{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T19:25:12Z","timestamp":1785007512320,"version":"3.55.0"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2022,11,12]],"date-time":"2022-11-12T00:00:00Z","timestamp":1668211200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,11,12]],"date-time":"2022-11-12T00:00:00Z","timestamp":1668211200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82172015"],"award-info":[{"award-number":["82172015"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2022A1515011264"],"award-info":[{"award-number":["2022A1515011264"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2021A1515012279"],"award-info":[{"award-number":["2021A1515012279"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2020A1515011436"],"award-info":[{"award-number":["2020A1515011436"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Radiol"],"DOI":"10.1007\/s00330-022-09214-3","type":"journal-article","created":{"date-parts":[[2022,11,12]],"date-time":"2022-11-12T07:03:58Z","timestamp":1668236638000},"page":"2881-2894","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Structural alterations of spinocerebellar ataxias type 3: from pre-symptomatic to symptomatic stage"],"prefix":"10.1007","volume":"33","author":[{"given":"Haishan","family":"Qiu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahui","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manshi","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingqian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihuan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5483-2169","authenticated-orcid":false,"given":"Jianping","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,11,12]]},"reference":[{"key":"9214_CR1","first-page":"809","volume":"4","author":"GAN Cancel","year":"1995","unstructured":"Cancel GAN, Stevanin G, D\u00fcrr A et al (1995) Marked phenotypic heterogeneity associated with expansion of a CAG repeat sequence at the spinocerebellar atazxia 3 Machado-Joseph disease locus. Am J Hum Genet 4:809\u2013816","journal-title":"Am J Hum Genet"},{"key":"9214_CR2","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1097\/WCO.0000000000000832","volume":"33","author":"MDC Costa","year":"2020","unstructured":"Costa MDC (2020) Recent therapeutic prospects for Machado-Joseph disease. Curr Opin Neurol 33:519\u2013526","journal-title":"Curr Opin Neurol"},{"key":"9214_CR3","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1590\/1678-4685-gmb-2018-0103","volume":"42","author":"GV Furtado","year":"2019","unstructured":"Furtado GV, Oliveira CM, Bolzan G, Saute JAM, Saraiva-Pereira ML, Jardim LB (2019) State biomarkers for Machado Joseph disease: validation, feasibility and responsiveness to change. Genet Mol Biol 42:238\u2013251","journal-title":"Genet Mol Biol"},{"key":"9214_CR4","doi-asserted-by":"publisher","first-page":"858","DOI":"10.1016\/j.nicl.2018.06.011","volume":"19","author":"IM Adanyeguh","year":"2018","unstructured":"Adanyeguh IM, Perlbarg V, Henry P-G et al (2018) Autosomal dominant cerebellar ataxias: Imaging biomarkers with high effect sizes. Neuroimage Clin 19:858\u2013867","journal-title":"Neuroimage Clin"},{"key":"9214_CR5","doi-asserted-by":"crossref","unstructured":"Seidel K, Siswanto S, Brunt ER, den Dunnen W, Korf HW, R\u00fcb U (2012) Brain pathology of spinocerebellar ataxias. Acta Neuropathol 124(1):1\u201321","DOI":"10.1007\/s00401-012-1000-x"},{"key":"9214_CR6","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1007\/978-3-319-71779-1_11","volume-title":"Polyglutamine disorders","author":"AH Koeppen","year":"2018","unstructured":"Koeppen AH (2018) The neuropathology of spinocerebellar ataxia type 3\/Machado-Joseph disease. In: N\u00f3brega C, Pereira de Almeida L (eds) Polyglutamine disorders. Springer International Publishing, Cham, pp 233\u2013241"},{"key":"9214_CR7","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1002\/ana.25212","volume":"83","author":"JM Joers","year":"2018","unstructured":"Joers JM, Deelchand DK, Lyu T et al (2018) Neurochemical abnormalities in premanifest and early spinocerebellar ataxias. Ann Neurol 83:816\u2013829","journal-title":"Ann Neurol"},{"key":"9214_CR8","doi-asserted-by":"publisher","first-page":"2273","DOI":"10.1002\/mds.28610","volume":"36","author":"J Faber","year":"2021","unstructured":"Faber J, Schaprian T, Berkan K et al (2021) Regional brain and spinal cord volume loss in spinocerebellar ataxia type 3. Mov Disord 36:2273\u20132281","journal-title":"Mov Disord"},{"key":"9214_CR9","doi-asserted-by":"publisher","first-page":"749","DOI":"10.3389\/fnins.2020.00749","volume":"14","author":"N Wan","year":"2020","unstructured":"Wan N, Chen Z, Wan L, Tang B, Jiang H (2020) MR Imaging of SCA3\/MJD. Front Neurosci 14:749","journal-title":"Front Neurosci"},{"issue":"277-283","key":"9214_CR10","first-page":"e223","volume":"22","author":"TJ de Rezende","year":"2015","unstructured":"de Rezende TJ, D'Abreu A, Guimaraes RP et al (2015) Cerebral cortex involvement in Machado-Joseph disease. Eur J Neurol 22(277-283):e223\u2013e274","journal-title":"Eur J Neurol"},{"key":"9214_CR11","doi-asserted-by":"publisher","first-page":"411","DOI":"10.3389\/fneur.2020.00411","volume":"11","author":"YW Park","year":"2020","unstructured":"Park YW, Joers JM, Guo B et al (2020) Assessment of cerebral and cerebellar white matter microstructure in spinocerebellar ataxias 1, 2, 3, and 6 using diffusion MRI. Front Neurol 11:411","journal-title":"Front Neurol"},{"key":"9214_CR12","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1007\/s12311-020-01137-3","volume":"19","author":"WO Arruda","year":"2020","unstructured":"Arruda WO, Meira AT, Ono SE et al (2020) Volumetric MRI changes in spinocerebellar ataxia (SCA3 and SCA10) patients. Cerebellum 19:536\u2013543","journal-title":"Cerebellum"},{"key":"9214_CR13","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1016\/S1474-4422(13)70104-2","volume":"12","author":"H Jacobi","year":"2013","unstructured":"Jacobi H, Reetz K, du Montcel ST et al (2013) Biological and clinical characteristics of individuals at risk for spinocerebellar ataxia types 1, 2, 3, and 6 in the longitudinal RISCA study: analysis of baseline data. Lancet Neurol 12:650\u2013658","journal-title":"Lancet Neurol"},{"key":"9214_CR14","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1002\/ana.25297","volume":"84","author":"TJR Rezende","year":"2018","unstructured":"Rezende TJR, de Paiva JLR, Martinez ARM et al (2018) Structural signature of SCA3: from presymptomatic to late disease stages. Ann Neurol 84:401\u2013408","journal-title":"Ann Neurol"},{"key":"9214_CR15","doi-asserted-by":"publisher","first-page":"714","DOI":"10.3389\/fneur.2017.00714","volume":"8","author":"X Wu","year":"2017","unstructured":"Wu X, Liao X, Zhan Y et al (2017) Microstructural alterations in asymptomatic and symptomatic patients with spinocerebellar ataxia type 3: a tract-based spatial statistics study. Front Neurol 8:714","journal-title":"Front Neurol"},{"key":"9214_CR16","doi-asserted-by":"publisher","unstructured":"Akcimen F, Ross JP, Liao C, Spiegelman D, Dion PA, Rouleau GA (2020) Expanded CAG Repeats in ATXN1, ATXN2, ATXN3, and HTT in the 1000 Genomes Project. Mov Disord. https:\/\/doi.org\/10.1002\/mds.28341","DOI":"10.1002\/mds.28341"},{"key":"9214_CR17","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1111\/ene.13779","volume":"26","author":"EP de Mattos","year":"2019","unstructured":"de Mattos EP, Leotti VB, Soong BW et al (2019) Age at onset prediction in spinocerebellar ataxia type 3 changes according to population of origin. Eur J Neurol 26:113\u2013120","journal-title":"Eur J Neurol"},{"key":"9214_CR18","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.parkreldis.2020.02.004","volume":"72","author":"SR Gan","year":"2020","unstructured":"Gan SR, Figueroa KP, Xu HL et al (2020) The impact of ethnicity on the clinical presentations of spinocerebellar ataxia type 3. Parkinsonism Relat Disord 72:37\u201343","journal-title":"Parkinsonism Relat Disord"},{"key":"9214_CR19","doi-asserted-by":"publisher","first-page":"2107","DOI":"10.1016\/j.neurobiolaging.2015.02.029","volume":"36","author":"T Billiet","year":"2015","unstructured":"Billiet T, Vandenbulcke M, Madler B et al (2015) Age-related microstructural differences quantified using myelin water imaging and advanced diffusion MRI. Neurobiol Aging 36:2107\u20132121","journal-title":"Neurobiol Aging"},{"key":"9214_CR20","doi-asserted-by":"publisher","unstructured":"Cheung J, Doerr M, Hu R, Sun PZ (2020) Refined ischemic penumbra imaging with tissue ph and diffusion kurtosis magnetic resonance imaging. Transl Stroke Res. https:\/\/doi.org\/10.1007\/s12975-020-00868-z","DOI":"10.1007\/s12975-020-00868-z"},{"key":"9214_CR21","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1007\/s11060-018-03025-7","volume":"141","author":"J Zhao","year":"2019","unstructured":"Zhao J, Wang YL, Li XB et al (2019) Comparative analysis of the diffusion kurtosis imaging and diffusion tensor imaging in grading gliomas, predicting tumour cell proliferation and IDH-1 gene mutation status. J Neurooncol 141:195\u2013203","journal-title":"J Neurooncol"},{"key":"9214_CR22","doi-asserted-by":"publisher","first-page":"791","DOI":"10.3389\/fneur.2020.00791","volume":"11","author":"G Arribarat","year":"2020","unstructured":"Arribarat G, De Barros A, Peran P (2020) Modern brainstem MRI techniques for the diagnosis of Parkinson\u2019s disease and Parkinsonisms. Front Neurol 11:791","journal-title":"Front Neurol"},{"key":"9214_CR23","doi-asserted-by":"crossref","unstructured":"Maas RPPWM, van Gaalen J, Klockgether T, van de Warrenburg BPC (2015) The preclinical stage of spinocerebellar ataxias. Neurology 85:96-103","DOI":"10.1212\/WNL.0000000000001711"},{"key":"9214_CR24","doi-asserted-by":"publisher","first-page":"1644","DOI":"10.1002\/mds.28519","volume":"36","author":"KR Servelhere","year":"2021","unstructured":"Servelhere KR, Rezende TJR, de Lima FD et al (2021) Brain damage and gene expression across hereditary spastic paraplegia subtypes. Mov Disord 36:1644\u20131653","journal-title":"Mov Disord"},{"key":"9214_CR25","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1016\/j.neuroimage.2006.01.021","volume":"31","author":"RS Desikan","year":"2006","unstructured":"Desikan RS, Segonne F, Fischl B et al (2006) An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest. Neuroimage 31:968\u2013980","journal-title":"Neuroimage"},{"key":"9214_CR26","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.neuroimage.2009.01.045","volume":"46","author":"J Diedrichsen","year":"2009","unstructured":"Diedrichsen J, Balsters JH, Flavell J, Cussans E, Ramnani N (2009) A probabilistic MR atlas of the human cerebellum. Neuroimage 46:39\u201346","journal-title":"Neuroimage"},{"key":"9214_CR27","doi-asserted-by":"publisher","first-page":"e0133402","DOI":"10.1371\/journal.pone.0133402","volume":"10","author":"J Diedrichsen","year":"2015","unstructured":"Diedrichsen J, Zotow E (2015) Surface-based display of volume-averaged cerebellar imaging data. PLoS One 10:e0133402","journal-title":"PLoS One"},{"key":"9214_CR28","doi-asserted-by":"crossref","unstructured":"Schmitz-H\u00fcbsch T, Fimmers R, Rakowicz M et al (2010) Responsiveness of different rating instruments in spinocerebellar ataxia patients. Neurology 74:678-684","DOI":"10.1212\/WNL.0b013e3181d1a6c9"},{"key":"9214_CR29","doi-asserted-by":"publisher","first-page":"124","DOI":"10.3389\/fneur.2020.00124","volume":"11","author":"PS Wang","year":"2020","unstructured":"Wang PS, Wu YT, Wang TY, Wu HM, Soong BW, Jao CW (2020) Supratentorial and infratentorial lesions in spinocerebellar ataxia type 3. Front Neurol 11:124","journal-title":"Front Neurol"},{"key":"9214_CR30","doi-asserted-by":"publisher","unstructured":"Li M, Chen X, Xu HL et al (2021) Brain structural abnormalities in the preclinical stage of Machado-Joseph disease\/spinocerebellar ataxia type 3 (MJD\/SCA3): evaluation by MRI morphometry, diffusion tensor imaging and neurite orientation dispersion and density imaging. J Neurol. https:\/\/doi.org\/10.1007\/s00415-021-10890-2","DOI":"10.1007\/s00415-021-10890-2"},{"key":"9214_CR31","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1007\/s00415-013-7186-6","volume":"261","author":"JS Kang","year":"2014","unstructured":"Kang JS, Klein JC, Baudrexel S, Deichmann R, Nolte D, Hilker R (2014) White matter damage is related to ataxia severity in SCA3. J Neurol 261:291\u2013299","journal-title":"J Neurol"},{"key":"9214_CR32","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1016\/j.neuroimage.2015.09.028","volume":"124","author":"ND Kelm","year":"2016","unstructured":"Kelm ND, West KL, Carson RP, Gochberg DF, Ess KC, Does MD (2016) Evaluation of diffusion kurtosis imaging in ex vivo hypomyelinated mouse brains. Neuroimage 124:612\u2013626","journal-title":"Neuroimage"},{"key":"9214_CR33","doi-asserted-by":"publisher","first-page":"1433","DOI":"10.1007\/s00234-020-02479-9","volume":"62","author":"Y Nakata","year":"2020","unstructured":"Nakata Y, Sakamoto A, Kawata A (2020) Neuromelanin imaging analyses of the substantia nigra in patients with Machado-Joseph disease. Neuroradiology 62:1433\u20131439","journal-title":"Neuroradiology"},{"key":"9214_CR34","doi-asserted-by":"publisher","first-page":"1679","DOI":"10.1002\/mds.28113","volume":"35","author":"CC Piccinin","year":"2020","unstructured":"Piccinin CC, Rezende TJR, de Paiva JLR et al (2020) A 5-year longitudinal clinical and magnetic resonance imaging study in spinocerebellar ataxia type 3. Mov Disord 35:1679\u20131684","journal-title":"Mov Disord"}],"container-title":["European Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00330-022-09214-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00330-022-09214-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00330-022-09214-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,15]],"date-time":"2023-03-15T13:05:50Z","timestamp":1678885550000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00330-022-09214-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,12]]},"references-count":34,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2023,4]]}},"alternative-id":["9214"],"URL":"https:\/\/doi.org\/10.1007\/s00330-022-09214-3","relation":{},"ISSN":["1432-1084"],"issn-type":[{"value":"1432-1084","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,12]]},"assertion":[{"value":"14 May 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 September 2022","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 September 2022","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 November 2022","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The scientific guarantor of this publication is Chu Jianping.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Guarantor"}},{"value":"The authors of this manuscript declare no relationships with any companies whose products or services may be related to the subject matter of the article.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"No complex statistical methods were necessary for this paper.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Statistics and biometry"}},{"value":"Written informed consent was obtained from all subjects (patients) in this study.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"Institutional Review Board approval was obtained.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"\u2022 prospective\u2022 cross-sectional study\u2022 performed at one institution","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Methodology"}}]}}