiol"}],"container-title":["European Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00330-022-08758-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00330-022-08758-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00330-022-08758-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,22]],"date-time":"2022-10-22T02:04:48Z","timestamp":1666404288000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00330-022-08758-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,1]]},"references-count":50,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2022,9]]}},"alternative-id":["8758"],"URL":"https:\/\/doi.org\/10.1007\/s00330-022-08758-8","relation":{},"ISSN":["1432-1084"],"issn-type":[{"value":"1432-1084","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,1]]},"assertion":[{"value":"17 December 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 February 2022","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 March 2022","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 April 2022","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The scientific guarantor of this publication is Prof. U. Joseph Schoepf.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Guarantor"}},{"value":"The authors of this manuscript declare relationships with the following companies: Dr. Schoepf receives institutional research support and \/ or honoraria for speaking and consulting from Bayer, Bracco, Elucid BioImaging, Guerbet, HeartFlow Inc., Keya Medical, and Siemens Healthineers. Dr. Varga-Szemes receives institutional research and travel support from Siemens Healthineers and is a consultant for Bayer and Elucid Bioimaging. Dr. Emrich receives travel support and speaker fee from Siemens Healthineers. Dr. Tesche has received speaker\u2019s fees from Siemens Healthineers and Heartflow Inc. Dr Bayer receive institutional research support from Bayer, Siemens, and HeartFlow. The other authors have no conflicts of interest to disclose.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"No complex statistical methods were necessary for this paper.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Statistics and biometry"}},{"value":"Written informed consent was waived by the Institutional Review Board.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"Institutional Review Board approval was obtained.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"\u2022 retrospective\u2022 observational\u2022 performed at one institution","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Methodology"}}]}}