{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:50:46Z","timestamp":1761061846646,"version":"3.37.3"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,8,2]],"date-time":"2023-08-02T00:00:00Z","timestamp":1690934400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,8,2]],"date-time":"2023-08-02T00:00:00Z","timestamp":1690934400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Agence R\u00e9gionale de Sant\u00e9"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Radiol"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Objectives<\/jats:title>\n                <jats:p>To evaluate the prevalence of intra-myocardial fatty scars (IMFS) most likely indicating previous silent myocardial infarction (SMI), as detected on coronary artery calcium (CAC) computed tomography (CT) scans in diabetic patients without history of coronary heart disease (CHD).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Diabetic patients screened for silent coronary insufficiency in a tertiary-care, university hospital between Jan-2015 and Dec-2016 were categorized according to their CAC score in two groups comprising 242 patients with CACS\u2009=\u20090 and 145 patients with CACS\u2009\u2265\u2009300. CAC-CT scans were retrospectively evaluated for subendorcardial and transmural IMFS of the left ventricle. Adipose remodeling, patients\u2019 characteristics, cardiovascular risk factors and metabolic profile were compared between groups.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Eighty-three (21%) patients with IMFS were identified, 55 (37.9%) in the group CACS\u2009\u2265\u2009300 and 28 (11.6%) in the CACS\u2009=\u20090 (OR\u2009=\u20094.67; 95% CI\u2009=\u20092.78\u20137.84; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Total and average surface of IMFS and their number per patient were similar in both groups (<jats:italic>p<\/jats:italic>\u2009=\u20090.55; <jats:italic>p<\/jats:italic>\u2009=\u20090.29; <jats:italic>p<\/jats:italic>\u2009=\u20090.61, respectively). In the group CACS\u2009\u2265\u2009300, patients with IMFS were older (<jats:italic>p<\/jats:italic>\u2009=\u20090.03) and had longer-lasting diabetes (<jats:italic>p<\/jats:italic>\u2009=\u20090.04). Patients with IMFS were older and had longer history of diabetes, reduced glomerular filtration rate, more coronary calcifications (all <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05), and higher prevalence of carotid plaques (OR\u2009=\u20093.03; 95% CI\u2009=\u20091.43\u20136.39, <jats:italic>p<\/jats:italic>\u2009=\u20090.004). After correction for other variables, only a CACS\u2009\u2265\u2009300 (OR\u2009=\u20095.12; 95% CI\u2009=\u20092.66\u20139.85; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) was associated with an increased risk of having IMFS.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>In diabetic patients without known CHD, IMFSs were found in patients without coronary calcifications, although not as frequently as in patients with heavily calcified coronary arteries. It remains to be established if this marker translates in an upwards cardiovascular risk restratification especially in diabetic patients with CACS\u2009=\u20090.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Clinical relevance statement<\/jats:title>\n                <jats:p>In diabetic patients without history of coronary heart disease, intramyocardial fatty scars, presumably of post-infarction origin, can be detected on coronary artery calcium CT scans more frequently, but not exclusively, if the coronary arteries are heavily calcified as compared to those without calcifications.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Key Points<\/jats:title>\n                <jats:p><jats:italic>\u2022 Intramyocardial fatty scars (IMFS), presumably of post-infarction origin, can be detected on coronary artery calcium (CAC) CT scans more frequently, but not exclusively, in diabetic patients with CACS\u2009\u2265\u2009300 as compared to patients CACS\u2009=\u20090.<\/jats:italic><\/jats:p>\n                <jats:p><jats:italic>\u2022 Patients with IMFS were older and had longer history of diabetes, reduced glomerular filtration rate, and more coronary calcifications.<\/jats:italic><\/jats:p>\n                <jats:p><jats:italic>\u2022 Carotid plaques and CACS\u2009\u2265\u2009300 were associated with an increased risk of having IMFS, about three and five folds respectively.<\/jats:italic><\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00330-023-09940-2","type":"journal-article","created":{"date-parts":[[2023,8,2]],"date-time":"2023-08-02T13:02:26Z","timestamp":1690981346000},"page":"214-225","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Silent myocardial infarction fatty scars detected by coronary calcium score CT scan in diabetic patients without history of coronary heart disease"],"prefix":"10.1007","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1829-5834","authenticated-orcid":false,"given":"Sara","family":"Boccalini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie","family":"Teulade","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilie","family":"Paquet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salim","family":"Si-Mohamed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Rapallo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Moreau-Triby","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sybil","family":"Charri\u00e8re","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathan","family":"Mewton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Loic","family":"Boussel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cyrille","family":"Bergerot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Douek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Moulin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,8,2]]},"reference":[{"key":"9940_CR1","doi-asserted-by":"publisher","first-page":"1527","DOI":"10.1161\/01.CIR.0000091257.27563.32","volume":"108","author":"MA Creager","year":"2003","unstructured":"Creager MA, L\u00fcscher TF, Cosentino F, Beckman JA (2003) Diabetes and vascular disease. Pathophysiology, clinical consequences, and medical therapy: part I. Circulation 108:1527\u20131532. https:\/\/doi.org\/10.1161\/01.CIR.0000091257.27563.32","journal-title":"Circulation"},{"key":"9940_CR2","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.acvd.2010.11.013","volume":"104","author":"P Valensi","year":"2011","unstructured":"Valensi P, Lorgis L, Cottin Y (2011) Prevalence, incidence, predictive factors and prognosis of silent myocardial infarction: a review of the literature. Arch Cardiovasc Dis 104:178\u2013188. https:\/\/doi.org\/10.1016\/j.acvd.2010.11.013","journal-title":"Arch Cardiovasc Dis"},{"key":"9940_CR3","doi-asserted-by":"publisher","first-page":"3035","DOI":"10.1093\/eurheartj\/eht108","volume":"34","author":"L Ryden","year":"2013","unstructured":"Ryden L, Grant PJ, Anker SD et al (2013) ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD. Eur Heart J 34:3035\u20133087. https:\/\/doi.org\/10.1093\/eurheartj\/eht108","journal-title":"Eur Heart J"},{"key":"9940_CR4","doi-asserted-by":"publisher","first-page":"2101","DOI":"10.2337\/dc11-0480","volume":"34","author":"E Cosson","year":"2011","unstructured":"Cosson E, Nguyen MT, Chanu B et al (2011) Cardiovascular risk prediction is improved by adding asymptomatic coronary status to routine risk assessment in type 2 diabetic patients. Diabetes Care 34:2101\u20132107. https:\/\/doi.org\/10.2337\/dc11-0480","journal-title":"Diabetes Care"},{"key":"9940_CR5","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1093\/eurheartj\/ehz486","volume":"41","author":"F Cosentino","year":"2020","unstructured":"Cosentino F, Grant PJ, Aboyans V et al (2020) 2019 ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD. Eur Heart J 41:255\u2013323. https:\/\/doi.org\/10.1093\/eurheartj\/ehz486","journal-title":"Eur Heart J"},{"key":"9940_CR6","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1093\/eurheartj\/ehi808","volume":"27","author":"DV Anand","year":"2006","unstructured":"Anand DV, Lim E, Hopkins D et al (2006) Risk stratification in uncomplicated type 2 diabetes: prospective evaluation of the combined use of coronary artery calcium imaging and selective myocardial perfusion scintigraphy. Eur Heart J 27:713\u2013721. https:\/\/doi.org\/10.1093\/eurheartj\/ehi808","journal-title":"Eur Heart J"},{"key":"9940_CR7","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/S1054-8807(03)00134-0","volume":"13","author":"L Su","year":"2004","unstructured":"Su L, Siegel JE, Fishbein MC (2004) Adipose tissue in myocardial infarction. Cardiovasc Pathol 13:98\u2013102. https:\/\/doi.org\/10.1016\/S1054-8807(03)00134-0","journal-title":"Cardiovasc Pathol"},{"key":"9940_CR8","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1016\/j.jcmg.2009.01.010","volume":"2","author":"Y Ichikawa","year":"2009","unstructured":"Ichikawa Y, Kitagawa K, Chino S et al (2009) Adipose tissue detected by multislice computed tomography in patients after myocardial infarction. J Am Coll Cardiol 2:548\u2013555. https:\/\/doi.org\/10.1016\/j.jcmg.2009.01.010","journal-title":"J Am Coll Cardiol"},{"key":"9940_CR9","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.jcct.2009.12.003","volume":"4","author":"GA Rodr\u00edguez-Granillo","year":"2010","unstructured":"Rodr\u00edguez-Granillo GA, Rosales MA, Renes P et al (2010) Chronic myocardial infarction detection and characterization during coronary artery calcium scoring acquisitions. J Cardiovasc Comput Tomogr 4:99\u2013107. https:\/\/doi.org\/10.1016\/j.jcct.2009.12.003","journal-title":"J Cardiovasc Comput Tomogr"},{"key":"9940_CR10","doi-asserted-by":"publisher","first-page":"1920","DOI":"10.1007\/s00259-012-2212-y","volume":"39","author":"TA Fuchs","year":"2012","unstructured":"Fuchs TA, Ghadri JR, Stehli J et al (2012) Hypodense regions in unenhanced CT identify nonviable myocardium: validation versus 18F-FDG PET. Eur J Nucl Med Mol Imaging 39:1920\u20131926. https:\/\/doi.org\/10.1007\/s00259-012-2212-y","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"9940_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1161\/JAHA.119.012482","volume":"8","author":"G Cheniti","year":"2019","unstructured":"Cheniti G, Sridi S, Sacher F et al (2019) Post\u2013myocardial infarction scar with fat deposition shows specific electrophysiological properties and worse outcome after ventricular tachycardia ablation. J Am Heart Assoc 8:1\u201311. https:\/\/doi.org\/10.1161\/JAHA.119.012482","journal-title":"J Am Heart Assoc"},{"key":"9940_CR12","doi-asserted-by":"publisher","first-page":"980","DOI":"10.1161\/CIRCULATIONAHA.112.000908","volume":"127","author":"TME Davis","year":"2013","unstructured":"Davis TME, Coleman RL, Holman RR (2013) Prognostic significance of silent myocardial infarction in newly diagnosed type 2 diabetes mellitus: United Kingdom prospective diabetes study (UKPDS) 79. Circulation 127:980\u2013987. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.112.000908","journal-title":"Circulation"},{"key":"9940_CR13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0251693","volume":"16","author":"M Gaudilli\u00e8re","year":"2021","unstructured":"Gaudilli\u00e8re M, Marsot C, Balaire L et al (2021) Higher prevalence of incidental findings identified upon coronary calcium score assessment in type 2 and type 3 diabetes versus type 1 diabetes. PLoS One 16:1\u201311. https:\/\/doi.org\/10.1371\/journal.pone.0251693","journal-title":"PLoS One"},{"key":"9940_CR14","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.jcmg.2015.11.011","volume":"9","author":"MJ Budoff","year":"2016","unstructured":"Budoff MJ, Raggi P, Beller GA et al (2016) Noninvasive cardiovascular risk assessment of the asymptomatic diabetic patient. JACC Cardiovasc Imaging 9:176\u2013192. https:\/\/doi.org\/10.1016\/j.jcmg.2015.11.011","journal-title":"JACC Cardiovasc Imaging"},{"key":"9940_CR15","doi-asserted-by":"publisher","first-page":"1336","DOI":"10.1056\/nejmoa072100","volume":"358","author":"R Detrano","year":"2008","unstructured":"Detrano R, Guerci AD, Carr JJ et al (2008) Coronary calcium as a predictor of coronary events in four racial or ethnic groups. N Engl J Med 358:1336\u20131345. https:\/\/doi.org\/10.1056\/nejmoa072100","journal-title":"N Engl J Med"},{"key":"9940_CR16","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1161\/CIRCULATIONAHA.107.727826","volume":"118","author":"RY Kwong","year":"2008","unstructured":"Kwong RY, Sattar H, Wu H et al (2008) Incidence and prognostic implication of unrecognized myocardial scar characterized by cardiac magnetic resonance in diabetic patients without clinical evidence of myocardial infarction. Circulation 118:1011\u20131020. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.107.727826","journal-title":"Circulation"},{"key":"9940_CR17","doi-asserted-by":"publisher","first-page":"2722","DOI":"10.2337\/diacare.28.11.2722","volume":"28","author":"P Valensi","year":"2005","unstructured":"Valensi P, Pari\u00e8s J, Brulport-Cerisier V et al (2005) Predictive value of silent myocardial ischemia for cardiac events in diabetic patients: influence of age in a French multicenter study. Diabetes Care 28:2722\u20132727. https:\/\/doi.org\/10.2337\/diacare.28.11.2722","journal-title":"Diabetes Care"},{"key":"9940_CR18","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1093\/eurheartj\/ehp377","volume":"31","author":"DC Burgess","year":"2010","unstructured":"Burgess DC, Hunt D, Li L et al (2010) Incidence and predictors of silent myocardial infarction in type 2 diabetes and the effect of fenofibrate: an analysis from the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study. Eur Heart J 31:92\u201399. https:\/\/doi.org\/10.1093\/eurheartj\/ehp377","journal-title":"Eur Heart J"},{"key":"9940_CR19","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1148\/radiol.11110967","volume":"262","author":"YE Yoon","year":"2012","unstructured":"Yoon YE, Kitagawa K, Kato S et al (2012) Prognostic significance of unrecognized myocardial infarction detected with MR imaging in patients with impaired fasting glucose compared with those with diabetes. Radiology 262:807\u2013815. https:\/\/doi.org\/10.1148\/radiol.11110967","journal-title":"Radiology"},{"key":"9940_CR20","first-page":"65","volume":"13","author":"G Baroldi","year":"1997","unstructured":"Baroldi G, Silver MD, De Maria R et al (1997) Lipomatous metaplasia in left ventricular scar. Can J Cardiol 13:65\u201371","journal-title":"Can J Cardiol"},{"key":"9940_CR21","doi-asserted-by":"publisher","unstructured":"Feng Y, Chen F, Xie Y et al (2013) Lipomatous metaplasia identified in rabbits with reperfused myocardial infarction by 3 . 0 T magnetic resonance imaging and histopathology. BMC Med Imaging 13:18. https:\/\/doi.org\/10.1186\/1471-2342-13-18","DOI":"10.1186\/1471-2342-13-18"},{"key":"9940_CR22","doi-asserted-by":"publisher","unstructured":"Pouliopoulos J, Chik WWB, Kanthan A et al (2013) Intramyocardial adiposity after myocardial infarction new implications of a substrate for ventricular tachycardia. Circulation 128:2296\u20132308. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.113.002238","DOI":"10.1161\/CIRCULATIONAHA.113.002238"},{"key":"9940_CR23","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1148\/radiol.2532082290","volume":"253","author":"JW Goldfarb","year":"2009","unstructured":"Goldfarb JW, Roth M, Han J (2009) Myocardial fat deposition after left ventricular myocardial infarction: assessment by using MR water-fat separation imaging. Radiology 253:65\u201373. https:\/\/doi.org\/10.1148\/radiol.2532082290","journal-title":"Radiology"},{"key":"9940_CR24","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1016\/j.jcmg.2014.07.024","volume":"8","author":"IM Mbchb","year":"2015","unstructured":"Mbchb IM, Radjenovic A, Mbchb TS et al (2015) Prevalence and prognostic significance of lipomatous metaplasia in patients with prior myocardial infarction. JACC Cardiovasc Imaging 8:1111\u20131112. https:\/\/doi.org\/10.1016\/j.jcmg.2014.07.024","journal-title":"JACC Cardiovasc Imaging"},{"key":"9940_CR25","doi-asserted-by":"publisher","first-page":"1587","DOI":"10.1148\/rg.306105519","volume":"30","author":"F Kimura","year":"2010","unstructured":"Kimura F, Matsuo Y, Nakajima T et al (2010) Myocardial fat at cardiac imaging: how can we differentiate pathologic from physiologic fatty infiltration? Radiographics 30:1587\u20131602. https:\/\/doi.org\/10.1148\/rg.306105519","journal-title":"Radiographics"},{"key":"9940_CR26","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1007\/s10554-013-0243-5","volume":"29","author":"EA Park","year":"2013","unstructured":"Park EA, Lee W, Na SH et al (2013) Left ventricular fat deposition on CT in patients without proven myocardial disease. Int J Cardiovasc Imaging 29:37\u201345. https:\/\/doi.org\/10.1007\/s10554-013-0243-5","journal-title":"Int J Cardiovasc Imaging"},{"key":"9940_CR27","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.jcct.2008.01.004","volume":"2","author":"AR Raney","year":"2008","unstructured":"Raney AR, Saremi F, Kenchaiah S et al (2008) Multidetector computed tomography shows intramyocardial fat deposition. J Cardiovasc Comput Tomogr 2:152\u2013163. https:\/\/doi.org\/10.1016\/j.jcct.2008.01.004","journal-title":"J Cardiovasc Comput Tomogr"},{"key":"9940_CR28","doi-asserted-by":"publisher","first-page":"3082","DOI":"10.1007\/s00330-017-5264-3","volume":"28","author":"D Bos","year":"2018","unstructured":"Bos D, Leening MJG (2018) Leveraging the coronary calcium scan beyond the coronary calcium score. Eur Radiol 28:3082\u20133087","journal-title":"Eur Radiol"},{"key":"9940_CR29","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1007\/s00125-004-1344-4","volume":"47","author":"TME Davis","year":"2004","unstructured":"Davis TME, Fortun P, Mulder J et al (2004) Silent myocardial infarction and its prognosis in a community-based cohort of type 2 diabetic patients: the Fremantle Diabetes Study. Diabetologia 47:395\u2013399. https:\/\/doi.org\/10.1007\/s00125-004-1344-4","journal-title":"Diabetologia"},{"key":"9940_CR30","doi-asserted-by":"publisher","first-page":"1290","DOI":"10.2337\/dc18-2266","volume":"42","author":"MD Elliott","year":"2019","unstructured":"Elliott MD, Heitner JF, Kim H et al (2019) Prevalence and prognosis of unrecognized myocardial infarction in asymptomatic patients with diabetes: a two-center study with up to 5 years of follow-up. Diabetes Care 42:1290\u20131296. https:\/\/doi.org\/10.2337\/dc18-2266","journal-title":"Diabetes Care"},{"key":"9940_CR31","doi-asserted-by":"publisher","first-page":"1773","DOI":"10.1016\/j.jcmg.2018.02.009","volume":"11","author":"RP Amier","year":"2018","unstructured":"Amier RP, Smulders MW, van der Flier WM et al (2018) Long-term prognostic implications of previous silent myocardial infarction in patients presenting with acute myocardial infarction. JACC Cardiovasc Imaging 11:1773\u20131781. https:\/\/doi.org\/10.1016\/j.jcmg.2018.02.009","journal-title":"JACC Cardiovasc Imaging"},{"key":"9940_CR32","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.atherosclerosis.2011.06.044","volume":"220","author":"Y Inaba","year":"2012","unstructured":"Inaba Y, Chen JA, Bergmann SR (2012) Carotid plaque, compared with carotid intima-media thickness, more accurately predicts coronary artery disease events: a meta-analysis. Atherosclerosis 220:128\u2013133. https:\/\/doi.org\/10.1016\/j.atherosclerosis.2011.06.044","journal-title":"Atherosclerosis"},{"key":"9940_CR33","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1111\/jdi.12403","volume":"7","author":"S Akazawa","year":"2016","unstructured":"Akazawa S, Tojikubo M, Nakano Y et al (2016) Usefulness of carotid plaque (sum and maximum of plaque thickness) in combination with intima-media thickness for the detection of coronary artery disease in asymptomatic patients with diabetes. J Diabetes Investig 7:396\u2013403. https:\/\/doi.org\/10.1111\/jdi.12403","journal-title":"J Diabetes Investig"},{"key":"9940_CR34","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1016\/S0140-6736(03)12389-6","volume":"361","author":"A Wagner","year":"2003","unstructured":"Wagner A, Mahrholdt H, Holly TA et al (2003) Contrast-enhanced MRI and routine single photon emission computed tomography (SPECT) perfusion imaging for detection of subendocardial myocardial infarcts: an imaging study. Lancet 361:374\u2013379. https:\/\/doi.org\/10.1016\/S0140-6736(03)12389-6","journal-title":"Lancet"},{"key":"9940_CR35","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/j.jacc.2006.08.047","volume":"49","author":"T Ibrahim","year":"2007","unstructured":"Ibrahim T, B\u00fclow HP, Hackl T et al (2007) Diagnostic value of contrast-enhanced magnetic resonance imaging and single-photon emission computed tomography for detection of myocardial necrosis early after acute myocardial infarction. J Am Coll Cardiol 49:208\u2013216. https:\/\/doi.org\/10.1016\/j.jacc.2006.08.047","journal-title":"J Am Coll Cardiol"},{"key":"9940_CR36","doi-asserted-by":"publisher","first-page":"15","DOI":"10.5530\/jcdr.2018.1.4","volume":"9","author":"A Bucha","year":"2018","unstructured":"Bucha A, D\u2019Souza J, Pant R, Joseph JM (2018) Delayed hyper-enhancement in cardiac MRI compared to nuclear perfusion scintigraphy in identification of viable myocardium in patients of myocardial infarction - a study. J Cardiovasc Dis Res 9:15\u201319. https:\/\/doi.org\/10.5530\/jcdr.2018.1.4","journal-title":"J Cardiovasc Dis Res"},{"key":"9940_CR37","doi-asserted-by":"publisher","first-page":"25","DOI":"10.2214\/AJR.08.1389","volume":"193","author":"JM Andrade","year":"2009","unstructured":"Andrade JM, Gowdak LHW, Giorgi MCP et al (2009) Cardiac MRI for detection of unrecognized myocardial infarction in patients with end-stage renal disease: comparison with ECG and scintigraphy. AJR Am J Roentgenol 193:25\u201332. https:\/\/doi.org\/10.2214\/AJR.08.1389","journal-title":"AJR Am J Roentgenol"},{"key":"9940_CR38","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1148\/radiol.2261012108","volume":"226","author":"K Kitagawa","year":"2003","unstructured":"Kitagawa K, Sakuma H, Hirano T et al (2003) Acute myocardial infarction: myocardial viability assessment in patients early thereafter\u2014comparison of contrast-enhanced MR imaging with resting 201 Tl SPECT. Radiology 226:138\u2013144. https:\/\/doi.org\/10.1148\/radiol.2261012108","journal-title":"Radiology"}],"container-title":["European Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00330-023-09940-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00330-023-09940-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00330-023-09940-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,12]],"date-time":"2024-07-12T10:03:34Z","timestamp":1720778614000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00330-023-09940-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,2]]},"references-count":38,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,1]]}},"alternative-id":["9940"],"URL":"https:\/\/doi.org\/10.1007\/s00330-023-09940-2","relation":{},"ISSN":["1432-1084"],"issn-type":[{"type":"electronic","value":"1432-1084"}],"subject":[],"published":{"date-parts":[[2023,8,2]]},"assertion":[{"value":"5 December 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 May 2023","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 May 2023","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 August 2023","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The scientific guarantor of this publication is Pr Philippe Moulin.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Guarantor"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Fabio Rapallo kindly provided statistical advice for this manuscript.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Statistics and biometry"}},{"value":"Written informed consent was waived by the Institutional Review Board.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"Institutional Review Board approval was obtained.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The same cohort of patients has already been the object of a previous analysis: \u201cHigher prevalence of incidental findings identified upon coronary calcium score assessment in type 2 and type 3 diabetes versus type 1 diabetes\u201d by M Gaudilli\u00e8re, C Marsot, L Balaire, L Groisne, M Moret, S Villar-Fimbel, P Douek, P Moulin and S Charri\u00e8re, . However, the previous study examined completely different variables than the ones we have focused on in the present study. Therefore, there is no overlap with the present study.","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Study subjects or cohorts overlap"}},{"value":"\u2022 retrospective\u2022 cross sectional study\u2022 performed at one institution","order":8,"name":"Ethics","group":{"name":"EthicsHeading","label":"Methodology"}}]}}