{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T14:08:02Z","timestamp":1793196482008,"version":"4.5.0"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T00:00:00Z","timestamp":1667347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T00:00:00Z","timestamp":1667347200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100014584","name":"Universit\u00e4tsmedizin der Johannes Gutenberg-Universit\u00e4t Mainz","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100014584","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Radiol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Cardiac involvement in Anderson-Fabry disease (AFD) results in myocardial lipid depositions. An early diagnosis can maximize therapeutic benefit. Thus, this study aims to investigate the potential of cardiac MRI (CMR) based parameters of left atrial (LA) function and strain to detect early stages of AFD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Patients (\n                      <jats:italic>n<\/jats:italic>\n                      = 58, age 40 (29\u201351) years, 31 female) with genetically proven AFD had undergone CMR including left ventricular (LV) volumetry, mass index (LVMi), T1, and late gadolinium enhancement, complemented by LA and LV strain measurements and atrial emptying fractions. Patients were stratified into three disease phases and compared to age and sex-matched healthy controls (HC,\n                      <jats:italic>n<\/jats:italic>\n                      = 58, age 41 [26\u201356] years, 31 female).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 19 early-, 20 intermediate-, and 19 advanced-phase patients were included. LV and LA reservoir strain was significantly impaired in all AFD phases, including early disease (both\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001). In contrast, LA volumetry, T1, and LVMi showed no significant differences between the early phase and HC (\n                      <jats:italic>p<\/jats:italic>\n                      &gt; 0.05). In the intermediate phase, LVMi and T1 demonstrated significant differences. In advanced phase, all parameters except active emptying fractions differed significantly from HC. ROC curve analyses of early disease phases revealed superior diagnostic confidence for the LA reservoir strain (AUC 0.88, sensitivity 89%, specificity 75%) over the LV strain (AUC 0.82).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>LA reservoir strain showed impairment in early AFD and significantly correlated with disease severity. The novel approach performed better in identifying early disease than the established approach using LVMi and T1. Further studies are needed to evaluate whether these results justify earlier initiation of therapy and help minimize cardiac complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Points<\/jats:title>\n                    <jats:p>\n                      <jats:italic>\u2022 Parameters of left atrial function and deformation showed impairments in the early stages of Anderson-Fabry disease and correlated significantly with the severity of Anderson-Fabry disease.<\/jats:italic>\n                    <\/jats:p>\n                    <jats:p>\n                      <jats:italic>\u2022 Left atrial reservoir strain performed superior to ventricular strain in detecting early myocardial involvement in Anderson-Fabry disease and improved diagnostic accuracies of approaches already using ventricular strain.<\/jats:italic>\n                    <\/jats:p>\n                    <jats:p>\n                      <jats:italic>\u2022 Further studies are needed to evaluate whether earlier initiation of enzyme replacement therapy based on these results can help minimize cardiac complications from Anderson-Fabry disease.<\/jats:italic>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00330-022-09183-7","type":"journal-article","created":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T04:03:03Z","timestamp":1667361783000},"page":"2039-2051","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Left atrial strain correlates with severity of cardiac involvement in Anderson-Fabry disease"],"prefix":"10.1007","volume":"33","author":[{"given":"Moritz C.","family":"Halfmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Altmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U. Joseph","family":"Schoepf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constantin","family":"Reichardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia B.","family":"Hennermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl-Friedrich","family":"Kreitner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman","family":"Kloeckner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Hahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Dueber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akos","family":"Varga-Szemes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Kampmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6096-3154","authenticated-orcid":false,"given":"Tilman","family":"Emrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,11,2]]},"reference":[{"key":"9183_CR1","first-page":"1751","volume-title":"The metabolic basis of inherited disease","author":"RJBD Desnick","year":"1989","unstructured":"Desnick RJBD (1989) Fabry disease: \u03b1-galactosidase A deficiency; Schindler disease: \u03b1-N-acetylgalactosaminidase deficiency. In: Scriver C, Beaudet A, Sly W, Valle D (eds) The metabolic basis of inherited disease, 6th edn. McGraw-Hill, New York, pp 1751\u20131796","edition":"6"},{"key":"9183_CR2","unstructured":"Mehta A HD. Fabry Disease. In: Adam MP, Ardinger HH, Pagon RA, et al, eds. GeneReviews\u00ae Seattle University of Washington, 2002."},{"issue":"FI2","key":"9183_CR3","doi-asserted-by":"publisher","first-page":"f153","DOI":"10.1093\/europace\/eux261","volume":"20","author":"S Baig","year":"2018","unstructured":"Baig S, Edward NC, Kotecha D, Liu B, Nordin S, Kozor R et al (2018) Ventricular arrhythmia and sudden cardiac death in Fabry disease: a systematic review of risk factors in clinical practice. Europace 20(FI2):f153\u2013ff61","journal-title":"Europace"},{"issue":"8 Pt 2","key":"9183_CR4","doi-asserted-by":"publisher","first-page":"1673","DOI":"10.1016\/j.jcmg.2018.03.020","volume":"12","author":"S Nordin","year":"2019","unstructured":"Nordin S, Kozor R, Medina-Menacho K, Abdel-Gadir A, Baig S, Sado DM et al (2019) Proposed stages of myocardial phenotype development in Fabry disease. JACC Cardiovasc Imaging 12(8 Pt 2):1673\u20131683","journal-title":"JACC Cardiovasc Imaging"},{"issue":"1","key":"9183_CR5","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1056\/NEJM200107053450102","volume":"345","author":"CM Eng","year":"2001","unstructured":"Eng CM, Guffon N, Wilcox WR, Germain DP, Lee P, Waldek S et al (2001) Safety and efficacy of recombinant human alpha-galactosidase A replacement therapy in Fabry's disease. N Engl J Med 345(1):9\u201316","journal-title":"N Engl J Med"},{"issue":"4","key":"9183_CR6","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1161\/CIRCULATIONAHA.108.794529","volume":"119","author":"F Weidemann","year":"2009","unstructured":"Weidemann F, Niemann M, Breunig F, Herrmann S, Beer M, Stork S et al (2009) Long-term effects of enzyme replacement therapy on fabry cardiomyopathy: evidence for a better outcome with early treatment. Circulation. 119(4):524\u2013529","journal-title":"Circulation."},{"key":"9183_CR7","first-page":"CD006663","volume":"7","author":"R El Dib","year":"2016","unstructured":"El Dib R, Gomaa H, Carvalho RP, Camargo SE, Bazan R, Barretti P et al (2016) Enzyme replacement therapy for Anderson-Fabry disease. Cochrane Database Syst Rev 7:CD006663","journal-title":"Cochrane Database Syst Rev"},{"key":"9183_CR8","doi-asserted-by":"crossref","unstructured":"Goker-Alpan O, Longo N, McDonald M, Shankar SP, Schiffmann R, Chang P, et al. An open-label clinical trial of agalsidase alfa enzyme replacement therapy in children with Fabry disease who are naive to enzyme replacement therapy. Drug Des Devel Ther 2016;10:1771-1781.","DOI":"10.2147\/DDDT.S102761"},{"issue":"1","key":"9183_CR9","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1186\/s40360-017-0152-7","volume":"18","author":"K Tsuboi","year":"2017","unstructured":"Tsuboi K, Yamamoto H (2017) Efficacy and safety of enzyme-replacement-therapy with agalsidase alfa in 36 treatment-naive Fabry disease patients. BMC Pharmacol Toxicol 18(1):43","journal-title":"BMC Pharmacol Toxicol"},{"issue":"23","key":"9183_CR10","doi-asserted-by":"publisher","first-page":"2151","DOI":"10.1016\/j.ehj.2003.09.017","volume":"24","author":"JC Moon","year":"2003","unstructured":"Moon JC, Sachdev B, Elkington AG, McKenna WJ, Mehta A, Pennell DJ et al (2003) Gadolinium enhanced cardiovascular magnetic resonance in Anderson-Fabry disease. Evidence for a disease specific abnormality of the myocardial interstitium. Eur Heart J 24(23):2151\u20132155","journal-title":"Eur Heart J"},{"issue":"3","key":"9183_CR11","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1080\/10976640600605002","volume":"8","author":"JC Moon","year":"2006","unstructured":"Moon JC, Sheppard M, Reed E, Lee P, Elliott PM, Pennell DJ (2006) The histological basis of late gadolinium enhancement cardiovascular magnetic resonance in a patient with Anderson-Fabry disease. J Cardiovasc Magn Reson 8(3):479\u2013482","journal-title":"J Cardiovasc Magn Reson"},{"key":"9183_CR12","doi-asserted-by":"crossref","unstructured":"Augusto JB, Johner N, Shah D, Nordin S, Knott KD, Rosmini S et al (2020) The myocardial phenotype of Fabry disease pre-hypertrophy and pre-detectable storage. Eur Heart J Cardiovasc Imaging","DOI":"10.1093\/ehjci\/jeaa101"},{"issue":"12","key":"9183_CR13","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.1016\/j.echo.2013.08.024","volume":"26","author":"AC Boyd","year":"2013","unstructured":"Boyd AC, Lo Q, Devine K, Tchan MC, Sillence DO (2013) Sadick N, et al Left atrial enlargement and reduced atrial compliance occurs early in Fabry cardiomyopathy. J Am Soc Echocardiogr 26(12):1415\u20131423","journal-title":"J Am Soc Echocardiogr"},{"issue":"Supplement_2","key":"9183_CR14","doi-asserted-by":"publisher","first-page":"jeab090","DOI":"10.1093\/ehjci\/jeab090.075","volume":"22","author":"A Moroni","year":"2021","unstructured":"Moroni A, Tondi L, Camporeale A, Milani V, Pica S, Pieroni M et al (2021) Left atrial morpho-functional changes in hypertrophic cardiomyopathy and Fabry disease: a CMR-feature tracking study. Eur Heart J Cardiovasc Imaging 22(Supplement_2):jeab090\u2013jeab075","journal-title":"Eur Heart J Cardiovasc Imaging"},{"issue":"2","key":"9183_CR15","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.echo.2016.10.014","volume":"30","author":"M Pichette","year":"2017","unstructured":"Pichette M, Serri K, Page M, Di LZ, Bichet DG, Poulin F (2017) Impaired left atrial function in fabry disease: a longitudinal speckle-tracking echocardiography study. J Am Soc Echocardiogr 30(2):170\u20139e2","journal-title":"J Am Soc Echocardiogr"},{"issue":"6","key":"9183_CR16","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1136\/heartjnl-2018-313699","volume":"105","author":"R Vijapurapu","year":"2019","unstructured":"Vijapurapu R, Nordin S, Baig S, Liu B, Rosmini S, Augusto J et al (2019) Global longitudinal strain, myocardial storage and hypertrophy in Fabry disease. Heart. 105(6):470\u2013476","journal-title":"Heart."},{"issue":"3","key":"9183_CR17","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1161\/CIRCIMAGING.109.865683","volume":"3","author":"SS Kuppahally","year":"2010","unstructured":"Kuppahally SS, Akoum N, Burgon NS, Badger TJ, Kholmovski EG, Vijayakumar S et al (2010) Left atrial strain and strain rate in patients with paroxysmal and persistent atrial fibrillation: relationship to left atrial structural remodeling detected by delayed-enhancement MRI. Circ Cardiovasc Imaging 3(3):231\u2013239","journal-title":"Circ Cardiovasc Imaging"},{"issue":"2","key":"9183_CR18","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1002\/jmri.24851","volume":"42","author":"M Evin","year":"2015","unstructured":"Evin M, Cluzel P, Lamy J, Rosenbaum D, Kusmia S, Defrance C et al (2015) Assessment of left atrial function by MRI myocardial feature tracking. J Magn Reson Imaging 42(2):379\u2013389","journal-title":"J Magn Reson Imaging"},{"issue":"2","key":"9183_CR19","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.hfc.2018.12.001","volume":"15","author":"KY Kebed","year":"2019","unstructured":"Kebed KY, Addetia K, Lang RM (2019) Importance of the Left Atrium: More Than a Bystander? Heart Fail Clin 15(2):191\u2013204","journal-title":"Heart Fail Clin"},{"issue":"7","key":"9183_CR20","doi-asserted-by":"publisher","first-page":"1309","DOI":"10.1007\/s10554-019-01551-7","volume":"35","author":"SR Latif","year":"2019","unstructured":"Latif SR, Nguyen VQ, Peters DC, Soufer A, Henry ML, Grunseich K et al (2019) Left atrial fibrosis correlates with extent of left ventricular myocardial delayed enhancement and left ventricular strain in hypertrophic cardiomyopathy. Int J Card Imaging 35(7):1309\u20131318","journal-title":"Int J Card Imaging"},{"issue":"2","key":"9183_CR21","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1148\/radiol.2019190559","volume":"293","author":"A Schuster","year":"2019","unstructured":"Schuster A, Backhaus SJ, Stiermaier T, Navarra JL, Uhlig J, Rommel KP et al (2019) Left atrial function with MRI enables prediction of cardiovascular events after myocardial infarction: insights from the AIDA STEMI and TATORT NSTEMI trials. Radiology. 293(2):292\u2013302","journal-title":"Radiology."},{"issue":"5","key":"9183_CR22","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1093\/eurheartj\/ehq005","volume":"31","author":"LF Tops","year":"2010","unstructured":"Tops LF, Schalij MJ, Bax JJ (2010) Imaging and atrial fibrillation: the role of multimodality imaging in patient evaluation and management of atrial fibrillation. Eur Heart J 31(5):542\u2013551","journal-title":"Eur Heart J"},{"issue":"5","key":"9183_CR23","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1093\/ehjci\/jet239","volume":"15","author":"BF Agner","year":"2014","unstructured":"Agner BF, Kuhl JT, Linde JJ, Kofoed KF, Akeson P (2014) Rasmussen BV, et al Assessment of left atrial volume and function in patients with permanent atrial fibrillation: comparison of cardiac magnetic resonance imaging, 320-slice multi-detector computed tomography, and transthoracic echocardiography. Eur Heart J Cardiovasc Imaging 15(5):532\u2013540","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"9183_CR24","doi-asserted-by":"publisher","first-page":"247865","DOI":"10.1155\/2015\/247865","volume":"2015","author":"P Kuchynka","year":"2015","unstructured":"Kuchynka P, Podzimkova J, Masek M, Lambert L, Cerny V, Danek B et al (2015) The Role of magnetic resonance imaging and cardiac computed tomography in the assessment of left atrial anatomy, size, and function. Biomed Res Int 2015:247865","journal-title":"Biomed Res Int"},{"issue":"27","key":"9183_CR25","doi-asserted-by":"publisher","first-page":"2129","DOI":"10.1093\/eurheartj\/ehw128","volume":"37","author":"P Ponikowski","year":"2016","unstructured":"Ponikowski P, Voors AA, Anker SD, Bueno H, Cleland JGF, Coats AJS et al (2016) 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: the Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC)Developed with the special contribution of the Heart Failure Association (HFA) of the ESC. Eur Heart J 37(27):2129\u20132200","journal-title":"Eur Heart J"},{"key":"9183_CR26","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.compbiomed.2017.11.015","volume":"92","author":"J Lamy","year":"2018","unstructured":"Lamy J, Soulat G, Evin M, Huber A, de Cesare A, Giron A et al (2018) Scan-rescan reproducibility of ventricular and atrial MRI feature tracking strain. Comput Biol Med 92:197\u2013203","journal-title":"Comput Biol Med"},{"issue":"6","key":"9183_CR27","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1093\/ejechocard\/jeq175","volume":"12","author":"GG Blume","year":"2011","unstructured":"Blume GG, McLeod CJ, Barnes ME, Seward JB, Pellikka PA, Bastiansen PM et al (2011) Left atrial function: physiology, assessment, and clinical implications. Eur J Echocardiogr 12(6):421\u2013430","journal-title":"Eur J Echocardiogr"},{"issue":"4","key":"9183_CR28","first-page":"446","volume":"21","author":"VT Truong","year":"2020","unstructured":"Truong VT, Palmer C, Wolking S, Sheets B, Young M, Ngo TNM et al (2020) Normal left atrial strain and strain rate using cardiac magnetic resonance feature tracking in healthy volunteers. Eur Heart J Cardiovasc Imaging 21(4):446\u2013453","journal-title":"Eur Heart J Cardiovasc Imaging"},{"issue":"3","key":"9183_CR29","first-page":"213","volume":"19","author":"MS Nacif","year":"2013","unstructured":"Nacif MS, Barranhas AD, Turkbey E, Marchiori E, Kawel N (2013) Mello RA, et al Left atrial volume quantification using cardiac MRI in atrial fibrillation: comparison of the Simpson's method with biplane area-length, ellipse, and three-dimensional methods. Diagn Interv Radiol 19(3):213\u2013220","journal-title":"Diagn Interv Radiol"},{"issue":"2","key":"9183_CR30","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1148\/radiol.2020200176","volume":"296","author":"S Leng","year":"2020","unstructured":"Leng S, Ge H, He J, Kong L, Yang Y, Yan F et al (2020) Long-term prognostic value of cardiac MRI left atrial strain in ST-segment elevation myocardial infarction. Radiology. 296(2):299\u2013309","journal-title":"Radiology."},{"issue":"1","key":"9183_CR31","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1186\/s12968-016-0284-8","volume":"18","author":"AM Maceira","year":"2016","unstructured":"Maceira AM, Cosin-Sales J, Prasad SK, Pennell DJ (2016) Characterization of left and right atrial function in healthy volunteers by cardiovascular magnetic resonance. J Cardiovasc Magn Reson 18(1):64","journal-title":"J Cardiovasc Magn Reson"},{"issue":"10","key":"9183_CR32","doi-asserted-by":"publisher","first-page":"7219","DOI":"10.1007\/s00330-021-07830-z","volume":"31","author":"S Altmann","year":"2021","unstructured":"Altmann S, Halfmann MC, Abidoye I, Yacoub B, Schmidt M, Wenzel P et al (2021) Compressed sensing acceleration of cardiac cine imaging allows reliable and reproducible assessment of volumetric and functional parameters of the left and right atrium. Eur Radiol 31(10):7219\u20137230","journal-title":"Eur Radiol"},{"issue":"6","key":"9183_CR33","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1016\/j.jacc.2013.10.055","volume":"63","author":"BD Hoit","year":"2014","unstructured":"Hoit BD (2014) Left atrial size and function: role in prognosis. J Am Coll Cardiol 63(6):493\u2013505","journal-title":"J Am Coll Cardiol"},{"key":"9183_CR34","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1186\/1532-429X-12-65","volume":"12","author":"AM Maceira","year":"2010","unstructured":"Maceira AM, Cosin-Sales J, Roughton M, Prasad SK, Pennell DJ (2010) Reference left atrial dimensions and volumes by steady state free precession cardiovascular magnetic resonance. J Cardiovasc Magn Reson 12:65","journal-title":"J Cardiovasc Magn Reson"},{"key":"9183_CR35","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1186\/1532-429X-15-29","volume":"15","author":"AM Maceira","year":"2013","unstructured":"Maceira AM, Cosin-Sales J, Roughton M, Prasad SK, Pennell DJ (2013) Reference right atrial dimensions and volume estimation by steady state free precession cardiovascular magnetic resonance. J Cardiovasc Magn Reson 15:29","journal-title":"J Cardiovasc Magn Reson"},{"issue":"9","key":"9183_CR36","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1093\/ehjci\/jev217","volume":"17","author":"F Le Ven","year":"2016","unstructured":"Le Ven F, Bibeau K, De Larochelliere E, Tizon-Marcos H, Deneault-Bissonnette S, Pibarot P et al (2016) Cardiac morphology and function reference values derived from a large subset of healthy young Caucasian adults by magnetic resonance imaging. Eur Heart J Cardiovasc Imaging 17(9):981\u2013990","journal-title":"Eur Heart J Cardiovasc Imaging"},{"issue":"7","key":"9183_CR37","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1016\/j.jcmg.2011.02.018","volume":"4","author":"AC To","year":"2011","unstructured":"To AC, Flamm SD, Marwick TH, Klein AL (2011) Clinical utility of multimodality LA imaging: assessment of size, function, and structure. JACC Cardiovasc Imaging 4(7):788\u2013798","journal-title":"JACC Cardiovasc Imaging"},{"issue":"3","key":"9183_CR38","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1161\/CIRCIMAGING.112.000070","volume":"6","author":"DM Sado","year":"2013","unstructured":"Sado DM, White SK, Piechnik SK, Banypersad SM, Treibel T, Captur G et al (2013) Identification and assessment of Anderson-Fabry disease by cardiovascular magnetic resonance noncontrast myocardial T1 mapping. Circ Cardiovasc Imaging 6(3):392\u2013398","journal-title":"Circ Cardiovasc Imaging"},{"issue":"12","key":"9183_CR39","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1038\/gim.2016.55","volume":"18","author":"R Schiffmann","year":"2016","unstructured":"Schiffmann R, Fuller M, Clarke LA, Aerts JM (2016) Is it Fabry disease? Genet Med 18(12):1181\u20131185","journal-title":"Genet Med"},{"key":"9183_CR40","doi-asserted-by":"publisher","first-page":"551","DOI":"10.2147\/TCRM.S247814","volume":"16","author":"I Vardarli","year":"2020","unstructured":"Vardarli I, Rischpler C, Herrmann K, Weidemann F (2020) Diagnosis and screening of patients with fabry disease. Ther Clin Risk Manag 16:551\u2013558","journal-title":"Ther Clin Risk Manag"},{"issue":"12","key":"9183_CR41","doi-asserted-by":"publisher","first-page":"e007512","DOI":"10.1161\/CIRCIMAGING.117.007512","volume":"11","author":"JA Chirinos","year":"2018","unstructured":"Chirinos JA, Sardana M, Ansari B, Satija V, Kuriakose D, Edelstein I et al (2018) Left atrial phasic function by cardiac magnetic resonance feature tracking is a strong predictor of incident cardiovascular events. Circ Cardiovasc Imaging 11(12):e007512","journal-title":"Circ Cardiovasc Imaging"},{"issue":"1","key":"9183_CR42","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12968-019-0589-5","volume":"22","author":"Y Yang","year":"2020","unstructured":"Yang Y, Yin G, Jiang Y, Song L, Zhao S, Lu M (2020) Quantification of left atrial function in patients with non-obstructive hypertrophic cardiomyopathy by cardiovascular magnetic resonance feature tracking imaging: a feasibility and reproducibility study. J Cardiovasc Magn Reson 22(1):1","journal-title":"J Cardiovasc Magn Reson"},{"issue":"4","key":"9183_CR43","doi-asserted-by":"publisher","first-page":"e005467","DOI":"10.1161\/CIRCIMAGING.116.005467","volume":"10","author":"M von Roeder","year":"2017","unstructured":"von Roeder M, Rommel KP, Kowallick JT, Blazek S, Besler C, Fengler K et al (2017) Influence of left atrial function on exercise capacity and left ventricular function in patients with heart failure and preserved ejection fraction. Circ Cardiovasc Imaging 10(4):e005467","journal-title":"Circ Cardiovasc Imaging"},{"issue":"5","key":"9183_CR44","doi-asserted-by":"publisher","first-page":"e008582","DOI":"10.1161\/CIRCIMAGING.118.008582","volume":"12","author":"S Leng","year":"2019","unstructured":"Leng S, Dong Y, Wu Y, Zhao X, Ruan W (2019) Zhang G, et al Impaired cardiovascular magnetic resonance-derived rapid semiautomated right atrial longitudinal strain is associated with decompensated hemodynamics in pulmonary arterial hypertension. Circ Cardiovasc Imaging 12(5):e008582","journal-title":"Circ Cardiovasc Imaging"},{"issue":"1","key":"9183_CR45","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/0002-9149(69)90055-1","volume":"24","author":"VJ Ferrans","year":"1969","unstructured":"Ferrans VJ, Hibbs RG, Burda CD (1969) The heart in Fabry's disease. A histochemical and electron microscopic study. Am J Cardiol 24(1):95\u2013110","journal-title":"Am J Cardiol"},{"issue":"Suppl 2","key":"9183_CR46","doi-asserted-by":"publisher","first-page":"S147","DOI":"10.1097\/01.ASN.0000015238.98011.AF","volume":"13","author":"C Kampmann","year":"2002","unstructured":"Kampmann C, Baehner F, Ries M, Beck M (2002) Cardiac involvement in Anderson-Fabry disease. J Am Soc Nephrol 13(Suppl 2):S147\u2013S149","journal-title":"J Am Soc Nephrol"},{"issue":"5","key":"9183_CR47","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/j.carpath.2009.05.003","volume":"19","author":"MN Sheppard","year":"2010","unstructured":"Sheppard MN, Cane P, Florio R, Kavantzas N, Close L, Shah J et al (2010) A detailed pathologic examination of heart tissue from three older patients with Anderson-Fabry disease on enzyme replacement therapy. Cardiovasc Pathol 19(5):293\u2013301","journal-title":"Cardiovasc Pathol"},{"issue":"11","key":"9183_CR48","doi-asserted-by":"publisher","first-page":"1461","DOI":"10.1136\/hrt.2007.116467","volume":"93","author":"LF Tops","year":"2007","unstructured":"Tops LF, van der Wall EE, Schalij MJ, Bax JJ (2007) Multi-modality imaging to assess left atrial size, anatomy and function. Heart. 93(11):1461\u20131470","journal-title":"Heart."},{"issue":"1","key":"9183_CR49","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1148\/radiol.2017162787","volume":"286","author":"AT Huber","year":"2018","unstructured":"Huber AT, Lamy J, Rahhal A, Evin M, Atassi F, Defrance C et al (2018) Cardiac MR Strain: a noninvasive biomarker of fibrofatty remodeling of the left atrial myocardium. Radiology. 286(1):83\u201392","journal-title":"Radiology."},{"issue":"40","key":"9183_CR50","doi-asserted-by":"publisher","first-page":"3297","DOI":"10.1093\/eurheartj\/ehz641","volume":"40","author":"B Pieske","year":"2019","unstructured":"Pieske B, Tsch\u00f6pe C, de Boer RA, Fraser AG, Anker SD, Donal E et al (2019) How to diagnose heart failure with preserved ejection fraction: the HFA\u2013PEFF diagnostic algorithm: a consensus recommendation from the Heart Failure Association (HFA) of the European Society of Cardiology (ESC). Eur Heart J 40(40):3297\u20133317","journal-title":"Eur Heart J"},{"issue":"6","key":"9183_CR51","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1067\/mhj.2000.105105","volume":"139","author":"A Linhart","year":"2000","unstructured":"Linhart A, Palecek T, Bultas J, Ferguson JJ, Hrudova J, Karetova D et al (2000) New insights in cardiac structural changes in patients with Fabry\u2019s disease. Am Heart J 139(6):1101\u20131108","journal-title":"Am Heart J"},{"issue":"3","key":"9183_CR52","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1093\/ejechocard\/jer021","volume":"12","author":"V Mor-Avi","year":"2011","unstructured":"Mor-Avi V, Lang RM, Badano LP, Belohlavek M, Cardim NM, Derumeaux G et al (2011) Current and evolving echocardiographic techniques for the quantitative evaluation of cardiac mechanics: ASE\/EAE consensus statement on methodology and indications endorsed by the Japanese Society of Echocardiography. Eur J Echocardiogr 12(3):167\u2013205","journal-title":"Eur J Echocardiogr"},{"key":"9183_CR53","doi-asserted-by":"crossref","unstructured":"Fern\u00e1ndez A, Politei J (2016) Cardiac manifestation of fabry disease: from hypertrophic cardiomyopathy to early diagnosis and treatment in patients without left ventricular hypertrophy. J Inborn Errors Metab Screen 4:1\u20139","DOI":"10.1177\/2326409816661352"},{"key":"9183_CR54","doi-asserted-by":"crossref","unstructured":"Pathan F, Zainal Abidin HA, Vo QH, Zhou H, D'Angelo T, Elen E et al (2021) Left atrial strain: a multi-modality, multi-vendor comparison study. Eur Heart J Cardiovasc Imaging 22(1):102\u2013110","DOI":"10.1093\/ehjci\/jez303"},{"issue":"2","key":"9183_CR55","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1111\/cge.13546","volume":"96","author":"DP Germain","year":"2019","unstructured":"Germain DP, Fouilhoux A, Decramer S, Tardieu M, Pillet P (2019) Fila M, et al Consensus recommendations for diagnosis, management and treatment of Fabry disease in paediatric patients. Clin Genet 96(2):107\u2013117","journal-title":"Clin Genet"}],"container-title":["European Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00330-022-09183-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00330-022-09183-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00330-022-09183-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,16]],"date-time":"2023-02-16T13:09:37Z","timestamp":1676552977000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00330-022-09183-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,2]]},"references-count":55,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2023,3]]}},"alternative-id":["9183"],"URL":"https:\/\/doi.org\/10.1007\/s00330-022-09183-7","relation":{},"ISSN":["1432-1084"],"issn-type":[{"value":"1432-1084","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,2]]},"assertion":[{"value":"10 June 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 August 2022","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 September 2022","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 November 2022","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors of this manuscript declare relationships with the following companies: UJS has received institutional research support and\/or honoraria for speaking and consulting from Astellas, Bayer, Bracco, Elucid BioImaging, General Electric, Guerbet, HeartFlow Inc., Keya Medical, and Siemens Healthineers. AVS receives institutional research support and travel support from Siemens Healthineers and is a consultant for Bayer and Elucid Bioimaging. TE has received a speaker fee and travel support from Siemens Healthineers. None of these companies supported this study and none of the other authors report a conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"No complex statistical methods were necessary for this paper.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Statistics and biometry"}},{"value":"Written informed consent was waived by the Institutional Review Board.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"Institutional Review Board approval was obtained.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Some study subjects or cohorts have been previously reported in studies concerning ventricular strain parameters, which are currently under review. This study contains parts of the doctoral thesis of one of theauthors (C.R.)","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Study subjects or cohorts overlap"}},{"value":"\u2022 retrospective\u2022 observational\u2022 performed at one institution","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Methodology"}}]}}