{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T03:09:46Z","timestamp":1740107386618,"version":"3.37.3"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2022,9,30]],"date-time":"2022-09-30T00:00:00Z","timestamp":1664496000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,9,30]],"date-time":"2022-09-30T00:00:00Z","timestamp":1664496000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100004622","name":"KWF Kankerbestrijding","doi-asserted-by":"publisher","award":["2013-6486"],"award-info":[{"award-number":["2013-6486"]}],"id":[{"id":"10.13039\/501100004622","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Radiol"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Objectives<\/jats:title>\n                <jats:p>For patients with ductal carcinoma in situ (DCIS), data about the impact of breast MRI at primary diagnosis on the incidence and characteristics of contralateral breast cancers are scarce.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We selected all 8486 women diagnosed with primary DCIS in the Netherlands in 2011\u20132015 from the Netherlands Cancer Registry. The synchronous and metachronous detection of contralateral DCIS (cDCIS) and contralateral invasive breast cancer (cIBC) was assessed for patients who received an MRI upon diagnosis (MRI group) and for an age-matched control group without MRI.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Nineteen percent of patients received an MRI, of which 0.8% was diagnosed with synchronous cDCIS and 1.3% with synchronous cIBC not found by mammography. The 5-year cumulative incidence of synchronous plus metachronous cDCIS was higher for the MRI versus age-matched control group (2.0% versus 0.9%, <jats:italic>p<\/jats:italic> = 0.02) and similar for cIBC (3.5% versus 2.3%, <jats:italic>p<\/jats:italic> = 0.17). The increased incidence of cDCIS was observed in patients aged &lt; 50 years (sHR = 4.22, 95% CI: 1.19\u201314.99), but not in patients aged 50\u201374 years (sHR = 0.89, 95% CI: 0.41\u20131.93).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>MRI at primary DCIS diagnosis detected additional synchronous cDCIS and cIBC, and was associated with a higher rate of metachronous cDCIS without decreasing the rate of metachronous cIBC. This finding was most evident in younger patients.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Key Points<\/jats:title>\n                <jats:p><jats:italic>\u2022 Magnetic resonance imaging at primary diagnosis of ductal carcinoma in situ detected an additional synchronous breast lesion in 2.1% of patients.<\/jats:italic><\/jats:p>\n                <jats:p><jats:italic>\u2022 In patients aged younger than 50 years, the use of pre-operative MRI was associated with a fourfold increase in the incidence of a second contralateral DCIS without decreasing the incidence of metachronous invasive breast cancers up to 5 years after diagnosis.<\/jats:italic><\/jats:p>\n                <jats:p><jats:italic>\u2022 In patients aged over 50 years, the use of pre-operative MRI did not result in a difference in the incidence of a second contralateral DCIS or metachronous invasive breast cancer.<\/jats:italic><\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00330-022-09115-5","type":"journal-article","created":{"date-parts":[[2022,9,30]],"date-time":"2022-09-30T17:04:15Z","timestamp":1664557455000},"page":"2209-2217","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Clinical value of contralateral breast cancers detected by pre-operative MRI in patients diagnosed with DCIS: a population-based cohort study"],"prefix":"10.1007","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5992-7087","authenticated-orcid":false,"given":"Kristien B. I. M.","family":"Keymeulen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra M. E.","family":"Geurts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Loes F. S.","family":"Kooreman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucien E. M.","family":"Duijm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanne","family":"Engelen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sigrid","family":"Vanwetswinkel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ernest","family":"Luiten","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabine","family":"Siesling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adri C.","family":"Voogd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vivianne C. G.","family":"Tjan-Heijnen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,9,30]]},"reference":[{"unstructured":"Comprehensive Cancer Centre the Netherlands (2020) Incidence ductal carcinoma in situ., www.cijfersoverkanker.nl. Accessed 03-07-2020","key":"9115_CR1"},{"key":"9115_CR2","doi-asserted-by":"publisher","first-page":"3381","DOI":"10.1200\/JCO.2006.06.1366","volume":"24","author":"N Bijker","year":"2006","unstructured":"Bijker N, Meijnen P, Peterse JL et al (2006) Breast-conserving treatment with or without radiotherapy in ductal carcinoma-in-situ: ten-year results of European Organisation for Research and Treatment of Cancer randomized phase III trial 10853--a study by the EORTC Breast Cancer Cooperative Group and EORTC Radiotherapy Group. J Clin Oncol 24:3381\u20133387","journal-title":"J Clin Oncol"},{"key":"9115_CR3","doi-asserted-by":"publisher","first-page":"e2017124","DOI":"10.1001\/jamanetworkopen.2020.17124","volume":"3","author":"V Giannakeas","year":"2020","unstructured":"Giannakeas V, Sopik V, Narod SA (2020) Association of a diagnosis of ductal carcinoma in situ with death from breast cancer. JAMA Netw Open 3:e2017124","journal-title":"JAMA Netw Open"},{"key":"9115_CR4","doi-asserted-by":"publisher","first-page":"952","DOI":"10.1097\/SLA.0000000000002239","volume":"267","author":"LE Elshof","year":"2018","unstructured":"Elshof LE, Schmidt MK, Rutgers EJT, van Leeuwen FE, Wesseling J, Schaapveld M (2018) Cause-specific mortality in a population-based cohort of 9799 women treated for ductal carcinoma in situ. Ann Surg 267:952\u2013958","journal-title":"Ann Surg"},{"key":"9115_CR5","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1245\/s10434-007-9661-8","volume":"15","author":"S Dawood","year":"2008","unstructured":"Dawood S, Broglio K, Gonzalez-Angulo AM et al (2008) Development of new cancers in patients with DCIS: the M.D. Anderson experience. Ann Surg Oncol 15:244\u2013249","journal-title":"Ann Surg Oncol"},{"key":"9115_CR6","doi-asserted-by":"publisher","first-page":"888","DOI":"10.1001\/jamaoncol.2015.2510","volume":"1","author":"SA Narod","year":"2015","unstructured":"Narod SA, Iqbal J, Giannakeas V, Sopik V, Sun P (2015) Breast cancer mortality after a diagnosis of ductal carcinoma in situ. JAMA Oncol 1:888\u2013896","journal-title":"JAMA Oncol"},{"key":"9115_CR7","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1111\/j.1524-4741.2012.01273.x","volume":"18","author":"AB Hollingsworth","year":"2012","unstructured":"Hollingsworth AB, Stough RG (2012) Multicentric and contralateral invasive tumors identified with pre-op MRI in patients newly diagnosed with ductal carcinoma in situ of the breast. Breast J 18:420\u2013427","journal-title":"Breast J"},{"key":"9115_CR8","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1245\/s10434-007-9690-3","volume":"15","author":"MD Lagios","year":"2008","unstructured":"Lagios MD, Silverstein MJ (2008) Ductal carcinoma in situ: through a glass, darkly. Ann Surg Oncol 15:16\u201317","journal-title":"Ann Surg Oncol"},{"key":"9115_CR9","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1111\/j.1075-122X.2005.00121.x","volume":"11","author":"JH Menell","year":"2005","unstructured":"Menell JH, Morris EA, Dershaw DD, Abramson AF, Brogi E, Liberman L (2005) Determination of the presence and extent of pure ductal carcinoma in situ by mammography and magnetic resonance imaging. Breast J 11:382\u2013390","journal-title":"Breast J"},{"key":"9115_CR10","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1148\/radiology.220.1.r01jl3113","volume":"220","author":"SG Orel","year":"2001","unstructured":"Orel SG, Schnall MD (2001) MR imaging of the breast for the detection, diagnosis, and staging of breast cancer. Radiology 220:13\u201330","journal-title":"Radiology"},{"key":"9115_CR11","doi-asserted-by":"publisher","first-page":"3248","DOI":"10.1200\/JCO.2007.15.2108","volume":"26","author":"N Houssami","year":"2008","unstructured":"Houssami N, Ciatto S, Macaskill P et al (2008) Accuracy and surgical impact of magnetic resonance imaging in breast cancer staging: systematic review and meta-analysis in detection of multifocal and multicentric cancer. J Clin Oncol 26:3248\u20133258","journal-title":"J Clin Oncol"},{"key":"9115_CR12","doi-asserted-by":"publisher","first-page":"5640","DOI":"10.1200\/JCO.2008.21.5756","volume":"27","author":"ME Brennan","year":"2009","unstructured":"Brennan ME, Houssami N, Lord S et al (2009) Magnetic resonance imaging screening of the contralateral breast in women with newly diagnosed breast cancer: systematic review and meta-analysis of incremental cancer detection and impact on surgical management. J Clin Oncol 27:5640\u20135649","journal-title":"J Clin Oncol"},{"key":"9115_CR13","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1007\/s10549-017-4117-8","volume":"162","author":"MB Lobbes","year":"2017","unstructured":"Lobbes MB, Vriens IJ, van Bommel AC et al (2017) Breast MRI increases the number of mastectomies for ductal cancers, but decreases them for lobular cancers. Breast Cancer Res Treat 162:353\u2013364","journal-title":"Breast Cancer Res Treat"},{"key":"9115_CR14","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.ejca.2017.05.012","volume":"81","author":"IJH Vriens","year":"2017","unstructured":"Vriens IJH, Keymeulen K, Lobbes MBI et al (2017) Breast magnetic resonance imaging use in patients undergoing neoadjuvant chemotherapy is associated with less mastectomies in large ductal cancers but not in lobular cancers. Eur J Cancer 81:74\u201380","journal-title":"Eur J Cancer"},{"key":"9115_CR15","doi-asserted-by":"publisher","first-page":"1488","DOI":"10.1002\/bjs.11299","volume":"106","author":"KBIM Keymeulen","year":"2019","unstructured":"Keymeulen KBIM, Geurts SME, Lobbes MBI et al (2019) Population-based study of the effect of preoperative breast MRI on the surgical management of ductal carcinoma in situ. Br J Surg 106:1488\u20131494","journal-title":"Br J Surg"},{"key":"9115_CR16","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1007\/s10549-013-2656-1","volume":"141","author":"BK Killelea","year":"2013","unstructured":"Killelea BK, Long JB, Chagpar AB et al (2013) Trends and clinical implications of preoperative breast MRI in Medicare beneficiaries with breast cancer. Breast Cancer Res Treat 141:155\u2013163","journal-title":"Breast Cancer Res Treat"},{"key":"9115_CR17","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1002\/bjs.9797","volume":"102","author":"A Fancellu","year":"2015","unstructured":"Fancellu A, Turner RM, Dixon JM, Pinna A, Cottu P, Houssami N (2015) Meta-analysis of the effect of preoperative breast MRI on the surgical management of ductal carcinoma in situ. Br J Surg 102:883\u2013893","journal-title":"Br J Surg"},{"unstructured":"National Breast Cancer Organization of the Netherlands (NABON) (2012) Breast Cancer, richtlijnendatabase.nl","key":"9115_CR18"},{"key":"9115_CR19","volume-title":"UICC TNM classification of malignant tumours","author":"L Sobin","year":"2009","unstructured":"Sobin L, Gospodarowicz M, Wittekind CH (2009) UICC TNM classification of malignant tumours, vol 184, 7th edn. Wiley-Blackwell, West Sussex, England","edition":"7"},{"key":"9115_CR20","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.breast.2017.01.015","volume":"32","author":"ME Brennan","year":"2017","unstructured":"Brennan ME, McKessar M, Snook K, Burgess I, Spillane AJ (2017) Impact of selective use of breast MRI on surgical decision-making in women with newly diagnosed operable breast cancer. Breast 32:135\u2013143","journal-title":"Breast"},{"key":"9115_CR21","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.1056\/NEJMoa065447","volume":"356","author":"CD Lehman","year":"2007","unstructured":"Lehman CD, Gatsonis C, Kuhl CK et al (2007) MRI evaluation of the contralateral breast in women with recently diagnosed breast cancer. N Engl J Med 356:1295\u20131303","journal-title":"N Engl J Med"},{"key":"9115_CR22","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1007\/s10549-016-3858-0","volume":"158","author":"SY Wang","year":"2016","unstructured":"Wang SY, Long JB, Killelea BK et al (2016) Preoperative breast magnetic resonance imaging and contralateral breast cancer occurrence among older women with ductal carcinoma in situ. Breast Cancer Res Treat 158:139\u2013148","journal-title":"Breast Cancer Res Treat"},{"key":"9115_CR23","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1093\/jnci\/djz010","volume":"111","author":"I Kramer","year":"2019","unstructured":"Kramer I, Schaapveld M, Oldenburg HSA et al (2019) The influence of adjuvant systemic regimens on contralateral breast cancer risk and receptor subtype. J Natl Cancer Inst 111:709\u2013718","journal-title":"J Natl Cancer Inst"},{"key":"9115_CR24","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1186\/s13058-020-01287-6","volume":"22","author":"S Chootipongchaivat","year":"2020","unstructured":"Chootipongchaivat S, van Ravesteyn NT, Li X et al (2020) Modeling the natural history of ductal carcinoma in situ based on population data. Breast Cancer Res 22:53","journal-title":"Breast Cancer Res"},{"key":"9115_CR25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.20892\/j.issn.2095-3941.2016.0050","volume":"14","author":"N Houssami","year":"2017","unstructured":"Houssami N (2017) Overdiagnosis of breast cancer in population screening: does it make breast screening worthless? Cancer Biol Med 14:1\u20138","journal-title":"Cancer Biol Med"},{"key":"9115_CR26","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1016\/j.breast.2016.10.011","volume":"31","author":"A Evans","year":"2017","unstructured":"Evans A, Vinnicombe S (2017) Overdiagnosis in breast imaging. Breast 31:270\u2013273","journal-title":"Breast"},{"key":"9115_CR27","doi-asserted-by":"publisher","first-page":"2889","DOI":"10.1245\/s10434-017-5931-2","volume":"24","author":"ME Miller","year":"2017","unstructured":"Miller ME, Muhsen S, Olcese C, Patil S, Morrow M, Van Zee KJ (2017) Contralateral breast cancer risk in women with ductal carcinoma in situ: is it high enough to justify bilateral mastectomy? Ann Surg Oncol 24:2889\u20132897","journal-title":"Ann Surg Oncol"},{"key":"9115_CR28","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1038\/s41523-020-00202-8","volume":"6","author":"D Giardiello","year":"2020","unstructured":"Giardiello D, Kramer I, Hooning MJ et al (2020) Contralateral breast cancer risk in patients with ductal carcinoma in situ and invasive breast cancer. NPJ Breast Cancer 6:60","journal-title":"NPJ Breast Cancer"}],"container-title":["European Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00330-022-09115-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00330-022-09115-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00330-022-09115-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,16]],"date-time":"2023-02-16T18:05:26Z","timestamp":1676570726000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00330-022-09115-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,30]]},"references-count":28,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2023,3]]}},"alternative-id":["9115"],"URL":"https:\/\/doi.org\/10.1007\/s00330-022-09115-5","relation":{},"ISSN":["1432-1084"],"issn-type":[{"type":"electronic","value":"1432-1084"}],"subject":[],"published":{"date-parts":[[2022,9,30]]},"assertion":[{"value":"25 March 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 July 2022","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 August 2022","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 September 2022","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The scientific guarantor of this publication is Prof. Vivianne C.G. Tjan-Heijnen, MD, PhD.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Guarantor"}},{"value":"The authors of this manuscript declare no relationships with any companies whose products or services may be related to the subject matter of the article.Potential conflicts of interest <i>not<\/i> related to the subject of this article: SG reports grants from Roche, Pfizer, Novartis, Eli Lilly, Daiichi Sankyo and Gilead, and personal fees from AstraZeneca. All outside the submitted work, VT-H reports grants and personal fees from Roche, Novartis, Pfizer and Eli Lilly, and grants from AstraZeneca, Eisai, Daiichi Sankyo and Gilead.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"One of the authors has significant statistical expertise.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Statistics and biometry"}},{"value":"Written informed consent was waived by the Institutional Review Board.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"Institutional Review Board approval was not required because anonymised data from the Netherlands Cancer Registry are used.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Some study subjects or cohorts have been previously reported in Br J Surg. 2019;106(11): 1488-1494.doi: 10.1002\/bjs.11299.","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Study subjects or cohorts overlap"}},{"value":"\u2022 retrospective\u2022 observational\u2022 multicentre study","order":8,"name":"Ethics","group":{"name":"EthicsHeading","label":"Methodology"}}]}}