{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T02:28:10Z","timestamp":1793672890510,"version":"4.5.1"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2023,5,12]],"date-time":"2023-05-12T00:00:00Z","timestamp":1683849600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,5,12]],"date-time":"2023-05-12T00:00:00Z","timestamp":1683849600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Regional Innovation and Development Joint Fund of National Natural Science Foundation of China","award":["U22A20345"],"award-info":[{"award-number":["U22A20345"]}]},{"name":"the National Key Research and Development Program of China","award":["2021YFF1201003"],"award-info":[{"award-number":["2021YFF1201003"]}]},{"name":"the National Science Fund for Distinguished Young Scholars","award":["81925023"],"award-info":[{"award-number":["81925023"]}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Scientific Foundation of China","doi-asserted-by":"crossref","award":["82072090"],"award-info":[{"award-number":["82072090"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Guangdong Provincial Key Laboratory of Artificial Intelligence in Medical Image Analysis and Application","award":["2022B1212010011"],"award-info":[{"award-number":["2022B1212010011"]}]},{"DOI":"10.13039\/501100018609","name":"High-level Hospital Construction Project","doi-asserted-by":"crossref","award":["DFJHBF202105"],"award-info":[{"award-number":["DFJHBF202105"]}],"id":[{"id":"10.13039\/501100018609","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Science and technology Projects in Guangzhou","award":["202201020001"],"award-info":[{"award-number":["202201020001"]}]},{"name":"Science and technology Projects in Guangzhou","award":["202201010513"],"award-info":[{"award-number":["202201010513"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Radiol"],"DOI":"10.1007\/s00330-023-09688-9","type":"journal-article","created":{"date-parts":[[2023,5,12]],"date-time":"2023-05-12T09:02:26Z","timestamp":1683882146000},"page":"6861-6871","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["CT morphological features for predicting the risk of lymph node metastasis in T1 colorectal cancer"],"prefix":"10.1007","volume":"33","author":[{"given":"Suyun","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenhui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mimi","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobo","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chutong","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyi","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanting","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3873-9041","authenticated-orcid":false,"given":"Xin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaiyi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,5,12]]},"reference":[{"key":"9688_CR1","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1136\/gutjnl-2015-310691","volume":"66","author":"S Moss","year":"2017","unstructured":"Moss S, Mathews C, Day J et al (2017) Increased uptake and improved outcomes of bowel cancer screening with a faecal immunochemical test: results from a pilot study within the national screening programme in England. Gut 66:1631\u20131644","journal-title":"Gut"},{"key":"9688_CR2","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1136\/gutjnl-2018-316882","volume":"69","author":"JLA Vleugels","year":"2020","unstructured":"Vleugels JLA, Koens L, Dijkgraaf MGW et al (2020) Suboptimal endoscopic cancer recognition in colorectal lesions in a national bowel screening programme. Gut 69:977\u2013980","journal-title":"Gut"},{"key":"9688_CR3","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1007\/s10151-019-02076-w","volume":"23","author":"G Chao","year":"2019","unstructured":"Chao G, Ye F, Li T, Gong W, Zhang S (2019) Estimation of invasion depth of early colorectal cancer using EUS and NBI-ME: a meta-analysis. Tech Coloproctol 23:821\u2013830","journal-title":"Tech Coloproctol"},{"key":"9688_CR4","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1111\/codi.13221","volume":"18","author":"MJ Nam","year":"2016","unstructured":"Nam MJ, Han KS, Kim BC et al (2016) Long-term outcomes of locally or radically resected T1 colorectal cancer. Colorectal Dis 18:852\u2013860","journal-title":"Colorectal Dis"},{"key":"9688_CR5","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1016\/S0140-6736(13)61649-9","volume":"383","author":"H Brenner","year":"2014","unstructured":"Brenner H, Kloor M, Pox CP (2014) Colorectal cancer. Lancet 383:1490\u20131502","journal-title":"Lancet"},{"key":"9688_CR6","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1053\/j.gastro.2020.09.027","volume":"160","author":"S-e Kudo","year":"2021","unstructured":"Kudo S-e, Ichimasa K, Villard B et al (2021) Artificial intelligence system to determine risk of T1 colorectal cancer metastasis to lymph node. Gastroenterology 160:1075\u20131984","journal-title":"Gastroenterology"},{"key":"9688_CR7","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1093\/annonc\/mdx224","volume":"28","author":"R Glynne-Jones","year":"2017","unstructured":"Glynne-Jones R, Wyrwicz L, Tiret E et al (2017) Rectal cancer: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol 28:22\u201340","journal-title":"Ann Oncol"},{"key":"9688_CR8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10147-019-01485-z","volume":"25","author":"Y Hashiguchi","year":"2020","unstructured":"Hashiguchi Y, Muro K, Saito Y et al (2020) Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2019 for the treatment of colorectal cancer. Int J Clin Oncol 25:1\u201342","journal-title":"Int J Clin Oncol"},{"key":"9688_CR9","doi-asserted-by":"crossref","first-page":"329","DOI":"10.6004\/jnccn.2021.0012","volume":"19","author":"AB Benson","year":"2021","unstructured":"Benson AB, Venook AP, Al-Hawary MM et al (2021) Colon cancer, version 2.2021. J Natl Compr Canc Netw 19:329\u2013359","journal-title":"J Natl Compr Canc Netw"},{"key":"9688_CR10","doi-asserted-by":"crossref","first-page":"266","DOI":"10.4174\/astr.2017.93.5.266","volume":"93","author":"RK Ha","year":"2017","unstructured":"Ha RK, Han KS, Sohn DK et al (2017) Histopathologic risk factors for lymph node metastasis in patients with T1 colorectal cancer. Ann Surg Treat Res 93:266\u2013271","journal-title":"Ann Surg Treat Res"},{"key":"9688_CR11","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1038\/modpathol.2010.88","volume":"23","author":"Y Tateishi","year":"2010","unstructured":"Tateishi Y, Nakanishi Y, Taniguchi H, Shimoda T, Umemura S (2010) Pathological prognostic factors predicting lymph node metastasis in submucosal invasive (T1) colorectal carcinoma. Mod Pathol 23:1068\u20131072","journal-title":"Mod Pathol"},{"key":"9688_CR12","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1007\/s003300050632","volume":"9","author":"W Hundt","year":"1999","unstructured":"Hundt W, Braunschweig R, Reiser M (1999) Evaluation of spiral CT in staging of colon and rectum carcinoma. Eur Radiol 9:78\u201384","journal-title":"Eur Radiol"},{"key":"9688_CR13","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1148\/radiol.2311021152","volume":"231","author":"A Filippone","year":"2004","unstructured":"Filippone A, Ambrosini R, Fuschi M, Marinelli T, Genovesi D, Bonomo L (2004) Preoperative T and N staging of colorectal cancer: accuracy of contrast-enhanced multi-detector row CT colonography - initial experience. Radiology 231:83\u201390","journal-title":"Radiology"},{"key":"9688_CR14","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1007\/BF02305790","volume":"3","author":"MA Rodriguez-Bigas","year":"1996","unstructured":"Rodriguez-Bigas MA, Maamoun S, Weber TK, Penetrante RB, Blumenson LE, Petrelli NJ (1996) Clinical significance of colorectal cancer: metastases in lymph nodes < 5 mm in size. Ann Surg Oncol 3:124\u2013130","journal-title":"Ann Surg Oncol"},{"key":"9688_CR15","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1097\/DCR.0000000000000321","volume":"58","author":"G Langman","year":"2015","unstructured":"Langman G, Patel A, Bowley DM (2015) Size and distribution of lymph nodes in rectal cancer resection specimens. Dis Colon Rectum 58:406\u2013414","journal-title":"Dis Colon Rectum"},{"key":"9688_CR16","doi-asserted-by":"crossref","first-page":"984","DOI":"10.2214\/AJR.15.15785","volume":"207","author":"E Nerad","year":"2016","unstructured":"Nerad E, Lahaye MJ, Maas M et al (2016) Diagnostic accuracy of CT for local staging of colon cancer: a systematic review and meta-analysis. AJR Am J Roentgenol 207:984\u2013995","journal-title":"AJR Am J Roentgenol"},{"key":"9688_CR17","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1007\/s00261-019-01900-z","volume":"44","author":"E Rollven","year":"2019","unstructured":"Rollven E, Blomqvist L, Oistamo E, Hjern F, Csanaky G, Abraham-Nordling M (2019) Morphological predictors for lymph node metastases on computed tomography in colon cancer. Abdom Radiol (NY) 44:1712\u20131721","journal-title":"Abdom Radiol (NY)"},{"key":"9688_CR18","doi-asserted-by":"crossref","first-page":"4096","DOI":"10.1007\/s00261-021-03057-0","volume":"46","author":"EK Hong","year":"2021","unstructured":"Hong EK, Landolfi F, Castagnoli F et al (2021) CT for lymph node staging of colon cancer: not only size but also location and number of lymph node count. Abdom Radiol (NY) 46:4096\u20134105","journal-title":"Abdom Radiol (NY)"},{"key":"9688_CR19","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s40644-016-0104-2","volume":"17","author":"E Rollven","year":"2017","unstructured":"Rollven E, Abraham-Nordling M, Holm T, Blomqvist L (2017) Assessment and diagnostic accuracy of lymph node status to predict stage III colon cancer using computed tomography. Cancer Imaging 17:3","journal-title":"Cancer Imaging"},{"key":"9688_CR20","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1007\/s00423-017-1628-z","volume":"402","author":"Y Yamaoka","year":"2017","unstructured":"Yamaoka Y, Kinugasa Y, Shiomi A et al (2017) The distribution of lymph node metastases and their size in colon cancer. Langenbecks Arch Surg 402:1213\u20131221","journal-title":"Langenbecks Arch Surg"},{"key":"9688_CR21","doi-asserted-by":"crossref","first-page":"556","DOI":"10.3748\/wjg.v21.i2.556","volume":"21","author":"J Choi","year":"2015","unstructured":"Choi J, Oh SN, Yeo D-M et al (2015) Computed tomography and magnetic resonance imaging evaluation of lymph node metastasis in early colorectal cancer. World J Gastroenterol 21:556\u2013562","journal-title":"World J Gastroenterol"},{"key":"9688_CR22","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1007\/s00268-018-4824-2","volume":"43","author":"D Kitaguchi","year":"2019","unstructured":"Kitaguchi D, Sasaki T, Nishizawa Y, Tsukada Y, Ito M (2019) Long-term outcomes and lymph node metastasis in patients receiving radical surgery for pathological T1 lower rectal cancer. World J Surg 43:649\u2013656","journal-title":"World J Surg"},{"key":"9688_CR23","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1111\/jgh.13257","volume":"31","author":"H Miyachi","year":"2016","unstructured":"Miyachi H, Kudo S-e, Ichimasa K et al (2016) Management of T1 colorectal cancers after endoscopic treatment based on the risk stratification of lymph node metastasis. J Gastroenterol Hepatol 31:1126\u20131132","journal-title":"J Gastroenterol Hepatol"},{"key":"9688_CR24","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.4143\/crt.2018.569","volume":"51","author":"JR Oh","year":"2019","unstructured":"Oh JR, Park B, Lee S et al (2019) Nomogram development and external validation for predicting the risk of lymph node metastasis in T1 colorectal cancer. Cancer Res Treat 51:1275\u20131284","journal-title":"Cancer Res Treat"},{"key":"9688_CR25","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1007\/s00535-019-01564-y","volume":"54","author":"C Yasue","year":"2019","unstructured":"Yasue C, Chino A, Takamatsu M et al (2019) Pathological risk factors and predictive endoscopic factors for lymph node metastasis of T1 colorectal cancer: a single-center study of 846 lesions. J Gastroenterol 54:708\u2013717","journal-title":"J Gastroenterol"},{"key":"9688_CR26","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1053\/j.gastro.2018.01.023","volume":"154","author":"Y Backes","year":"2018","unstructured":"Backes Y, Elias SG, Groen JN et al (2018) Histologic factors associated with need for surgery in patients with pedunculated T1 colorectal carcinomas. Gastroenterology 154:1647\u20131659","journal-title":"Gastroenterology"},{"key":"9688_CR27","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1053\/j.gastro.2017.11.275","volume":"154","author":"T Ozawa","year":"2018","unstructured":"Ozawa T, Kandimalla R, Gao F et al (2018) A microRNA signature associated with metastasis of T1 colorectal cancers to lymph nodes. Gastroenterology 154:844\u2013848","journal-title":"Gastroenterology"},{"key":"9688_CR28","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1053\/j.gastro.2021.03.062","volume":"161","author":"Y Wada","year":"2021","unstructured":"Wada Y, Shimada M, Murano T et al (2021) A liquid biopsy assay for noninvasive identification of lymph node metastases in T1 colorectal cancer. Gastroenterology 161:151\u2013162","journal-title":"Gastroenterology"},{"key":"9688_CR29","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1007\/s00109-011-0764-0","volume":"89","author":"EL Servais","year":"2011","unstructured":"Servais EL, Colovos C, Bograd AJ, White J, Sadelain M, Adusumilli PS (2011) Animal models and molecular imaging tools to investigate lymph node metastases. J Mol Med-Jmm 89:753\u2013769","journal-title":"J Mol Med-Jmm"},{"key":"9688_CR30","doi-asserted-by":"crossref","first-page":"8223","DOI":"10.1158\/0008-5472.CAN-07-1237","volume":"67","author":"K Hayashi","year":"2007","unstructured":"Hayashi K, Jiang P, Yamauchi K et al (2007) Real-time Imaging of tumor-cell shedding and trafficking in lymphatic channels. Can Res 67:8223\u20138228","journal-title":"Can Res"},{"key":"9688_CR31","volume":"8","author":"L Li","year":"2013","unstructured":"Li L, Mori S, Sakamoto M, Takahashi S, Kodama T (2013) Mouse model of lymph node metastasis via afferent lymphatic vessels for development of imaging modalities. PLoS One 8:e55797","journal-title":"PLoS One"},{"key":"9688_CR32","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1007\/s00384-020-03668-x","volume":"35","author":"K Mochizuki","year":"2020","unstructured":"Mochizuki K, Kudo S-e, Ichimasa K et al (2020) Left-sided location is a risk factor for lymph node metastasis of T1 colorectal cancer: a single-center retrospective study. Int J Colorectal Dis 35:1911\u20131919","journal-title":"Int J Colorectal Dis"},{"key":"9688_CR33","doi-asserted-by":"crossref","first-page":"5095","DOI":"10.1002\/cam4.3114","volume":"9","author":"K Guo","year":"2020","unstructured":"Guo K, Feng Y, Yuan L et al (2020) Risk factors and predictors of lymph nodes metastasis and distant metastasis in newly diagnosed T1 colorectal cancer. Cancer Med 9:5095\u20135113","journal-title":"Cancer Med"},{"key":"9688_CR34","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1007\/s10147-020-01642-9","volume":"25","author":"A Ouchi","year":"2020","unstructured":"Ouchi A, Toriyama K, Kinoshita T et al (2020) Variations in clinical features and oncologic behaviors of T1 colorectal cancer according to tumor location. Int J Clin Oncol 25:1130\u20131136","journal-title":"Int J Clin Oncol"},{"key":"9688_CR35","doi-asserted-by":"crossref","first-page":"4401","DOI":"10.1200\/JCO.2011.36.4414","volume":"29","author":"JM Weiss","year":"2011","unstructured":"Weiss JM, Pfau PR, O\u2019Connor ES et al (2011) Mortality by stage for right- versus left-sided colon cancer: analysis of surveillance, epidemiology, and end results-Medicare data. J Clin Oncol 29:4401\u20134409","journal-title":"J Clin Oncol"},{"key":"9688_CR36","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1186\/s12943-018-0923-9","volume":"17","author":"R Imperial","year":"2018","unstructured":"Imperial R, Ahmed Z, Toor OM et al (2018) Comparative proteogenomic analysis of right-sided colon cancer, left-sided colon cancer and rectal cancer reveals distinct mutational profiles. Mol Cancer 17:177","journal-title":"Mol Cancer"},{"key":"9688_CR37","doi-asserted-by":"crossref","first-page":"7217","DOI":"10.1007\/s00330-021-07795-z","volume":"31","author":"FHJ Elsholtz","year":"2021","unstructured":"Elsholtz FHJ, Asbach P, Haas M et al (2021) Introducing the Node Reporting and Data System 1.0 (Node-RADS): a concept for standardized assessment of lymph nodes in cancer. Eur Radiol 31:7217\u20137217","journal-title":"Eur Radiol"},{"key":"9688_CR38","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1159\/000487239","volume":"80","author":"MR Patel","year":"2018","unstructured":"Patel MR, Hudgins PA, Beitler JJ et al (2018) Radiographic imaging does not reliably predict macroscopic extranodal extension in human papilloma virus-associated oropharyngeal cancer. ORL J Otorhinolaryngol Relat Spec 80:85\u201395","journal-title":"ORL J Otorhinolaryngol Relat Spec"},{"key":"9688_CR39","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1259\/0007-1285-68-807-266","volume":"68","author":"HJ Steinkamp","year":"1995","unstructured":"Steinkamp HJ, Cornehl M, Hosten N, Pegios W, Vogl T, Felix R (1995) Cervical lymphadenopathy: ratio of long- to short-axis diameter as a predictor of malignancy. Br J Radiol 68:266\u2013270","journal-title":"Br J Radiol"},{"key":"9688_CR40","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0201072","volume":"13","author":"P Schrembs","year":"2018","unstructured":"Schrembs P, Martin B, Anthuber M, Schenkirsch G, Maerkl B (2018) The prognostic significance of lymph node size in node-positive colon cancer. PLoS One 13:e0201072","journal-title":"PLoS One"},{"key":"9688_CR41","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1148\/radiology.205.3.9393544","volume":"205","author":"J Feu","year":"1997","unstructured":"Feu J, Tresserra F, Fabregas R et al (1997) Metastatic breast carcinoma in axillary lymph nodes: in vitro US detection. Radiology 205:831\u2013835","journal-title":"Radiology"},{"key":"9688_CR42","first-page":"315","volume":"76","author":"JA Rosa","year":"2021","unstructured":"Rosa JA, Calle-Toro JS, Kidd M, Andronikou S (2021) Normal head and neck lymph nodes in the paediatric population. Clin Radiol 76:315","journal-title":"Clin Radiol"}],"container-title":["European Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00330-023-09688-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00330-023-09688-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00330-023-09688-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T12:12:38Z","timestamp":1695211958000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00330-023-09688-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,12]]},"references-count":42,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2023,10]]}},"alternative-id":["9688"],"URL":"https:\/\/doi.org\/10.1007\/s00330-023-09688-9","relation":{},"ISSN":["1432-1084"],"issn-type":[{"value":"1432-1084","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,12]]},"assertion":[{"value":"26 May 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 February 2023","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 February 2023","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 May 2023","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The scientific guarantor of this publication is Zaiyi Liu.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Guarantor"}},{"value":"The authors of this manuscript declare no relationships with any companies whose products or services may be related to the subject matter of the article.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Suyun Li, Mimi Wu, and Xin Chen kindly provided statistical advice for this manuscript.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Statistics and biometry"}},{"value":"Written informed consent was waived by the Institutional Review Board.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"Institutional Review Board approval was obtained.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The study subjects or cohorts have never been previously reported.","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Study subjects or cohorts overlap"}},{"value":"\u2022 Retrospective\u2022 Diagnostic or prognostic study\u2022 Multicenter study","order":8,"name":"Ethics","group":{"name":"EthicsHeading","label":"Methodology"}}]}}