{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:09:47Z","timestamp":1792782587871,"version":"4.5.0"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2023,2,3]],"date-time":"2023-02-03T00:00:00Z","timestamp":1675382400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,2,3]],"date-time":"2023-02-03T00:00:00Z","timestamp":1675382400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"the Research Program on Emerging and Re-emerging Infectious Diseases from AMED Grant","award":["JP20he0622035"],"award-info":[{"award-number":["JP20he0622035"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Radiol"],"DOI":"10.1007\/s00330-023-09427-0","type":"journal-article","created":{"date-parts":[[2023,2,3]],"date-time":"2023-02-03T03:03:57Z","timestamp":1675393437000},"page":"4713-4722","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Association of subpleural ground-glass opacities with respiratory failure and RNAemia in COVID-19"],"prefix":"10.1007","volume":"33","author":[{"given":"K.","family":"Nagaoka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Kawasuji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Takegoshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Murai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Kaneda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Ueno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Miyajima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Wakasugi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Noguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Morimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Morinaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,2,3]]},"reference":[{"key":"9427_CR1","doi-asserted-by":"crossref","unstructured":"Guan WJ, Ni ZY, Hu Y et al (2020) China Medical Treatment Expert Group for Covid-19. Clinical characteristics of Coronavirus Disease 2019 in China. N Eng J Med 382:1708\u20131720","DOI":"10.1056\/NEJMoa2002032"},{"key":"9427_CR2","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1016\/j.chest.2021.04.004","volume":"160","author":"S Machnicki","year":"2021","unstructured":"Machnicki S, Patel D, Singh A et al (2021) The usefulness of chest CT imaging in patients with suspected or diagnosed COVID-19: a review of literature. Chest 160:652\u2013670","journal-title":"Chest"},{"key":"9427_CR3","doi-asserted-by":"publisher","first-page":"6129","DOI":"10.1007\/s00330-020-06975-7","volume":"30","author":"V Ojha","year":"2020","unstructured":"Ojha V, Mani A, Pandey NN et al (2020) CT in coronavirus disease 2019 (COVID-19): a systematic review of chest CT findings in 4410 adult patients. Eur Radiol 30:6129\u20136138","journal-title":"Eur Radiol"},{"key":"9427_CR4","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.2214\/AJR.20.22976","volume":"214","author":"W Zhao","year":"2020","unstructured":"Zhao W, Zhong Z, Xie X et al (2020) Relation between chest CT findings and clinical conditions of Coronavirus Disease (COVID-19) pneumonia: a multicenter study. AJR Am J Roentgenol 214:1072\u20131077","journal-title":"AJR Am J Roentgenol"},{"key":"9427_CR5","doi-asserted-by":"publisher","first-page":"E86","DOI":"10.1148\/radiol.2020201433","volume":"296","author":"D Colombi","year":"2020","unstructured":"Colombi D, Bodini FC, Petrini M et al (2020) Well-aerated lung on admitting chest CT to predict adverse outcome in COVID-19 pneumonia. Radiology 296:E86\u2013E96","journal-title":"Radiology"},{"key":"9427_CR6","doi-asserted-by":"publisher","first-page":"6808","DOI":"10.1007\/s00330-020-07033-y","volume":"30","author":"M Francone","year":"2020","unstructured":"Francone M, Iafrate F, Masci GM et al (2020) Chest CT score in COVID-19 patients: correlation with disease severity and short-term prognosis. Eur Radiol 30:6808\u20136817","journal-title":"Eur Radiol"},{"key":"9427_CR7","doi-asserted-by":"crossref","unstructured":"Meiler S, Schaible J, Poschenrieder F et al (2020) Can CT performed in the early disease phase predict outcome of patients with COVID 19 pneumonia? Analysis of a cohort of 64 patients from Germany. Eur J Radiol 131:109256","DOI":"10.1016\/j.ejrad.2020.109256"},{"key":"9427_CR8","doi-asserted-by":"crossref","unstructured":"Tabatabaei SMH, Rahimi H, Moghaddas F et al (2020) Predictive value of CT in the short-term mortality of Coronavirus Disease 2019 (COVID-19) pneumonia in nonelderly patients: a case-control study. Eur J Radiol 132:109298","DOI":"10.1016\/j.ejrad.2020.109298"},{"key":"9427_CR9","doi-asserted-by":"crossref","unstructured":"Peng S, Chen J, Zhang W et al (2021) The role of chest CT quantitative pulmonary inflammatory index in the evaluation of the course and treatment outcome of COVID-19 pneumonia. Sci Rep 11:7752","DOI":"10.1038\/s41598-021-87430-5"},{"key":"9427_CR10","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1148\/radiol.2020200370","volume":"295","author":"F Pan","year":"2020","unstructured":"Pan F, Ye T, Sun P et al (2020) Time course of lung changes at chest CT during recovery from coronavirus disease 2019 (COVID-19). Radiology 295:715\u2013721","journal-title":"Radiology"},{"key":"9427_CR11","doi-asserted-by":"publisher","first-page":"3501","DOI":"10.1007\/s00330-021-08432-5","volume":"32","author":"AH Elmokadem","year":"2022","unstructured":"Elmokadem AH, Mounir AM, Ramadan ZA et al (2022) Comparison of chest CT severity scoring systems for COVID-19. Eur Radiol 32:3501\u20133512","journal-title":"Eur Radiol"},{"key":"9427_CR12","doi-asserted-by":"publisher","first-page":"3513","DOI":"10.1007\/s00330-021-08435-2","volume":"32","author":"A Inoue","year":"2022","unstructured":"Inoue A, Takahashi H, Ibe T et al (2022) Comparison of semiquantitative chest CT scoring systems to estimate severity in coronavirus disease 2019 (COVID-19) pneumonia. Eur Radiol 32:3513\u20133524","journal-title":"Eur Radiol"},{"key":"9427_CR13","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1016\/S2213-2600(20)30076-X","volume":"8","author":"Z Xu","year":"2020","unstructured":"Xu Z, Shi L, Wang Y et al (2020) Pathological findings of COVID-19 associated with acute respiratory distress syndrome. Lancet Respir Med 8:420\u2013422","journal-title":"Lancet Respir Med"},{"key":"9427_CR14","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1007\/s11604-021-01118-4","volume":"39","author":"A Fukuda","year":"2021","unstructured":"Fukuda A, Yanagawa N, Sekiya N et al (2021) An analysis of the radiological factors associated with respiratory failure in COVID-19 pneumonia and the CT features among different age categories. Jpn J Radiol 39:783\u2013790","journal-title":"Jpn J Radiol"},{"key":"9427_CR15","doi-asserted-by":"crossref","unstructured":"Miki S, Sasaki H, Horiuchi H et al (2021) On-admission SARS-CoV-2 RNAemia as a single potent predictive marker of critical condition development and mortality in COVID-19.\u00a0PLoS One\u00a016:e0254640","DOI":"10.1371\/journal.pone.0254640"},{"key":"9427_CR16","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1093\/cid\/ciab394","volume":"74","author":"N Ram-Mohan","year":"2022","unstructured":"Ram-Mohan N, Kim D, Zudock EJ et al (2022) Stanford COVID-19 biobank study group SARS-CoV-2 RNAemia predicts clinical deterioration and extrapulmonary complications from COVID-19. Clin Infect Dis 74:218\u2013226","journal-title":"Clin Infect Dis"},{"key":"9427_CR17","doi-asserted-by":"crossref","unstructured":"van Riel D, Embregts CWE, Sips GJ et al (2021) Temporal kinetics of RNAemia and associated systemic cytokines in hospitalized COVID-19 Patients. mSphere 6:e0031121","DOI":"10.1128\/mSphere.00311-21"},{"key":"9427_CR18","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1016\/j.cell.2022.01.014","volume":"185","author":"Y Su","year":"2022","unstructured":"Su Y, Yuan D, Chen DG et al (2022) Multiple early factors anticipate post-acute COVID-19 sequelae. Cell 185:881-895.e20","journal-title":"Cell"},{"key":"9427_CR19","doi-asserted-by":"crossref","unstructured":"Wang YC, Lu MC, Yang SF et al (2021) Respiratory care for the critical patients with 2019 novel coronavirus. Respir Med 186:106516","DOI":"10.1016\/j.rmed.2021.106516"},{"key":"9427_CR20","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1038\/s41577-021-00542-x","volume":"21","author":"PC Taylor","year":"2021","unstructured":"Taylor PC, Adams AC, Hufford MM et al (2021) Neutralizing monoclonal antibodies for treatment of COVID-19. Nat Rev Immunol 21:382\u2013393","journal-title":"Nat Rev Immunol"},{"key":"9427_CR21","doi-asserted-by":"publisher","first-page":"2457","DOI":"10.1001\/jama.2021.7152","volume":"325","author":"Y Angel","year":"2021","unstructured":"Angel Y, Spitzer A, Henig O et al (2021) Association between vaccination with BNT162b2 and incidence of symptomatic and asymptomatic SARS-CoV-2 infections among health care workers. JAMA 325:2457\u20132465","journal-title":"JAMA"},{"key":"9427_CR22","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1148\/radiol.2462070712","volume":"246","author":"DM Hansell","year":"2008","unstructured":"Hansell DM, Bankier AA, MacMahon H et al (2008) Fleischner Society: glossary of terms for thoracic imaging. Radiology 246:697\u2013722","journal-title":"Radiology"},{"key":"9427_CR23","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1002\/jmv.27282","volume":"94","author":"H Kawasuji","year":"2022","unstructured":"Kawasuji H, Morinaga Y, Tani H et al (2022) SARS-CoV-2 RNAemia with higher nasopharyngeal viral load is strongly associated with severity and mortality in patients with COVID-19. J Med Virol 94:147\u2013153","journal-title":"J Med Virol"},{"key":"9427_CR24","unstructured":"R Core Team (2021) R: a Language and environment for statistical computing. r foundation for statistical computing, Vienna, Austria. Available at: https:\/\/www.R-project.org\/. Accessed 26 Oct 2022"},{"key":"9427_CR25","doi-asserted-by":"crossref","unstructured":"Nagaoka K, Kawasuji H, Murai Y et al (2022) Circulating type I interferon levels in the early phase of COVID-19 are associated with the development of respiratory failure. Front Immunol 13:844304","DOI":"10.3389\/fimmu.2022.844304"},{"key":"9427_CR26","doi-asserted-by":"publisher","first-page":"1399","DOI":"10.3390\/v14071399","volume":"14","author":"K Nagaoka","year":"2022","unstructured":"Nagaoka K, Kawasuji H, Takegoshi Y et al (2022) Effect of casirivimab\/imdevimab treatment on serum type I interferon levels in SARS-CoV-2 infection. Viruses 14:1399","journal-title":"Viruses"},{"key":"9427_CR27","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1186\/s13054-020-03374-8","volume":"24","author":"X Li","year":"2020","unstructured":"Li X, Liu C, Mao Z et al (2020) Predictive values of neutrophil-to-lymphocyte ratio on disease severity and mortality in COVID-19 patients: a systematic review and meta-analysis. Crit Care 24:647","journal-title":"Crit Care"},{"key":"9427_CR28","doi-asserted-by":"publisher","first-page":"289","DOI":"10.4329\/wjr.v12.i12.289","volume":"12","author":"A Eslambolchi","year":"2020","unstructured":"Eslambolchi A, Maliglig A, Gupta A et al (2020) COVID-19 or non-COVID viral pneumonia: How to differentiate based on the radiologic findings? World J Radiol 12:289\u2013301","journal-title":"World J Radiol"},{"key":"9427_CR29","doi-asserted-by":"publisher","first-page":"1380","DOI":"10.1016\/j.rmed.2011.05.006","volume":"105","author":"K Tanizawa","year":"2011","unstructured":"Tanizawa K, Handa T, Nakashima R et al (2011) HRCT features of interstitial lung disease in dermatomyositis with anti-CADM-140 antibody. Respir Med 105:1380\u20131387","journal-title":"Respir Med"},{"key":"9427_CR30","doi-asserted-by":"publisher","first-page":"130","DOI":"10.2185\/jrm.2935","volume":"12","author":"M Nakao","year":"2017","unstructured":"Nakao M, Muramatsu H, Yamamoto E et al (2017) A case of wild-type transthyretin amyloidosis associated with organizing pneumonia. J Rural Med 12:130\u2013134","journal-title":"J Rural Med"},{"key":"9427_CR31","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1111\/resp.14101","volume":"26","author":"A Kianzad","year":"2021","unstructured":"Kianzad A, Meijboom LJ, Nossent EJ et al (2021) COVID-19: histopathological correlates of imaging patterns on chest computed tomography. Respirology 26:869\u2013877","journal-title":"Respirology"},{"key":"9427_CR32","doi-asserted-by":"crossref","unstructured":"Henkel M, Weikert T, Marston K et al (2020) Lethal COVID-19: radiologic-pathologic correlation of the lungs. Radiol Cardiothorac Imaging 2:e200406","DOI":"10.1148\/ryct.2020200406"},{"key":"9427_CR33","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1007\/s10140-021-01976-5","volume":"29","author":"B Gosangi","year":"2022","unstructured":"Gosangi B, Rubinowitz AN, Irugu D et al (2022) COVID-19 ARDS: a review of imaging features and overview of mechanical ventilation and its complications. Emerg Radiol 29:23\u201334","journal-title":"Emerg Radiol"},{"key":"9427_CR34","doi-asserted-by":"publisher","first-page":"188","DOI":"10.5152\/dir.2020.20304","volume":"27","author":"S Bayraktaro\u011flu","year":"2021","unstructured":"Bayraktaro\u011flu S, \u00c7inkoo\u011flu A, Ceylan N et al (2021) The novel coronavirus pneumonia (COVID-19): a pictorial review of chest CT features. Diagn Interv Radiol 27:188\u2013194","journal-title":"Diagn Interv Radiol"}],"container-title":["European Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00330-023-09427-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00330-023-09427-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00330-023-09427-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,23]],"date-time":"2023-06-23T18:18:25Z","timestamp":1687544305000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00330-023-09427-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,3]]},"references-count":34,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2023,7]]}},"alternative-id":["9427"],"URL":"https:\/\/doi.org\/10.1007\/s00330-023-09427-0","relation":{},"ISSN":["1432-1084"],"issn-type":[{"value":"1432-1084","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,3]]},"assertion":[{"value":"21 July 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 November 2022","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 January 2023","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 February 2023","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The scientific guarantor of this publication is Kentaro Nagaoka.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Guarantor"}},{"value":"The authors of this manuscript declare no relationships with any companies whose products or services may be related to the subject matter of the article.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Morimoto Shinpei has significant statistical expertise, and kindly provided statistical advice and performed statistical analyses for this manuscript.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Statistics and biometry"}},{"value":"Written informed consent was obtained from all subjects (patients) in this study.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"This study was approved by the Ethical Review Board of the University of Toyama (R2019167).","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"A portion of the study population had been included in the previous experimental reports that investigated the association between prognosis and RNAemia (<i>n<\/i> = 56) [\n                      \n                      ], type I interferon (<i>n<\/i> = 50) [\n                      \n                      ], and the effect of casirivimab\/imdevimab (<i>n<\/i> = 28) [\n                      \n                      ].","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Study subjects or cohorts overlap"}},{"value":"\u2022 prospective\u2022 observational\u2022 performed at one institution","order":8,"name":"Ethics","group":{"name":"EthicsHeading","label":"Methodology"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}